Download ID_2696_Physical methods of analysis a_English_sem_4

Назва наукового напрямку (модуля):
Семестр: 4
Physical methods of analysis and metrology
Опис:
Перелік питань:
1.
A.
B.
C.
D. *
E.
2.
At studying of the metrological characteristic "linearity", count the correlation factor which value
should be:
More than 2
Less than 1
From -3 to +3
From -1 to +1
From-2 to +2
At studying of the metrological characteristic "linearity", count the equation of calibration chart
which will look like:
A.
Yi  b  X i2  a
B.
Yi  b  X i  a
C.
Yi  b  X i2  a
D. *
Yi  b  Xi  a
E.
Yi  b  X i3  a
3.
The normalized coordinates count Yi under the formula in
A.
B.
C. *
D.
E.
4.
A.
B. *
C.
D.
E.
5.
A.
Yi 
Ai
 100%
Ast
which Ai is
Argument of function which is direct proportionality
Concentration of one of the solutions, expressed in terms of concentration
Analytical signal of substance in one of solutions
The normalized concentration
The normalized value of the measured physical size
C
X i  i  100%
C st
The normalized coordinates count X i under the formula in
which C i is
Argument of function which is direct proportionality
Concentration of substance in one of analyzed solutions
The unknown (not measured) size
Concentration is normalized
The normalized value of the measured physical size
To designation there corresponds Yi the name:
B.
C.
D.
E. *
6.
Argument of function which is direct proportionality
Argument of function of linear dependence
The size is unknown
The concentration coordinate is normalized
The normalized coordinate of the measured physical size
To designation there corresponds X i the name:
A.
B.
C.
D. *
Argument of function which is direct proportionality
Argument of function of linear dependence
Unknown size
The normalized coordinate of concentration
E.
7.
A. *
B.
C.
D.
E.
8.
A.
B.
C.
D.
E. *
9.
The normalized coordinate of the measured physical size
The normalized coordinates of concentration and the analytical response (physical size) at validation
the techniques of the analysis which are carried out by various methods have arisen because it was
necessary:
To unify criteria requirements for all methods
To unify the size of measured physical sizes
To unify a sort of measured physical sizes
To unify a way of measurement (direct or relative)
To unify a way of expression of concentration
The normalized coordinates of concentration and the analytical response (physical size) at validation
the techniques of the analysis which are carried out by various methods are represented in units:
g/ml
mol/l
mmol/l
mg/ml
Percent
To designation there corresponds  FAO the name:
A.
B.
C. *
D.
E.
10.
Predicted uncertainty of the analysis of a substance of medicinal substance
Predicted uncertainty of the analysis of a ready medical product
Predicted uncertainty of final analytical operation
Predicted uncertainty of sample preparation
Predicted uncertainty of the analysis
To designation there corresponds  As the name:
A.
B.
C.
D.
Predicted uncertainty of the analysis of a substance of medicinal substance
Predicted uncertainty of the analysis of a ready medical product
Predicted uncertainty of final analytical operation
Predicted uncertainty of simple preparation
Predicted uncertainty of the analysis
To designation there corresponds  SP the name:
E. *
11.
A.
A.
Predicted uncertainty of the analysis of a substance of medicinal substance
Predicted uncertainty of the analysis of a ready medical product
Predicted uncertainty of final analytical operation
Predicted uncertainty of simple preparation
Predicted uncertainty of the analysis
Full uncertainty of the analysis of a substance of medicinal substance in percentage pays off under
the formula:
SP  0,32 As
B.
SP  0,32 As
C. *
 As  BH  100%
D.
 As 
BH  BL
 0,12
2
E.
 As 
BH  BL
 0,32
2
B.
C.
D. *
E.
12.
13.
Full uncertainty of the analysis of a ready medical product in percentage pays off under the formula:
A.
SP  0,32 As
B.
SP  0,32 As
C.
 As  BH  100%
D.
 As 
BH  BL
 0,12
2
A.
BH  BL
 0,32
2
The technique will be correct if in it the requirement is put in pawn, about predicted uncertainty of
simple preparation which satisfies to a condition:
SP 0,32 As
B.
SP  0,32 As
C.
SP  0,32 As
D. *
SP  0,32 As
E.
SP  0,32 As
15.
A.
By working out of techniques it is recommended to choose so shot weight and measured flask that
uncertainty of simple preparation was insignificant - that the requirement was fulfilled:
SP 0,32 As
B.
SP  0,32 As
C.
SP  0,32 As
D.
SP  0,32 As
E. *
SP  0,32 As
16.
At the uncertainty forecast of sample preparation which spend before chromatographic definition,
consider uncertainty of everything, except:
Measured flask
Cells
Weight
Pipettes
Chemical utensils
At the uncertainty forecast of sample preparation which spend before chromatographic definition,
consider uncertainty of everything, except:
Measured flask
Chromatograph
Weight
Pipettes
Chemical utensils
At the forecast of uncertainty of final analytical operation which spend at spectrophotometric
definitions, consider uncertainty:
Measured flask
Spectrophotometer
Weight
Pipettes
E. *
14.
A.
B. *
C.
D.
E.
17.
A.
B. *
C.
D.
E.
18.
A.
B. *
C.
D.
 As 
E.
19.
A.
B. *
C.
D.
E.
20.
A.
B.
Chemical utensils
At the uncertainty forecast of sample preparation which spend for spectrophotometric definition,
consider uncertainty of everything, except:
Measured flask
Spectrophotometer
Weight
Pipettes
Chemical utensils
Uncertainty of final analytical operation is designated by a symbol:
C. *


 FAO
D.
 SP
E.
 As
21.
A.
B.
Predicted uncertainty of sample preparation is designated by a symbol:
C.
 FAO
D. *
 SP
E.
 As
22.
A.
Full uncertainty of the analysis is designated by a symbol:
B.

C.
 FAO
D.
 SP
E. *
 As
23.
A. *
As result of testing of a technique on validation characteristic “linearity”, provide data:
All listed
Tangent of a angle of an inclination of a straight line and all standard deviations for equation factors
Correlation factor
Factors of the equation of a straight line and correlation factor
The equation of a straight line with all its factors
Accuracy and precision are metrological characteristics which are investigated at test validation:
Definitions quantitative only biological methods
Limiting tests for the maintenance of impurity
Quantitative definition of an active pharmaceutical component and impurity
Identifications by physical and physical and chemical methods
Identifications by chemical methods
The validation characteristic "accuracy" specifies that received results are:
Close to each other are slightly different
Highly selective and very specific
Close to true or average arithmetic value
B.
C.
D.
E.
24.
A.
B.
C. *
D.
E.
25.
A. *
B.
C.



D.
E.
26.
A. *
B.
C.
D.
E.
27.
A.
B.
C.
D.
E. *
28.
A.
B.
C. *
D.
E.
29.
A.
B.
C.
D. *
E.
30.
A.
B.
C. *
D.
E.
31.
A.
B.
C.
D. *
E.
32.
A.
B.
C.
D.
Are close to average arithmetic value
Are close to true value
Method it is entered-is found, with use of standard samples of components defined by a given
technique, it is applied to studying validation characteristic:
Accuracy and precision
Application range
Linearity
Convergence
Accuracy
Studying of “accuracy” of an analytical technique spend a method:
Dispersion and an excess
Student's method
Fisher
The least square method
It is entered – it is found
Validation characteristic “accuracy” means that received results are:
Are close among themselves - not so differ
Highly selective and very specific
Are close to true or average arithmetic value
Are close to average arithmetic value
Are close to true value
Validation characteristic “accuracy” is typical for tests:
Identifications and tests for the limiting maintenance of impurity
Identification and quantitative definition
Identifications
Quantitative definition and quantitative test for the maintenance of impurity
Only quantitative definition
Validation an analytical technique or process is:
Feasibility study of their suitability
Scientifically based evidence of their ability to provide acceptable quality
The experimental proof of their suitability
Verification methodology or process logically
Theoretical justification of methods or processes
Validation of analytical methods - is experimental evidence that the technique .....:
Practical and rational
Theoretically scientifically proved
It is characterised by necessary metrological characteristics
Suited for the task
Very good and easy
Validation - actions in accordance with the principles of GMP argue that any method, process,
equipment, activity or system actually leads to:
To comprehensible results
To very good results
To positive results
To unpredictable results
E. *
33.
A.
B. *
C.
D.
E.
34.
A.
B. *
C.
D.
E.
35.
A.
B. *
C.
D.
E.
36.
A.
B.
C.
D. *
E.
37.
A.
B.
C.
D.
E. *
38.
A.
B.
C.
D.
E. *
39.
A.
B.
C.
D. *
E.
To expected results
Vibration spectra can be used for identification of all substances, except:
For what at fluctuations there is a change of an electric dipole
For what at fluctuations there is no change of an electric dipole
The metalloorganic
The organic
The inorganic
What substance can be identified by spent of IR-spectrum?
All
Benzoic acid
Oxygen
Ozone
Any
What substances can be identified by means of IR-spectroscopy?
All
HCl
O3
О2
He
For what substances identification it is the most expedient to use IR-spectroscopy?
Metals
Acids
The complex
The organic
The inorganic
Absorption spectra in spectrum IR-region are called:
The paramagnetic
The magnetic
The electronic
The rotary
The vibration
Vaseline oil apply to reception of suspension of solid samples. The analyst should be considered, that
it has bands of absorption in the field of stretching and bending vibrations of chemical bonds:
C=C
O-H
C-C
C=O
C-H
At reception of IR-spectra of solid substances, the sample disperses with..., receiving suspension.
Ethyl alcohol 95 %
NaCl
Water
Vaseline oil (nujol)
КВr
40.
A.
B.
C. *
D.
E.
41.
A.
B. *
C.
D.
E.
42.
A.
B. *
C.
D.
E.
43.
A.
B.
C. *
D.
E.
44.
A.
B.
C. *
D.
E.
45.
A.
B.
C. *
D.
E.
46.
A.
B.
C.
D.
E. *
Applying preparation of samples for IR-spectroscopy through pressing with КВr, it is necessary to
consider, that spectra can be deformed because of:
Interactions with О2
Absorption О2
Interactions with КВr
Interactions with СО2
Moisture absorption
Ditches for IR-spectroscopy should be transparent in spectrum IR-region, therefore them make of all
materials, except:
LiF
Glasses
Germany or silicon
CaF2
КВr
Ditches for IR-spectroscopy do not make from:
LiF
BiI3
(-CH2-CH2-)n
CaF2
КВr
IR-spectra of alkaline water solutions of investigated substances remove, placing them in ditches
from....
CaF2
LiF
(-CH2-CH2-)n
NaCl
КВr
To write down IR-spectra of sour water solutions follows in .... ditches.
CaF2
LiF
Si
NaCl
КВr
For record of IR-spectra of water solutions it is necessary to use the ditches made of a material:
CaF2
LiF
(-CH2-CH2-)n
NaCl
КВr
To reduce systematic errors in photometric measurements to be collected solution concentration and
the thickness of the layer so that the measured optical densities were in the range:
0,2-0,3
0,6-0,8
2-6
0,02-0,06
0,4-0,6
47.
A.
B. *
C.
D.
E.
48.
A.
B.
C. *
D.
E.
49.
A.
The analysis of a two-componental mix is not possible in a case, when:
Absorbs only one substance, and the second in an investigated range is transparent
Spectra of both substances are blocked also absorption maxima completely imposed
Spectra of both substances are blocked, but there is a spectrum site where absorbs only one substance
Spectra of both substances are blocked, but is absorption maxima are divided
Spectra of both substances are not blocked
Lack of refractometry is:
Definition possibility in one-, two- and three-componental systems after association with the
chemical analysis
Simplicity of service and analysis performance
Low sensitivity and nonselectivity
Speed of performance of the analysis
Simplicity of the applied device
The refractometric factor determine, having made two standard solutions and having measured their
indexes of refraction, under the formula:
n2 n2  n1 
C
F=
B.
n1  n2
F = C2  C1
C.
n2  n1
F = C1  C2
D. *
n2  n1
F = C2  C1
E.
С1  С2
F = n1  n2
50.
The refractometric factor determine, having made ... standard solutions and having measured their
indexes of refraction:
Some
A little
Four
Two
Three
Refractometric method of the analysis applies to substances definition in the solutions having rather
high concentration:
25 %
10 %
1 %
100 %
25 %
Correct record of the formula for refractometric concentration definitions in method with application
of the refractometric factor:
n0  n
A.
B.
C.
D. *
E.
51.
A.
B.
C. *
D.
E.
52.
A.
СN =
F
B.
n0  F
C= n
C.
C%=
nF
n
n0  n
D.
C%=
F
E. *
n  n0
С%= F
53.
When the calculated method of the substance concentration determining by refractometric method
n  n0
used the formula C= F . . Designation of "F":
A.
Refractometric an absorption index
Refractometric factor
Gravimetric factor
Faraday's constant
Stoichiometric factor
Which of the methods of calculation of the quantitative content of substances are not used in
refractometry?
Method with application refractometric tables
Method of additives
Method of data extrapolation on calibration curve
Method with application known refractometric factors
Method of calibration curve
Construction of calibration curve for refractometric determination is carried out in the coordinates:
n = f (C)
E = f (C)
N = f (C)
A = f (C)
T = f (C)
Absolute and relative index of refraction are connected by the relation:
n=1.00027N
N=1.00027n
 20D   *1000
C *l
-A
T=10
A=-lgT
The relative index of refraction is the relation:
T=10-A
A=-lgT
n=Cair/Сmedium
N=Cvacuum/Сmedium
B. *
C.
D.
E.
54.
A.
B. *
C.
D.
E.
55.
A. *
B.
C.
D.
E.
56.
A.
B. *
C.
D.
E.
57.
A.
B.
C. *
D.
E.
n=Cair/C H 2 O
58.
A.
B. *
C.
D.
E.
59.
A.
B.
C. *
D.
E.
60.
A.
B.
C.
D. *
E.
61.
A.
B.
C.
D. *
E.
62.
A.
B.
C.
D. *
E.
63.
A.
B.
C. *
D.
E.
64.
A.
B. *
C.
D.
E.
The relative index of refraction is the relation of speed of dissemination of light in... to speed of
dissemination of light in...
To the given environment; air
Air; to the given environment
Vacuum; to the given environment
Vacuum; air
To the given environment; vacuum
The absolute index of refraction is the relation of speed of dissemination of light in... to speed of
dissemination of light in...
To the given environment; air
Air; to the given environment
Vacuum; to the given environment
Vacuum; air
To the given environment; vacuum
In refractometry measure:
T
A
 20D
20
nD
N
Refractometry is based on measurement:
Specific rotation
Transmission factor
Optical density
Relative index of refraction
Absolute index of refraction
What identification of substance cannot be spent on specific rotation?
Isoleucine
Ascorbic acid
Glutamic acid
Glycine
Valine
What identification of substance can be spent on specific rotation?
Glycerol
Vanillin
Ascorbic acid
Glycine
Boric acid
What identification of substance can be spent on specific rotation?
Boric acid
Glutamic acid
Glycerol
Glycine
Vanillin
65.
A.
B. *
C.
D.
E.
66.
A.
B.
C. *
D.
E.
67.
A.
B.
C. *
D.
E.
68.
A.
For what substance in tests for cleanliness there can be a definition of specific rotation?
Boric acid
Glutamic acid
Glycerol
Glycine
Vanillin
For what substance in tests for cleanliness there can be a definition of specific rotation?
Boric acid
Vanillin
Alanine
Glycerol
Glycine
For what substance at tests for cleanliness there can be a test – definition of specific rotation?
Glycerol trinitrate solution
Sodium phosphate
Glucose waterless
Glycerol
Glycine
Specific rotation is connected with thickness of a layer (in dm), an angle of rotation and density (in
g/l) dependence:
 20Д  1000
 С
B.
 20Д 
C.
 20Д 

С  20

С 
1000 

С 
D.
 20Д
E. *
 20Д 
69.
Specific rotation is connected with concentration of substance (in g/l) and thickness of a layer (in dm)
and an angle of rotation by dependence:
 20Д  1000
 С
A.
B.
 20Д 
C.
 20Д 

  20

С  20

С 
1000 

С 
D. *
 20Д
E.
 20Д 

  20
70.
A.
B.
C.
D. *
E.
71.
A. *
B.
C.
D.
E.
72.
A.
B.
C.
D.
E. *
73.
A.
B.
C.
D. *
E.
74.
A. *
B.
C.
D.
E.
75.
A. *
B.
C.
D.
E.
76.
A.
Specific rotation of lactose +53,5. Have prepared a solution containing 10 г of lactose in 100 ml of
solution, and have measured a rotation angle at a thickness of a layer of 1 dm. The angle of rotation
of the given solution should be (in :
+10,7
-10,7
-5,35
+5,35
-5,3
Specific rotation of ascorbic acid +23,0, therefore solution with 10,0 г ascorbic acid in 100 ml of the
solution, placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle (in ):
+2,3
-230
+230
+23,0
-23,0
Specific rotation of fructose -93,0, therefore fructose solution of with concentration of 0,1 g/ml,
placed in polarimetric tube in the thickness of 1 dm, will have a rotation angle (in :
+9,3
-46,5
+18,6
-18,6
-9,3
Specific rotation of fructose -93,0, therefore fructose solution with concentration of 0,2 g/ml, placed
in polarimetric tube in the thickness of 1 dm, will have a rotation angle (in):
+9,3
-46,5
+18,6
-18,6
-9,3
Specific rotation of fructose -93,0. It means, that its solution with concentration... And thickness of a
layer... will rotate a polarisation plane on -93,0....
1 g/sm3, 1дм, at the left
1 g/sm3, 1дм, on the right
10 g/sm3, 10 dm, on the right
1 g/sm3, 10 dm, on the right
10 g/sm3, 1дм, at the left
Specific rotation is a constant which apply for:
In all listed cases
Definition of cleanliness from impurity which can be optical active
The quantitative analysis
Identification
The analysis
Measurement of the angle of rotation passes through the layer of the optically active substance
solution is carried out using an instrument:
Coulometer
B. *
C.
D.
E.
77.
A.
B.
C. *
D.
E.
78.
A.
B.
C.
D.
E. *
79.
A.
B. *
C.
D.
E.
80.
A.
B. *
C.
D.
E.
81.
A.
B. *
C.
D.
E.
82.
A.
B. *
C.
D.
Polarimeter
Polarograph
Potentiometer
Refractometer
Specific rotation of sucrose +66,4, therefore sucrose solution with concentration of 0,2 g/ml, placed
in polarimetric tube in the thickness of 1 dm, will have a rotation angle (in ):
+33,2
-13,28
+13,28
-6,64
+6,64
Specific rotation of glucose +53,1, therefore glucose solution with concentration of 0,1 g/ml, placed
in polarimetric tube in the thickness of 1 dm, will have a rotation angle (in ):
+53,1
-10,6
+10,6
-5,3
+5,3
Specific rotation of lactose +53,5. It means, that its solution with concentration ... and thickness of a
layer ... will rotate a polarisation plane on 53,5... .
1 g/sm3, 1дм, to the left
1 g/sm3, 1дм, to the right
10 g/sm3, 10 dm, to the right
1 g/sm3, 10 dm, to the right
10 g/sm3, 1дм, to the left
Specific rotation of sucrose +66,4. It means, that its solution with concentration ... and thickness of a
layer ... will rotate a polarisation plane on 66,4... .
1 g/sm3, 1dm, to the left
1 g/sm3, 1dm, to the right
10 g/sm3, 10 dm, to the right
1 g/sm3, 10 dm, to the right
10 g/sm3, 1dm, to the left
Specific rotation of ascorbic acid +23,0. It means, that its solution with concentration ... and
thickness of a layer ... will rotate a polarisation plane on 23,0 ... .
1 g/sm3, 1дм, to the left
1 g/sm3, 1дм, to the right
10 g/sm3, 10 dm, to the right
1 g/sm3, 10 dm, to the right
10 g/sm3, 1дм, to the left
Specific rotation of glucose +53,1. It means, that its solution with concentration ... and thickness of a
layer ... will rotate a polarisation plane on 53,1....
1 g/sm3, 1dm, to the left
1 g/sm3, 1dm, to the right
10 g/sm3, 10 dm, to the right
1 g/sm3, 10 dm, to the right
E.
83.
A.
B.
C. *
D.
E.
84.
A.
B.
C.
D. *
E.
85.
A.
B.
C.
D.
E. *
86.
A.
B.
C. *
D.
E.
87.
A.
B.
C. *
D.
E.
88.
A.
B.
C. *
D.
E.
89.
A. *
B.
C.
10 g/sm3, 1dm, to the left
20
To designation there corresponds   D specific rotation at:
To temperature of 20  C and the wavelength of light D - Line calcium atoms
To 20  C and the wavelength of light D - lines of the sodium atom
To temperature of 20  to the wavelength of light and D - the line of the cesium atom
To temperature of 20  K and the wavelength of light D - lines of the sodium atom
To temperature of 20  C and the wavelength of light D - Line of potassium
Specific rotation name rotation of a plane of polarisation in the right or left side which occurs at
passage of polarised light through a layer of a solution in the thickness ... with concentration....
10 dm, 1 g/sm3
1 sm, 1 g/sm3
10 sm, 10 g/sm3
1 dm, 1 g/sm3
1 sm, 10 g/sm3
Specific rotation name rotation of a plane of polarisation in the right or left side which occurs at
passage of polarised light through a layer of a solution in the thickness of 1 dm to concentration.....
1 g/dm3
10g/ml.
10 g/dm3
10 g/sm3
1 g/sm3
Specific rotation name rotation of a plane of polarisation in the right or left side which occurs at
passage of polarised light through a layer of a solution in the thickness ... with concentration 1g/sm3
2 sm
10 mm
1 dm
2 dm
1 sm
When passing through a layer of optically active material undergoes optical rotation only:
Radioactive radiation
Radiation of a visible region of spectrum
Polarised light
IR – radiation
UV – light
The angle of rotation of polarisation plane of does not depend from:
Temperature
Concentration of optical active substance
Atmospheric pressure
Thickness of a layer
Lengths of a wave of light
Passing through an optically active medium, a polarized beam changes the plane of polarization, in
comparison with the original polarization, at a certain angle. This angle is called ...
Rotation angle of a polarisation plane
Specific rotation
Polarisation angle
D.
E.
90.
A.
B. *
C.
D.
E.
91.
A.
B.
C. *
D.
E.
92.
A.
B.
C. *
D.
E.
93.
A.
B.
C.
D.
E. *
94.
A.
B.
C.
D. *
E.
95.
A.
B.
C. *
D.
E.
96.
A.
B.
C.
D.
E. *
Refraction angle
Angle of incidence
At passage of polarized light through optical active environment (substance) occurs:
Radiation – a luminescence
Rotation of polarization plane on some angle
Refractions of light ray
Light dispersion
Light absorption
Substances which cannot rotate a polarization plane, name:
Stereoisomers
Optically inactive
Optically active
Homologs
Isomers
Substances which can rotate a polarization plane, name:
Stereoisomers
Optically inactive
Optically active
Homologs
Isomers
The polarisation plane is...
The plane located along a plane of fluctuations
The plane placed under acute angle to a plane of fluctuations
Plane which is parallel to a plane of fluctuations
The plane placed under a sharp angle to a plane of fluctuations
Plane, perpendicular planes of fluctuations (vibrations)
The plane vibration is a plane ....
Placed at right angles to the direction of light dissemination
It is parallel to a direction of dissemination of light
In which there is no oscillation of a light wave
In which there is a oscillation of light wave
It is perpendicular to a direction of light dissemination
Polarized light apply in polarimetry. The polarized beam has an oscillation of light wave:
An acute angle to the direction of light
Only in several planes, perpendicular to a polarisation plane
Only one some plane
At a certain angle to the direction of light dissemination
In all planes which are coaxial to a direction of dissemination of light
For ordinary light fluctuations of the electromagnetic wave is :
An acute angle to the direction of light
At a certain angle to the direction of light dissemination
In all planes which are parallel to light direction
In all planes which are coaxial to light direction
In all planes, perpendicular to light direction
97.
A.
B. *
C.
D.
E.
98.
A.
B. *
C.
D.
E.
99.
A. *
B.
C.
D.
E.
100.
A.
B.
C.
D.
E. *
101.
A.
B.
C.
D.
E. *
102.
A.
B.
C.
D.
E. *
103.
A.
Identification of substances by the spectra in the UV and visible spectral region based on a
comparison of the wavelengths of the maxima, and inflection points of intersection. In addition,
further definition is sometimes necessary ... at these wavelengths
Angle of rotation of a polarisation plane
Relation of optical density at the specified waves lengths
Specific rotation
The refractometric factor
Refraction indexes
Identification of substances by the spectra in the UV and visible spectral region based on a
comparison of the wavelengths of the maxima, and inflection points of intersection. In addition,
further definition is sometimes necessary ... at these wavelengths.
Angle of rotation of a polarisation plane
Specific absorption index
Specific rotation
Refraction factor
Refraction indexes
According to the UkSPh requirements identification of substances by spectrophotometric method is
conducted by comparing the spectra of the test solution and standard solution of analyte. In this
region of the spectrum should be observed:
Performance of any or all from the specified requirements
The coincidence of crossing points
The coincidence of shoulders
The coincidence of absorption minima
The coincidence of absorption maxima
Due to the absorption of electromagnetic radiation of UV spectral region in the absorption band
appears, the cause of which:
Change a back of kernels of atoms
Change a back электронов in atom
Fluctuation of atoms in a molecule
Transition электронов between nuclear орбиталями
Changes in energy state of the outer electrons in molecular orbitals
Due to the absorption of radiation in the visible range is:
Changing the spin of the nuclei of atoms
Changing the spin of electrons in atoms
Vibrations of atoms in a molecule
Transfer of electrons between atomic orbitals
Changes in energy state of the outer electrons
Due to the absorption of infrared radiation of the substance molecule occurs:
Transfer of electrons between molecular orbitals
Changing the spin of the nuclei of atoms
Changing the spin of electrons in atoms
Transfer of electrons between atomic orbitals
Change the vibrational states of atoms in a molecule
Experimental studies have established that the same functional groups absorb light in a narrow range
of frequencies, called
Deformation (bending vibrations) or specific
B.
E.
104.
Stretching vibrations or specific
Characteristic or group
The stretching vibrations
The deformation
What symbol of stretching vibrations in infra-red spectroscopy?
A.
s
B. *
 s or as
C.
 as
D.
 s or  аs
 аs
C. *
D.
E.
105.
A. *
B.
C.
D.
E.
106.
A. *
B.
C.
D.
E.
107.
A.
B.
C.
D. *
E.
108.
A. *
B.
C.
D.
E.
109.
A.
B.
C. *
D.
E.
110.
A.
B.
What substance do not apply in IR-spectroscopy to manufacturing of lenses, prisms, a ditch?
AgCl
LiF
CaF2
NaCl
KBr
What solvents cannot be applied to IR-spectroscopy?
Water or any of the sated alcohols
Heptane
Hexane
Carbon tetrachloride
Chloroform
What techniques of quantitative analysis used in infrared spectroscopy?
Additive method
Method of comparison and performence method
Comparison method
Calibration chart
Method performance (estimated)
Theoretical base of the quantitative analysis in IR-spectroscopy is the law:
Bouguer-Beer-Lambert law
Nernst
Ohms
Mendeleyev
Lomonosov
In infra-red spectrometers as a light source it is applied:
Electric spark
Lamp with the hollow cathode
Pin Nernst or globar
Incandescent lamp
Deuterium lamp
The IR spectrometer can not in principle include:
The radiation receiver - a thermoelement
The radiation receiver – a bolometer
C.
D.
E. *
111.
A.
B.
C.
D. *
E.
112.
A. *
B.
C.
D.
E.
113.
A.
B.
C. *
D.
E.
114.
A.
B.
C.
D.
E. *
115.
A. *
B.
C.
D.
E.
116.
A.
B.
C.
D. *
E.
117.
A.
B.
C.
D.
Monohromatizator - mirror and prisms
Light Source - pin Nernst or globar
Light source - a lamp with the hollow cathode
Substance identification in IR-spectroscopy is spent:
On wave numbers of absorption bands in 4000-1500 sm-1 region
Over a range of wavelengths of the shoulder in the spectrum of test solution
On wavelength of transmission minimum a separate band
Comparison of investigated substance IR-spectrum with a standard spectrum of the given substance
resulted in the literature or the analytical documentation
On wavelength of a maximum of a separate band
The spectra of solids recorded in all these variants, except:
In special gas cell
In a solution in carbon tetrachloride
In a solution in transparent solvent for IR-spectroscopy
In suspension with vaseline oil (with nujol)
In disks with solid KBr
Spectra of liquid recorded in all these variants, except:
Films between disks with CaF2
Films between disks with NaCl
In disks with crystal KBr
Solution in film cell
Films between disks with KBr
Spectra of gases in IR-spectroscopy recording:
In disks with potassium bromide
Between disks with NaCl
In glass cell
In quartz cell
In special gas cell
Quantitative analysis within IR spectroscopy carried out on the parameter of the absorption band:
Intensity of absorption in maximum band
Wave number of maximum band
Wavelength of maximum band
Optical density in minimum band
Specific density in maximum band
The qualitative analysis in IR-spectroscopy carry out:
On wave numbers of absorption bands in a region of 4000-1500 sm-1
Over a range of wavelengths of the shoulder in the spectrum of test solution
Wavelength of minimum transmission of separate band
Comparison of investigated substance spectrum and standard sample of the same substance spectrum
Wavelength of a maximum of a separate band
The absorption band in the infrared spectrum is characterized by:
The frequency of fluctuation turned by fluctuation frequency
Wavelength of a minimum of absorption, in optical density
Energy of vibration, intensity of a luminescence
Wavelength of a maximum, intensity of absorption
E. *
118.
A.
B.
C. *
D.
E.
119.
A.
B.
C.
D.
E. *
120.
A. *
B.
C.
D.
E.
121.
A.
B.
C. *
D.
E.
122.
A.
B.
C.
D. *
E.
123.
A.
B.
C.
D. *
E.
124.
A.
B.
C.
D. *
E.
Frequency of vibration, intensity of absorption
The region of "prints of fingers" is applied in infra-red spectroscopy to identification of substances as
in this region the absorption connected with fluctuation is shown:
Benzene rings
All functional groups
Skeleton of the molecule
Amino groups
Hydroxy-groups
The spectrum region is applied to identification of substances in infra-red spectroscopy..., which is
called "prints of fingers" and is in limits
5000-1500 sm-1
2000-1500 sm-1
4000-2000 sm-1
4000-1500 sm-1
1500-700 sm-1
In infra-red spectroscopy the spectrum region is applied to identification of substances....
"Prints of fingers"
400-800 nanometers
Visible region
Ultra-violet region
200-400 nanometers
In infra-red spectroscopy use region spectrum:
200 - 800 nanometers
700 - 4000 nanometers
4000 - 700 sm-1
400 - 780 nanometers
200 - 400 nanometers
Infrared spectra are typically recorded in the coordinates:
A~
А-
А-
T ~
Т-
What fluctuations have the greatest energy?
Крутильные.
Any deformation;
The fanlike;
The valency asymmetric;
The pendular deformation;
What energy of fluctuation the greatest?
The scissoring
Any deformation
The rocking
The asymmetric stretching
The symmetric stretching
125.
A.
B.
C.
D. *
E.
126.
A.
B.
C.
D. *
E.
127.
A. *
B.
C.
D.
E.
128.
A.
B.
C. *
D.
E.
129.
A.
B.
C. *
D.
E.
130.
A.
B.
C.
D.
E. *
131.
A.
B.
C.
D.
E. *
132.
A.
B. *
Deformation vibrations in IR-spectroscopy method are connected with:
Change in the degree of oxidation of the element
Change in the bond angles
Change in bond angle
Changes in bond length
Change the valence state of the atom
Stretching vibrations in the IR-spectroscopy method are connected with:
Change of degree of oxidation of an element.
Change of corners between communications;
Change of a valency corner;
Change of length of communication;
Change of a valency condition of atom;
What fluctuations are not shown in an infra-red spectrum?
The nuclear
The rocking
The asymmetric stretching
The symmetric stretching
The deformation
In infra-red spectroscopy substance molecules are inactive:
C6H5NH2.
(CH3)2NH;
N2;
H2O;
CH3NH2;
In infra-red spectroscopy substance molecules are inactive:
Phenylamine
Dimethylamine
Oxygen
Water
Methylamine
In infra-red spectroscopy active molecules:
Molecules with heavy nucleus
Molecules with even mass number
Molecules with odd mass number
Nonpolar molecules
In the vibration process which changes the electric dipole moment
Energy of infra-red radiation is spent on:
Electron transfer from ligand to complexing
Electron transfer from complexing to ligand
Electron transfer between molecular orbital
Electron transfer between nuclear orbital
Electron transfer to excited vibrational levels
Infra-red spectra still name:
The radiating
The oscillatory
C.
D.
E.
133.
A.
B.
C.
D.
E. *
134.
A.
B.
C.
D.
E. *
135.
A.
B.
C.
D.
E. *
136.
A.
B. *
C.
D.
E.
137.
A.
B.
C.
D. *
E.
138.
A.
B.
C.
D. *
E.
139.
A. *
B.
C.
Mass spectra
The electronic
The emission
The IR-spectroscopy method is based on measurement:
Intensity of fluorescence.
Absorption of resonant radiation by metals atoms
Intensity of the metals atoms raised in a flame radiation
Absorption for electron transition on the higher molecular orbital
Absorption of radiation, enough to power for the vibrations of the molecules
What physical method is based on measurement of optical properties of investigated system?
Mass spectrometry
Electrogravimetry
Thin-layer chromatography
Potentiometry
Radiospectroscopy
What physical method is based on measurement of optical properties of investigated system?
Activation the analysis
The mass spectrometer analysis
Iono-exchange chromatography
Coulometry
IR-spectroscopy
What physical method is based on measurement of optical properties of investigated system?
The gas chromatography
The polarimetry
The polarography
The voltammetry
The conductometry
What physical method of the analysis is based on measurement of optical properties of investigated
system?
The radiometric method
The thermal method
The potentiometric method
The refractometric method
The chromatographic method
Property on which define the medicinal substance maintenance in polarimetry...
Viscosity
Density
Absorption of electromagnetic radiation
Optical rotation
Refraction index
The aminocaproic acid quantitative definition in 5 % solution spends by refractometric method, using
settlement reception of the quantitative analysis. In it n it is a refraction index of...
Investigated aminocaproic acid solution
Any organic solvent
Any liquid
D.
E.
140.
A.
B.
C.
D. *
E.
141.
A.
B.
C.
D.
E. *
142.
A.
B.
C.
D.
E. *
143.
A.
B.
C.
D. *
E.
144.
A.
B.
C.
D. *
E.
145.
A.
B.
C.
D.
E. *
146.
A.
Water
Ethanol
The aminocaproic acid quantitative definition in 5 % solution spends by refractometric method, using
settlement reception of the quantitative analysis. In it n0 it is a refraction index of...
Aminocaproic acid
Any organic solvent
Any liquid
Water
Ethanol
The physical method of glucose quantitative definition in the medicinal form: a 25 %glucose solution
is...
iodometry
electrogravimetry
nitritometry
chelatometry
refractometry
The calcium chloride maintenance in the medicinal form: the 5 % calcium chloride solution can be
defined by physical method...
polarimetry
electrogravimetry
nitritometry
iodometry
refractometry
The potassium iodide maintenance in the medicinal form: the 10 % potassium iodide solution can be
defined by physical method...
permanganatometry
electrogravimetry
chelatometry
refractometry
nitritometry
The sodium bromide maintenance in the medicinal form: the 20 % sodium bromide solution can be
defined by physical method...
permanganatometry
bromatometry
nitritometry
refractometry, argentometry
chelatometry
The magnesium sulphate maintenance in the medicinal form: the 25 % magnesium sulphate solution
can be defined by physical method...
polarimetry
titanometry
bromatometry
acidimetry
refractometry
The refractometric method in the drugstore conditions can be applied to the quantitative analysis:
Exclusively soft medicinal forms
B.
C.
D.
E. *
147.
A.
B.
C.
D. *
E.
148.
A.
B.
C.
D. *
E.
149.
A.
B.
C.
D.
E. *
150.
A. *
B.
C.
D.
E.
151.
A.
B.
C.
D.
E. *
152.
A.
B.
C.
D.
E. *
153.
A.
B. *
Liquid medicinal forms with the maintenance not above 1 %
Firm medicinal forms with the maintenance not above 0,1 %
Liquid medicinal forms with the maintenance of components not above 1 %
Chemist's preparations, powders, liquid medicinal forms with the maintenance of components not
below 3-5 %
The calcium chloride quantity in 5 % calcium chloride solution defines by physical method...
polarimetry
cerimetry
nitritometry
refractometry
alcalimetry
Most essentially such factors, as influence on of solution index refraction...
Degree complexing, solution colouring.
Hydrolysis degree, ionic force of a solution;
Solution colouring, рН value
Concentration of a solution, the substance nature, wave length of light, temperature
Temperature, pressure, solution density
The medical product maintenance defines in polarimetry which help constant of ...
Boiling temperature
Optical density
Electromotive power
Refraction index
Specific rotation
The medicinal substance maintenance defines in refractometry which help the measured size of ...
Refraction index
Refraction factor
Electromotive power
Optical density
Specific rotation
Physical constants which is the qualitative characteristic of substance in physical methods of the
analysis:
Fugitiveness, solubility
Solubility
Modular condition, smell
Fugitiveness, a smell, colouring
Index of refraction, melting temperature
Physical methods of the medicinal substances analysis it...
fluoridometry, acidimetric
argentometry, mercurometry
chelatometry, complexymetry
nitritometry and mercurometry
polarimetric and refractometric
At definition of the substances maintenance by polarimetric method define:
Mass fraction in solution
Mass-volume fraction in solution
C.
D.
E.
154.
A.
B.
C.
D.
E. *
155.
A. *
B.
C.
D.
E.
156.
A.
B.
C.
D.
E. *
157.
A. *
B.
C.
D.
E.
158.
A.
B.
C. *
D.
E.
159.
A.
B. *
C.
D.
E.
160.
Volume concentration
Titre
Molar concentration
What substances can be defined by two methods: polarimerty and refractometry?
Magnesium sulphate
Sodium thiosulfate
Potassium bromide
Sodium benzoate
Ascorbic acid
Polarimetric method of the analysis is one of instrumental methods of the analysis, used for the
analysis of some pharmaceutical preparations. Definition of substances by this method is based on...
Measurement of a angle rotation of polarisation plane of the polarised light which has passed through
the optical active environment
Ionic exchange between an analyzed solution and cationite
Power failure measurement in a cell filled by investigated solution
Potential difference measurement between electrodes poles in the course of titration
Measurement of polarisation of electrodes in a cell filled by investigated solution
The polarisation plane is:
Planes which are parallel to a direction of distribution of light
Parallel to fluctuation plane of the polarised light ray
Planes which are perpendicular to a direction of distribution of light
The plane of fluctuation of the polarised light ray
The plane is perpendicular to a fluctuation plane of the polarised light ray
The substances, capable to rotate a polarisation plane of light ray, name optical active substances.
Optical activity of substance can be connected with:
Features of crystal lattice of substances, features of molecules structure
Solvent in which the investigated substance is dissolved
Concentration of substance
In temperature a solution
Electrolitic dissosiation of investigated substance
Relative refraction index define in a method which is called...
Gravimetry
Polarography
Pefractometry
The thermal analysis
Polarimetry
The angle of rotation, wich is defined at temperature 20 C and wave length of a D-line of sodium
spectrum (= 589.3 nanometers), name:
Angle of light refraction
Specific angle of rotation
Angle of rotation of a polarisation plane
Refraction index
Angle of light falling
The refractometric method is widely used in drugstores and analytical laboratories for quantitative
definition of medicinal substances, and also their mixes, as one of the most convenient express
methods of the analysis. In basis refractometric measurements bases dependence between:
A.
B. *
C.
D.
E.
161.
A.
B. *
C.
D.
E.
162.
A.
B.
C.
D. *
E.
163.
A.
B.
C. *
D.
E.
164.
A.
B.
C.
D.
E. *
165.
A.
B.
C.
D. *
E.
166.
A.
B.
C. *
D.
E.
167.
Quantity of the visible light absorbed by a solution and its concentration.
Concentration of substance solution and its refraction index.
Concentration of substance solution and its angle rotation.
Concentration of substance solution and in its optical density.
Electric conductivity of a solution and its concentration.
In refractometric method of the analysis the size of refraction index depends from:
Temperatures and pressure
From all factors
Solution density
The substance nature
Lengths of falling light
The refractometric method is used in drugstores for:
Definition of very small concentration of substances
Definitions of impurity in substances
Qualitative definition of anions
Quantitative definition of medicinal substances
Qualitative definition of cations
In a basis of refractometric measurements of solutions bases the dependence between concentration
of substance solution and its refraction index, expressed by the formula: n = n0 + F • C, where F is:
The factor equal to a rotation angle of a light plane
The factor equal to an refraction index of a solution under normal conditions
The factor equal to a gain of an refraction index at increase of concentration on 1 %
The factor equal to a gain of an index at increase of concentration on 0,10 %
The factor equal to the relation of refraction index of solution to refraction index of solvent
The size of refraction index in refractometric method of the analysis depends:
Temperatures and pressure
Lengths of falling light
Solution density
The substance nature
With all factors
Optical density of an investigated solution measure in relation to one solution which is called:
Control or blank
The second investigated
The blank
The compensatory
The control
To obtaining of monochromatic radiation apply:
Light source.
System of lenses;
Diffraction grating;
Photocells;
Optical filters;
The maintenance of some substance defines by spectrophotometric method, knowing the equation of
linear dependence of optical density from concentration. For calculation of the quantitative
maintenance it is necessary to use:
A.
B.
C.
D. *
E.
168.
A.
B.
C. *
D.
E.
169.
A.
B. *
C.
D.
E.
170.
A.
B.
C.
D.
E. *
171.
A.
B.
C. *
D.
E.
172.
A.
B.
C.
D.
E. *
173.
A.
B.
C. *
D.
E.
Method of limiting solutions
Method of molar and specific absorptivity
Comparison method
Method of calibration chart
Method of additives
The maintenance of some substance define by spectrophotometric method, knowing optical density
of an investigated solution of substance and a standard solution of defined substance and
concentration of a standard solution. For calculation of the quantitative maintenance it is necessary to
use:
Method of limiting solutions
Method of molar and specific absorptivity
Comparison method
Method of calibration chart
Method of additives
Absorption optical methods of the analysis are used for the analysis of some pharmaceutical
preparations. What law use in absorption optical methods of the analysis?
Law of light refraction.
Bouguer-Lambert-Beer law.
Characteristic law for carbon asymmetric atoms.
The law of light dispersion by environment.
Laws of polarised light passage through a optical active substance solution.
With what decrease of intensity of light which has passed through a solution is connected:
Intensity of light does not vary
Only with light reflexion
Only with light dispersion
Only with light absorption by investigated substance
With absorption, dispersion, light reflexion
Transmission factor it is:
The relation of intensity of reflected light to intensity of absorbed light
The relation of intensity of absorbed light to intensity of falling light
The relation of intensity of light which has passed through a solution to intensity of falling light
The relation of intensity of falling light to intensity of light which has passed through a solution
Optical density of solution
Decrease of intensity of light which has passed through a solution is connected:
Intensity of light does not vary
Only with light reflexion
Only with light dispersion
Only with light absorption by investigated substance
With absorption, dispersion, light reflexion
Depending on the nature of substance interaction with electromagnetic radiation optical methods of
the analysis divide on:
voltammetric
conductometric
emission and absorption
kinetic
chromatographic