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Table 1
Genes down-regulated in p8-/- liver
Fold repression
Protein synthesis, transport and modification
SKD1 protein
plasma membrane protein syntaxin-4
vesicle trafficking protein sec22b
embryo neural precursor mRNA (Mus musculus ubiquitin protein ligase Nedd-4)
ancient ubiquitous 46 kDa protein AUP1 precursor (Aup1) (CDP-diacylglycerol synthase)
RIBOSOMAL PROTEIN L3
ribosomal protein L21
translation initiation factor (Eif4g2)
PHAS-II
26S proteasome subunit 4 ATPase
cyclophilin
mannosyl-oligosaccharide alpha-1,2-mannosidase
co-chaperonin cofactor A
L23 mitochondrial-related protein (L23mrp)
2.8
2.2
2.6
2.4
5.3
2.5
2.3
3.4
2.9
2.0
2.0
2.5
2.6
4.6
Signaling
conserved helix-loop-helix ubiquitous kinase (CHUK)
glycosyl-phosphatidyl-inositol-anchored protein homolog
protein phosphatase 1cgamma (PP1cgamma)
protein phosphatase 2A Balpha3 regulatory subunit
mothers-against-dpp-related-1 (Smad1)
protein tyrosine phosphatase (PRL-1)
suppressor of cytokine signalling-2 (SOCS-2)
retinally abundant regulator of G-protein signaling mRGS-r (RGS-r)
cardiac calsequestrin
38 kDa Mov34 isologue
magnesium dependent protein phosphatase (protein phosphatase 2C) alpha
3.4
2.6
3.5
4.9
2.1
2.0
3.5
3.7
2.1
3.8
2.5
Secreted factors
serum amyloid A protein (SAA5)
endothelial-monocyte activating polypeptide II
C10-like chemokine
angiopoietin-1
mast cell protease-4
kidney androgen-regulated protein (KAP)
extracellular superoxide dismutase (SOD3)
2.5
3.4
2.7
2.1
3.8
2.0
5.0
Cytoskeletal proteins
HGT keratin
cofilin isoform
3.2
2.4
Transcriptional factors and RNA processing
homeobox protein Nkx2.6 (Nkx2.6)
RPA16 (16-kDa subunit of mouse RNA polymerase I)
sm D small nuclear ribonucleoprotein sequence
orphan nuclear receptor RVR
albumin gene D-Box binding protein
Supt4h
ATP-dependent RNA helicase
putative CCR4 protein
NNP-1 (NNP-1)
putative histone deacetylase (HD1)
LEUCINE ZIPPER TRANSCRIPTION FACTOR(WEAK)
Dhm1 protein
CACCC-box binding protein BKLF
4.3
3.4
2.3
2.6
3.0
2.3
2.5
2.8
4.4
4.0
3.3
2.0
3.4
Apoptotic-related proteins
bcl-2 binding protein BAG-1
EAT/MCL-1
TDAG51
2.8
2.3
5.7
Membrane and transporters proteins
MHC class I Qa-Tla mRNA, (H2-d haplotype), clone pH2-d-37
polycystic kidney disease 2 (Pkd2)
gp49B gene
Lisch7 (lipolysis-stimulated receptor (LSR))
reduced folate carrier (RFC1)
Golgi 4-transmembrane spanning transporter MTP
peroxisomal PTS2 receptor
2.0
2.5
2.2
2.4
8.0
2.4
2.2
Cytosolic enzymes and detoxification factors
Tum-P91A antigen gene (diphenol oxidase (DOX) A2-encoding gene (Dox-A2))
calmodulin synthesis (CaM)
Aminopeptidase
prolidase (pep4)
glutathione-S-transferase homolog
flavin-containing monooxygenase 3
preprodipeptidyl peptidase I
alpha glucosidase II beta subunit
glycine tyrosine-rich hair keratin protein
protective protein (Mo54)
aldehyde deydrogenase (Ahd3)
alpha-D-mannosidase (Man2b1)
pyruvate dehydrogenase (pdha-1)
isocitrate dehydrogenase
cytochrome P450 monooxygenase (CYP2J5)
cytochrome P450 monooxygenase (CYP2J6)
dihydrolipoamide dehydrogenase (Dld)
3.4
2.2
2.2
4.4
3.8
3.8
2.2
2.8
2.5
2.4
3.8
4.7
2.9
2.0
2.7
2.8
3.3
Growth-related proteins
Cdk-inhibitor p57KIP2 (KIP2)
retinoblastoma-binding protein (mRbAp48)
deleted in split hand/split foot 1 homolog (Dss1)
elav G homolog (MelG)
3.1
4.4
2.1
3.2
Table 2
Genes up-regulated in p8-/- liver
Fold induction
Signaling
CAMP-REGULATED PHOSPHOPROTEIN
MIXED LINEAGE KINASE 1
KIF2 protein
inhibitor protein of cAMP-dependent protein kinase
MEK kinase 3
SH3 binding protein 3BP2
3.1
7.3
2.1
2.3
2.7
2.0
Secreted factors
Mouse tissue plasminogen activator
preproelastase II
serum amyloid A protein
bone morphogenetic protein 8B (Bmp8b)
2.4
2.6
2.1
2.5
Cytoskeletal proteins
alpha-tropomyosin slow
pericentrin
pmg-1 protein (pmg-1)
11.1
3.5
3.5
Transcriptional factors and RNA processing
transcription factor PBX1b (PBX1b)
zinc finger protein (Sna)
recombination protein RAD52 homolog
classII MHC transactivator CIITA
Mouse intracisternal A-particle-related retroviral elements
2.4
3.0
2.6
3.3
3.1
Apoptotic-related proteins
hemopoietic-specific early response protein (A1)
3.5
Membrane and transporters proteins
hyaluronan-mediated motility
ryudocan core protein
fibroblast growth factor receptor 3
adenosine receptor subtype
2.1
6.8
2.3
3.1
Cytosolic enzymes and detoxification factors
thimet oligopeptidase
carbonic anhydrase IV
4.5
5.1