Download King Saud University PHG434 College of Pharmacy 03/11/1431 H

King Saud University
PHG434
College of Pharmacy
03/11/1431 H
Department of Pharmacognosy
Marks: 10, Time: 7 min.
Quiz 1
Name of Student
KSU ID Number
A. Define: phytochemicals (2 Marks)
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B. Encircle the letter of the most correct item(s) (4 Marks)
1. These are examples of clinically tested marine natural products
a- Berberine and egometrine.
b.Berberine and ziconotide.
c- Ziconotide and bryostatins.
d-Bryostatin and dextromethorphan.
2. The first natural product is the prototype of the second drug
a- aspirin - salicylic acid
b- salicin – aspirin
c- d-tubocurarine - atracurium
d- Quinine - anthraquinone.
C- Rearrange the following steps to accomplish a systematic bioguided
phytochemical analysis ended by a drug discovery (Put numbers in the
circles to show the sequence of the plan): (4 Marks)
 Selection and collection of promising plant materials.
 Extraction and fractionation of constituents.
 Clinical studies.
 Bioguided isolation of chemical constituents.
 Authentication of plant material.
 Drying of plant materials.
 In vitro/in vivo study of identified bioactive compounds.
 Methods of identification of isolated compounds.
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Atallah F. Ahmed, PhD , PHG434