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ROBUST STUDY SUMMARY - Inherent Toxicity Item Yes No Reference:.Röderer G. 1990. Test-Bericht. Testung wassergefährdender Stoffe als Gruundlage für Wasserqualitätsstandards. Frauenhofer-Institut für Umweltchemie und Ökotoxikologie. Schmallenberg, Germany. Test Substance: CAS # 56-23-5 and tetrachloromethane = Tetrachlorkohlenstoff *Chemical composition of the substance ( including purity, by-products) x Persistence/stability of test substance in aquatic solution Flow-through test for x volatile substance, GC determination of actual concentrations. Method References x *OECD, EU, national, or other standard method? OECD-guidelines no 203 and 204 x Justification of the method/protocol if not a standard method was used *GLP (Good Laboratory Practice) ????? One of the most famous and best Institutes in x Germany for scientific research Test organisms (zebra fish (Brachydanio rerio)) Latin or both Latin and common names reported? Life cycle age / stage of test organism Sex Length and weight of test organisms 2.0 cm Number of test organisms per replicate 10 test organisms per test… Food type / feeding periods (acclimation/during test) During acclimation TetraMin food, not fed not fed during acute tests. Test design / conditions Test type – acute or chronic acute: Experiment type (laboratory or field) specified? Laboratory System type (static, semi-static, flow-through)? Flow-through Negative or positive controls (specify)? Number of replicates (including controls) and concentrations 7 Exposure pathways (food, water, both) Exposure duration 4 days *Measured concentrations reported? Exposure media conditions (temperature, pH, electrical conductivity, hardness, TOC, DOC, DO, major cations and anions; other) (25 C, rest consistent with OECD guidelines Was pH within 6-9 range? (8.15) Was temperature within 5-28 °C range? (25°C) Photoperiod and light intensity light/ dark 14 / 10 hours Stock and test solution preparation Detailed description of solution preparation and flow-through ssystem Use of emulgators / solubilizers (especially for poorly soluble / unstable substances) no use… Analytical monitoring intervals Statistical methods used Litchfild and Wilcoxon and graphical Results Toxicity values (LC50, EC50, or IC50 ) 48h –and 96h- LC50 = 24.34mg/L Other endpoints reported - BCF/BAF, LOEC/NOEC ( 14d-NOECo): *Was toxicity value below the chemical’s water solubility? WS = 793mg/L. Other adverse effects (carcinogenicity, mutagenicity, etc. No) x x NA x x x x x x x NA x x x x x x x NA NA x x x Score: major items - 79.2% EC Reliability code: Reliability category (high, satisfactory, low): Comments: excellent study, well reported….