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From: New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
JAMA. 2001;286(19):2450-2460. doi:10.1001/jama.286.19.2450
Figure Legend:
Electron micrograph illustrates both cysts (white arrowheads) andtrophozoites (black arrowheads).
Date of download: 4/30/2017
Copyright © 2001 American Medical
Association. All rights reserved.
From: New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
JAMA. 2001;286(19):2450-2460. doi:10.1001/jama.286.19.2450
Figure Legend:
A, Cases of PCP reported to the Centers for Disease Control and Prevention(CDC) in the pre-AIDS era compared with the AIDS
era. Horizontal bars at thetop indicate the period during which prophylaxis to prevent PCP (prophylaxis)and HAART were available.
The arrow indicates the time of publication of guidelinesby the US Public Health Service for prevention of PCP in human
immunodeficiencyvirus (HIV)–infected patients. B, Changein incidence of PCP in the pre-HAART and HAART era, demonstrating
the markeddecline in incidence that occurred following
the©introduction
of HAART.
Copyright
2001 American
Medical Inthe immediate pre-HAART era (1992 to 1995),
Date
download:
thereofwas
a 3.4% 4/30/2017
per year declinein incidence of PCP.
During
the
HAART
era, the incidence of PCP decreasedby 21.5% per year.
Association. All rights reserved.
Data are from the Adult and Adolescent Spectrum of DiseaseStudy.
From: New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
JAMA. 2001;286(19):2450-2460. doi:10.1001/jama.286.19.2450
Figure Legend:
A, Chest radiograph of a patient with PCP demonstrating diffuse bilateralinfiltrates. B, Detection of human-derived P cariniiby
immunofluorescence using monoclonal antibodies. C, Hematoxylin-eosin–stainedsection of lung from an HIV-infected patient with
PCP. An acellular eosinophilicexudate characteristic of PCP can be seen filling the alveoli.
Date of download: 4/30/2017
Copyright © 2001 American Medical
Association. All rights reserved.
From: New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
JAMA. 2001;286(19):2450-2460. doi:10.1001/jama.286.19.2450
Figure Legend:
Diagram of the Pneumocystis carinii DHPSenzyme shows position of key amino acids involved in binding 7,8-dihydropterinpyrophosphate(DHPPP), para-aminobenzoic acid (pABA), and sulfonamides (sulfa) based onhomology to the known crystal
structure of the Escherichiacoli enzyme. Two commonly seen mutationsthat may be associated with resistance are Thr55Ala and
Pro57Ser.
Date of download: 4/30/2017
Copyright © 2001 American Medical
Association. All rights reserved.
From: New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
JAMA. 2001;286(19):2450-2460. doi:10.1001/jama.286.19.2450
Figure Legend:
PPD indicates purified protein derivative.
Date of download: 4/30/2017
Copyright © 2001 American Medical
Association. All rights reserved.
From: New Insights Into Transmission, Diagnosis, and Drug Treatment of Pneumocystis carinii Pneumonia
JAMA. 2001;286(19):2450-2460. doi:10.1001/jama.286.19.2450
Figure Legend:
HIV indicates human immunodeficiency virus. Both the number of episodesof pulmonary symptoms evaluated for PCP (A) and the
number of cases of PCPdiagnosed (B) showed a decrease over time in patients with HIV infection (blackcircles) in contrast to
patients without HIV (gray circles).
Date of download: 4/30/2017
Copyright © 2001 American Medical
Association. All rights reserved.