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Curriculum Vitae
JOSEPH DOUGLAS SMITH, Ph.D.
1. Biographic information
Seattle Biomedical Research Institute
307 Westlake Ave. N., Suite 500
Seattle, WA 98109-5219
Phone: (206) 256-7384
Fax: (206) 256-7229
e-mail: joe.smith@ sbri.org
2. Educational background
1988
B.A.
Macalester College, St. Paul, MN
1994 Ph.D. Washington University in St. Louis, MO
3. Professional Positions
1994-99
Postdoctoral Fellow, Dr. Louis H. Miller’s Laboratory, Laboratory of Parasitic
Diseases, National Institute of Allergy and Infectious Diseases, National Institutes
of Health, Bethesda, MD: Antigenic variation and cytoadherence of Plasmodium
falciparum
1999-2002
Assistant Professor, Colorado State University, Fort Collins, CO
2000-2002
Faculty member, Cell and Molecular Biology Program, Colorado State
University, Fort Collins, CO
2002-present Assistant Member, Seattle Biomedical Research Institute, Seattle, WA
2003-present Research Assistant Professor, Department of Pathobiology, University of
Washington, Seattle, WA
2004-present Associate Faculty Member, Molecular & Cellular Biology Program, University of
Washington, Seattle, WA
4. Honors, Awards, Scholarships
1993
Spencer T. and Ann W. Olin Medical Scientist Fellow, awarded in recognition of
superior achievement in biomedical research
2000
National Foundation for Infectious Diseases New Investigator Award
2001
Ortho-McNeil/IDSA New Investigator Award in Infectious Disease (declined due
to requirements of a competing award)
2001
Ellison Medical Foundation New Investigator Award in Global Infectious
Diseases
5. Bibliography
*primary advisor to this graduate student
**primary advisor to this postdoctoral fellow
***primary advisor to this undergraduate
Research Papers in Refereed Journals
1.
Smith, J.D., W.-R. Lie, J. Gorka, C.S. Kindle, N.B. Myers, and T.H. Hansen. (1992)
Disparate interaction of peptide ligand with nascent versus mature class I major
histocompatibility complex molecules: comparisons of peptide binding to alternative forms
of Ld in cell lysates and the cell surface. 1992. J. Exp. Med. 175:191-202.
2.
Smith, J.D., W.-R. Lie, J. Gorka, N.B. Myers, and T.H. Hansen. (1992) Extensive peptide
ligand exchange by surface class I major histocompatibility complex molecules
independent of exogenous beta 2-microglobulin. Proc. Natl. Acad. Sci. USA. 89:7767-71.
3.
Solheim, J.C., B.M. Carreno, J.D. Smith, J. Gorka, N.B. Myers, Z. Wen, J.M. Martinko,
D.R. Lee, and T.H. Hansen. (1993) Binding of peptides lacking consensus anchor residue
alters serological recognition of H-2Ld. J. Immunol. 151:5387-97.
4.
Smith, J.D., N.B. Myers, J. Gorka, and T.H. Hansen. (1993) Model for the in vivo
assembly of nascent Ld class I molecules and for the expression of unfolded Ld molecules
at the cell surface. J. Exp. Med. 178:2035-46.
5.
Alexander-Miller, M., A.A. Robinson, J.D. Smith, W.E. Gillanders, L.G. Harrison, T.H.
Hansen, and J.M. Connolly. (1994) Definition of TCR recognition sites on Ld-tum
complexes. Int. Immunol. 6:1699-1707.
6.
Smith, J.D., J.C. Solheim, B.M. Carreno, and T.H. Hansen. (1995) Characterization of
class I MHC folding intermediates and their disparate interactions with peptide and beta 2microglobulin. Mol. Immunol. 32:531-40.
7.
Smith, J.D., C.E. Chitnis, A.G. Craig, D.J. Roberts, D.E. Hudson-Taylor, D.S. Peterson,
R.Pinches, C.I. Newbold, and L.H. Miller. (1995) Switches in Expression of Plasmodium
falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of
infected erythrocytes. Cell. 82:101-10.
8.
Smith, J.D., S. Keyes, A.G. Craig, T. Fagen, D. Hudson-Taylor, D. Baruch, C.I. Newbold,
L.H. Miller. (1998) Analysis of adhesive domains from the A4VAR Plasmodium
falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain. Mol. Biol.
Parasitol. 97:133-48.
9.
Buffet P., B. Gamain, C. Scheideg, D. Baruch, J. Smith, R. Hernandez-Rivas, B. Pouvelle,
S. Oishi, H. Fujii, T. Fusai, D. Parzy, L. Miller, A. Scherf. (1999) A Plasmodium
falciparum domain mediating adhesion to CSA: a receptor for human placental
sequestration. Proc. Natl. Acad. Sci. USA 96:12743-48.
10.
Smith, J.D., A.G. Craig, S. Kyes, D. Hudson-Taylor, T. Fagen, D. Baruch, C.I. Newbold,
L.H. Miller. (2000) Identification of a Plasmodium falciparum ICAM-1 binding domain: a
parasite adhesion trait implicated in cerebral malaria. Proc. Natl. Acad. Sci. USA 97:176671.
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11.
Smith, J.D., G. Subramanian, B. Gamain, D.I. Baruch, L.H. Miller. (2000) Classification
of Adhesive Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1
Family of Cytoadherent Receptors. Mol. Biochem. Parasitol. 110:293-310.
12.
Gamain, B., Smith, J.D., Miller, L.H., and D.I. Baruch. (2001) Modifications in the CD36
binding domain of the Plasmodium falciparum variant antigen are responsible for the
inability of chondroitin sulfate A adherent parasites to bind CD36. Blood 97:3268-74.
13.
Robinson, B.A.*, Welch, T.L., and J.D. Smith. (2003) Widespread functional
specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members
to bind CD36 analyzed across a parasite genome. Molecular Microbiology. 47:1265-78.
14.
Kraemer, S.M.**, Gupta, L.**, and J.D. Smith. (2003) New tools to identify var sequence
tags and clone full-length genes using type-specific primers to Duffy binding-like domains.
Mol. Biochem. Parasitol. 129:91-102.
15.
Gratepanche, S., Gamain, B., Smith, J.D., Robinson, B.A.*, Saul, A., L.H. Miller. (2003)
Induction of crossreactive antibodies against the Plasmodium falciparum variant protein.
Proc. Natl. Acad. Sci. USA. 100:13007-12.
16.
Kraemer, S.M.** and J.D. Smith. (2003) Evidence for the importance of genetic
structuring to the structural and functional specialization of the Plasmodium falciparum var
gene family. Molecular Microbiology. 50:1527-38.
17.
Gamain, B., J.D. Smith, Avril M., Baruch D.I., Scherf A., Gysin J., L.H. Miller. (2004)
Identification of a 67-amino acid region of the Plasmodium falciparum variant surface
antigen that binds chondroitin sulfate A and elicits antibodies reactive with the surface of
placental isolates. Molecular Microbiology. 53:445-55.
18.
Springer A.L.**, Smith, L.M., Mackay D.Q., Nelson S.O., J.D. Smith. (2004) Functional
Interdependence of the DBLbeta domain and c2 region for binding of the Plasmodium
falciparum variant antigen to ICAM-1. Mol. Biochem. Parasitol. 137:55-64.
19.
Gamain B., Trimnell, A.R.**, Scheidig C., Scherf A., Miller L.H., J.D. Smith.
Identification of multiple CSA binding domains in the var2csa gene transcribed in CSA
binding parasites. J. Infect. Dis. 191:1010-3.
Reviews
1.
Smith, J.D., B. Gamain, D.I. Baruch, S. Kyes. Decoding the language of var genes and
Plasmodium falciparum sequestration. 2001. Trends in Parasitology 17:538-545.
Book Chapters
1.
Smith, J.D. & A.G. Craig. 2004. The surface of the Plasmodium falciparum-infected
erythrocyte. Genomes and the Molecular Cell Biology of Malaria Parasites. (Waters, A.P.,
ed) Horizon Press.
Editorials/Commentaries
1.
Miller, L.H. and J.D. Smith. Motherhood and malaria. 1998. Nat. Med. 4:1244-45.
2.
Smith, J.D. & L.H. Miller. 2004. Infected erythrocyte binding to hyaluronic acid and
malaria in pregnant women. Editorial. JID. 189:165-168.
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3.
Smith, J.D. & K.W. Deitsch. 2004. Pregnancy-associated Malaria and the Prospects for
Syndrome-specific Antimalaria Vaccines. Commentary. J. Exp. Med. 200:1093-7.
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