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CURRICULUM VITAE
Professor To Chi Ho
PDip (Optom), PhD
Henry G. Leong Endowed Professor in Elderly Vision Health
Head,
School of Optometry,
The Hong Kong Polytechnic University
Email: [email protected]
Telephone: 27666102 / 94573833
Qualifications
1993
PhD, Cardiff University, Wales, UK
1987
Professional Diploma in Optometry (with Distinction),The Hong Kong
Polytechnic (HKP), Hong Kong
Positions held
Dates
2013-present
2013-present
2010-present
Position
Henry G. Leong Endowed Professor in Elderly Vision Health
Head, School of Optometry, PolyU
Associate Head, School of Optometry, PolyU
2010-present
BSc Programme Leader, School of Optometry, PolyU
2005-present
Professor, School of Optometry, PolyU
2002-present
2002 - 2005
Deputy Director, Centre for Myopia Research
1995 - 2002
Assistant Professor, Dept of Optometry & Radiography, PolyU
1994 - 95
Research Fellow, Dept of Optometry & Radiography, PolyU
1993 - 94
Lecturer (College of Degree Studies), Dept of Optometry & Radiography,
Hong Kong Polytechnic
Associate Professor, Dept of Optometry & Radiography, PolyU
External appointment
Dates
2008-present
Position
PhD supervisor ship, Sun Yat-sen University, Guangzhou, PRChina
2008-present
Visiting Professor, Zhongshan Ophthalmic Centre, Sun Yat-sen University,
1
Guangzhou, PR China
1998
Visiting scientist, Department of Ophthalmology, Mount Sinai School of
Medicine, New York
Editorial
Dates
2010 -present.
2012-present
2012-present
2012-3
Position
Editorial board member of SCI journal “Ophthalmic and Physiological
Optics”
Editorial board member of SCI journal “Journal of Ocular Pharmacology
and Therapeutics”
Editorial board member of open access Journal: “Conference Papers in
Medicine” Hindawi Publishing Corporation,
Editorial board member of special issue on Myopia Research of SCI
journal “Optometry and Vision Science” (Chief editor: Professor Anthony
Adams)
Memberships
Dates
1994-present
Position
Member of Associate of Research of Vision and Ophthalmology (ARVO)
2001- present
Honorary member, The Hong Kong Association of Private Practice
Optometrists
2009-present
Member of Society of Neuroscience
2006-2008
Member of Physiological Society
Major research interests:
Aqueous Humour Dyanmics
I have a long term interested in understanding the aqueous humour dynamics of the eye since
its mechanism of formation was one of the major mystery in ocular physiology. Most
importantly, the knowledge on aqueous humour dynamics will have very direct impact on
devisng effective hypotensive strategies for managing the intraocular pressure of glaucoma
patients. My team focuses on the ionic mechanism of aqueous humour formation by the
ocular ciliary epithelium. We study the ionic species that are transported by the ciliary
epithelium and how the in vitro fluid formation rate may be correlated with active ion
transport. I am also interested in identifying the membrane protein players that orchestrate
the ion transport that drives fluid or aqueous humour formation. Among many potential
targets, my team has been focusing on the gap junctions and chloride channel of the ciliary
epithelium. Apparently, these are profitable sites for novel drug design since they are very
responsive to pharmacological manipulation. In addition, since aqueous humour formation is
regulated by a host of intracellular and extracellular signals, we examine the effects of
signaling compounds, such as nitric oxide, adenosine, cAMP/cGMP, on the ion transport and
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fluid formation rate. Using a whole eye perfusion system, we study both the inflow and
outflow of aqueous humour and their characteristics with different hypotensive agents.
Through different research approaches and better understanding of aqueous humour
formation, more potent hypotensive drugs may be devised.
Myopia
Myopia is affecting a large population of children and young adults in Hong Kong and other
Asia countries. My research aim is to understand both the optical and molecular mechansim
underlying excessive eye growth in myopia. Using myopia animal models, my team studies
the characteristics of optical defocus on the rate of eye growth – a process that is called
emmetropization. We presented optical defocused images in front and behind the retina to
animal eyes and studied how the retina integrates simultaneously presented optical images
according to the dioptric powers and intensity. Apparently, the retina is capable of
integrating optical defocus spatially and temporally for guiding eye growth. Using this
information, we have designed myopia control lenses for young children and examined the
effect of defocus on human myopic growth. The data showed that myopic defocus can
indeed retard the progression of myopia in children.
I am also interested in understanding the molecular mechanism in myopic eye growth. The
quest is to find the “stop’ signals through a better understanding of biochemical mechanism
pertinent to eye growth. Using proteomics approach, we have been profiling protein changes
during normal and myopic eye growth at different time points. Using data from proteomics,
physiological experiments can be conducted so as to up or down-regulate potential
biochemical pathways and study their effects on eye growth. This information may help in
devising pharmacological agents that can retard excessive eye growth.
Teaching consultant
External member of curriculum review panel for Master of Science in Nursing, School of
Nursing 2001.
External member of curriculum review panel for Master of Ophthalmology and Visual
Sciences, Department of Ophthalmology and Visual Sciences, The Chinese University of
Hong Kong, 2013
Education development and teaching experience
Undergraduate subject list:
Subjects
Ocular Physiology
Advanced statistics and research methodology (ASRM)
Project 1, 2 & 3
Clinical Optometry Subjects
Ocular Pathology
Clinical practice and supervision
Optometry Clinic Primary Care Clinic
Optometry Clinic Fellow-up Clinic
Contact Lens Clinic
Date
1996-present
2004-present
1997-9, 2002-present
1993-1999
1999-2001
1993-1999
1993-1999
1993-1999
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Student SFQ and Peer Review
My SFQ of all these years in teaching a number of different subjects are of or above the
faculty norm.
My teaching has also been subjected to a number of peer reviews by fellow colleagues of the
same and different disciplines. I have also been reviewed by member and Chairman of our
Departmental Learning and Teaching Committee. These reviews found my teaching very
satisfactory and the comments were all very positive and encouraging. Recently, my teaching
was also peer reviewed and commented to be very satisfactory by a senior EDC colleague
(Dr Josephine Csete) in 2008.
Research Student Supervision
As Principal Supervisor:
Title of Theses
Mok Kwok Hei (MPhil 1997)
The roles of ion transport across the mammalian ciliary
epithelium
Sheng Ka Lee Caren (MPhil 2002) Localization of ion transporters and channels in the
bovine ciliary epithelium
Do Chi Wai (PhD 2002)
Characterization of chloride and bicarbonate transport
across the isolated bovine ciliary body/epithelium
Siu Wing Tak Andrew(PhD 2002)
A study of retinal oxidation: The effects of melatonin
and the roles of nitric oxide and hydroxyl radicals.
Kong Chi Wing Marco (PhD
2005)
Ion transport across the porcine ciliary epithelium
(Faculty note worthy PhD Thesis
Award)
Lam Chuen (PhD 2007)
Differential protein expression in the emmetropization
of chick retina by a proteomic approach
Tse Yan-yin (PhD 2008)
The modulation of emmetropization by visual inputs
(Faculty Distinguished Thesis
Award)
Law Cheung Sing (PhD 2010)
(Faculty Distinguished Thesis
Award)
Chun Ka Man PhD (2010)
(Faculty Distinguished Thesis
Award)
The regulation of aqueous humour formation via
secondary messengers
mechanism of choroidal changes in myopic and
recovering chick eyes using proteomics approach
As Co-supervisor:
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Zuo Bing (PhD 2011)
Early retinal protein signal expressions in myopic
guinea pigs
Ng Yiu Fai (PhD 2009)
Investigation in the aging effect - retinal ischemia - in
vitro arterially perfused eyes using multi-focal
electroretinogram (mfERG)
Ng Sheung Shun Vincent (PhD Human tear protein analysis and factors affecting the
2002)
concentrations of total and individual tear proteins.
Chan Chu Yan (PhD 2005) UK
Molecular characteristics of glucose transport in the
ciliary epithelium
Ling Yun Lan (PhD 2006)
PRChina
Aqueous humour
epithelium
Wu Yi (PhD 2010) PRChina
The effects of optical defocus on mammalian myopia
development
Yu Sin-Ying Bibianna (MPhil
2004)
Dynamics of accommodative and pupil Responses to
stimulus blur in myopic and emmetropic children
Lim Kim Poo (MPhil 2004)
Mutational analysis of the genes implicated in retinitis
pigmentosa
formation
in
human
ciliary
CURRENT RESEARCH STUDENT SUPERVISION
As Principal Supervisor
Title of Theses
Xiao Jingru PhD
A novel chamber system for studying clinical and
potential anti-glaucoma drugs and aqueous humour
formation
YU Fengjuan (PhD)
The Retinal Protein Profiling and Post-Translational
Modifications of Form Deprived Myopia (FDM) of
Chicks
Xiao Hu (PhD)
Effect of ApoA1 and myopia
Wang Jian Chao (PhD of ZOC)
Regional importance of retina in myopia development
(with Professor Liu Quan, Zhongshan Ophthalmic
Centre)
Bing Jie (PhD)
Post-translational modification of proteins during eye
growth
Xiao Hu (PhD)
ApoA1 and myopia
As Co-supervisor
Angela Chan (PhD)
Adenosine receptor and ciliary epithelium
Chu Chin Hung Geoffrey (PhD)
Structural Correlates of Astigmatism in Chickens
Li Ka Lok (MPhil)
Characterization of Gap Junction in Ciliary Epithelium
Josephine Zheng (MPhil)
Proteomics in myopia guinea pigs
Yun Yun Zhong (ZOC PhD)
Short term proteomic changes in myopic chicks
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Research personnel outcome measures
I have trained a number of research students, research assistants and associates and post-doc,
research fellow. All of them played significant roles in the profession as clinicians or
pursuing continuing studies. Some of them are continuing growing in academia and research:

Dr Dennis Yan Yin Tse (PhD student) – a post-doctoral scientist in Baylor School of
Medicine with Professor Samuel Wu on glaucoma and signaling
Dr Rachel Chun (PhD student) – Instructor in the School of Optometry, teaching and
research in optometry and proteomics.
Dr Chi-wai Do (PhD student) – Post-doc at Department of Physiology, Pennsylvania
University, currently Assistant Professor, School of Optometry, Hong Kong Polytechnic
University
Dr Ng Sheung Shun Vincent (PhD student) – consultant optometrist, School of
Optometry, Hong Kong Polytechnic University. He is now specialized in high myopia
clinical service and research.
Dr Mok Kwok Hei (MPhil student) – continued to pursue research study and completed
his PhD in Hong Kong University. He is now a senior optometrist in eye care centre.
Miss Yu Sin-Ying Bibianna (MPhil Student) – Senior Clinical Optometrist, School of
Optometry, Hong Kong Polytechnic University. She is specializing in children vision.
Miss Sheng Ka Lee Caren (MPhil student) – studying her PhD in City University of
New York with Professor Josh Wallman on myopia project.
Dr Marco Kong (PhD student) – Post-doc at Mount Sinai School of Medicine, New
York, currently Research Assistant Professor, Department of Medicine, The University
of Hong Kong. He is now working on stem cells.
Dr Thomas Lam Chuen (PhD student) – Lecturer at the Singapore PolytechnicManchester University programme, Currently Assistant Professor, School of Optometry,
Hong Kong Polytechnic University. He has become an independent research on ocular
proteomics.
Dr Andrew Siu Wing Tak (PhD student) – Associate Professor, School of Optometry,
Hong Kong Polytechnic University, currently retired. He was specialized in glaucoma
research and antioxidation
All my mainland research students went back to China after graduation and continued
with research and clinical work in various hospitals and research centres in China.
Dr Mohammed Shahidullah (Post-doc and research fellow) – Assistant Professor,
Department of Physiology, Arizona University, USA. He is continuing with glaucoma
and aqueous humour research.
Dr Michael Frost (Post-doc and research fellow) - Scientific Officer, Department of
Vision Sciences, Alabama University, Birmingham, USA. He is working with Professor
Tom Norton on myopia proteomics.
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Postgraduate thesis examiner
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External examiner of PhD candidate (Mi Xuesong) of Department of Anatomy, The
University of Hong Kong 2011
External examiner of PhD candidate (Li Suk Yee Rachel) of Department of Anatomy,
The University of Hong Kong 2007
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External examiner of PhD candidate (Chung Ho Lam) of Department of Physiology,
The Chinese University of Hong Kong 2007
External examiner of PhD candidate (Stephen Vincent) of Department of Optometry,
Queensland University of Technology, Brisbane, Australia 2011
External examiner of PhD candidate (Zhou,Xiangti) Department of Optometry, The
University of New South Wales, Sydney, Australia 2010
External examiner of MPhil candidate (Jang Wai Chi) of Department of Anatomy,
The University of Hong Kong 2009
External examiner for Master of Medical Sciences (MMedSc) candidate (Huang Lai),
The University of Hong Kong 2006
External examiner for Master of Medical Sciences (MMedSc) candidate (Chung
Chung Yee), The University of Hong Kong 2011-2
I have also been serving as Chairman of the Board of Examiners for PhD candidates both in
Optometry and in HTI in many occasions.
Continuing Professional Programmes Development

Member of Programme Team for the conversion of part IV to part II optometrist
(2010 – present). This course has been approved by the Optometrist Board of the
Hong Kong Government that successful candidates will be upgraded to part II status.

Organizing and teaching the conversion course (Ocular pharmacology course) for
Part II optometrists 1999-2001. This course was recognized by the Registration
Committee of the Hong Kong Government and successful candidates were upgraded
to part 1 optometrist status.
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Organizing continuing education on Advanced Glaucoma Management seminars for
professional optometrists, 2001
Education development grant
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E-learning grant (OPD, PolyU) for the production of a compact disc on glaucoma
assessment 2000-1 (HK$ 350,000)
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E-learning grant (OPD, PolyU) for WebCT development 2004-5 (HK$ 300,000, 2
subjects)
Publications
Book chapter
Do CW, Kong CW, Chan CY, Civan MM, To CH. Mechanisms of aqueous humour
formation: cellular model of aqueous flow. In: Tombran-Tink J, Barnstable CJ, eds. Ocular
transporters in ophthalmic diseases and drug delivery. Humana Press, 2008.
Referred journal papers from my research students/research team
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
I directly supervised the research work that produced journal paper publications below.
My contribution is described with the paper.
1. Tse DYY, To CH (2011) Graded Competing Regional Myopic and Hyperopic Defocus
Produce Summated Emmetropization Set Points in Chick. Invest Ophthalmol Vis Sci.
52:8056-8062
*I contributed to this research idea and Dr Tse, my PhD student, designed the
experiments jointly with me and carried out the study.
2. Zhang H, Wong CL, Shan SW, KK Li, Cheng AK, Lee KL Ge J, To CH, Do CW (2011)
Characterization of Cl- transporter and channels in experimentally-induced myopic chick
eyes. Clin Exp Optom 94:528–535
*I contributed the knowledge on ion transport and helped data analysis as well as
experimental planning.
3. Lo P, Tse DYY, Lam CSY, To CH. (2010) Alternating Monovision Contact Lens Wear
Arrested Fast Progressing Myopia. Clin Refract Optom 21:38-41
*I contributed to the idea of collecting clinical data on myopic defocus and myopia
control. Dr Lo, my collaborator, supplied the data and Dr Tse and I jointly wrote the
paper.
4. Liu Q, To CH, Ge J, Chan CY, Lv L, Lam TC, Siu AW. (2010) Astigmatic shift and
conjunctival epithelial ingrowths following late-onset iatrogenic LASIK flap dehiscence
during sclera buckling surgery. Clin Exp Optom 92:500-2
*I helped in collecting the clinical data and drafted the paper with all the authors. Dr Siu
was my PhD student, helping me to finalize the paper.
5. Law CS, Candia OA, To CH. (2009). Inhibitions of chloride transport and gap junction
reduce fluid flow across the whole porcine ciliary epithelium. Invest Ophthalmol Vis Sci.
50:1299-306.
*I contributed the idea of looking into gap junction and fluid transport. Dr Law, my PhD
student helped in the experiment and perfecting the techniques of measurement.
6. Lim K P, Yip SP, Cheung SC, Leung KW, Lam ST, To CH. (2009). Novel PRPF31 and
PRPH2 mutations and co-occurrence of PRPF31 and RHO mutations in Chinese patients
with retinitis pigmentosa. Arch Ophthalmol. 127:784-90.
*I helped in the discussion of clinical data as well as experimental direction in this
project. Mr Lim was my MPhil student with PI SP Yip. Mr Lim did the experimental
work in identifying the mutation.
7. Shahidullah M,To CH, Pelis RM, Delamere NA (2009). Studies on bicarbonate
transporters and carbonic anhydrase in porcine nonpigmented ciliary epithelium Invest
Ophthalmol Vis Sci.. 50, 1791-800.
*Dr Shahidullah was my research fellow and he has generated the idea of studying
bicarbonate transport usng cellular imaging method. I helped in analyzing data and
discussing the results. I also contributed in the manuscript writing.
8. Ng YF, Chan HH, To CH, Yap M (2008) The characteristics of multifocal
electroretinogram in isolated perfused porcine eye. Doc Ophthalmol 117:205-14
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*I contributed to the knowledge and technique in keeping an isolated perfused eye and
related discussion and data analysis. I was the co-supervisor of Dr Ng who has carried
out the study.
9. Ng YF, Chan HH, Chu PH, Siu AW, To CH, Beale BA GIlger, BC Wong F (2008)
Pharmacologically defined components of the normal porcine multifocal ERG. Doc
Ophthalmol.116:165-176
*I contributed to the knowledge and technique in keeping an isolated perfused eye and
related discussion and data analysis. I was the co-supervisor of Dr Ng who has carried
out the study.
10. Siu AW, Lau MK, Cheng JS, Chow CK, Tam WC, Li KK, Lee DKL, To SS, To CH, Do
CW (2008) Glutamate-induced retinal lipid and protein damage: The protective effects of
catechin. Neurosci Lett, 432:193-197
*I contributed to the experimental designed and discussion on results. Dr Siu was my
PhD student who has generated the idea of this project and he has carried out the
experiment by himself.
11. Lam C, Chun RKM, Li KK & To CH (2008) Application of proteomic technology in eye
research: a mini review. Clin Exp Optom 91:23-33
*The work was a collaborative effort in writing an review using our knowledge on ocular
proteomics. I contributed to the drafting and finalizing of the paper with Dr Lam who
was my PhD student.
12. Lam C, Li KK, Lo SCL, Guggenheim JA & To CH (2007) Application of DIGE
technology in searching for protein biomarkers in chick myopia. J Proteom Res. 6:413549
*I started the work on proteomics with Dr Lam who was my PhD student. I contributed
in the planning and discussion of the project and also on the drafting of the paper.
13. Tse DY, Guggenheim JA, Lam C, Li KK, Lam CSY, Liu Q & To CH (2007)
Simultaneous defocus integration during refractive development. Invest Ophthalmol Vis
Sci. 48:5352-59
*I contributed to the idea of using simultaneous defocus and Dr Tse carried out the
experiment. I also took part in the drafting of the paper and contributing intellectually to
the discussion.
14. Chan CY, Guggenheim JA & To CH (2007) Is active glucose transport present in the
bovine ciliary body epithelium (CBE). Am J Physiol (cell physiology) 292: C1087-93
*Dr Chan was my PhD student (as Co-I). I contributed my knowledge of transport
physiology and in the planning of experiments and discussion of data.
15. Candia OA, To CH & Law CS (2007) Fluid Transport across the Isolated Porcine Ciliary
Epithelium. Invest Ophthalmol Vis Sci 48:321-327.
*Dr Law was my PhD students and I had this idea of measuring fluid flow across the
preparation. He has perfected the technique. We both contributed to the drafting of paper.
16. Ling Y, To C, Lin M, et al. (2006) The in vitro electrical parameters of the isolated
porcine ciliary epithelium. Eye Sci 22:59-62.
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*Dr Ling was my PhD student jointly supervised by Prof Ge of Zhongshan Ophthalmic
Centre. I came up with the idea of studying electrical parameters of the ciliary epithelium.
Dr Ling carried out the work and I also took part in the data analysis.
17. Do CW, Kong CW, Chan CY & To CH (2006) Aqueous humor formation and its
regulation by nitric oxide (NO) – a mini review. Neuroembryology and Aging 4:8-11
*Dr Do and Dr Kong were my PhD students and we jointly wrote this review paper by
invitation using data that we have obtained earlier.
18. Kong CW, Li KK & To CH (2006). Chloride (Cl-) secretion by porcine ciliary
epithelium: new insight on species similarities and differences of aqueous humor
formation. Invest Ophthalmol Vis Sci 47:5428-5436
*I had the idea of measuring chloride transport in pig and Dr Kong, my research student,
carried out the study. I supervise the conduction of experiment and data analysis as well
as manuscript writing.
19. Lam TCL, Li KK, Lo SCL, Guggenheim, JA & To CH (2006). A chick retinal proteome
database and differential retinal protein expressions during early ocular development. J
Proteom Res 5:771-84.
*I initiated the project and contributed to the experimental design plus data analysis. Dr
Lam, my PhD student carried out the experiment and took part in drafting the paper with
me and other authors.
20. Shahidullah M, Yap M & To CH. (2005) Cyclic GMP, Sodium nitroprusside and sodium
azide reduce aqueous humor formation in the isolated arterially perfused pig eye. Br J
Pharmacol 145:84-92.
*Dr Shahidullah was my research fellow. I initiated the idea of studying transport using
the perfused eye. He completed the work with minimal supervision. I also took part in
data analysis and discussion of the work.
21. Shahidullah M, Chan HHL, Yap M & To CH. (2005) Multifocal electroretinography in
isolated arterially perfused bovine eye. Ophthalmol Physiol Opt 25:27-34.
*Dr Shahidullah was my research fellow. I contributed to the knowledge and technique
of ion transport physiology and related discussion and data analysis.
22. Do CW, Kong CW & To CH. (2004) cAMP inhibits transepithelial chloride secretion
across bovine ciliary body/epithelium. Invest Ophthalmol Vis Sci 45:3638-43.
*Dr Do and Dr Kong were my PhD students. I contributed in the idea and overall advice
on the experiment plus discussion of data. I also helped in drafting the paper with my
students.
23. Siu AW, Ortiz GG, Benitez-King G, To CH & Reiter RJ. (2004) Effects of melatonin on
the nitric oxide treated retina. Br J Ophthalmol 88:1078-81.
*I initiated the idea of studying NO with melatonin. The work was carried out by my
research student Dr Siu and I contributed to the discussion on data and the paper.
24. Shahidullah M, Wilson WS, Yap M & To CH. (2003) Effects of Ion Transport and
Channel-Blocking Drugs on Aqueous Humor Formation in Bovine Isolated Eye. Invest
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Ophthalmol Vis Sci 44:1185-91
*Dr Shahidullah was my research fellow. I initiated the research idea and contributed to
the knowledge and technique of ion transport physiology and related discussion and data
analysis.
25. To CH, Kong CW, Chan CY, Shahidullah M & Do CW. (2002) The mechanism of
aqueous humour formation. Clin Exp Optom 85:335-49.
*This review was written by me and my research students Dr Kong and Dr Chan. I
finalized the manuscript for publication.
26. Siu AW & To CH. (2002) Nitric oxide and hydroxyl radical-induced retinal lipid
peroxidation in vitro. Clin Exp Optom 85:378-82.
*Dr Siu, my PhD students initiated this idea with me. I contributed to the discussion and
planning of experiment plus paper drafting.
27. Siu AW, Leung MCP, To CH, Siu FKW, Ji JZ & So KF. (2002) Total retinal nitric oxide
production is increased in intraocular pressure-elevated rats. Exp Eye Res 75:401-6.
*Dr Siu, my PhD students initiated this idea and gather a team to help in this project. I
contributed to the discussion and planning of experiment plus paper drafting.
28. To CH, Do CW, Zamudio AC & Candia OA. (2001) Model of Ionic Transport for the
bovine ciliary epithelium: Effect of Acetazolamide and HCO3. Am J Physiol.
280:C1521-30
*I initiated the work with Prof Candia who has the chamber for measuring the
bicarbonate transport. Dr Do my PhD student helped in the conduction of experiment. I
also contributed to the writing of paper.
29. Siu AW, Cheung JP, To CH, Chan EK, Chan JK & Cheung JC. (2001)
N-acetyl-serotonin reduces copper (I) ion-induced lipid peroxidation in bovine retinal
homogenates. Acta Ophthalmol Scand 79:69-71.
*This project was initiated by Dr Siu and I contributed in experimental design and
discussion and also the writing of paper.
30. Ng V, Cho P & To CH. (2000) Tear proteins of normal young Hong-Kong Chinese.
Graefe's Arch Clin Exp Ophthalmol.238:738-45
*I was the co-supervisor of PhD student, Dr Ng (Prof Cho was the PI). I contributed to
the experimental design and protein analysis. I also commented the paper.
31. Do CW & To CH. (2000) An ionic model of aqueous humour formation. Invest
Ophthalmol Vis Sci.41:1853-1860
*Dr Do was my PhD students. This was one of the most important papers we produced
showing strong evidence that chloride is actively transported across ciliary epithelium.
The idea came from me and Dr Do carried out the study. He also contributed
significantly in the writing of paper.
32. To CH (2000). Diagnosis of Glaucoma. Eye Care 99 Conference Report. Asian J of
Ophthalmol 2:34-35.
*I gave this talk to one of the regional conference and was asked to produce a written
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form of my talk for the journal.
33. Siu AW, Reiter RJ & To CH. (1999) Vitamin E and pineal indoleamines in combating
nitric oxide (NO)-induced lipid peroxidation in rat retinal homogenates. J Pineal Res 27:
122-8
*Dr Siu was my PhD student and this was part of his PhD work. I contributed to the
experimental design, data analysis and discussion. Dr Siu carried out the experiment and
drafted the paper. All author contributed intellectually to the writing of this paper.
34. To CH & Hodson SA. (1999) A rapid method of preparing the plasma membrane
enriched fraction of the bovine retinal pigment epithelial cells. Eye Sci 15:22-28.
*This worked was produced during my PhD study. Prof Hodson supervised my work and
I devised the experimental method in rapidly separating the membrane enriched fraction.
35. To CH & Do CW (1998) Ion transport mechanism in the formation of aqueous humour.
The HK J Ophthalmol 2:35-42.
*I wrote this paper which described the early work that I have done myself with early
experiments done by Dr Do, my PhD student. I wrote the paper with some input from Dr
Do.
36. Siu AW, Reiter RJ & To CH. (1998) The efficacy of vitamin E and melatonin as
antioxidants against lipid peroxidation in rat retinal homogenates. J Pineal Res 24: 239244.
* Dr Siu was my PhD student. I contributed to the experimental design, data analysis and
discussion. Dr Siu carried out the experiment and drafted the paper. All author
contributed intellectually to the writing of this paper.
37. To CH, Mok KH, Do CW, Lee KL & Millodot M. (1998) Chloride and Sodium
Transport Across Bovine Ciliary Body/Epithelium (CBE) Curr Eye Res 17:896-902.
*Mr Mok was my MPhil student who had conducted the experiment. This work formed
part of his MPhil. The paper was written and finalized by me with input from Mr Mok.
38. To CH, Mok K, Tse S, Siu W, Millodot M, Lee K & Hodson S. (1998) In vitro bovine
ciliary/epithelium in a small continuously perfused Ussing type chamber. Cell Struct
Funct 23:247-254.
*The paper reported the first series of chamber experiments that I had carried out. The
work was done when I was a research fellow with Prof Millodot. I carried out most of the
experiments and wrote the paper.
39. To CH & Hodson SA. (1998) The glucose transport in retinal pigment epithelium is via
passive facilitated diffusion. Comp Biochem Physiol (A) 121:441-444.
*The paper described my major part of my PhD work and I have conducted the
experiments by myself. I also drafted the paper and I was also the corresponding author.
40. To CH, Cheung KK, Chiu SH, Lai HM & Lung KS. (1998) The saturation
characteristics of glucose transport in bovine retinal pigment epithelium. Eye Sci 14:126129.
*This paper came out from one of my undergraduate student research projects. The
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student did most of the experiment and paper consisted of some of my results from my
PhD project. I wrote this paper myself.
Other referred journal papers through collaborations
 I contributed ideas and part of the work towards these research publications through
scientific collaboration.
41. McFadden SA, Tse DY, Bowrey HE, Leotta AJ, Lam CS, Wildsoet CF, To CH.(2014)
Integration of Defocus by Dual Power Fresnel Lenses Inhibits Myopia in the Mammalian
Eye. Invest Ophthalmol Vis Sci. (in press)
42. Mutti DO, Gwiazda J, Norton TT, Smith EL, 3rd, Schaeffel F, To CH (2013) Guest
Editorial: Myopia--yesterday, today, and tomorrow. Optom Vis Sci 90:1161-1164.
43. Lam CS, Tang WC, Tse DY, Tang YY, To CH (2013) Defocus Incorporated Soft
Contact (DISC) lens slows myopia progression in Hong Kong Chinese schoolchildren: a
2-year randomised clinical trial. Br J Ophthalmol 98:40-45.
44. Patrick HW, Chu PHW, Ng YF, To CH, So KF, Brown B, Chan HHL (2012)
Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early
retinal functional changes in high-risk glaucoma patients. Graefes Arch Clin Exp
Ophthalmol. 250:261–270
45. Chen YB, Hocking PM, Wang L, Považay B, Prashar A, To CH, Erichsen JT,
Feldkaemper M, Hofer B, Drexler W, Schaeffel F, Guggenheim JA. (2011) Selective
breeding for susceptibility to myopia reveals a gene-environment interaction. Invest
Ophthalmol Vis Sci. 52:4003-11
46. Chen J, Gao Q, Liu Y, Ge J, Cao X, Luo Y, Huang D, Zhou G, Lin S, Lin J, To CH, Siu
AW (2011) Clinical device-related article evaluation of morphology and functions of a
foldable capsular vitreous body in the rabbit eye. J Biomed Mater Res B Appl Biomater
97B:396–404
47. Chen YB, Prashar A, Erichsen JT, To CH, Hocking PM, Guggenheim JA. (2011)
Heritability of ocular component dimensions in chickens: Genetic variants controlling
susceptibility to experimentally-induced myopia and pre-treatment eye size are distinct.
Invest Ophthalmol Vis Sci. 52:4012-20
48. Tarutta E, Chua WH, Young T, Goldschmidt W, Saw SM, Rose KA, Smith EIII, Mutti
DO, AshbyR, Stone RA, Wildsoet C, Howland HC, Fischer AJ, Stell WK, Reichenbach
A, Frost M, Gentle A, Zhu XY, Summers-Rada J, Barathi V, Jiang L, McFadden S,
Guggenheim JA, Hammond C, Schippert R,To CH, Gwiazda J, Marcos S, Collins M,
Charman WN, Artal P, Tabernero J, Atchison DA, Seidemann A, Uttenweiler D, Troilo
D, Norton TT, Wallman J.(2011) Myopia: Why Study the Mechanisms of Myopia?
Novel Approaches to Risk Factors Signaling Eye Growth- How Could Basic Biology Be
Translated into Clinical Insights? Where Are Genetic and Proteomic Approaches
Leading? How Does Visual Function Contribute to and Interact with Ametropia? Does
Eye Shape Matter? Why Ametropia at All? Optom Vis Sci. 88:404-7
49. Chen YP, Prashar A, Hocking PM, Erichsen JT, To CH Schaeffel F, Guggenheim JA .
(2010) Sex, eye size, and the rate of myopic eye growth due to form deprivation in
outbred white leghorn chickens. Invest Ophthalmol Vis Sci. 51: 651-7
50. Guggenheim JA, Zayats T, Prashar A, To CH (2008) Axes of astigmatism in fellow
eyes show mirror rather than direct symmetry. Ophthalmic Physiol Opt 28:327-333.
51. Ng YF, Chan HH, To CH, Wong Foulton (2008) Multifocal Electroretinogram in
Rhodopsin P347L Transgenic Pigs. Invest Ophthalmol Vis Sci.49:2208-2215
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52. Yip SP, Cheung TS, Chu MY, Cheung SC, Leung KW, Tsang KP, Lam S, and To CH
(2007) Novel Truncating Mutations of the CHM Gene in Chinese Patients with
Choroideremia. Mol Vis 13:2183-93
53. Gao Q, Mou S, Ge J, To CH, Hui Y, Liu A, Wang Z, Long C & Tan J (2007) A new
strategy to replace the natural vitreous by a novel capsular artificial vitreous body with
pressure-control valve. Eye. 27:106-9
54. Shen J, Han W, To CH & Wang J (2007) A case of choroidal tuberculoma in pregnancy.
Retina 27:106-109.
55. Qin XJ, Margrain TH, To CH, Bromham N & Guggenheim JA (2005). Anisometropia is
independently associated with both spherical and cylindrical ametropia. Invest
Ophthalmol Vis Sci 46:4024-4031.
56. Candia OA, To CH, Gerometta RM & Zamudio AC. (2005) Spontaneous fluid transport
across isolated rabbit and bovine ciliary body preparations. Invest Ophthalmol Vis Sci
46:939-947
57. Guggenheim JA & To CH (2005) Monovision slows myopia progression. Br J
Ophthalmol 89:1076-1077.
58. Liu Q, Gong XM, Chen JQ, Yang B, Ge J & To CH. (2005) Laser in situ keratomileusis
induced corneal perforation and recurrent corneal epithelial ingrowth. J Cat Refract Surg
31:857-859
59. Davies N, Akhtar S, Turner HC, Candia OA, To CH & Guggenheim JA. (2004) Chloride
channel gene expression in the rabbit cornea. Mol Vis 10:1028-37.
60. Lam AKC, Wong S, Lam CSY & To CH. (2002) The effect of myopic axial elongation
and posture on the Pulsatile Ocular Blood Flow in young normal subjects. Optom Vis Sci
79: 300-5
61. Lam AKC, Wong S, Lam CSY & To CH. (2001) Daytime variation of pulsatile ocular
blood flow (POBF) in normal Chinese. Clin Exp Optom 84:190-4.
62. Li FK, To CH, Leung JKH, Chan TM & Lai KN. (2001) Electrophysiology and glucose
transport of human peritoneal mesothelial cells – implications on peritoneal dialysis.
Perit Dial Int. 21:115-21.
63. Lam AKC, To CH, Chan HL & Fan CS (2000). A preliminary study on the ocular blood
flow (OBF) of Hong Kong Chinese. Ophthalmol Physiol Opt. 19:512-7
Invited speakers and keynote speakers
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Plenary lecture: “Myopia –growth and degeneration” Seventh International Symposium
on Healthy Aging, University of Hong Kong, March 2012, Hong Kong
Plenary lecture: “Myopia: Where Do We Stand and How Do We Control It?” Hong
Kong Orthokeratology Conference, Oct 2012, Hong Kong
Plenary lecture: “Myopia update” The 4th ASEAN Optometric Conference, Sept 2012,
Malaysia
Keynote lecture: “Differential retinal protein expressions in animal myopia” The 16th
Chinese Ophthalmology Congress, Sept 2011, Guangzhou, China
Invited lecture: “Myopic Defocus - a novel approach in myopia control” Department of
Ophthalmology, Boston University, Nov 2011, Boston, USA
Invited lecture: A story of aqueous humor formation research” Second National Postgraduate Ophthalmology Student Forum, August 2011, Guangzhou, China
14
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Invited lecture: “Myopia Control by Defocus Incorporated Soft Contact (DISC) Lens”
The 16th Chinese Ophthalmology Congress, Sept 2011, Guangzhou, China
Invited lecture: “Signal integration in eye growth” Asia-ARVO, Oct 2011, Singapore
Invited lecture: “Myopic Defocus - a novel approach in myopia control” Hong Kong
Polytechnic University Alumini Society Nov 2011, Hong Kong
Invited lecture “A paradigm shift in myopia control” The Hong Kong Association of
Private Practice Optometrists, Nov 2009, Hong Kong
Invited lecture “Myopia development - the effects of optical defocus on eye growth”
China Optometric Academic Conference, Dec 2009, Guangzhou
Invited lecture: “Signal integration in eye growth and myopia” Nobel Laureate Dr
Torsten Wiesel Eye Research Symposium, May 2009, Chengdu, China
Invited lecture: “Myopia development - the effects of optical defocus on eye growth”
China Optometry Academic Conference Dec 2009, Guangzhou, China
Invited lecture: “The In vitro aqueous humour formation” World Council of Optometry
and Association of Malaysian Optometry (AMO) Joint Optometric Conference, June
2009, Melaka, Malaysia
Invited lecture: “In vitro Aqueous humor formation” The 7th Congress of the AsianOceanic Glaucoma Society, Dec 2008, Hong Kong
Invited lecture :” Myopia care - from basic research to clinical application” Innovating
Future Healthcare Conference, PolyU, Dec 2007, Hong Kong
Invited lecture: “Proteomic Research – a new approach to understand myopia”
Optometrists association Australia Victoria, Southern Regional Congress, May 2007,
Melbourne, Australia
Invited lecture “Made in Hong Kong” Hong Kong Institute of Science, PolyU, Oct 2005,
Hong Kong
Invite lecture: “Is there a species difference in the ionic mechanism of aqueous humour
formation?” XVI International Congress of Eye Research, Sept 2004, Sydney
Invite symposium lecture: “Identification of chick retina proteins by MALDI-TOF
Mass Spectrometry” XVI International Congress of Eye Research, Sept 2004, Sydney
Invited seminar: "Chloride secretion across the bovine ciliary epithelium", Zhongshan
Ophthalmic Centre, San Yat-sen University of Medical Sciences, PRChina, January 2001
Invited seminar:"Aqueous humour production– an in vitro model" The Hong Kong Eye
Hospital, May 1998, Hong Kong,
Invited seminar "Ion transport across bovine ciliary epithelium," XIII International
Congress of Eye Research July 1998, Paris
Invited seminar: “Ion transport model of the aqueous humor formation” Department of
Optometry and Vision Sciences, University of Wales, 1997, Cardiff.
Conference presentations
I have given over one hundred presentations in local and international eye and research
conferences in the last 20 years.
Significant research grants
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Hong Kong Scholar Scheme (as PI) 2012-14 - Mainland – Hong Kong Joint
Postdoctoral Fellows Program (Successful Candidate: Dr Wang Pan-feng) “Biological
signals in normal and myopic eye growth”
National Natural Science Foundation of China (NSFC) and the Austrian Science
Fund (FWF) project number: 81261130021/H1210) (as Co-I, PI: Professor Liu Quan)
2012-2015 (RMB 960,000; €221,635.20) "Characterization of choroidal changes in
children and its temporal response to optical defocus”.
Wing Tat Lee Foundation of the Boston University, USA (USD 50,000) “Proteomic
analysis of the anterior structures including trabecular meshwork” (as Co-I with PI Dr
Haiyan Gong)
Research Grants Council General Research Fund (as PI: RGC GRF) 2011-2012
(HK$930K). Proteomic Profiling and Post-Translational Modifications in retina of Lens
Induced Myopic (LIM) Guinea pigs
Research Grants Council General Research Fund (as Co-I: RGC GRF) 2011-2012
(HK$900K). “Modulation of mammalian ocular growth with competing defocus”
Innovative Technology Fund, ITF (as Co-I: PI Dr Benny Cheung ISE) 2010-2012
(HK$1M) Development of a Process Modeling and Optimization System for Supporting
Design and Fabrication of Advanced Freeform Progressive Lenses for optometric
applications
Research Grants Council General Research Fund (as PI: RGC GRF) 2008-2011
(HK$798K). “The Retinal Protein Profiling and Post-Translational Modification in Form
Deprived Myopia of Chicks”
PolyU Niche Funding – (Co-investigator) 2008-2012 (HK$10M) “Freeing the world
from Myopia”
PolyU Niche Funding – (Principal Investigator) “Glaucoma Research – A Program
Approach” 2007-2010 (HK$ 8.01M)
Research Grants Council General Research Fund (as Co-I: RGC GRF) 2007-2010
(HK$487K) “The Functional Significance of A3 Adenosine Receptor in Regulating
Aqueous Humor Secretion”
Research Grants Council General Research Fund (as PI: RGC GRF) 2006-9
(HK$697.5K) “A Novel Chamber System for Studying Clinical and Potential AntiGlaucoma Drugs and Aqueous Humor Formation”
Research Grants Council General Research Fund (as Co-I: RGC GRF) 2006-9
(HK$830K) “Control of Myopia Progression in Myopic Children Using Simultaneous
Vision Approach”
Special large equipment funding (PolyU) "An automated post-translational modification
discovery system" for proteomic research 2006-7 (HK$4.5M)
National Natural Science Foundation of China (as Co-I: NSFC) 2004-6 (RMB 200,000).
“Proteomic analysis in lens induced myopic myopia monkey eyes”
Contract Grant to PolyU from the National Eye Institute and National Institute of Health
(as PI: NEI/ NIH, RO1 EY013749) 2003-7 (USD 200,000) “Measurements of fluid flow
across the ocular ciliary epithelium”
The Retina Hong Kong (as PI) –“The registry for Hong Kong retinal degeneration
patients” 2003-7 (HK$ 250,000)
Polytechnic University Area of Strategic Development fund (as PI: Renewal) – “Centre
for Prevention of Myopia” 2002-2005 (total renewed funding 10.5 millions)
Polytechnic University Area of Strategic Development fund (as Co-I) – “Centre for
Prevention of Myopia” 1998-2002 (total funding 13.9 millions)
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The UK/HK exchange grant (as PI: From British Council/RGC jointly) with Dr.
William Wilson (Glasgow University) 1999-2001 (HK$74K) “The study of aqueous
humour formation in arterially perfused bovine eye”
The Health Care Promotion Fund (as PI: HCPF)1998-2001 ($702K) “Retinitis
Pigmentosa in Hong Kong”
The Croucher Foundation Research Project Grant 1997-2000 (as PI: HK$270K)
“Aqueous humour secretion and ion transport - a novel in vitro approach”
Research Grants Council Competitive Earmarked Research Grant (as PI: RGC CERG)
1994-97 (HK$516K) “The production of aqueous humour of the eye - a study towards
understanding the sight threatening eye disease – glaucoma”
Patents and knowledge transfer with impact
My two directions of research in myopia and glaucoma have resulted in a number of
knowledge transfer opportunities
“A method and system for retarding the progression of myopia”.
PCT/CN2010/076839
2010
2009
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“Method of Optical correction”, patent number US 7,506,983 (issued 24
March 2009)
These two above patents are generated from work with my research student Dr Tse
Yan Yin. His papers published in 2007 and 2012 highlighted the possibility to control
myopia with optical defocus. This method has further been proven by our research
clinical trial in slowing down myopia progression by 50%. The application value is
huge given the big myopia problem in this region and all over the world.
“Apparatus and method for objective perimetry visual field test”
PCT/CA08/00472 (filed)
2009
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My teaching of clinical optometry subject made me aware of the need of objective
testing technology in disease diagnosis. This is an objective way to measure visual
field and will likely benefit many patients who cannot conduct subjective testing.
2011
“Method for lowering intraocular pressure using gap junction blocker(s)” PCT
application submitted
2011
“Method for lowering intraocular pressure using baicalein” PCT application
submitted
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These patents came out from our animal studies in unraveling the basic mechanism of
aqueous humour production. These groups of drugs will add to the repertoire of antiglaucoma drugs in lowering the intraocular pressure of the glaucoma patients. In
particular and in contrast to existing hypotensive agents, their mode and mechanism of
actions are known. In addition, the agent baicalein has the potential to become a
multipurpose agents with its antioxidative characteristics.
Research Collaborators
On going
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Professor Sally McFadden, Department of Psychology, University of Newcastle,
Australia
Professor Oscar Candia, Department of Ophthalmology, Mount Sinai School of Medicine,
New York, USA
Professor Ge Jian, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical
Science, Guangzhou, PR China
Professor Liu Quan, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical
Science, Guangzhou, PR China
Professor Guo Gianyang, Zhongshan Ophthalmic Center, Sun Yat-Sen University of
Medical Science, Guangzhou, PR China
Professor John Danias, Department of Ophthalmology, SUNY, New York, USA.
Dr Haiyan Gong, Department of Ophthalmology, Boston University, USA
Dr. Jeremy Guggenheim, Department of Optometry and Vision Sciences, University of
Wales Cardiff, UK (now at the School of Optometry, Hong Kong Polytechnic University)
Professor Samuel Lo, Applied Biology and Chemical Technology, Hong Kong
Polytechnic University
Professor Shea ping Yip, Department of Health Technology and Informatics, Hong Kong
Polytechnic University
Professor So Kwok Fai, Department of Anatomy, The University of Hong Kong
Professor Mortimer Civan, Department of Physiology, University of Pennsylvania, USA
Professor Bill Stell, Department of Ophthalmology, University of Calgary, Canada
Professor Earl Smith, Department of Optometry, Houston University, Texas, USA
Professor Ian Morgan, Department of Biology, Australian National University, Australia
Professor Samuel Wu, Baylor College of Medicine, Texas, USA
Professor Seang Mei Saw, Saw Swee Hock School of Public Health, National University
of Singapore
Professor Frank Schaeffel, Department of Ophthalmology, Tubingen, Germany
Professor Fulton Wong, Department of Ophthalmology, Duke University, USA
Professor Jimmy Lai, Department of Ophthalmology, The University of Hong Kong
Professor Carly Lam, School of Optometry, Hong Kong Polytechnic University
Dr Chi-wai Do, School of Optometry, Hong Kong Polytechnic University
Dr Chea Su Kee, School of Optometry, Hong Kong Polytechnic University
Dr Henry Ho Lung Chan, School of Optometry, Hong Kong Polytechnic University
Dr Andrew Kwong Cheung Lam, School of Optometry, Hong Kong Polytechnic
University
Dr Thomas Lam Chuen, School of Optometry, Hong Kong Polytechnic University
Dr Jacky Kwong, Department of Ophthalmology, UCSF, USA
Dr Zhou Lei, Proteomic Centre, National University of Singapore
Dr Polly Leung, Department of Health Technology and Informatics, Hong Kong
Polytechnic University
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Previous collaboration
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Professor Stuart Hodson, Professorial Scholar, Oxford University, UK
Professor Russell Reiter, Department of Cellular and Structural Biology, University of
Texas, USA
Professor Jake Sivak, Department of Optometry, Waterloo University, Canada
Professor Pauline Cho, School of Optometry, Hong Kong Polytechnic University
Professor Maurice Yap, School of Optometry, Hong Kong Polytechnic University
Dr. William Wilson, Institute of Biomedical & Life Sciences (IBLS), Glasgow
University, Scotland, UK
Dr. Helen Turner, Department of Ophthalmololgy, Mount Sinai School of Medicine,
New York, USA
Dr Tim T Lam, Department of Ophthalmology and Vision Sciences, The Chinese
University of Hong Kong
Dr Li Fu Keung Felix, Division of Nephrology, Department of Medicine, The University
of Hong Kong
Dr Andrew Siu, School of Optometry, Hong Kong Polytechnic University
Dr Daniel Lee, Applied Biology and Chemical Technology, Hong Kong Polytechnic
University
Dr Tony To, Department of Health Technology and Informatics, Hong Kong Polytechnic
University
Assessor for academics/grants
Assessor for research grants:
 RGC GRF Hong Kong
 New Zealand Prevention of Blindness foundation
 Biotechnology and Biological Sciences Research Council (BBSRC)
Assessor for academics
 Promotion to readership, Cardiff University, UK
Journal reviewer
Investigative Ophthalmology and Visual Sciences,
Experimental Eye Research,
Clinical and Experimental Optometry,
British Journal of Ophthalmology,
Optometry and Vision Science
Ophthalmic and Physiological Optics
Current Eye Research
Molecular Vision
Journal of Pharmacology and Therapeutics
PLOS ONE
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Advisory board
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Member, Scientific and Medical Advisory Board, Retina Hong Kong (formerly Hong
Kong Retinitis Pigmentosa Society, 1995 - present).
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Member of Ad-hoc Investigation and Advisory Committee – Hong Kong United
Christian Hospital (2012)
Conference organizer
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Organizer, Annual Joint Eye Research Day (co-hosted by the School of Optometry
PolyU and Zhongshan Ophthalmic Centre (ZOC) of Sun Yat-Sen University of Medical
Sciences, China) - 2002-2012.
- facilitate scientific communication between eye researchers in Hong Kong and China. It
started off with involvements from PolyU and ZOC only but gradually becoming more
inclusive of other eye researchers from HKU, CU, Taiwan and other institutions from
China
Chairman of Scientific Committee and Member of Organizing Committee of the 9th
International Myopia Conference, Hong Kong & Guangzhou Nov 10-14. 2002.
- I was responsible for organizing the whole conference as well as arranging for scientific
presentations. This was in effect two conferences, one in Hong Kong and the other one in
Guangzhou. I am responsible for the scientific programmes for both sites.
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International Member of the Organizing Committee for Physiology and
Pharmacology Section. XVI International Congress of Eye Research (ICER), Sydney,
2004.
- I was involved in designating 10 research symposia for this international eye research
congress under physiology and pharmacology. I invited world-renowned scientists to
chair these symposia and organized the programme accordingly.
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International Member of the Organizing Committee for the 13th International
Myopia Conference, Tubingen, 2010
- Helps in organizing symposium and inviting speakers to speak in these symposia
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Member of organizing Committee, Made in Hong Kong. Hong Kong Institute of
Science. 2006
Symposium Chairs for Association of Research in Vision and Ophthalmology (ARVO)
conference 2000, 2010, ICER 2004, ICER 2006
- I was invited to take part in chairing a number of research symposia in these
international eye research conferences. ARVO and ICER are the largest eye research
conference in the world, attracting most prominent eye researchers all over the world to
join. The work involved inviting researchers to talk and overseeing the smooth
conduction of talks in these symposia.
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Symposium Chair for 11th International Myopia Conference, Singapore 2006.
- I invited speakers and modulated the scientific talk and exchange.
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Symposium Chair “Ion Transport”, XVII ICER Buenos Aires, Argentina, Aug 2006
- I was responsible to organize this symposium by inviting ocular physiology to talk on
ion transport and I modulated the talks and scientific communication during the
symposium.
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International Member of the Organizing Committee for the 12th International
Myopia Conference, Cairn, Australia, 2008
- I played an advisory role to the scientific programme as well as the general theme of the
myopia conference.
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Symposium Chair “Myopia Signals”, XVIII ICER Beijing, China, 2008
- I invited a number of world renowned scientists to talk on the hottest topic myopia
signals and I modulated the talks and scientific communication during the symposium.
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Symposium Chair “ Seminar day” Retinal Hong Kong, Hong Kong, Nov 2009
Symposium Chair “Myopia basic science” APOC, Hong Kong, Oct 2009
Organizer, the first Postgraduate Conference in Eye Research, April 1997, at the Hong
Kong Polytechnic University
Invited lectures for professionals
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Invited Speaker “In search of a solution to myopia – insight from myopia research” The
Fourth Hong Kong Optometric Conference, Nov 2006, Hong Kong
Invited Speaker “Myopia update” The Nineth Hong Kong Optometric Conference, Nov
2011, Hong Kong
Invited lecture: “Myopia research” Hong Kong Rotary Club, Feb 2011, Hong Kong
Invited lecture: “Myopia and Glaucoma from basic to clinical research” Hong Kong
Optical Association 2005, Hong Kong
University service
Departmental level
2010 - present
BSc Programme Leader, School of Optometry
2007-present
Member of School Executive Committee of Optometry
2005-2008
Chairman of Departmental Research Committee
1995-2001, 2002-05 Member of Departmental Research Committee
2002-present
Member of Advisory Committee on BSc Optometry
2002-present
Member of Departmental Human Ethics Sub-committee
2002-present
Deputy Director of Myopia Research Centre –Area of Strategic
Development, PolyU
2000-present
Member of Management Committee for Faculty Area of Strategic
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Development (FASD) – “Centre for Myopia Research”
1999-Present
Member of Departmental Health and Safety Committee
1997-9, 2004-2011
Departmental Health and Safety Officer and Chairman of Departmental
Health and Safety Committee
1999-2001
Departmental Peer Review Teaching Panel Member
1999-2000
Chairman of Clinic Grievance Committee
Faculty level
2011-present
Chairman of Faculty Staffing Committee, Faculty of Health and Social
Sciences
2010-present
Member of Faculty Board, FHSS
2002-present
Member of Faculty Research Committee
Institutional level
2010-present
Senate member, PolyU
2012- present
Working Group on University Research Strategy (chaired by Prof Alex Wai,
VP(RD))
2012-present
Member of University Student Discipline Committee
2002-2005
Member of University Research Committee
2003-2005
Central Animal Facility Management Committee
2002-present
Member of Animal Subjects Ethics Sub-committee
2002-present
Member of Appointments Committee for Academic Staff (II)
Other services involve interviewing panel member for staff recruitment for a number of
academic and non-academic departments.
Donation
Year
1996
Purpose
Setting up of The Laboratory of
Experimental Optometry
Amount
HK$ 40000
Donor
Bausch and Lomb
Company Limited.
Consultancy service
 Consultancy for Applied Science and Technology Research Institute (ASTRI) on “Ebooking learning and visual comfort” 2011-2
 Consultancy on Medmont Visual field Analysis – Well-link Company 1995
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Awards/Honours
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Gold Award with the Congratulations of the Jury; Grand Prize of the Technical
University of Cluj-Napoca- Romania, 39th International Exhibition of Inventions of
Geneva -“A Novel Optical Method for Retarding Myopia Progression” (2011)
Young Professorship Competitive Grant , PolyU (2008-9)
PhD supervisorship of Sun Yat-sen University, Guangzhou, PRChina (2008- present)
Departmental Nominee for the President’s Awards – Overall Outstanding Achievement
2002
Professional and Community Services
Service at professional organization
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Period of Service
Honorary member, The Hong Kong Association of Private
Practice Optometrists
Committee member of Scientific Committee, The Hong
Kong Society of Professional Optometrists
2001- present
Member, Ad hoc Advisory and investigative panel, United
Christian board
2012
2001- present
Community service and public education events
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Public seminar: "Retinitis Pigmentosa," The Hong Kong Retinitis Pigmentosa Society
1997.
Public seminar: "Diagnosis of Glaucoma," Glaucoma, Eye Care 99. The Hong Kong
Federation of Societies for Prevention of Blindness 3-4 July 1999
Public seminar:"Primary Care Optometry" Invited by Evangel Adult Education Centre in
Macau.
This talk aims at promoting the optometric profession in Macau and a number of Health
Department official of Macau have attended my seminars. Macau Adult Education
Centre 2001.
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Public seminar:“Pharmacological control of myopia – past and future” Myopia workshop
series for professional optometrists and other health care providers. PolyU, 2002.
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Public seminar: “Myopia Control in Hong Kong.” Organized jointly by the Association
of Private Practice Optometrists and the Hong Kong Society of Professional Optometrists.
Science Museum, 2002.
Public media and press interviews
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I have taken part in numerous TV interviews, programmes, press releases and newspaper
reports related to ocular health, optometry education and research information release.
Recent examples (2011-2):
Year 2012
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Radio interview: Reasons of why young Asian students are more susceptible to myopia.
China Radio International, 25 June 2012
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Interview: The prospect of being an optometrist. Ming Pao Daily News, 12 October
2012
Year 2011
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TV interview: Prolonged exposure to the computer may affect students' eyesight. TVB
Jade, 6 Feburary 2011
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Interview: Keeping an eye on serious illnesses and common problems. Classified Post –
Fuel, 18 March 2011
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TV interview: The effect of using smart phone and iPad on children’s eye health. TVB
Jade, 26 March 2011
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Press conference: “PolyU reaps the harvest of innovations in Geneva's Invention Expo”
on 16 May 2011
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TV interview: A novel optical method for retarding myopia progression. TVB Jade, 21
June 2011
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Interview: The effect of using iPad and smart phone on eye health. Ming Pao Daily
News, 12 October 2011
24