Download View Presentation - Ayurveda Pancreatitis Clinic

A Collaborative Project of Uttarakhand Council of
Science and Technology (UCOST) and Vaidya
Chandra Prakash Cancer Research Foundation
(VCPCRF), Dehradun, Uttarakhand, India
Opportunity

India is the only country in the world
where different systems of medicines like
Ayurveda, Unani, Siddha, Homeopathy
and Naturopathy are officially recognized
as independent medical systems in
conjunction with western medicine
(allopath).
Opportunity- II
A registered physician of Ayurveda and
Unani can prepare medicines for the use
in his own clinical practice without
obtaining manufacturing license
 Integrated system of education and
research
 Blending of modern diagnostics with
traditional knowledge
 Scope
of
documentation
(GCP
guidelines)

Positivism: A Scientific Approach
Observation
Drug
Discovery
15 years
$1.8 billion
Hypothesis
Penicillin
Nitrous Oxide
Theory
Discovery & Development of Nitrous Oxide and
Penicillin
Acute Promyelocytic Leukemia : Model Studied
Under GOI(1997-2000)
Observation
Preliminary Study:
Sorting out of patients of APML
Pilot Study:
1.
Bone marrow aspiration peripheral blood smear measurement
2.
Liver and kidney function test for toxicological evaluation
 Hypothesis
Can silver based compound be effective for treating APML Patients?
 Methodology
1. Standardization of raw material
2. Development of in-process quality control technique
3. Standardization of finished products
4. Toxicological studies
5. Effective dose studies
6. Human trials

Acute Promyelocytic Leukemia Model
Studied (Outcome and Current Scenario)



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
US and European patent 191708 dated
08/23/1999 through NDRC, Govt. of India
Padamashri by President of India 1999
Prakash et al. 2010. Herbo-mineral ayurvedic
treatment in a high risk acute promyelocytic
leukemia patient with second relapse: 12
years follow up J-AIM, 1, (3): 215-218
Limited availability of treatment…
Waste of time, resources and efforts…
Revisiting the Rationality:
Partnership with UCOST
Theme:
Chronic Pancreatitis
What is Chronic Pancreatitis?
Chronic Pancreatitis (CP) is a progressive
inflammatory disease of the Pancreas
 Irreversible morphological changes
 Primary symptoms- recurrent abdominal and back
pain, indigestion , nausea , vomiting ,
steatorrhorea with weight loss
 Mild elevation of Serum Amylase and Lipase
 Diagnostics: X-Ray, Ultra Sound, CT Scan, ERCP &
MRCP

What is the cause of CP?
Heavy and prolonged use of alcohol
(Though only 3% alcoholic develop CP)
 Smoking, high fat diet and stress
 Commonly used etiological classification:
TIGAR-O

T- Toxins
I- Idiopathic
G- Genetic
A- Auto immune
R- Recurrent
O -Obstructive

Tropical CP – India, Africa and South
America
Prevalence and impact of CP
Worldwide increasing incidence
 1.6 to 23/1,00,000. South India 114/1,00,000
 Rising cost of hospitalization and medicines
 340 million dollar annual sale of Creon
(Pancrelipase)

(Source: Abbot Pharmaceuticals 2011)
Six more brands* available in global market.
 Total annual sale > one billion US Dollar
 32% mortality (104 months follow up)
 Progression to fibrosis, Pancreatic ascitis and
cancer

*Pancreaze, Pertzye, Ultresa,Viokace, Zenpep and Lipancreatin
Conventional Treatment of CP
 Life
long enzymes
 Periodical Emergency hospitalisation –
IV fluids, painkillers, anti-inflammatory,
enzymes and antibiotic
 ERCP stenting
 Surgical intervention
 It involves high cost, side effects and
in many case progression of disease
Ayurvedic Treatment for CP
 Single mineral complex in a daily dose of 125 mg





three times a day with high protein diet
One year duration
Effects start from the day one and remain
sustainable
Astonishing success stories with no side effects
End product is devoid of free metals
In house animal studies – No Grade II toxicity
Future Direction
Need of R & D to ascertain:
- Reproducibly, Characterisation
- Experimental & clinical studies
 Continuity of treatment through Speciality
Ayurvedic Clinics (SAC) in India; presently at
Dehradun and Kolkata
 Systematic development of NEW CLINICAL
ENTITY (NCE)
 Availability within India and other countries
following the regulations

Current Scenario
Strong evidence of clinical efficacy
(over 30 years of experience)
 Rich traditional literature
 Scientific and technological inputs
 Raw material and manpower
 Need of the society
 Regulations and resources…..

Highlights of the Project (7 years)
Standardization of raw material
Development of in process quality
control technique
Standardization of finished products
Toxicological Evaluation
Effective dose studies
Human trials
Three
Years
Two
Years
Two
Years
Proposed Partners
 IIT
Roorkee, Uttarakhand
 Wadia Institute of Himalayan
Studies, Dehradun
 Uttarakhand Medical University,
Srinagar
 Paramedical and Medical Institutes
of Uttarakhand
Budgetary Requirement
1st
Year
2nd
Year
3rd
4th
Year Year
Amount
in Rs.
94.25 68.15 70.50 70.00
lacs
5th
Year
6th
Year
7th
Year
100.00 57.50 47.50
A total of Rs. Five Crore Seven Lacs Ninety Thousand
will be required in seven years limited period
Benefits
Innovation in the treatment of Chronic
Pancreatitis from Uttarakhand
 Big boost to scientific Ayurveda
 Substantial savings of resources and human
lives
 Forex earning and revenue generation
 Pride to State, Country and Ayurveda

Need
SALVO ACTION
All power is within you. You can do anything and
everything. Believe in that. Do not believe that you
are weak; do not believe that you are half-crazy
lunatics, as most of us do nowadays. Stand up
and express the divinity within you.
- Swami Vivekanada