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SBI 4U
E: Homeostasis
Alessia, Laura, Paul, & Sheena
AGENDA
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Essential Question
Hook
Unit Plan
Historical Topic: History of Homeostatic Systems
Dry Lab
Wet Lab
STSE Culminating Activity
Recent Research: Article Analysis and Forum
Essential Question
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“What is the effect on homeostasis of the
introduction of performance-enhancing
drugs?”
Hook
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Mouse Party
– Introduces homeostasis of neural systems
– Important hook for STSE Activity
– http://learn.genetics.utah.edu/content/addicti
on/drugs/mouse.html
– Not meant to endorse drug use!
Dry Lab

The Urinary System
Exposed!
– the urinary system
– feedback mechanisms
– water balance
– effects of alcohol
 links to the STSE activity!
Image from http://www.ciccaracas.org/departments/science/Topic12.php
Dry lab – Part A
H+,
NH3
H2O, HCO3-,
NaCl, K+,
nutrients
NaCl, urea,
H2O
H2O
Afferent
arteriole
Proximal
tubule
Loop of
Henle
descending
Collecting
duct
Glomerulus
Bowman’s
capsule
Loop of
Henle
ascending
Distal
tubule
Efferent
arteriole
NaCl
H+, K+
NaCl,
H2O,
HCO3-
Dry lab – Part B

Comparing solutes in plasma, nephron and urine
 Sample question: What happened to the levels of
urea and ammonia after filtration? Explain why
this occurs.
Table 1. Concentrations of solutes in the Bowman's capsule, glomerulus, loop of Henle and collecting duct in g/100
mL (from Nelson 2003)
Solute
protein
urea
glucose
chloride (Cl-)
ammonia (NH3)
substance X
Bowman’s capsule
Glomerulus
Loop of Henle
Collecting duct
0
0.8
0
0
0.05
0.05
1.5
2
0.1
no data
0
0
0.37
no data
no data
0.6
0.0001
0.0001
0.0001
0.04
0
9.15
0
0
Dry lab – Part C
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Antidiuretic hormone (ADH)
 Negative feedback system
 Effect of alcohol on ADH and urine
formation
Osmoreceptors
detect high
pressure
Pituitary
gland
releases
ADH
Blood osmotic
pressure
decreases
H2O
conserved
Wet Lab
STSE Culminating Activity
Article Analysis and Forum