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Lectures in Early Breast Cancer
A PowerPoint slide set based on images from:
Lectures in Early Breast Cancer Part 3:
Adjuvant Therapy in Early Breast Cancer
Lectures in Early Breast Cancer
Reproduced with permission from the EBCTCG (2005).
Lectures in Early Breast Cancer
Participants (n=10,386) had either oestrogen receptor (ER)-positive or ER-unknown disease: 20% ER-unknown, 30% node-positive. Error bars are ±1SE.
Reproduced with permission from the EBCTCG (2005).
Lectures in Early Breast Cancer
*Odds ratio calculated instead of hazard ratio. A, anastrozole; T, tamoxifen; HR +, hormone-receptor-positive.
Reproduced with permission from Howell et al. (2005).
Lectures in Early Breast Cancer
The second non-breast cancers included endometrial cancer (6 patients in the letrozole group and 15 patients in the tamoxifen group), colon cancer (8 and 13 patients, respectively), lung cancer (5
and 8 patients), ovarian cancer (4 and 8 patients), renal cancer (4 and 8 patients) and other types (42 and 30 patients). Causes of death without a prior cancer event included cerebrovascular
accident (7 patients in the letrozole group and 1 patient in the tamoxifen group), thromboembolic event (2 patients in each group), cardiac causes (13 and 6 patients, respectively), sudden death of
unknown cause (10 patients in each group), and other causes (23 and 19 patients, respectively). Patients with multiple causes of death were classified as having ‘other causes’. Two-sided p values
for the cumulative incidence were calculated with the use of Gray's test.
Reproduced with permission from Thurlimann et al. (2005).
Lectures in Early Breast Cancer
*A disease-free survival event was defined as the first of any of the following events: any breast-cancer recurrence; a new invasive cancer in the contralateral breast; a
second non-breast cancer; or death without a prior cancer event.
Reproduced with permission from Thurlimann et al. (2005).
Lectures in Early Breast Cancer
Reproduced with permission from Jakesz et al. (2005).
Lectures in Early Breast Cancer
Data taken from Coombes et al. (2006) and Kaufman et al. (2006).
Lectures in Early Breast Cancer
Of breast cancer recurrences, 60% occur more than 5 years postsurgery. Annual risk of late recurrence is particularly high in oestrogen-receptor-positive (ER+) tumours.
PgR+, progesterone-receptor-positive.
Reproduced with permission from Saphner et al. (1996).
Lectures in Early Breast Cancer
Reproduced from the EBCTCG (2005).
Lectures in Early Breast Cancer
Reproduced with permission from Ingle et al. (2001).
Lectures in Early Breast Cancer
*In favour of tamoxifen. †n=2229 for anastrozole, 2236 for tamoxifen, excluding patients with hysterectomy at baseline, recorded at any time. ‡Patients with one or more
fractures occurring at any time before recurrence (includes patients no longer receiving treatment). §Patients may have had one or more fractures at difference sites.
Reproduced with permission from Howell et al. (2005).
Lectures in Early Breast Cancer
Reproduced with permission from Dowsett et al. (2005).
References
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2006; 24(18, Suppl):LBA527.
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Kaufman M, Jonat W, Hilfrich J et al; the German Adjuvant Breast Cancer Group. Survival benefit of switching to anastrozole after 2 years' treatment with
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