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SUSAN MAHLER ZNEIMER, PH.D., FACMGG
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7546 ATHERTON LANE  WEST HILLS, CA 91304
818 884.4843  CELL 818 808.9192  [email protected]
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2007 – PRESENT
MOSYS (MEDICAL, OPERATIONS, SYSTEMS) CONSULTING, LOS ANGELES, CA
SCIENTIFIC DIRECTOR AND CEO
Clinical Cytogenetics Laboratory Director offering consulting services to laboratories for clinical case review in cytogenetics,
laboratory expertise for quality improvement and cost reduction through Six Sigma. Offer expertise to consulting firms and
companies on information and medical writing regarding genetics, molecular biology, laboratory services and related fields.
Current clients include City of Hope Medical Center, Kaiser Permanente Medical Group and CombiMatrix, Inc. Past clients
included Integrated Oncology, Genzyme Genetics, UCSF, Signature Genomics, University of Utah/ARUP Laboratories, and
Ascend Genomics (formerly PathCentral).
MOORPARK COMMUNITY COLLEGE, MOORPARK, CA
2008 - PRESENT
ADJUNCT ASSISTANT PROFESSOR, DEPARTMENT OF BIOLOGY
Teaching undergraduate Biology 2A lecture and laboratory course.
NATERA, INC., SAN CARLOS, CA
2013 - PRESENT
DIRECTOR - GENOMICS LABORATORY (PART-TIME)
Laboratory Director for highly complex molecular and cytogenetic testing, including non-invasive prenatal testing (NIPT) for
aneuploid and microdeletion detection, carrier screening, preimplantation genetics diagnosis (PGD) and screening (PGS), and
product of conception aneuploid detection.
STERLING PATHOLOGY, SEAL BEACH, CA
2013 - PRESENT
DIRECTOR - CYTOGENETICS LABORATORY (PART-TIME)
Cytogenetics Laboratory Director (part-time) for highly complex cytogenetic and FISH testing on cancer specimens for the
diagnosis and prognosis of leukemias and lymphomas.
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INTEGRATED ONCOLOGY (A LABCORP COMPANY) IRVINE/CALABASAS, CA
DIRECTOR, CYTOGENETICS
2009 – 2013
LABORATORY
Director (part-time) of the cytogenetics laboratory, performing cytogenetic and FISH analysis on cancer specimens for the diagnosis
and prognosis of leukemias, lymphomas and solid tumors.
UNIVERSITY OF SOUTHERN CALIFORNIA KECK SCHOOL OF MEDICINE LOS ANGELES, CA
2003 – 2013
ADJUNCT CLINICAL ASSISTANT PROFESSOR OF PATHOLOGY
Responsible for the supervision and training of the Pathology Residents and Fellows of the USC School of Medicine in clinical
cytogenetics.
UNIVERSITY OF CALIFORNIA AT SAN FRANCISCO SCHOOL OF MEDICINE SAN FRANCISCO, CA
2007 – 2012
CLINICAL ASSOCIATE – DEPARTMENT OF LABORATORY MEDICINE
Responsible for the review and sign-out of clinical cytogenetic and FISH cases for the UCSF Cytogenetics Laboratory.
QUEST DIAGNOSTICS (FORMERLY SMITHKLINE BEECHAM) WEST HILLS, CA
1998 – 2007
DIRECTOR AND CHIEF OF THE CYTOGENETICS LABORATORY
Director of a staff of over 75 people, including 3 Ph.D. cytogeneticists, and over 70 cytogenetic technologists, technicians and
support staff, of a full service laboratory performing prenatal, solid tissue and tumor, blood, and bone marrow specimens comprising
over 25,000 specimens per year. The laboratory utilized fluorescence in situ hybridization (FISH) for diagnosis of specific genetic
disorders (microdeletion disorders, cancers), and chromosomal identification. The laboratory also included biochemical genetics
testing for amniotic fluid alpha-fetoprotein, acetylcholinesterase and fetal hemoglobin testing.
 Established Cytogenetics Technology Training Program that provided education and training for a profession as a cytogenetic
technologist with NCA certification.
 Initiated Pathology Residency Training Program with USC and Loma Linda Medical Schools.
Susan Mahler Zneimer, Ph.D., FACMG
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Responsible for the full spectrum of laboratory activities including: administration, technical quality, research, development,
expansion of testing services, training and teaching responsibilities for lab staff, physicians and community.
As a Six Sigma certified Green Belt, utilized lean, 5-S and DMAIIC processes to improve laboratory practices.
1993 – 1998
KAISER PERMANENTE MEDICAL CENTER SAN JOSE & OAKLAND, CA
DIRECTOR, NORTHERN CALIFORNIA REGIONAL CYTOGENETICS LABORATORY
1991 – 1993
GENETRIX, INC. ALAMEDA, CA
DIRECTOR, CYTOGENETICS LABORATORY
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Board Certification in Clinical Cytogenetics, American Board of Medical Genetics, Since June 1993.
Laboratory Director Certification in Cytogenetics, New York State, Since 1998.
Laboratory Director Licensure in Cytogenetics, California State, Since 2002, Lic. # DRM 024.
Certification, Six Sigma Green Belt, Quest Diagnostics, September 2006.
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Diplomat, American Board of Medical Genetics
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Association for Molecular Pathology
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Fellow, American College of Medical Genetics
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New York Academy of Sciences
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American Association for the Advancement of Science
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American Cytogenetics Conference
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American Society of Human Genetics
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American Medical Writers Association
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Inter. Standards for Cytogenomic Array Consortium
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Cancer Cytogenomics Microarray Consortium
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American Society of Hematology
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Clinical Laboratory Management Association
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Exam writer for the American College of Medical Genetics
Laboratory Inspector, College of American Pathologists
Program Chair, American Cytogenetics Conference (2006-2010)
Member, Best Practices Team for Cytogenetics Standardization, Quest Diagnostics
Participant, Women’s Unlimited program for leadership training
Member, Children's Cancer Group Reference Laboratories
Chair, Cytogenetics Section, Annual Kaiser Interregional Genetics Meeting (1995, 1997)
Private Industry Council Board Member, Alameda County, CA
Member and Lecturer, National Tay-Sachs Foundation, North Texas Chapter
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Cambridge Who’s Who – VIP award for Recognition of Leadership in the Biology Field, 2010
Leadership Award, Women’s Unlimited, 2002
Postdoctoral Presentation Award, Texas Genetics Society Meeting, 1990.
Gamma Sigma Delta, National Honor Society of Agriculture, 1988.
Hillel Foundation Graduate Student Achievement Award, Texas A & M University, 1987.
2004 –2013
2000 - 2013
2006 – 2010
2000 – 2007
2001 – 2002
1994 – 2002
1994 – 1998
1992 – 1994
1989 – 1991
Susan Mahler Zneimer, Ph.D., FACMG
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Postdoctoral Fellow: University of Texas Southwestern Medical Center, Department of Pathology, 1989-1991.
Field of Study: Clinical Cytogenetics
Doctorate: Texas A & M University, College of Veterinary Medicine, 1989.
Field of Study: Genetics
Dissertation Title: Comparative Regional Localization of the Fibronectin and Gamma Crystallin Genes in the Mouse and Cow, and
Karyotypic Analysis of Bovine-Hamster Hybrid Somatic Cells for Use in Cattle Gene Mapping.
Master of Art: University of California at Los Angeles, College of Letters and Science, 1986.
Major: Biochemical Genetics.
Thesis Title: Intraspecific Genetic Variation and Systematics of Agosia chrysogaster (Cipriniformes: Cyprinidae).
Graduate Study: Hebrew University, Jerusalem, Israel, 1981. Non-matriculate study in genetics.
Bachelor of Art: University of California at San Diego, Revelle College, 1980.
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Major: Zoological Biology.
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Instructor, General Biology for majors-with laboratory, Moorpark College, 2008-present.
Instructor for Continuing Education at US Labs, 2009 to present; teaching genetics, cancer genetics and case conferences for
pathologists and laboratory staff.
Director, Cytogenetics Technology Training Program, Quest Diagnostics, 1998-2007; one year program with course-work and
on-site training for NCA technology certification in clinical cytogenetics.
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Instruction of Pathology Residents and Fellows from USC Keck School of Medicine and Loma Linda Medical School, in
Cytogenetics, 2002-2007.
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Instruction and supervision of Genetic Counselor Graduate Students from California State University at Northridge, for rotation in
Cytogenetics, 2000-2002.
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Instruction and supervision of Residents, Kaiser Permanente, 1993-1998; including pediatric, obstetric and pathology departments
residency rotations in Cytogenetics Laboratory.
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Cytogenetic Technology Training Program, Genetrix, 1991-1993; course work and on-site training for NCA certification.
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Genetics, Department of Biochemistry, Texas A & M University, 1986-87; upper-level undergraduate genetics.
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General Biology Laboratory, Department of Biology, University of California at Los Angeles, 1985; biology.
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Cytogenetic Laboratory Techniques, Department of Biology, California State University at Dominguez Hills, 1983;
undergraduate/graduate course for certification as a cytogenetic technologist.
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Department of Public Health, University of California at Los Angeles, 1982; Human cytogenetics graduate course for genetic
counselor students.
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University of Texas San Antonio, Dec 2012: Mantle Cell Lymphoma
Arizona Cytology Association, May 2012: The Cancer Genome, Implications for Leukemias and Lymphomas
University of Texas San Antonio, May 2011: Microarrays in Cancer
University of Texas San Antonio, May 2010: Cytogenetic and FISH Abnormalities in Lymphoid Malignancies
University of Texas San Antonio, December 2009: Human Cancer Genome Project
STS Sisterhood and Mens Club, October 2009: Stem Cell Research and Cancer
Brandeis Men’s Group Lecture Series, December 2008; Title: Stem cell research and cancer.
Susan Mahler Zneimer, Ph.D., FACMG
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Women's League, Southwest Conference, March 2014; Title: The Ashenazic Jewish Panel, who should be tested?
STS Rambam Community Lecture, October 2007; Title: Genetics and the Jewish People: a DNA Chain of Tradition.
STS Sisterhood Community Lecture, February 2006; Title: Genetics and the Jewish People: a DNA Chain of Tradition.
Memorial Sloan Kettering-Cancer Center, September 2005; Faculty member of workshop entitled: FISH in Cancer.
California State CLS Inland Empire Chapter, October 2004; Title: New Laboratory Insights into Hematologic Malignancy: CML
and Mantle Cell Lymphoma.
Moorpark College, May 2000; Title: The Genetics Laboratory Workplace-SCANS Competency, for the College Success
Strategies course.
Univ. of California at San Francisco, 1995-1998; graduate genetic counseling students -topics include cancer cytogenetics.
Calif. Association. for Medical Laboratory Technology Annual Meeting, Santa Clara, CA, October 1997; Title: Ethical Issues in
Genetics.
Calif Society for Clinical Lab Science Annual Meeting, Oakland, CA, April 1997; Title: Genetics Testing and Ethics.
California State University at San Jose Faculty Seminar, November 1996; Title: Evolutionary Genetics.
Foothill Community College, July 1996; Genetics lecture for an introductory biology course.
Northern Region Medical Technologist Symposium, Emeryville, CA. and Santa Clara, CA., February, 1995. Title: Update in
Hematological Malignancies-Cytogenetic Analysis.
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Martin Luther King-Drew Medical Center – Los Angeles, CA, January 2003.
Clinical Laboratory Scientists of Chantilly – Chantilly, Pennsylvania, June 2002.
California Laboratory Scientists of Alaska Annual Meeting– Alieska, Alaska, April 2002.
Clinical Leadership and Management Association Annual Meeting, Saint Louis, MO, June 2001.
California State University at Northridge, November 2000.
Victorville Community Hospital - Victorville, CA, July 2000.
California Laboratory Scientists of Riverside - Riverside, CA, April 2000.
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2011
Increased FISH abnormality detection rate using plasma cell enriched cell sorting for plasma cell disorders.
- Poster presentation at the International Congress of Human Genetics Meeting, Montreal, Canada.
2009
The Human Cancer Genome Project
- Platform presentation at the CLMA ThinkLab Conference.
2008
Laboratory quality improvement and financial success through six sigma methodology.
- Platform presentation at the American Cytogenetics Conference.
2001
Complex chromosome rearrangements: a new mechanism in cell division.
- Poster presentation at the International Congress of Human Genetics, Vienna, Austria.
- Poster presentation at the American Society of Human genetics annual meeting.
2000
Complex chromosome rearrangement involving two cytogenetic abnormalities in chromosome 5.
- Platform presentation at the American Cytogenetics Conference.
2000
Abnormal phenotype including mental retardation associated with an apparently balanced interchromosomal insertion
(X;8)(p22.1;p23.1p23.3) in a female.
- Poster presentation at the Association of Genetics Technologists Annual Meeting.
1999
Telomere-telomere fusion of chromosome 7 and 22 with an interstitial deletion of chromosome 7p11.2-p15.1: phenotypic
consequences and possible mechanisms.
- Poster presentation at the American Society of Human Genetics Annual Meeting.
1999
Double recombinant chromosome 22’s in a family with an inherited pericentric inversion through 3 generations.
- Poster presentation at the American Society of Human genetics annual Meeting (with J. Kelly, presenter).
1998
BCR/ABL Gene Rearrangement Present on Chromosome 9 in a Case of a Philadelphia Positive Acute Myeloid Leukemia.
Susan Mahler Zneimer, Ph.D., FACMG
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- Platform presentation at the FISH-New Technologies and Clinical Applications Annual Meeting.
1998
Familial Deletion of 5p15.2 in a Child with Cri du Chat Syndrome.
- Platform presentation at the Interregional Kaiser Genetics Annual Conference.
1996
Mosaicism for Multiple Structural Abnormalities in Chorionic Villus Samples Confirmed in the Fetus.
- Platform presentation at the American Society of Human Genetics Annual Meeting.
1995
Partial Trisomy of chromosome 6q, an Interstitial Duplication of the Long Arm.
- Platform presentation at the Interregional Kaiser Genetics Annual Conference.
- Poster presentation at the Association of Cytogenetic Technologists Annual Meeting.
- Poster presentation at the American Society of Human Genetics Annual Meeting.
Bi-phenotypic Leukemia Case Showing Both Acute Lymphoid and Myeloid Karyotypic Changes.
- Platform presentation at the Interregional Kaiser Genetics Annual Conference.
- Poster presentation at the Association of Cytogenetic Technologists Annual Meeting.
1994
Velocardiofacial and DiGeorge Syndromes: Differential Diagnosis Using FISH Analysis.
- Poster Presentation at Association of Cytogenetic Technologists Annual Meeting.
- Poster Presentation at the Interregional Kaiser Genetics Annual Conference.
- Poster Presentation at the AAAS-Pacific Division Meeting.
Utilization of FISH Analysis For Identification of a Chromosome Marker and Correlation With Phenotypic Characteristics.
- Poster Presentation at the Association of Cytogenetic Technologists Annual Meeting.
- Poster presentation at the AAAS-Pacific Division Meeting.
Association of Confined Placental Mosaicism with Intrauterine Growth Restriction.
- Poster presentation at the Society of Perinatal Obstetricians Annual Meeting.
Molecular Genetic Analysis: Confined Placental Trisomy 2 Associated with Severe Intrauterine and Postnatal Growth
Deficiency.
- Poster presentation at the American Society of Human Genetics Annual Meeting.
1991
Chromosome Analysis of Human Epithelial Cells Transformed by Ionizing Radiation in
- Poster presentation at the Association of Cellular Biology Annual Meeting.
vitro.
1990
In Situ Hybridization Shows Direct Evidence of Uneven X Inactivation in Monozygotic Twin Females Discordant
Duchenne Muscular Dystrophy.
- Platform presentation at the Texas Genetics Society Annual Meeting (Postdoctoral Presentation Award).
- Platform presentation at the American Society of Human Genetics Meeting (Postdoc Clin Research Award Finalist).
1989
Regional Localization of Fibronectin & Gamma Crystallin Genes to Bovine Chrom. 8.
- Platform presentation at the Texas Genetics Society Annual Meeting.
1988
Regional Localization of the fibronectin & Gamma Crystallin Genes to Mouse Chromosome 1 by In Situ Hybridization.
- Platform presentation at the Texas Genetics Society Annual Meeting.
1986
Intraspecific Genetic Variation and Systematics of Agosia chrysogaster, a Cyprinid Fish.
- Platform presentation at the American Society of Ichthyologists and Herpetologists.
1978
Comparative Chromosomal Banding Patterns of Two Langur Monkey Species.
- Platform presentation at the San Diego Zoo Research Symposium.
for
Susan Mahler Zneimer, Ph.D., FACMG
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Liu, S.V., Zneimer, S., Tahbaz A, Douer D. (2011) Therapy Related AML Following Treatment with Trabectedin for Ewing’s
Sarcoma. Acta Hematologica, 126:76-78.
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Cutter, D., & Zneimer, S. M. (2009) Early Acquisition of American Sign Language: An Innovative Approach for Treating
Attention-Deficit/Hyperactivity Disorder. Sign Language Journal, 1(1), Retrieved January 8, 2009, from Lifeprint:
http://lifeprint.com/signlanguagejournal/content/2009-01.htm.
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Zneimer, S.M. (2002) The Human Genome Project: Exploring its progress and successes and the ethical, legal, and social
implication. Clin Leadership and Management Review 16:151-161.
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Zneimer, S.M., P. Cotter, S.D. Stewart (2000) Telomere-telomere fusion of chromosomes 7 and 22 with an interstitial deletion of
chromosome 7p11.2-p15.1: phenotypic consequences and possible mechanisms. Clin Genet 58:129-133.
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Zneimer, S.M., B. Zeil, R. Bachman (1998) Partial Trisomy of chromosome 6q, an interstitial duplication of the long arm. AJMG
80:133-135.
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Zneimer, S.M., J.B. Ravnan, L.S. Jenkins (1997) Assessment of cytogenetic results of 1339 cancer bone marrow chromosome
studies. AJHG 61:A2144.
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Zneimer, S.M. and J.B. Ravnan (1996) Fluorescent in situ hybridization-FISHing for answers. The Screen, Kaiser Permanente
Genetics/Perinatal Newsletter vol. 2, issue 7.
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Ravnan, J.B, LS. Jenkins and S.M. Zneimer (1996) Mosaicism for multiple structural abnormalities in chorionic villus samples
confirmed in the fetus. AJHG 59:A130.
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Cowles, T.A., S.M. Zneimer and F.B. Elder (1996) A prospective cytogenetic study in third trimester placentas of fetuses with
unexplained intrauterine growth restriction. J. Maternal-Fetal Investigation 6:207-209.
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Zneimer, S.M., N.R. Schneider and C.S. Richards (1993) In situ hybridization shows direct evidence of skewed X inactivation in
one of monozygotic twin females manifesting Duchenne muscular dystrophy. AJMG 45:601-605.
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Zneimer, S.M., K.S. Lau, R.L. Eddy, T.B. Shows, D.T. Chuang and R.P. Cox (1991) Regional Assignment of two genes of the
human branched-chain a-keto acid dehydrogenase complex: the E1B gene (BCKDHB) to chromosome 6p21-22 and the E2 gene
(DBT) to 1p31. Genomics 10:740-747.
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Wilson, G.N., J.P. Stout, N.R. Schneider, S.M. Zneimer, and L.C. Gilstrap (1991) Balanced translocation 12/13 and situs
abnormalities: homology of early pattern formation in man and lower organisms? Am J Med Genet 38:601-607.
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Fleishman, R.A., D.L. Saltman, V. Stastney and S. Zneimer (1991) Deletion of the c-kit proto-oncogene in the human
developmental defect piebald trait. PNAS 23:10885.
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Zneimer, S.M., D. Crawford, N.R. Schneider and B. Beutler (1990) Mapping of the human ribonuclease inhibitor gene (RNH) to
chromosome 11p15 by in situ hybridization. Genomics 8:175-178.
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Zneimer, S.M. and J.E. Womack (1989) Regional localization of the fibronectin and gamma crystallin genes to bovine
chromosome 8. Genomics 5:215-220.
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Womack, J.E., D.W. Threadgill, Y.D. Moll, L.K. Faber, M.L. Foreman, A.B. Dietz, T.C. Dobin, L.C. Skow, S.M. Zneimer, D.S.
Gallagher and D.S. Rogers (1989) Syntenic mapping of 37 loci in cattle. Cytogenet Cell Genet.
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Zneimer, S.M. and J.E. Womack (1988) Regional localization of the fibronectin and gamma crystallin genes to mouse
chromosome 1 by in situ hybridization. Cytogenet Cell Genet 48:238-241.
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Zneimer, S.M., A.T. Kumamoto and K. Benirschke (1979) Banding patterns of the chromosomes of two langur species, Pygathrix
nemeus and Presbytis entellus; a comparative study. Chrom Info Serv 26:19-22.
Susan Mahler Zneimer, Ph.D., FACMG
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Essays for Salem Health Genetics and Inherited Disorders, Revised Edition, J. A. Knight, Editor, Salem Press, Pasadena, CA
(2010). Titles of essays include:
Genomics
The Human Genome Project
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Essays for Magill’s Medical Guide, Sixth Edition, Salem Press (2011). Title of essay: Biological Therapy.
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Essays for Salem Science: Applied Science, Salem Press (2011). Title of essays:
Stem Cell Research and Therapies
Proteomics and Protein Engineering
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Essays for Salem Health: Infectious Diseases and Conditions (2011). Title of essays:
Prion diseases
Prion Diagnosis
Treatment and Immune Response of Prion Diseases
Retroviral Infection.
Immune Response of Viral Infections
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Cytogenetic Abnormalities: Chromosomal, FISH and Microarray-Based Clinical Reporting by Susan M. Zneimer (Sept. 2014).
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Cytogenetic Laboratory Management: Chromosomal, FISH and Microarray-Based Best Practices and Standard Operating
Procedures by Susan M. Zneimer (in progress).
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Hot Topics In Genetics and Biology: A Series of Essays in the Field of Biology by Susan M. Zneimer (in progress).