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CV. Margaret Sällberg Chen, Swedish Citizen 1a. Higher education degree Doctor of Dental Surgery (DDS), Karolinska Institutet (KI), 1992 Licensed Dental Surgeon, Sweden, 1993 2. Doctoral degree (PhD) PhD in Oral Microbiology and Clinical Virology, KI, 1998 3. Docent level (Associate professor) Infection Biology, 2004, KI 4. Postdoctoral positions I. The Scripps Research Institute, Dept. of Molecular Biology, La Jolla, USA, 1995-96 - Developed T cell receptor transgenic mouse models for studies of T cell immunology. II. Karolinska Institutet, Dept. of Microbiology, Tumor- and Cell Biology (MTC), KI, 1998-1999 - Studied self-replicating viral RNA vectors for delivery of vaccines and gene therapy 5. Current position Senior lecturer, Director of Doctoral Education, Head of Unit, Research Theme Group Leader Infection, Inflammation and Immunology, at Department of Dental Medicine, KI. 6. Previous positions and periods of appointment General Dentist, Jönköpings läns landsting 1993-1994 PhD student fellow, KI, 1994-1998 Postdoc fellow, The Scripps Research Institute, San Diego, USA, 1995-1998 Postdoc fellow, Dept of Microbiology Tumor and Cell Biology, KI, 1998-1999 Assistant professor, KI, 1999-2000 Research Scientist, Swedish Institute for Infections Disease Control, 2000-2008 7. Bibliometrics (Web of Science by March 30th, 2016) Total publications: 50. Sum of the Times Cited: 1983. Average citations per publication: 38,3. H-index: 21 8.1. Commission of Trust National Director Postgraduate studies, Dept of Dental Medicine, KI, 2010-present Director Postgraduate studies, Dept of Microbiology, Tumor biology and Cell biology, KI, 2003 Board member Dissertation Committee, KI, 2015 -present Board member Research Council Dept of Dental Medicine, KI, 2013-present Board member ABC Academic Programme Group of Paedatric Dentistry, KI/SLL, 2016-present Examination Board Member: 7 PhD thesis/ 7 Half-time/ 1 Docent Chairman of Admissions Board PhD education, Dept of Dental Medicine, 2010-present Conference organizer, Swedish Society for Cariology, 2014 International Editorial Board Member, Scientific Report, Nature Publishing Group (NPG), 2014-present Reviewer for Academy of Finland, Research Grant International Expert Panel, 2009-2011 Scientific consultant, The Vaccine Research Institute in San Diego, USA, 2000-present Scientific consultant, International health, Health Ministry Taipei Taiwan, 2004-2009 Referee for scientific journals: J Immunol, Am J Pathol, Oncotarget, Plos One, Cancer Detec and Prev, Clin and Exp Immuno, Vaccine, Eur J of Oral Sci. 8.2. Supervision of doctorates and postdoctoral fellows (* present) Appendix B. CV * Main supervisor for Haleh Davian, PhD, Postdoc. Dr. Davanina holds a PhD degree in RNA sequencing from Karolinska Institutet. * Main supervisor for Rogier Gaiser, PhD, Postdoc. Dr. Gaiser holds a PhD degree in microbiology from university of Wageningen, The Netherlands. * Co-supervisor of Michal Sobkowiak, PhD student registered 2013 March 5th, KI. Main supervisor of Anna Pasetto, PhD thesis defended on 2012. Dr. Pasetto holds now a postdoctoral fellowship at National Institute of Cancer, Bethesda, NIH, USA. Main supervisor of Anila Yasmeen, PhD, postdocfellow. Dr. Yasmeen is today Research fellow at Weill Cornell Medical College, NY, USA. Main supervisor for Balasiddaiah Anangi, PhD, postdoc. Dr. Anangi holds a PhD degree in cancer gene therapy. He is now postdoctoral fellow at Inst of Cancer Research, Univ of Oslo, Norway. Co-supervisor of Haleh Davanian, PhD defense 2014 Feb, KI Co-supervisor of Tanja Näslund PhD thesis defended 2009. Dr. 8.3. Research grants KI KID faculty funds 2017-2020 (PI: PhD student grant 1 280 000 SEK) Cancerfonden CAN 2016/731 2017-2019 (PI: Research grant 1 500 000 SEK) Cancerfonden CAN 2013/833 2014-2016 (PI: Research grant 1 500 000 SEK) KI/SLL Strategiska Odontologisk Forskningsmedel 2014-2018A (PI: Research grant 2 760 000 SEK) KI/SLL Strategiska Odontologisk Forskningsmedel 2014-2016B (Co-PI Research grant 1 260 000 SEK) Ruth och Richard Julins stiftelsen and KI stiftelser 2010-2014 (PI: Research grant 200 000SEK) VR/KI Odontologiska Forskarskola, 2009-2014 (Co-PI: PhD-student grant) 8.4. Selected publications (of total 50) Davanian H, Balasiddaiah A. Heymann R, Sundström M, Redenström P, Silfverberg M, Brodin D, Sällberg M, Lindskog M, Weiner CK, Chen M, Ameloblastoma RNA profiling uncovers a distinct noncoding RNA signature. 2016. Oncotarget. Dec 10. doi: 10.18632/oncotarget.13889. Ahlen G, Frelin F, Brenndörfer E, Brass A, Weiland O, Chen M, and M Sällberg. Containing “The Great Houdini” of viruses: Combining directly acting antivirals with the host immune response for the treatment of chronic hepatitis C. Drug Resistance Updates. 2013 Aug. doi:pii: S1368-7646(13)00025-3. Pasetto A, Frelin L, Aleman S, Brass A, Ahlen A, Brenndörfer E, Lohmann V, Bartenschlager R, Sällberg M, Bertoletti A and Chen M. Effective inhibition of hepatitis C virus replication by T Cell Receptor(TCR) redirected human T cells: Hepatotoxic potential is linked to antigen specificity and functional avidity. J Immunol. 2012 Nov 1;189(9):4510-9. Schulz O, Diebold SS, Chen M, Näslund T, Nolte M, Alexopoulou L, Azuma YT Flavell R, Liljeström P, and C Reis e Sousa. 2005. Toll-like receptor 3 mediates dendritic cell activation by virus-infected cells and promotes cross-priming in vivo. Nature. 433:887. Chen M, Billaud JM, Sällberg M, Guidotti L, Chisari F, Jones J, Hughes J and Milich DR. 2004. A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc Natl Acad Sci U S A. 12;101(41):14913-8. Chen M, Sällberg M, Sönnerborg A, Weiland O, Mattsson L, Jin L, Birkett A, Peterson D, Milich D.R. 1999. Limited immunogenicity of the hepatitis C virus proteins. Gastroenterology 116(1):135-143. Milich DR, Chen M, Schödel F, Peterson D, Jones J, Hughes J. 1997. Role of B cells in antigen presentation of the hepatitis B core. Proc Natl Acad Sci U S A. 94(26): 14648-14653. 8.5. Patents T cell receptors specific for an immunodominant CTL epitope of HCV. EP2504358 B1. US patent US9193778 B2. Treatment of hepatitis D virus infections by redirection of T cells. US patent. EP3046936 A1, provisional. 8.6. Language Skills Swedish: Fluent. English: Highly proficient spoken and written. Chinese: Basic communication skills 2