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Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes by Kai Kisand, Maire Link, Anette S. B. Wolff, Anthony Meager, Liina Tserel, Tõnis Org, Astrid Murumägi, Raivo Uibo, Nick Willcox, Katarina Trebušak Podkrajšek, Tadej Battelino, Anna Lobell, Olle Kämpe, Kari Lima, Antonella Meloni, Berrin ErgunLongmire, Noel K. Maclaren, Jaakko Perheentupa, Kai J. E. Krohn, Hamish S. Scott, Eystein S. Husebye, and Pärt Peterson Blood Volume 112(7):2657-2666 October 1, 2008 ©2008 by American Society of Hematology Microarray analysis of APECED and control monocytes and monocyte-derived DCs. (A) The gene expression profiles (log2 of fold change between APECED patient A8 and control 2) of 61 differentially expressed ISGs in monocytes, iDCs, and mDCs. Kai Kisand et al. Blood 2008;112:2657-2666 ©2008 by American Society of Hematology Decreased expression of ISGs in APECED cell populations. Kai Kisand et al. Blood 2008;112:2657-2666 ©2008 by American Society of Hematology Effect of APECED sera on ISG expression and STAT1 phosphorylation. Kai Kisand et al. Blood 2008;112:2657-2666 ©2008 by American Society of Hematology Normal plasmacytoid DC numbers and dendritic cell IFN production in APECED. (A) Percentages of plasmacytoid DCs (pDCs) among PBMCs in APECED and control groups (P = .079, t test). Kai Kisand et al. Blood 2008;112:2657-2666 ©2008 by American Society of Hematology CXCL10 levels in APECED and control sera. Kai Kisand et al. Blood 2008;112:2657-2666 ©2008 by American Society of Hematology Schematic illustration of thymic and peripheral events in APECED. Tissue-restricted antigenspecific T cells are not deleted in APECED thymus because of the deficient function of AIRE in medullary thymic epithelial cells (mTEC), and escape to cause tissue d... Kai Kisand et al. Blood 2008;112:2657-2666 ©2008 by American Society of Hematology