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Breakthrough in understanding how cancer cells ‘hijack’ and
spread
A new research study is investigating how cancer cells spread around the body.
A BREAKTHROUGH IN investigating how cancer cells spread around the body has
been reported at the annual Royal College of Surgeons in Ireland research day.
The research examines how cancer cells ‘hijack’ blood cells known as platelets,
enabling cancer to spread around the body and promoting the growth of new
tumours.
Professor Niamh Moran, Associate Professor in Molecular and Cellular therapeutics
explained:
This is the first time that the exact molecular mechanisms at play between prostate
cancer cells and platelets have been understood. It was already known that cancer
patients with a higher platelet count had worse outcomes but we now know what
causes this negative effect. Our study paves the way for the development of new
anti-cancer treatments that may potentially prevent the spread of cancer.
The research shows that cancer cells cause clusters of platelets to establish new
blood vessels, and also to clot around the cancer cell, protecting it from the body’s
immune system. This enables the cancer to spread to other parts of the body.
The first author on the study was PhD student Annachiara Mitrugno who worked in
collaboration with Professor Moran and Professor David Williams, Associate
Professor in Geriatric and Stroke Medicine, RCSI and Beaumont Hospital.
Research day
RCSI’s annual Research Day provides scientists with the opportunity to showcase
their most recent research findings.
It also heard new insights into bone disease caused by multi-resistant bacteria,
MRSA, which is a growing problem. Bone disease affects one in 5,000 people
around the world.
RCSI researchers have discovered that the ability of Staphylococcus aureus, which
causes the disease, to latch onto bone cells depends on a specific protein on the
bacterium’s surface called ‘Spa’.
Once attached to the bone cell via Spa, the bacteria transmit signals prompting the
bone to stop growing. The protein is also responsible for causing destructive
inflammation in the bone. The gradual loss of bone cells leads to bone destruction
and weakening of the skeletal system.
Dr Steve Kerrigan, principal investigator on the research, explained that blocking
bacterial attachment to cells via Spa could be a way of treating the disease, or even
preventing it.