Download Advice Summary - Australian Pesticides and Veterinary Medicines

ADVICE SUMMARY
APPLICATION FOR REGISTRATION OF A CHEMICAL PRODUCT
Product name:
SPINNER TURF INSECTICIDE
Applicant:
SYNGENTA AUSTRALIA PTY LTD
Product number:
66637
Application number:
54071
Purpose of Application and Description of Use: Registration of a 200 g/kg cyantraniliprole + 200 g/kg thiamethoxam, water dispersible granule product,
for control of Argentine Stem Weevil larvae, Scarab Beetle larvae and caterpillars (Armyworm and Cutworm) in established turf.
Active Constituent(s):
CYANTRANILIPROLE
THIAMETHOXAM
Regulatory Decision:
To grant the application subject to the following conditions:
Standard Conditions of Registration/Approval
1. Containers must meet AgVet Code Regulation 18
2. Agricultural products must meet Active Constituents Quality Assurance Requirements
Label must contain a Date of Manufacture and Batch Number
For full conditions, refer to Standard Conditions for Applications on the APVMA website.
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ADVICE
Australian Government Department of Health, Office of Chemical Safety (OCS)
The OCS conducted the assessment by taking into consideration of the recently assessed data package (for granting the approval of the new active constituent cyantraniliprole and registration of the primary product- DuPont Exirel Insecticide) and the additional data submitted by the applicant to support the registration of the new
product Spinner Turf Insecticide (previously called - A16901B Turf Insecticide), a water-dispersible granule formulation containing 200 g/kg cyantraniliprole and 200 g/kg
thiamethoxam intended for use in established turf for control of various pests (Argentine Stem Weevil and Scarab Beetle larvae and Armyworm/Cutworm caterpillars).
Cyantraniliprole is an anthranilic diamide insecticide compound structurally related to chlorantraniliprole, and similar in mode of action to flubendiamide. The insecticidal mode
of action involves unregulated activation of ryanodine receptor channels, leading to internal calcium store depletion that impairs regulation of muscle contraction. This results in
lethargy and muscle paralysis in insects, leading to eventual death.
The toxicology assessment of cyantraniliprole was conducted jointly as part of a Global Joint Review (GJR) by scientists from Canada Pest Management Regulatory Agency
(PMRA), the United States Environmental Protection Agency (EPA), the Australia Office of Chemical Safety (OCS), the United Kingdom Chemicals Regulation Directorate
(CRD) and the French Agency for Food, Environmental and Occupational Health and Safety (ANSES). The US EPA was the primary reviewer for the toxicology studies, with all
other partners as secondary reviewers.
Australian independent toxicology assessments have used the terms of no observed effect level (NOEL) and lowest observed effect level (LOEL). However, since the
assessment relies significantly on the international work share, the OCS adopted the no observed adverse effect level (NOAEL) and low observed adverse effect level
(LOAEL) approach using scientific justification for their adoption, which are included within the international assessment.
Studies were submitted on toxicokinetics and metabolism, acute toxicity, short-term, sub-chronic and chronic (carcinogenicity) toxicity, genotoxicity (in vitro and in vivo),
reproductive and developmental toxicity, neurotoxicity, immunotoxicity and mechanistic toxicity studies on cyantraniliprole. The toxicology studies were conducted in
accordance with contemporary test guidelines. The data provided in the acute and repeat dose studies were relied on in considering whether the proposed use of the product
would not be an undue health hazard to human health.
Based on the findings of the acute toxicological studies evaluated, cyantraniliprole was of low acute oral, dermal and inhalational toxicity in rats. It was a not a skin irritant in the
rabbit but was a slight eye irritant in the same species. Cyantraniliprole was not a skin sensitiser in the mouse.
Cyantraniliprole is generally of a low order of toxicity in all tested species in short term studies. Dogs were slightly more sensitive than rats to cyantraniliprole-mediated toxicity,
particularly liver-related effects. The major systemic effects consisted alterations in the liver (increased weights, metabolic enzyme induction, hypertrophy) and thyroid (follicular
hypertrophy, thyroid weights, effects on hormone homeostatis). Limited findings in the adrenal cortex (microvesiculation) were observed in rodent studies, but not in dogs. No
treatment-related effects were observed upon short-term dermal administration of cyantraniliprole at up to the limit dose of 1000 mg/kg bw/day, and upon short-term
inhalational administration at up to 100 mg/m3.
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In long-term toxicity studies, cyantraniliprole was more sensitive in the dog than in rodents. Major systemic effects included alterations in clinical chemistry (albumin, ALP) and
liver weights considered toxicologically significant, along with changes in liver histopathology at higher doses. Cyantraniliprole was not carcinogenic in both rodent studies.
Cyantraniliprole was not a reproductive or developmental toxicant, and tested negative in vitro and in vivo in a battery of mutagenicity and/or genotoxicity studies. Additionally,
the available data indicated that cyantraniliprole did not demonstrate neurotoxic or immunotoxic potential.
Based on the findings of the toxicological studies evaluated, the product Spinner Turf Insecticide is a low acute oral, dermal and inhalational toxicant in rats. It is not a skin
irritant in rabbits but is a slight eye irritant in the same species, and is not a skin sensitiser in guinea pigs.
The ADI for cyantraniliprole is established at 0.01 mg/kg bw/day, based on a NOAEL of 1 mg/kg bw/day in a one-year dietary toxicity study in the dog, and using a default
100-fold safety factor. No ARfD has been established for cyantraniliprole, as the toxicology database for cyantraniliprole indicated the active constituent to be of low acute
toxicity, and cyantraniliprole did not demonstrate evidence of a genotoxic, neurotoxic or reproductive/developmental toxicity potential after a single dose. Cyantraniliprole has
been included in Schedule 5 of the Standard for the Uniform Scheduling of Medicines and Poisons (SUSMP) with no cut-off (implemented from 1 September 2013).
The ADI for thiamethoxam was established in 2000 at 0.02 mg/kg bw/d based on a NOEL of 2 mg/kg bw/d from a 2-generation reproduction rat study, and using a default
100-fold safety factor. No ARfD value has been established for thiamethoxam at this stage. Thiamethoxam is currently in Schedule 6 of the SUSMP, except in preparations
containing 60% or less of thiamethoxam which are in Schedule 5.
On the basis of the product toxicology and concentrations of the two active constituents, a Schedule 5 classification for the product is considered appropriate.
Based on the assessment of the toxicology data on the active constituent and the product and taking into consideration of the potential toxicological hazard, use pattern and
likelihood of handler exposure, the OCS recommended the First Aid Instruction, Safety Directions and Re-entry statements for the product label.
The OCS therefore advised the APVMA that there are no objections on human health grounds to the registration of Spinner Turf Insecticide, containing 200 g/kg
cyantraniliprole and 200 g/kg thiamethoxam as a water-dispersible granule formulation. Furthermore, the OCS recommended that, the proposed use of the active constituent
cyantraniliprole and the product Spinner Turf Insecticide will not be an undue health hazard to humans according to the criteria stipulated in Section 14 of the Ag/Vet Code Act
of 1994.
Data relied on to provide the advice
Data No
Data
Source*
62371
S
62372
S
54071
Author(s)
Title
Date
Data Type
Data Sub-type
Authorising
Party
E Shepard
Cyantraniliprole - Dissipation of Transferable Turf Residues on Turf Treated
with Water-Dispersible Granule (WG) and Granule (GR) Formulations of
Cyantraniliprole. Amendment 1
26 April 2011
OH and S
Dislodgable foliar
residues
Applicant
V Zelenak
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Dermal Toxicity
Study in the Rat
17 June 2010
Toxicology
Acute Dermal
Studies, Product
Applicant
Page 3 of 9
Inherited
Application
No.
KP25S_F39 Version: 2 Issued: 14/08/2007
Data No
Data
Source*
Author(s)
62373
S
J Tavaszi
62374
S
62375
Title
Date
Data Type
Data Sub-type
Authorising
Party
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Eye Irritation Study
in Rabbits
6 August 2010
Toxicology
Acute Eye Irritation
Studies, Product
Applicant
K Nagy
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Inhalation Toxicity
Study (Nose-Only) in the Rat
13 July 2010
Toxicology
Acute Inhalation
Studies, Product
Applicant
S
J Tavaszi
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Oral Toxicity Study
in the Rat (Up and Down Procedure)
15 July 2010
Toxicology
Acute Oral Studies,
Product
Applicant
62376
S
V Zelenak
Cyantraniliprole/Thiamethoxam WG (A16901B) - Primary Skin Irritation
Study in Rabbits
8 June 2010
Toxicology
Acute Skin Irritation
Studies, Product
Applicant
62377
S
M Torok-Batho
Cyantraniliprole/Thiamethoxam WG (A16901B) - Skin Sensitization in
Guinea Pigs by the Buehler Method (3 Induction)
2 July 2010
Toxicology
Acute Skin
Sensitisation
Studies, Product
Applicant
62378
S
D Davies
Cyantraniliprole/Thiamethoxam WG (A16901B) - In Vitro Absorption through
Human Epidermal Membranes using [14C]-Cyantraniliprole
28 March 2011
Toxicology
Genotoxicity
(Mutagenicity)
Studies
Applicant
62379
S
S Runacres, S
Harris
Cyantraniliprole/Thiamethoxam WG (A16901B) - In vivo Dermal Absorption
in the Rat from WG Formulation A16901B
30 March 2011
Toxicology
Genotoxicity
(Mutagenicity)
Studies
Applicant
62380
S
D Davies
Cyantraniliprole/Thiamethoxam WG (A16901B) - In Vitro Absorption through
Rat Epidermal Membranes using [14C]-Cyantraniliprole
28 March 2011
Toxicology
Genotoxicity
(Mutagenicity)
Studies
Applicant
Inherited
Application
No.
Australian Government Department of Environment
The Department of Environment (DotE) has assessed the comprehensive data package provided by the applicant in support of the proposed use of the new product as a part
of the OECD Global Joint Review for approval of the new active cyantraniliprole and relevant products, with simultaneous submission of the data package to the EU, the
USEPA and Canadian PMRA, with this formulation as a secondary product. The new active cyantraniliprole has recently been approved by the APVMA along with the
registration of the primary product- DuPont Exirel Insecticide. The applicant has provided a set of data specifically with the Spinner Turf Insecticide formulation or a similar
formulation not containing thiamethoxam. Information from the Department of the Environment’s data holdings and publicly available sources has been used for assessment of
the thiamethoxam component.
In order to control insect pests in established turf, Spinner Turf Insecticide will be applied at a maximum of two applications per crop season by ground application, each at a
rate of 1 kg product/ha (200 g of each active constituent/ha, minimum spray interval 42 d).
Cyantraniliprole is moderately soluble in water (6–17 mg ac/L at 20°C, varying with pH) and is very slightly volatile. Laboratory studies indicate that it undergoes degradation by
hydrolysis (pH dependent, DT50 at 20°C = 260.5 at pH 4 to 1.77 d at pH 9), biotic processes in soil and water under both aerobic and anaerobic conditions (DT50 in soil
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according to best fit models = 4.4-91.9 d, DT50 in water/sediment systems [whole system] = 2.1–25.1 d) and photolysis in water (DT50 < 1 d) and moist soil (DT50 = 12.2 d). A
range of metabolites is formed and DT50 and mobility data for these have also been obtained. Cyantraniliprole is classified as having medium to high mobility in soil
(KFOC = 128–266 mL/g), whereas the metabolites range from immobile to very highly mobile. Field dissipation studies indicated DT50 values ranging from 9.7 to 44 d (best
fitting model for each site; geomean = 17.2 d) and DT90 values from 55.5 to 333 d (geomean = 157 d) and confirmed low mobility of cyantraniliprole and higher mobility of
some metabolites. Cyantraniliprole does not bioconcentrate in fish (BCF < 1).
Cyantraniliprole is practically nontoxic to birds with acute oral or short term dietary exposure and did not exhibit toxicity in reproduction studies (NOEC = 1000 ppm diet). Acute
toxicity studies with fish indicated LC50 values were above the practical limit of water solubility in the test medium, while early life stage studies indicated very slight toxicity to
fish (NOEC > 1 mg ac/L). It is moderately toxic to at most slightly toxic to green and blue-green algae and diatoms. The acute toxicity to aquatic and benthic invertebrates
ranges from slightly toxic to very highly toxic (most sensitive species Daphnia magna, 48 h EC50 = 0.0204 mg ac/L), and it was highly toxic to aquatic invertebrates with
chronic exposure (21 d NOEC = 0.00969 mg ac/L). Cyantraniliprole as the active substance or as solo formulations is toxic to honeybees with acute oral or contact exposure
and field and semi-field studies show limited, short term effects on mortality, flight activity and behaviour following application to flowering plants. Its toxicity to insect predators
and parasites in the laboratory varied between species (low to mites and spiders, highest to parasitoid wasps). In laboratory studies it was very slightly toxic to earthworms and
soil mites and did not have harmful long term impacts on soil microbial nitrogen or carbon transformation, whereas it was highly toxic to collembola. Glasshouse studies with
terrestrial plants indicated most species would not be harmed by direct overspray to soil or foliage at the maximum proposed application rate.
Thiamethoxam is a neonicotinoid insecticide already in use in Australia for various purposes, including at similar or higher rates as the sole active constituent in a similar turf
product. There are concerns regarding the risk that thiamethoxam and other neonicotinoid insecticides pose to bees, and the European Commission has restricted use of 3
neonicotinoid pesticides, including thiamethoxam. However, potential exposure of bees to thiamethoxam is very limited with use as a turf insecticide provided it is not applied
on swards containing flowering plants.
Laboratory studies with the Spinner Turf Insecticide formulation (containing both active constituents) indicate that the combination product is slightly toxic to fish, practically
non-toxic to algae, very slightly toxic to earthworms, and that it did not have harmful long term impacts on soil microbial nitrogen or carbon transformation. However, the
product is very highly toxic to daphnids (48 h EC50 = 27 µg product/L), i.e. greater toxicity than expected from either of the active constituents alone. The product is toxic to
bees with acute contact exposure and highly toxic to bees with acute oral exposure.
In considering the submitted data, the Department of the Environment has given particular attention to the potential risks to organisms in the aquatic environment from spray
drift and run-off, to bees and other terrestrial arthropods in the treated field and off field, and to environmental exposure arising from persistent metabolites of cyantraniliprole
and thiamethoxam. Based on the submitted data, the risks to birds, mammals, plants, earthworms, and soil nitrogen and carbon metabolism processes were found acceptable.
A risk that can be managed with specification of appropriate downwind no-spray zones to aquatic areas was identified to aquatic invertebrates with the proposed uses.
Concentrations of the active constituents that may be reached in surface water through runoff or in groundwater are not expected to reach levels harmful to aquatic organisms.
Risks that can be managed through appropriate label statements were identified to bees.
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The DotE recommended protection statements, restraints and mandatory no-spray zones have been incorporated to the Spinner Turf Insecticide label and therefore the
APVMA is satisfied that the proposed use of cyantraniliprole and thiamethoxam in Spinner Turf Insecticide for the control of various insect pests in turf would not be likely to
have an unintended effect that is harmful to animals, plants or things or to the environment.
Data relied on to provide the advice
Data No
Data
Source*
Date
Data Type
Data Sub-type
Authorising
Party
62369
S
T Wiepke, B
Jacobson, E
Vogl
Dissipation of SYN545377 WG (40) in a Cool-Season Turf in the Finger
Lakes Region of New York
18 April 2011
Environment
Fate
Field Dissipation
Plants
Applicant
62117
I
Snyder, N.J.,
White, M.
Field dissipation of Cyantraniliprole (DPX-HGW86) in North America and
Europe – summary of normalized kinetic calculations [DuPont-31454]
18 November 2010
Environment
Fate
Field Dissipation
Soils
Du Pont
(Australia) Pty
Ltd
62368
S
T Wiepke, B
Jacobson, E
Vogl
Dissipation of SYN545377 WG (40) and G (0.23) Formulations in a WarmSeason Turf in the Coastal Plain of Georgia
13 April 2011
Environment
Fate
Field Dissipation
Plants
Applicant
67431
S
D Patterson
Predicted Environmental Concentrations in Surface Water for
Cyantraniliprole and its Metabolites using FOCUS Surface Water Scenarios
at Steps 3 & 4 following applications to Tree Crops
16 August 2012
Environment
Fate
Modelling Studies
Applicant
61623
I
Russell, M.
The degradation of cyantraniliprole (DPX-HGW86) in aquatic systems, via
photolysis and in anaerobic soil - summary of kinetic calculations [DuPont29552]
18 August 2010
Environment
Fate
Modelling Studies
Du Pont
(Australia) Pty
Ltd
54110
61624
I
Khanijo, I.,
Russell, M.
The degradation of cyantraniliprole (DPX-HGW86) and metabolites in
aerobic soil - summary of kinetic calculations [DuPont-29554 R2]
10 November 2010
Environment
Fate
Modelling Studies
Du Pont
(Australia) Pty
Ltd
54110
62385
S
R Kuhl, V
Wydra
Cyantraniliprole/thiamethoxam WG (A16901B) - Acute Toxicity to Common
Carp (Cyprinus carpio) in a 96-hour Static Limit-Test. Amendment 1
25 October 2010
Environment
Toxicology
Aquatic Organisms
Acute
Applicant
62364
S
R Kuhl, V
Wydra
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Toxicity to Daphnia
magna in a Static 48-hour Immobilisation Test
25 October 2010
Environment
Toxicology
Aquatic Organisms
Acute
Applicant
62365
S
R. Kuhl, V
Wydra
Cyantraniliprole/Thiamethoxam WG (A16901B) - Toxicity to
Pseudokirchneriella subcapitata in an Algal Growth Inhibition Test
25 October 2010
Environment
Toxicology
Aquatic Organisms
Acute
Applicant
62363
S
R Kuhl,V
Wydra
Cyantraniliprole/thiamethoxam WG (A16901B) - Acute Toxicity to Rainbow
Trout (Oncorhynchus mykiss) in a 96-hour Static Limit-Test
21 July 2010
Environment
Toxicology
Aquatic Organisms
Acute
Applicant
62109
I
Samel, A.,
Green, J.W.,
Russell, M.
Cyantraniliprole: Rationale for selection of acute and chronic aquatic
invertebrate endpoints [DuPont-31209]
30 March 2011
Environment
Toxicology
Aquatic Organisms
Other
Du Pont
(Australia) Pty
Ltd
54071
Author(s)
Title
Page 6 of 9
Inherited
Application
No.
54112
54112
KP25S_F39 Version: 2 Issued: 14/08/2007
Data No
Data
Source*
Author(s)
62366
S
T Sekine
62367
S
62388
Title
Date
Data Type
Data Sub-type
Authorising
Party
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Oral and Contact
Toxicity on Honey Bees (Apis mellifera L.). Amendment 1
22 June 2010
Environment
Toxicology
Non-target
Invertebrates
(terrestrial) Bees
Applicant
S Friedrich
Cyantraniliprole/Thiamethoxam WG (A16901B) - Acute Toxicity to the
Earthworm Eisenia fetida
21 April 2010
Environment
Toxicology
Non-target
Invertebrates
(terrestrial)
Earthworms
Applicant
S
J Stevens
Cyantraniliprole WG (A16971B) - A semi-field bioassay of the effects of
fresh residues on the parasitic wasp Aphidius rhopalosiphi (Hymenoptera,
Braconidae)
3 November 2009
Environment
Toxicology
Non-target
Invertebrates
(terrestrial)
Parasites
Applicant
62387
S
J Stevens
Cyantraniliprole WG (A16971B) - A rate-response extended laboratory
bioassay of the effects of fresh residues on the parasitic wasp Aphidius
rhopalosiphi (Hymenoptera, Braconidae)
21 June 2010
Environment
Toxicology
Non-target
Invertebrates
(terrestrial)
Parasites
Applicant
62386
S
L Fallowfield
SYN545377 WG (A16971B) - A rate-response extended laboratory bioassay
of the effects of fresh residues on the predatory mite, Typhlodromus pyri
(Acari: Phytoseiidae)
27 April 2010
Environment
Toxicology
Non-target
Invertebrates
(terrestrial)
Predators
Applicant
62370
S
L Schulz
Cyantraniliprole/Thiamethoxam WG (A16901B) - Effects on the Activity of
Soil Microflora (Nitrogen and Carbon Transformation Tests)
19 May 2010
Environment
Toxicology
Non-target
Invertebrates
(terrestrial) Soil
Micros
Applicant
Inherited
Application
No.
State/External Efficacy Reviewer
Twelve trials were submitted in support of the claim for registration approval for Spinner Turf Insecticide containing 200 g/kg cyantraniliprole and 200 g/kg thiamethoxam, for
the control of larvae of African black beetle, Heteronychus arator, Argentinian scarab, Cyclocephala signaticollis, June beetle, Phyllophaga sp., Argentine stem weevil,
Listronotus bonariensis, billbug larvae, Sphenophorus brunnipennis,and caterpillars of black cutworm, Agrotis ipsilon and lawn armyworm, Spodoptera mauritia, in turf.
The trials were conducted on a range of turf grasses including kikuyu, wintergreen couch, bentgrass and paspalum with a single application of A16901B at rates above and
below the respective proposed label rates against moderate pest populations of the target species. In all cases, target pests were appropriately identified. In each trial the
proposed product - Spinner Turf Insecticide was compared against the appropriate industry standards; there was an untreated control and all treatments were replicated four
times. Treatment application, methods of assessment and data analysis were acceptable. Observations were made for signs of phytotoxicity.
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The reviewer’s assessment concluded that the trial data demonstrated efficacy under various regional and seasonal conditions at the proposed label rates of A16901B against
larvae of African black beetle, Heteronychus arator, Argentinian scarab, Cyclocephala signaticollis, June beetle, Phyllophaga sp., Argentine stem weevil, Listronotus
bonariensis, and caterpillars of black cutworm, Agrotis ipsilon and lawn armyworm, Spodoptera mauritia, in turf. Trial data also demonstrated crop safety of Spinner Turf
Insecticide at the proposed label rates when used in turf and the adopted spray application technique is consistent with the proposed advice on the label. Label advice
contained in Directions for Use, Critical Comments and General Instructions were appropriate.
Additional information provided by the applicant in support the claim to billbug larvae was considered acceptable.
Therefore, in terms of the evidence of the efficacy and crop safety of the product, the APVMA is satisfied that the use of the product – Spinner Turf Insecticide would be
effective and safe when used in accordance with the proposed label instructions.
Data relied on to provide the advice
Data No
Data
Source*
Author(s)
Title
Date
Data Type
Data Sub-type
Authorising
Party
2 March 2009
Efficacy and Safety
Efficacy
Applicant
62358
S
S Harvey
Efficacy and Tolerance of Various Syngenta Insecticides
62360
S
S Harvey
Efficacy and Tolerance of Various Syngenta Insecticides in Controlling
African Black Beetle (Heteronychus arator) Larvae
9 April 2009
Efficacy and Safety
Efficacy
Applicant
62351
S
S Harvey, P
Looby
Evaluate the Efficacy and Phytotoxicity of Various Insecticides for the
Control of Argentine Stem Weevil (Listronotus bonariensis)
13 July 2010
Efficacy and Safety
Efficacy
Applicant
62352
S
S Harvey, P
Looby
Evaluate the Efficacy and Phytotoxicity of Various Insecticides for both
Preventative and Curative Control of Argentine Stem Weevil (Listronotus
bonariensis)
18 March 2011
Efficacy and Safety
Efficacy
Applicant
62353
S
P OConnell
Efficacy and Tolerance of Various Syngenta Insecticides
21 March 2011
Efficacy and Safety
Efficacy
Applicant
62361
S
S Harvey
Efficacy and Tolerance of Various Syngenta Insecticides in Controlling
African Black Beetle (Heteronychus arator) Larvae
8 April 2009
Efficacy and Safety
Efficacy
Applicant
62355
S
S Harvey, P
Looby
Efficacy and Tolerance of Various Syngenta Insecticides on Argentinian
Scarab (Cyclocephala signaticollis)
11 May 2010
Efficacy and Safety
Efficacy
Applicant
62359
S
P OConnell
Efficacy and Tolerance of Various Syngenta Insecticides
20 August 2010
Efficacy and Safety
Efficacy
Applicant
62357
S
S Harvey
The Efficacy and Tolerance of Various Syngenta Insecticides in Controlling
Armyworm (Spodoptera maurita) in Turf Areas
21 April 2009
Efficacy and Safety
Efficacy
Applicant
62354
S
S Harvey
Efficacy and Tolerance of Various Syngenta Insecticides in Controlling
Argentine Scarab (Cyclocephala signaticollis) Larvae
31 March 2009
Efficacy and Safety
Efficacy
Applicant
62356
S
S Harvey
The Efficacy and Tolerance of Various Syngenta Insecticides in Controlling
Armyworm (Spodoptera maurita) in Turf Areas
22 April 2009
Efficacy and Safety
Efficacy
Applicant
54071
Page 8 of 9
Inherited
Application
No.
KP25S_F39 Version: 2 Issued: 14/08/2007
Data No
62362
Data
Source*
S
Author(s)
S Harvey
Title
Efficacy and Tolerance of Various Syngenta Insecticides in Controlling
African Black Beetle (Heteronychus arator) Larvae
Date
Data Type
Data Sub-type
Authorising
Party
2 April 2009
Efficacy and Safety
Efficacy
Applicant
Inherited
Application
No.
* S = Data submitted with the application
I = Data inherited (that is, referenced) from another application
54071
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