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MIP-1α and MIP-1β differentially mediate mucosal and
systemic adaptive immunity
by James W. Lillard, Udai P. Singh, Prosper N. Boyaka, Shailesh Singh, Dennis D.
Taub, and Jerry R. McGhee
Blood
Volume 101(3):807-814
February 1, 2003
©2003 by American Society of Hematology
OVA-specific serum IgA, IgM, IgG, and IgE Ab responses following nasal immunization with MIP1α or MIP-1β.Groups of 5 C57BL/6 mice were nasally immunized on days 0, 7, and 14 with 75 μg
OVA and 0.0 (■) or 1.0 μg MIP-1α or MIP-1β (▪) in PBS. The data present...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
OVA-specific serum IgG subclass Ab responses following nasal immunization with MIP-1α or
MIP-1β.Groups of 5 C57BL/6 mice were nasally immunized on days 0, 7, and 14 with 75 μg OVA
and 0.0 (■) or 1.0 μg MIP-1α or MIP-1β (▪) in PBS. The data presented are the...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
OVA-specific AFCs in spleen, nasal tract, lung, and intestinal lamina propria.Groups of 5
C57BL/6 mice were nasally immunized on days 0, 7, and 14 with 75 μg OVA and 0.0 (■)or 1.0 μg
MIP-1α (▨) or MIP-1β (▪) in PBS. Levels of OVA-specific AFCs present in sp...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
Proliferation responses by OVA-specific CD4+T cells from mice immunized with OVA plus MIP1α or MIP-1β.Groups of 5 C57BL/6 mice were nasally immunized on days 0, 7, and 14 with 75 μg
OVA and 0.0 (■)or 1.0 μg MIP-1α (▨) or MIP-1β (▪) in PBS. One week after t...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
MIP-1α and MIP-1β differentially regulate Ag-specific Th cytokine responses.Groups of 5
C57BL/6 mice were intranasally immunized on days 0, 7, and 14 with 75 μg OVA and 0.0 (■) or 1.0
μg MIP-1α (▨) or MIP-1β (▪) in PBS. One week after the last immunization,...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
MIP-1α– and MIP-1β–mediated OVA-specific CTL responses.Groups of 5 C57BL/6 mice were
nasally immunized on days 0, 7, and 14 with 75 μg OVA and 0.0 (▪) or 1.0 μg MIP-1α (♦) or MIP-1β
(●) in PBS. One week after the last immunization, spleen-, Peyer patch–, an...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
Regulation of CD80, CD86, and CD40 expression by B220+ cells by MIP-1α and MIP1β.Splenocytes from DO11.10 mice were incubated with 0, 1, 10, 100, or 1000 ng/mL MIP-1α
(triangles) or MIP-1β (squares) in plates containing 0 (open symbols) or 500 (filled symb...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
Regulation of CD28 and CD154 (CD40L) expression on CD4+ cells by MIP-1α and MIP-1β.Spleen
cells from DO11.10 mice were incubated with 0, 1, 10, 100, or 1000 ng/mL MIP-1α (triangles) or
MIP-1β (squares) in plates containing 0 (open symbols) or 500 (filled sy...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
Regulation of CD137 (4-1BB) expression on CD4+ and CD8+ cells by MIP-1α and MIP-1β.Spleen
cells from DO11.10 mice were incubated with 0, 1, 10, 100, or 1000 ng/mL MIP-1α (triangles) or
MIP-1β (squares) in plates containing 0 (open symbols) or 500 (filled sy...
James W. Lillard, Jr et al. Blood 2003;101:807-814
©2003 by American Society of Hematology
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