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Sup. Table 6 Gene function annotation based on Saccharomyces Genome Database
(http://www.yeastgenome.org/) showed in heatmap (Figure 2) in response to salt treatment (0.5
M NaCl for 45 min) in microarrays of bdf1Δ vs WT.
Standard_name Ratio
Description
"Mannoprotein that is incorporated into the cell wall via a
FIT2
0.1587 glycosylphosphatidylinositol (GPI) anchor, involved in the retention of
siderophore-iron in the cell wall"
"Mannoprotein that is incorporated into the cell wall via a
FIT3
0.4948 glycosylphosphatidylinositol (GPI) anchor, involved in the retention of
siderophore-iron in the cell wall"
"Ferro-O2-oxidoreductase required for high-affinity iron uptake and
FET3
0.2000 involved in mediating resistance to copper ion toxicity, belongs to class
of integral membrane multicopper oxidases"
Type 2A-related serine-threonine phosphatase that functions in the
G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein
SIT4
0.4839
that modulates functions mediated by Pkc1p including cell wall and
actin cytoskeleton organization
"Mitochondrial iron transporter of the mitochondrial carrier family
(MCF), very similar to and functionally redundant with Mrs4p;
MRS3
0.4185
functions under low-iron conditions; may transport other cations in
addition to iron"
Putative protein of unknown function with similarity to glutamine
amidotransferase proteins; has Aft1p-binding motif in the promoter;
YLR126C
0.3269
may be involved in copper and iron homeostasis; YLR126C is not an
essential protein
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c;
CUP5
0.2553 dicyclohexylcarbodiimide binding subunit); required for vacuolar
acidification and important for copper and iron metal ion homeostasis
SMF3
0.1710 Putative divalent metal ion transporter involved in iron homeostasis;
transcriptionally regulated by metal ions; member of the Nramp family
of metal transport proteins
"Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the
RIP1
0.0373 mitochondrial cytochrome bc1 complex; transfers electrons from
ubiquinol to cytochrome c1 during respiration"
Putative high affinity iron transporter involved in transport of
FTH1
0.4625 intravacuolar stores of iron; forms complex with Fet5p; expression is
regulated by iron; proposed to play indirect role in endocytosis
"Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic
enzyme that transfers an acetyl group from one acetyl-CoA molecule to
ERG10
0.1906
another, forming acetoacetyl-CoA; involved in the first step in
mevalonate biosynthesis"
"3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the
ERG13
0.1523 formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA;
involved in the second step in mevalonate biosynthesis"
"C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double
ERG2
0.3699 bond to the delta-7 position at an intermediate step in ergosterol
biosynthesis"
"Farnesyl pyrophosphate synthetase, has both
dimethylallyltranstransferase and geranyltranstransferase activities;
ERG20
0.0976
catalyzes the formation of C15 farnesyl pyrophosphate units for
isoprenoid and sterol biosynthesis"
"C-3 sterol dehydrogenase, catalyzes the second of three steps required
ERG26
0.0824 to remove two C-4 methyl groups from an intermediate in ergosterol
biosynthesis"
"3-keto sterol reductase, catalyzes the last of three steps required to
ERG27
0.1265 remove two C-4 methyl groups from an intermediate in ergosterol
biosynthesis; mutants are sterol auxotrophs"
ERG3
0.0243 "C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double
bond into episterol, a precursor in ergosterol biosynthesis; mutants are
viable, but cannot grow on non-fermentable carbon sources"
"C-24(28) sterol reductase, catalyzes the final step in ergosterol
ERG4
0.1419
biosynthesis; mutants are viable, but lack ergosterol"
"C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the
ERG5
0.0891 formation of the C-22(23) double bond in the sterol side chain in
ergosterol biosynthesis; may be a target of azole antifungal drugs"
"Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins
ERG9
0.1961 two farnesyl pyrophosphate moieties to form squalene in the sterol
biosynthesis pathway"
"Conserved protein of the mitochondrial matrix, required for synthesis
of mitochondrial and cytosolic iron-sulfur proteins, performs a
ISU2
0.1393
scaffolding function in mitochondria during Fe/S cluster assembly; isu1
isu2 double mutant is inviable"
Hypothetical protein; open reading frame overlaps 5' end of essential
YPL251W
0.0329
YAH1 gene required for iron-sulfur protein biogenesis
"Highly conserved, putative P-loop ATPase localized in the cytoplasm;
CFD1
0.0313
has a potential role in assembly of iron-sulfur clusters in proteins"
"Flavin-linked sulfhydryl oxidase localized to the mitochondrial
ERV1
0.0217 intermembrane space, has a role in the maturation of cytosolic
iron-sulfur proteins; ortholog of human hepatopoietin (ALR)"
Ferredoxin of the mitochondrial matrix required for formation of
YAH1
0.0202 cellular iron-sulfur proteins; involved in heme A biosynthesis;
homologous to human adrenodoxin
"Protein involved in iron metabolism in mitochondria; similar to NifU,
NFU1
0.2362 which is a protein required for the maturation of the Fe/S clusters of
nitrogenase in nitrogen-fixing bacteria"