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What is Marfan Syndrome? Marfan Syndrome is an inherited connective tissue disorder that can affect many different parts of the body. Because connective tissue is found throughout the body, the Marfan syndrome can affect many body systems, including the skeleton, eyes, heart and blood vessels, nervous system, skin and lungs. Marfans is a degenerative condition. The heart abnormalities associated with this condition are the most life-threatening and the most important to detect. The major heart abnormality is weakening of the root of the aorta which leads to dilation of that root and, at extremes, aneurysm formation and rupture. tissue in individuals with Marfan syndrome is damaged, the tissue holding the lens can become weak or tear. The dislocation can be so severe How it affects the eyes: Dislocated Lenses that the lens of the eye may float freely within the cavity instead of remaining attached by connective tissue. Some of the symptoms include mild or severe nearsightedness, blurry vision or an astigmatism which occurs when your eye is irregularly shaped like a football instead of being round. An ophthalmologist can confirm this condition using a slit-lamp eye exam One or both lenses may sit higher or lower than normal or they may shift to one side. One eye may also be worse than the other. Most people with Marfan syndrome will experience dislocated lenses before they reach the age of 10. Because the connective that involves a specialized microscope. Other ocular abnormalities may include nearsightedness, cataracts, detached retinas, or glaucoma. Outlook Early diagnosis and advances in medical technology allows doctors to intervene and prevent or delay complications. Advances being made by researchers provide hope for the future. With early diagnosis and appropriate management, the life expectancy for someone with the Marfan syndrome is similar to that of the average person. Sources: 1. http://en.wikipedia.org/wiki/Ma rfan_syndrome 2. http://www.childrensheartinstitu te.org/educate/marfan/skeletal.h tm 3. http://www.marfan.org/nmf/Get ContentRequestHandler.do?me nu_item_id=2 4. http://marfanlife.net/home/ 5. http://www.americanheart.org/p resenter.jhtml?identifier=4672 What is Marfan Syndrome?