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HERMAN OSTROW SCHOOL OF DENTISTRY OF USC
INSTRUCTIONAL SYLLABUS - CBY 575 Biologic Basis of Oral-Facial Disease
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I. Basic Information
 Course ID: CBY 575
 Course title: Biologic Basis of Oral-Facial Disease
 Course type: Lecture
 Program: Advanced Specialties in Endodontics, Periodontics and Prosthodontics
 Students: ENDO 2018, PERI 2019, PROS 2018
 Semester and day/time: Fall 2016, Mondays 9:00-10:00AM, Fridays 8:00-10:00AM
 Lecture rooms: Mondays, Seminar C – Fridays: Guggenheim
 Units: 3
 Name of Instructor(s): Jorgen Slots
o Office: DEN 4306
o Office hours: By appointment
o Phone: (213) 740-1091
o Email: [email protected]
o Blackboard address, homepage (if relevant): N/A
o TA(s)/Volunteers; including contact information and office hours, if relevant: N/A
II. Course/Unit Description
Cell and molecular biology of oral tissues in disease; emphasis on molecular oral pathology.
III. Course/Unit Objectives
Upon completion of the course, each student should be able to understand and describe:
1) Major morphological characteristics, biochemical features and taxonomical aspects of human
bacteria, viruses, fungi and parasites.
2) Basic principles in microbial molecular biology as it relates to virulence and methods of
identification.
3) Basic features of humoral and cellular host immune responses in infectious processes.
4) Major clinical and microbiological features of major nonoral infectious diseases.
5) The antimicrobial spectrum and potential adverse effects of commonly used antimicrobial
agents.
6) The major microorganisms in and the microbial ecology of the human oral cavity.
7) The microbiology and immunology of dental caries.
8) The microbiology and immunology of periodontal disease.
9) The microbiology and immunology of endodontic lesions.
10) The microbiology of oral mucosal infections.
11) Transmissible infections in dentistry, infections disease control and Hepatitis B vaccination.
IV. Competency Alignment or Advanced Specialty Proficiency
This course helps students (USCSD competencies)
8. Perform a comprehensive diagnostic evaluation based upon the application of scientific
principles, and current literature, with consultations as appropriate.
13. Provide patient education and preventive procedures to maximize oral health.
14. Recognize periodontal disease, treating uncomplicated conditions, and referring
complicated periodontal procedures.
17. Recognize pulpal and periradicular disease, treating uncomplicated conditions and
referring complicated endodontic procedures.
22. Recognize and manage pain, hemorrhage, trauma and infection of the orofacial complex.
23. Select and administer or prescribe pharmacological agents in the treatment of dental
patients.
V. Learning Resources (textbooks, articles, digital resources)
Recommended Reading material
 CONTEMPORARY ORAL MICROBIOLOGY AND IMMUNOLOGY (Slots &
Taubman),
 THE IMMUNE SYSTEM 4th edition (Garland)
 E-books
 E-journals.
VI. Schedule/Course Calendar
Sep 09: Introduction to immunology: cells and tissues of the immune system and immune
recognition
Learning needs:
1) Moncytes/macrophages ABULHAMAEL
2) T-cells and B-cells ELBWARDY
3) Polymorphonuclear leukocytes WHARTON‐LAKE
4) Antibody classes and production FATH
5) Cellular immunity EL HUSSEINI
Sep 12: Inflammation, immunodeficiency, hypersensitivity
Learning needs:
1) Complement system MAGAR
2) Immunodeficiency OLSON
3) Hypersensitivity reactions HAGHPARAST
Sep 16: Molecular biology I
Learning needs:
Sep 19: Molecular biology II
Learning needs:
Sep 23: Major bacterial diseases
Learning needs:
Sep 26: Major viral diseases I
Learning needs:
Sep 30: Major viral diseases II
Learning needs:
1) Structure of DNA and genetic code HAGHPARAST
2) Transcription and translation PATEL
3) Operon TANDON
4) Restriction endonucleases WADIA
1) Methods of creating recombinant DNA molecules CHOI
2) The polymerase chain reaction FATH
3) Pyrosequencing and illuminasequencing LIM
1) Pathogenic properties of bacteria EL HUSSEINI
2) Respiratory infections SEDLER
3) Sexually transmitted diseases MORENO‐ALEMAN
4) Skin infections ALSATIAN
1) Viral pathogenesis and host defense ABULHAMAEL
2) Laboratory identification of viruses OLSON
3) Control of viral infections/antiviral agents MAGAR
4) Childhood viral diseases TANDON
1) Hepatitis viruses FATH
2) HIV ALBABTAIN
3) Herpesviruses HAGHPARAST
Oct 03: Major mycotic/parasitic diseases
Learning needs:
1) Respiratory viruses ALSATIAN
2) Mycosis caused by yeasts SEDLER
3) Major parasitic diseases WHARTON‐LAKE
4) Antiseptics ELBWARDY
Oct 07: Antibiotics
Learning needs:
1) Factors in antibiotic selection MORENO‐ALEMAN
2) The penicillins/cephalosporins WADIA
3) The tetracyclines HE
4) Antibiotics against anaerobic infections CHOI
5) The macrolides, the quinolones EL HUSSEINI
Oct 10: Introduction to oral microbiology I
Learning needs:
1) Oral microbial ecology TANDON
2) Methods to diagnose oral bacteria ALBABTAIN
3) Oral gram-positive cocci JEONG
Oct 14: Introduction to oral microbiology II
Learning needs:
1) Oral gram-positive rods MORENO‐ALEMAN
2) Non-pigmented oral gram-negative rods ELBWARDY
3) Black-pigmented oral gram-negative rods MAGAR
4) Spirochetes WHARTON‐LAKE
Oct 17: Microbiology of periodontal disease I
Learning needs:
1) Microbiology of acute and chronic gingivitis SEDLER
2) Microbiology of juvenile/aggressive periodontitis
EL HUSSEINI
3) Microbiology of chronic (adult) periodontitis WADIA
Oct 21: Microbiology of periodontal disease II
Lecture/Catching up
Oct 24: Microbiology of dental caries
Learning needs:
1) Relationship between mutans streptococci and dental
caries CANESSA
2) Relationship between lactobacilli, actinomyces and other
bacteria and dental caries ALSATIAN
3) Monitoring the cariogenic flora in clinical practice LIM
Oct 28: Microbiology of endodontic infections I
Learning needs:
1) Endodontic bacterial sampling FATH
2) Pulpitis microbiota ABULHAMAEL
3) Microbiota with necrotic pulps HAGHPARAST
4) Cellular infiltrate, cytokines and chemokines in
endodontal diseases CHOI
Oct 31: MIDTERM I
Nov 04: MIDTERM II
Nov 07: Microbiology of endodontic infections II
Lecture/Catching up
Nov 11: Various microbiological topics
Lecture/Catching up
Nov 14: Microbiology of oral mucosal and submucosal infections
Learning needs:
1) Superinfections CANESSA
2) Systemic manifestations of oral infections MAGAR
3) Stomatitis HE
Nov 18: Introduction to oral immunology
Learning needs:
1) Development and general features of oral immune
system PATEL
2) Innate immunity in the oral cavity OLSON
3) Secretory antibodies LIM
4) Gingival crevice fluid environment WADIA
Nov 21: Immunology of periodontal diseases and transplantation immunology
Learning needs:
1) Humoral immunity in periodontitis SEDLER
2) Cellular immunity in periodontitis EL HUSSEINI
3) Transplantation of teeth and bone CANESSA
Nov 24: THANKSGIVING
Nov 28: Immunology of dental caries/pulpal immunobiology
Learning needs:
1) Role of antibodies in dental caries JEONG
2) Immunization approaches against dental caries HE
3) Pulpal response to infection ABULHAMAEL
4) Periapical response to infection CHOI
Dec 02: Transmissible infections in dentistry, infectious disease control, vaccination of
dental personnel
Learning needs:
1) Transmissible viral infections ALBABTAIN
2) Transmissible bacterial infections WHARTON‐LAKE
3) Disinfection and sterilization in the dental office
CANESSA
4) Guidelines for vaccination of dental personnel PATEL
Dec 05: Endocarditis prophylaxis
Learning needs:
1) Oral causes of endocarditis JEONG
2) Guidelines for endocarditis prophylaxis in dentistry –
current recommendations and trends TANDON
Dec 09: FINAL EXAMINATION
VII. Course/Unit Requirements and Grading/Evaluation
POLICIES:
1. Each resident is responsible for reading and having a detailed knowledge of each learning
need before coming to class. All residents must prepare for a discussion in the class of each
learning need.
2. Residents will be identified to produce a PowerPoint presentation pertaining to the learning
needs of the week. Residents’ presentations must be e-mailed to each course participant and the
course director no later than Wednesday preceding each Friday session and Thursday preceding
each Monday session. Residents must also prepare for an oral presentation for the class.
3. Class attendance is mandatory.
4. Grades will be based on
•
class participation (10%),
•
participant write-up and presentation (25%),
•
two midterm examinations (15% for each, take-home essay tests, to be submitted by email to the course director at the day of the midterm),
•
and final examination (35%, written essay test in class covering 3 topics selected from
the entire set of topics of the course).
5. Minimum satisfactory achievement is 67% positive score.
6. Make-up exams are allowed only in the case of illness or acts of God; the course director
must be notified prior to the hour of the exam.
7. Residents who fail the course may repeat the final exam. Residents who fail the make-up
exam must repeat the entire course.
8. The University policy regarding academic dishonesty is adhered to.
VIII. Board Preparation
This course/unit prepares students for Dental Specialist Board exams to achieve diplomat status.
Academic and Professional Conduct: Should there be any suspicion of academic, professional or
ethical dishonesty, students are referred to the Ostrow Student Professional Performance
Evaluation Committee (SPPEC). The review process can be found in the Code of Ethics and
Behavioral Guidelines on the School intranet.
Plagiarism – presenting someone else’s ideas as your own, either verbatim or recast in your own
words – is a serious academic offense with serious consequences. Please familiarize yourself
with the discussion of plagiarism in SCampus in Section 11, Behavior Violating University
Standards https://scampus.usc.edu/1100-behavior-violating-university-standards-andappropriate-sanctions/. Other forms of academic dishonesty are equally unacceptable. See
additional information in SCampus and university policies on scientific misconduct,
http://policy.usc.edu/scientific-misconduct/.
Discrimination, sexual assault, and harassment are not tolerated by the university. You are
encouraged to report any incidents to the Office of Equity and Diversity http://equity.usc.edu/
or to the Department of Public Safety http://capsnet.usc.edu/department/department-publicsafety/online-forms/contact-us. This is important for the safety whole USC community. Another
member of the university community – such as a friend, classmate, advisor, or faculty member –
can help initiate the report, or can initiate the report on behalf of another person. The Center for
Women and Men
http://www.usc.edu/student-affairs/cwm/ provides 24/7 confidential support, and the sexual
assault resource center webpage [email protected] describes reporting options and other resources.
Support Systems: A number of USC’s schools provide support for students who need help with
scholarly writing. Check with your advisor or program staff to find out more. Students whose
primary language is not English should check with the American Language Institute
http://dornsife.usc.edu/ali , which sponsors courses and workshops specifically for international
graduate students.
The Office of Disability Services and Programs
http://sait.usc.edu/academicsupport/centerprograms/dsp/home_index.html provides certification
for students with disabilities and helps arrange the relevant accommodations. Any student
requesting academic accommodations based on a disability is required to register with Disability
Services and Programs (DSP) each trimester. A letter of verification for approved
accommodations can be obtained from DSP. Please be sure the letter is delivered to DSP as
early in the trimester as possible. DSP is located in STU 301 and is open 8:30 a.m.–5:00 p.m.,
Monday through Friday. The phone number for DSP is (213) 740-0776.
If an officially declared emergency makes travel to campus infeasible, USC Emergency
Information http://emergency.usc.edu/ will provide safety and other updates, including ways in
which instruction will be continued by means of blackboard, teleconferencing, case library,
intranet, email listserv, and other technology. Ostrow students should also access the Ostrow
School of Dentistry Intranet for additional specific information in the event of an emergency.