Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download A variant allele of Growth Factor Independence 1
Document related concepts
no text concepts found
Transcript
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia by Cyrus Khandanpour, Christian Thiede, Peter J. M. Valk, Ehssan Sharif-Askari, Holger Nückel, Dietmar Lohmann, Bernhard Horsthemke, Winfried Siffert, Andreas Neubauer, Karl-Heinz Grzeschik, Clara D. Bloomfield, Guido Marcucci, Kati Maharry, Marilyn L. Slovak, Bert A. van der Reijden, Joop H. Jansen, Hans K. Schackert, Khashayar Afshar, Susanne Schnittger, Justine K. Peeters, Frank Kroschinsky, Gerhard Ehninger, Bob Lowenberg, Ulrich Dührsen, and Tarik Möröy Blood Volume 115(12):2462-2472 March 25, 2010 ©2010 by American Society of Hematology Expression, genomic representation, and LD of GFI136N. Cyrus Khandanpour et al. Blood 2010;115:2462-2472 ©2010 by American Society of Hematology Influence of GFI136N allele on progression. Cyrus Khandanpour et al. Blood 2010;115:2462-2472 ©2010 by American Society of Hematology GFI136S and GFI136N proteins show different subnuclear localization. Cyrus Khandanpour et al. Blood 2010;115:2462-2472 ©2010 by American Society of Hematology GFI136S and GFI136N maintain similar repressor activity but are differentially regulated by AML1/ETO. Cyrus Khandanpour et al. Blood 2010;115:2462-2472 ©2010 by American Society of Hematology AML1/ETO colocalizes with GFI136S but not with the variant GFI136N. Cyrus Khandanpour et al. Blood 2010;115:2462-2472 ©2010 by American Society of Hematology
