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GROWTH AND PUBERTY Puberty - Females Breast development: First sign occurs at 8.5-12.5 years. Pubic hair growth and a rapid height spurt. Menarche – occurs on average 2.5 years after the start of puberty. Female breast (STAGES): (1) Pre-pubertal (2) Breast bud (3) Juvenile smooth contour (4) Areola and papilla project above breast (5) Adult Puberty - Males The first sign of puberty: Pubic hair growth Testicular enlargement to 4ml o (Measured using an Orchidometer) Testicular volume grows to 12-15ml Height spurt occurs between 10 and 14 years of age Pubic Hair (STAGES) – Female/Male Pre-adolescent no sexual hair Sparse, pigmented, long, straight, mainly along labia or at base of penis Dark, coarser, culier Filling out towards adult distribution Adult in quantity and type with spread to medial thighs in male Development of: Acne Axillary hair Body odor Mood changes Age Determination: X ray of wrist and hand Short Stature Height = below the second centile Etiology: Hypothyroidism Growth hormone deficiency Corticosteroids excess, Cushing syndrome Chronic illness: o Crohn disease o Chronic renal failure Chromosomal disorder: o Down syndrome o Turner syndrome o Noonan syndrome o Russell-Silver syndrome Tall Stature Etiology: Familial obesity True gigantism Marfan syndrome Klinefelter syndrome Sotos syndrome Precocious Puberty Definition: Development of secondary sexual characteristics before 8 years (female)/9 years (male) Accompanied by a growth spurt Premature breast development (thelarche) Premature pubic hair development (pubarche) Categorization: (according to FSH and LH levels) Gonadotropin-dependent: Central, (True PP) Gonadotropin-independent: Pseudo, (False PP) Central Precocious Puberty - Etiology Idiopathic/Familial CNS abnormalities Hydrocephalus Post-irradiation Infection Tumors Pseudo Precocious Puberty - Etiology Adrenal disorders Tumors Congenital Adrenal Hyperplasia Ovarian tumor Testicular tumor Delayed Puberty Definition: Absence of pubertal development by 14 years (male) / 15 years (female) Etiology: Constitutional delay of growth and puberty Hypogonadotropic hypogonadism Hypergonadotropic hypogonadism Cystic Fibrosis Severe asthma Crohn disease Anorexia nervosa Intracranial tumours Kallmann syndrome Klinefelter syndrome Turner syndrome