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The Role of Clinical Pathologist in Infection Management Ida Parwati Indonesian Society of Clinical Pathologist and Laboratory Medicine 20160602 The Role of Clinical Pathologist in Management infectious disease VISI Menjadi organisasi profesi di bidang Patologi Klinik dan Kedokteran Laboratorium yang unggul dan profesional bertaraf internasional 20160602 The Role of Clinical Pathologist in Management infectious disease MISI 1. Memelihara dan meningkatkan kompetensi dan profesionalitas anggota PDSPatKLIn 2. Meningkatkan kualitas dan kuantitas pendidikan dan penelitian di bidang Patologi Klinik dan Kedokteran Laboratorium 3. Meningkatkan kerjasama dengan organisasi profesi lain dan organisasi keseminatan di tingkat nasional maupun internasional 4. Meningkatkan peran serta profesi PDSPatKLIn dalam menunjang program pemerintah di bidang kesehatan masyarakat 20160602 The Role of Clinical Pathologist in Management infectious disease Organization Academy of Medicine of Indonesia (MKKI) Ministry of culture and Education Indonesian Medical Association (IDI) Faculty of Medicine Collegium of CPLM Ministry Of Health Teaching Hospital Department of CPLM 20160602 The Role of Clinical Pathologist in Management infectious disease Profesional organization: ISCPLM Benchmark: Colleague of American Pathologist (CAP) ACGME (Accreditation Council for Graduate Medical Education) “Education in clinical pathology must include microbiology (including bacteriology, mycology, parasitology, and virology), immunopathology, blood banking/transfusion medicine, chemical pathology, cytogenetics, hematology, coagulation, toxicology, medical microscopy (including urinalysis), molecular biologic techniques, aspiration techniques, and other advanced diagnostic techniques as they become available.” Smith BR. Am J Clin Pathol 2006 20160602 The Role of Clinical Pathologist in Management infectious disease MICROBIOLOGY I. General Microbiology II. Bacteriology III. Susceptibility Testing IV. Mycobacteriology V. Mycology VI. Parasitology VII. Virology VIII. Molecular biology Skill Level I Skill level II Skill level III 20160602 The Role of Clinical Pathologist in Management infectious disease MICROBIOLOGY in CLINICAL PATHOLOGY I. General Microbiology Clinical Immunology II. Bacteriology chemistry III. Susceptibility Testing IV. Mycobacteriology V. Mycology VI. Parasitology Laboratory Hematology VII. Virology management VIII. Molecular Biology Urinalysis and body fluid Microbiology continously implemented throughout curriculla 20160602 The Role of Clinical Pathologist in Management infectious disease Multispectrum laboratory role Start from praanalytical→post analytical From risk factor → Diagnosis → Monitoring Therapy Service in health care → research in community → Epidemiology Different laboratory role: Promotion-Prevention-Curative 20160602 The Role of Clinical Pathologist in Management infectious disease The multispectrum laboratory aspect for management of infection Pathogen Virulence resistance Host: immune competent /deficiency Laboratory results Management of infection hostpathogen interaction Lab test spesific non spesific Host/Immun response 20160602 The Role of Clinical Pathologist in Management infectious disease Role of diagnostic tests in the management of Infection 1. Patient management: to confirm, rule out diagnosis 2. Screening for asymptomatic infections: prevent clinical disease/complication, reduce transmission in community 3. Surveillance, including verification of elimination 4. Epidemiological studies; rapid assessment of disease burden, outbreak investigation 5. Detection of drug resistance 20160602 The Role of Clinical Pathologist in Management infectious disease Laboratory diagnosis for infectious diseases Causative Agent: 1. Culture is gold standard, but some are imperfect! →need other tests 2. Antigen detection (serology/NAAT/proteomic) Host response: 1. Serology: IgA, IgM, IgG (not for TB) 2. Hematology: involvement of WBC (MN/PMN), thrombocyte (M/IP), coagulation system 3. Clinical Chemistry: biomarker/depend on organ involved: LFT/KFT etc 20160602 The Role of Clinical Pathologist in Management infectious disease Example of Multi spectrum laboratory tests SEPSIS 20160602 The Role of Clinical Pathologist in Management infectious disease Campaign to Prevent Antimicrobial Resistance in Healthcare Settings 12 Steps to Prevent Antimicrobial Resistance: Hospitalized Adults 12 Contain your contagion Prevent Transmission 11 Isolate the pathogen 10 Stop treatment when cured 9 Know when to say “no” to vanco 8 Treat infection, not colonization Use Antimicrobials Wisely 7 Treat infection, not contamination 6 Use local data 5 Practice antimicrobial control 4 Access the experts Diagnose and Treat Effectively 3 Target the pathogen 2 Get the catheters out Prevent Infection 1 Vaccinate 20160602 The Role of Clinical Pathologist in Management infectious disease Six Essential Elements of ASP Information Technology Microbiology Lab Monitoring of Process and Outcome Measurement Suplemental Strategies Active Strategies Effective Antimicrobial Stewardship Program 20160602 The Role of Clinical Pathologist in Management infectious disease Comprehensive Multidiciplinary Team Approach Surveillance of bacteriological and antibiotics susceptibility pattern 20160602 The Role of Clinical Pathologist in Management infectious disease INFECTIOUS DISEASE INTEGRATED SERVICE TEAM KLINISI PERAWAT/BIDAN DALIN/PPIRS SKFT FARMASI LAB 20160602 The Role of Clinical Pathologist in MIKROBIOLOGI Management infectious disease 16 LABORATORIUM MIKROBIOLOGI RSHS DOTS PPRA Jejaring Lab PPIRS TB Jejaring lab PPRA Jejaring lab EID HIV Pelayanan pasien Integrated Infectious Diseases team Metadon IO Penelitian Internasional 20160602 The Role of Clinical Pathologist in Management infectious disease Rujukan ↔ Narasumber DinKes Penelitian di komunitas 8 0 3 2 2 1 5 2 2 4 6 1 2 1 1 1 2 4 2 1 20160602 The Role of Clinical Pathologist in Management infectious disease Clinical Pathologist and Centers of Clinical Pathology Education v v 11 Centers 23 branches Center Branch 1134 Clin. pathologists 20160602 The Role of Clinical Pathologist in Management infectious disease Tantangan vs Peluang • AFTA (ASEAN Free Trade Area) 2015 • Kompetensi minimal setara dengan profesi sejenis di ASEAN • Akreditasi laboratorium nasional/internasional • Penyakit Infeksi emerging-re emerging: MERS CoV, Ebola dll • Sistem Jaminan Kesehatan Nasional (SJKN) • Tuntutan Pelayanan Laboratorium untuk ‘preventive medicine’ 20160602 The Role of Clinical Pathologist in Management infectious disease Thank you for your attention 20160602 The Role of Clinical Pathologist in Management infectious disease