Download 12015_2010_9180_MOESM3_ESM

Supplementary Table 2. Identified Networks in umbilical cord blood-derived CD34+ cells
ID
1
2
3
4
5
6
7
8
9
10
11
12
13
14
Molecules in Network
ACTB, ACTG1, AHNAK, Alpha Actinin, Alpha catenin, ANXA2, ANXA5,
C22ORF28, Calpain, COL10A1, CSPG4, CTNNA1, DYSF, EIF5A, EIF5B,
ERK1/2, Focal adhesion kinase, HNRNPK, INSL4, LCN2, MAP4, MYO7A,
NEDD8, P2RY6, PLEC1, RPL17, RPL30, RPS2, RPS7, RPS13, SNRPD3,
SPTA1, SPTBN1, SPTBN2, TLN1
ABCA2, ATPase, DENND4A, ECHS1, EEF1A1, EEF1B2, ENO1, ENO3,
Enolase, GLUD1, HSPD1, KIF20B, LYPLA1, LYST, MAP2K1/2, MDH2,
MYH6, MYH7, PACSIN1, PDCD5, PRL, Ras, RPLP1, RPLP0 (includes
EG:6175), RPS6KA6, Rsk, TKT, TP53BP2, TPT1 (includes EG:7178), UTP14A,
VCP, VDAC2, VPS4B, XPO5, YWHAZ
ALB, C1q, C1QBP, CALR, CORO1A, CPSF2, Cytokeratin, DES, DSP, Eif4g,
EVPL, FABP5, HNRNPD, HNRNPF, HNRNPH1, HSPB1, IgG, IGHG1, IGHM,
IGKC, IGLL1, Igm, KHSRP, KRT1, KRT2, KRT10, LDHA, LGALS1, NEB,
NFkB (complex), PLA2, TTN, UBE2, UBE2E2, VIM
ADA, Alpha tubulin, ARPC4, ARPC5, Cbp/p300, CCT2, CCT5, CCT7, CCT6A,
CEP350, CLCA1 (includes EG:1179), Creb, DCHS1, FBL, Histone h4,
HNRNPA1, HNRNPC, HNRNPM, HNRNPU, Insulin, Lh, MUC5AC, MYO5A,
MYO5C, NCL, NME1, PFDN2, PPARG, RAN, Rb, RBM39, RNA polymerase
II, SUMO2 (includes EG:6613), TPO, Vegf
ACADS, Adaptor protein 2, ALDOA, Ap1, APOB, Caspase, Ck2, COL4A1,
FBP1, FOLH1, HSP, Hsp27, Hsp70, Hsp90, HSP90AA1, HSP90AB1, HSPA6,
HSPA8, HSPA9, IGF2R, LNPEP, MYH13, Nuclear factor 1, NUMA1, PDIA3,
peptidase, PGK1, PLIN3, RANBP2, STIP1, TCOF1, TCP1, TNKS, TPP1,
XRCC6
APOC3, ATP2B1, ATP2B4, ATP2C2 (includes EG:9914), Ca2 ATPase,
CABIN1, CACNA1A, Calcineurin A, Calcineurin protein(s), Calmodulin, CD3D,
FBXW7, H2AFZ, L-type Calcium Channel, MYBPC2, MYH2, MYH3, MYH4,
MYH10, MYL12B, Myosin, Myosin2, NOTCH3, P38 MAPK, Pka catalytic
subunit, RAB17, RAB7A, Ryr, RYR2, RYR3, RYR1 (includes EG:6261),
SCN2B, SCN5A, SLC12A2, SNTG2
ABCA1, ABCD1, Akt, BRD2, CBX3, CHAF1A, DNMT3B, E2f, Estrogen
Receptor, Gcn5l, Hdac, HDAC10, HISTONE, Histone h3, HOXC9, MAX,
MLH3, MUC4, N-cor, NCOR2, NRIP1, PHB (includes EG:5245), PLA2G1B,
Rar, RARG, RBBP4, RPN1, Rxr, SMC2, SMC4, SPEN, THBS2, thymidine
kinase, Thyroid hormone receptor, TRRAP
APP, ATM, BANF1, Basc, BLM, CLIC1, Cyclin A, Cytochrome c oxidase,
ECH1, FRAT2, GALK1, GAPDH (includes EG:2597), Glutathione peroxidase,
Glycogen synthase, GPX1, HIST1H1A, HIST1H1C, HIST1H1D (includes
EG:3007), HIST1H1T, Histone H1, Ldh, Mre11, NBS1-Rad50-MRE11, PGAM1,
PP1, PPI, PPIA (includes EG:5478), PPIE, PRDX3, PRDX6, RAD50, RPA,
RPA2, TOMM40, UBE2K
20s proteasome, 26s Proteasome, BRCA2, CD3, CD52, CNTN2, DAXX, FLNA,
FUBP1, HSPB7, Ifn gamma, Immunoproteasome Pa28/20s, Jnk, MGC29506,
MHC Class I (complex), MHC CLASS I (family), Proteasome PA700/20s,
PSMA, PSMA3, PSMA5, PSMA6, PSMB6, PSMB9, PSME1, PSME2,
RAD51L1, RUNX1, SHB, Sos, SOS1, TCR, TMEM189-UBE2V1, TRB@,
UBE2N, VAV
Actin, Alpha actin, Arp2/3, CALD1, CAP1, CFL1, Cofilin, DMD, EIF1, Eif2,
EIF3, EIF2A, EIF3A, EIF3B, EIF3I (includes EG:8668), F Actin, Fascin, GActin, G6PD, MIR1, MYH11, p70 S6k, PDHA1 (includes EG:5160), PDK1,
PDK3, PI3K, PP1-C, PRX, TAGLN2, TPI1, TPM1, TPM3, TPM4, Tropomyosin,
UTRN
ADCY, ALP, CHEMOKINE, CXCL11, DDX21, Fgf, GLO1, GMPS, GNB2,
Gpcr, HINT1, HLA-B, IFI27, IFN Beta, Iga, Ikb, IKK (complex), IL1, IL15, IL12
(complex), Interferon alpha, KIT, NCR3, NONO, NUDT5, PCNA, Pka, RAB32,
S100A9, SHMT2, SMURF1, TBCA, Tgf beta, UBB, Ubiquitin
14-3-3, ACTN2, ACTN4, Ap2 alpha, ARHGDIB, BSN, Clathrin, CLTC, CRKL,
Dynamin, FSCN1, GRIA4, GRIN1, HNRNPL, LRRC7, NADPH oxidase, Nfat
(family), NMDA Receptor, OGG1, PCBP1 (includes EG:5093), Pkc(s), PTBP1,
Ptk, RAB13, RAC2, Sapk, Sod, SOD3, STMN1, STRAP, SYNJ1, TUBA1C,
TUBB, TUBG1, Tubulin
APRT, ARL1, ATIC, CCNI, CDKN2A, DYNLRB1, EHD3, ETFA, ETFB, FH,
FUNDC2 (includes EG:65991), GLOD4, GOLGA1, GOLGA4, IKBKE,
LYPLA1, MACF1, MLEC, MYH8, NDUFA10 (includes EG:678759), NDUFA9
(includes EG:362440), NDUFAF1, NDUFV1, NDUFV2, NSF, PGRMC2,
RAB2B, RAB6A, RPL10A (includes EG:19896), SFXN1, SKIV2L, SLC2A4,
TMEM111, TPP1, UQCRC1
ADAM10, AKR1A1, ANXA8L2, ATL3, CEP290, ENDOD1, EXOSC4,
FAM83H, GAS2L1, HADH, HEBP2, KITLG, KLHL24, LRRC58, MIR124,
MIR124-1, MKKS, NEUROD6, OSBPL8, PEX1, PGLS, QSER1, RAG1AP1,
Score
Focus
Molecules
Top Functions
45
30
Protein Synthesis
45
30
Molecular Transport, Metabolism, Small
Molecule Biochemistry
38
27
Hair and Skin Development and Function,
Organ Development, Dermatological
Diseases and Conditions
35
26
Cell Death, Cell Morphology, Molecular
Transport
34
25
Cancer, Post-Translational Modification
33
25
Molecular Transport, Cell Signaling,
Vitamin and Mineral Metabolism
28
23
Gene Expression, Cancer, Immunological
Disease
28
23
Lipid Metabolism, Molecular Transport,
Small Molecule Biochemistry
22
Cell-mediated
Immune
Response,
Cellular Development, Cellular Function
and Maintenance
21
Protein
Synthesis,
Developmental
Disorder, Skeletal and Muscular System
Development and Function
20
Dermatological Diseases and Conditions,
Hematological Disease, Immunological
Disease
24
23
Cellular Assembly and Organization,
DNA Replication, Recombination, and
Repair, Molecular Transport
16
15
Genetic Disorder, Metabolic Disease,
Cardiovascular Disease
16
15
Cellular Development,
Genetic Disorder
27
25
24
Cell
Death,
22
RDH10, retinoic acid, RPGR (includes EG:6103), RPGRIP1, SERPINB6,
SLC25A30, SMG1, SYCP1, TMBIM1, TTC7A, UPF1, ZNF790
ABCA4, AIM1 (includes EG:202), ATP, ATP8B2 (includes EG:57198), BAI1,
CaMKII, CER1, CHRAC1, CMAS, CTNNB1, DDAH1, DHX40, DLG4, DPEP1,
ERBB2, ERBB2IP (includes EG:365662), HDAC1-PS, ITGB4, LPHN1, MIR9-1
(includes EG:407046), MIRN324, NETO1, OLA1, PFKFB2, PP95, PP2A,
PRKAG3, RB1, SHOX, SMARCA5, STAB1, WIF1, Wnt, WNT2, ZDHHC15
ALDH18A1, ALDH5A1, APBB2, ARF4, ARNT2, CAMLG, CDKN3,
COL11A1, COL6A2, CRYGD, DNPEP, EEF1D, EGFR, GOLGB1, HYAL2,
ITIH3, KAP, KCNJ15, KDELR2, KDELR3, KIF3C, KTN1, LRRFIP1, MGAT2,
MGEA5, NAB1, PDLIM4, PHLDA2, SH3BGRL, TARDBP, TGFB1, TPSAB1,
VPS24, WFS1, XBP1
ANXA11, Collagen type I, Collagen(s), COPS8, ERK, GDNF, GFER, Growth
hormone, GSTA1, HMGB1 (includes EG:3146), HSPA5, Ige, ITGA2B (includes
EG:3674), Laminin, LDL, LRP, LRP1, LRP2, LRP1B, Mapk, Mek, Mlc, MSN,
Pak, Pdgf, PDGF BB, PEBP1, Pld, PP2A, Rac, Rock, RPSA, Shc, STAT5a/b,
VCAN
ARHGAP17, CUTA, DLD, DLST, EPHX4, ERBB, GRB2, H1F0, IMPDH2,
MERTK, Met dimer, MYO1B, NRG1, NRG3, OLIG2, PAX6, PLC gamma,
RACGAP1, RALGPS1, RGPD5, RHOU, RPL18A, SHC4, SLC26A8, SVIL,
SYNCRIP, TEC/BTK/ITK/TXK/BMX, TNK2, TNPO1, TPX2, TUB, TUBB2C,
UNC5C, ZHX2, ZNF217
AARS, ARID1A, BAF110, beta-estradiol, C21ORF33, COX6A2, CST8, Dglucose, DDX54, GMEB2, H1FOO, IFT122, INHIBIN B, KLK11, KLK15,
LYL1, MLLT10, MTL5, NFKBIA, NR3C1, PCSK2, REG1A, RWDD3, SCN9A,
SMARCB1, SNAP29, SON, SPINK5, SPRR3 (includes EG:6707), SS18,
STXBP4, TOP3B, Trypsin, VAMP2, VAPA
BAX, butyric acid, C5, CA5A, CAPZA1, CD300C, CST6, Cytochrome c,
DDX3Y (includes EG:8653), FCGR1B, FCGR1C, FSH, HBE1, HBG1, HBG2,
HBZ, hCG, IL6, IL1/IL6/TNF, IL17B, IL1B, Inhibin A, ITPA, MFN1, MMP2,
MRVI1, RARB, SAA4, SHBG, SLC14A1, SLC25A25, SLC5A2, SPOCK1,
TAS1R2, ZC3H12A
ASTN1, C1ORF96, CD160, COX6B1, COX8A, DECR1, EP300, ERAP1,
FEZF2, FLRT2, FRYL, GALNT2, GART, GLI1, GMFG, HLX, HNRNPA3,
IDH3B, IFNG, JOSD1, LZTS1, ME2, MIR206 (includes EG:406989), NFYB,
RAB12, RAB3C, RHCE, SCD5, SRP54, SS18L1, STX16, USP10, USP9X,
VEGFA, WNT2B
ABCA6, APOA1, APOC1, APOF, BCCIP, C17ORF81, C1ORF212,
DSCAML1, GBF1, GPLD1, HIST1H2BN, HNF4A, HNRNPA0, HPX, LECT1,
MICAL3 (includes EG:57553), MOCOS, NBAS, PLCL2, PPP1CA, PPP1R10,
PPP1R11, PPP1R12B, PPP1R14D, PPP1R15B, PPP1R3B, PPP1R3D, RAB1B
(includes EG:81876), ROBO3, RRP1B, SAA2, SERTAD3, TMEM176A,
TOR1AIP1, ZAN
23
CCDC85B, TTC14
1
1
24
CMTM4, MIR373
1
1
25
DNA-directed RNA polymerase, POLR3B, POLR3D
1
1
15
16
17
18
19
20
21
15
Cellular Assembly and Organization,
DNA Replication, Recombination, and
Repair, Cancer
14
Carbohydrate
Metabolism,
Small
Molecule Biochemistry, Cellular Growth
and Proliferation
15
Antigen
Presentation,
Cell-To-Cell
Signaling and Interaction, Hematological
System Development and Function
13
13
Cellular Development, Nervous System
Development
and
Function,
Cell
Morphology
13
13
Cellular Assembly and Organization,
Cellular Compromise, Gene Expression
12
13
Drug Metabolism, Lipid Metabolism,
Small Molecule Biochemistry
11
12
Cardiovascular System Development and
Function, Lipid Metabolism, Small
Molecule Biochemistry
10
11
Carbohydrate Metabolism,
Transport, Lipid Metabolism
15
14
13
Molecular
Cancer, Reproductive System Disease