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MicroRNA-24 Regulates Macrophage Behavior and Retards AtherosclerosisSignificance by Karina Di Gregoli, Nicholas Jenkins, Rebecca Salter, Stephen White, Andrew C. Newby, and Jason L. Johnson Arterioscler Thromb Vasc Biol Volume 34(9):1990-2000 August 20, 2014 Copyright © American Heart Association, Inc. All rights reserved. Granulocyte/macrophage colony stimulating factor (GM-CSF) macrophages exhibit increased matrix metalloproteinase (MMP)-14 protein expression and invasion. Karina Di Gregoli et al. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 Copyright © American Heart Association, Inc. All rights reserved. MicroRNA-24 (miR-24) regulates macrophage colony stimulating factor (M-CSF) macrophage matrix metalloproteinase (MMP)-14 expression and invasion. Karina Di Gregoli et al. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 Copyright © American Heart Association, Inc. All rights reserved. Granulocyte/macrophage colony stimulating factor (GM-CSF) macrophage polarization or microRNA-24 (miR-24) inhibition is not associated with changes in M1 or M2 macrophage gene expression or macrophage maturation. Karina Di Gregoli et al. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 Copyright © American Heart Association, Inc. All rights reserved. MicroRNA-24 (miR-24) inhibition increased intraplaque matrix metalloproteinase (MMP)-14 macrophage expression and MMP-14–dependent proteolytic activity. Karina Di Gregoli et al. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 Copyright © American Heart Association, Inc. All rights reserved. MicroRNA-24 (miR-24) inhibition drives brachiocephalic plaque progression. Karina Di Gregoli et al. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 Copyright © American Heart Association, Inc. All rights reserved. MicroRNA-24 (miR-24) expression is inversely related to macrophage matrix metalloproteinase (MMP)-14 expression and plaque instability in human coronary atherosclerosis. Karina Di Gregoli et al. Arterioscler Thromb Vasc Biol. 2014;34:1990-2000 Copyright © American Heart Association, Inc. All rights reserved.
