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BRIEF CURRICULUM VITAE Surname: PISTOS Name: CONSTANTINOS Father’s name: MICHAEL Date of Birth: 19-04-1970 Position at N.K.U.A: LABORATORY OF FORENSIC MEDICINE AND TOXICOLOGY, SCHOOL OF MEDICINE Rank: ASSISTANT PROFESSOR Specification: Toxicology Telephone numbers: 210-7462433 (Laboratory) 210-6729337 (Home) 6977409800 (Office) e-mail: [email protected] Academic Degrees-Professional Experience: B.Sc. in Pharmacy, Department of Pharmacy, Aristotle University of Thessaloniki (1995) M.Sc. in Pharmaceutical Analysis-Quality Control (1998) Ph.D. in Pharmaceutical Analysis-Quality Control (2001) Post doctoral fellowship in Pharmaceutical Analysis in U.S.A. (The University of Georgia Athens, U.S.A.) (2002) Director of ILS bioanalytical laboratory for pharmacokinetic studies and bioequivalence studies of pharmaceutical products (2006) Lecturer of Toxicology (2006-2012) Assistant Professor of Toxicology (2012-Today) Teaching experience: During the academic years 1999-2001 and 2003-04, taught of pharmacology, clinical pharmacology and cosmetology courses at the private college Ι.Ι.Ε.Κ. Σ.Β.Ι.Ε. Since 2006: 1. Courses of Toxicology (Forensic, Clinical, Environmental and Industrial) at Pharmacy and Medicine students. 2. Course of “Drufs of Abuse” at Medicine students. 3. Post-graduate courses of Toxicology at graduate students of Pharmacy, Medicine and Biology. 1 Publications: Publication of 36 scientific articles in foreign scientific journals Presentation of 20 scientific works at Greek and International scientific congresses. Publication of 2 chapters of Toxicological interest in International books. MEMBER IN LOCAL AND INTERNATIONAL SCIENTIFIC GROUPS The International Association of Forensic Toxicologists (TIAFT) International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) Greek Association of Toxicology Greek Association of Pharmacist Publications 1. A fully validated method for the simultaneous determination of 11 antidepressant drugs in whole blood by gas chromatography-mass spectrometry I. Papoutsis, A. Khraiwesh, P. Nikolaou, C. Pistos, Ch. Spiliopoulou, S. Athanaselis J. Pharm. Biomed. Anal., 70, 557-562, 2012 2. Direct urine analysis for the identification and quantification of selected benzodiazepines for toxicology screening S. Karampela, I. Vardakou, I. Papoutsis, A. Dona, Ch. Spiliopoulou, S. Athanaselis, C. Pistos J. Chromatogr. B, 902, 42-46, 2012 3. A validated GC-MS method for the determination of Δ 9tetrahydrocannabinol and 11-nor-Δ 9-tetrahydrocannabinol-9- carboxylic acid in bile samples I. Papoutsis, A. Khraiwesh, P. Nikolaou, C. Pistos, Ch. Spiliopoulou, S. Athanaselis For. Toxicol. 30 (1), 51-58, 2012 4. Naphyrone: a "legal high" not legal any more Vardakou I., C. Pistos, A. Dona, Ch. Spiliopoulou, S. Athanaselis Drug and Chemical toxicology, 35(4), 467-71, 2012 5. Migration study of 1,3 butadiene in eye drops solutions Pistos C., Karampela S., Vardakou I, Papoutsis I., Spiliopoulou Ch., Athanaselis S. Drugs and Chem. Toxicol. 35(3), 293-9, 2012 6. Development and validation of a simple GC-MS method for the simultaneous determination of 11 anticholinesterase pesticides in blood Clinical and Forensic Toxicology applications I. Papoutsis, M. Mendonis, P. Nikolaou, S. Athanaselis, C. Pistos, C. Maravelias, Ch. Spiliopoulou J Forensic Sci., 57(3), 806-12, 2012 7. Carbon monoxide - related deaths in Greece: a 23-year survey 2 M. Stefanidou, S. Athanaselis, A. Dona, C. Pistos, Ch. Spiliopoulou, C. Maravelias Am J Forensic Med. Pathol., 33(2), 128-31, 2012 8. Development and validation of a method for the determination of buprenorphine and norbuprenorphine in breast milk by gas chromatography– mass spectrometry P. Nikolaou, I. Papoutsis, S. Athanaselis, C. Pistos, A. Dona, Ch. Spiliopoulou Biomed. Chromatogr. 26(3), 358-62, 2012 9. A simple and sensitive GC/MS method for the determination of atropine during therapy of anticholinesterase poisoning in serum samples Papoutsis I., P. Nikolaou, Ch. Spiliopoulou, C. Pistos, M. Stefanidou, S. Athanaselis. Drug Test Anal. 4(3-4):229-34, 2012 10. Development and validation of an EI-GC/MS method for the determination of sertraline and its major metabolite desmethyl-sertraline in blood Khraiwesh A, Papoutsis I, Nikolaou P, Pistos C, Spiliopoulou C, Athanaselis S. J Chromatogr B Analyt Technol Biomed Life Sci., 879(25), 2576-82, 2011 11. Development and validation of a gas chromatography-mass spectrometric method for the determination of sildenafil and desmethylsildenafil in whole blood Papoutsis I., P. Nikolaou, S. Athanaselis, G. Alevizopoulos, C. Pistos, Ch. Paraskevopoulou, Ch. Spiliopoulou J Sep Sci., 34(21):3037-42, 2011. 12. Development and validation of a GC/MS method for the determination of tadalafil in whole blood J. Pharm. Biomed. Anal. 56 (3), 577-581, 2011 P. Nikolaou, I. Papoutsis, S. Athanaselis, G. Alevizopoulos, A. Khraiwesh, C. Pistos, Ch. Spiliopoulou 13. Drugs for youth via internet and the example of mephedrone Vardakou I, Pistos C, Spiliopoulou Ch. Toxicol Lett. 201, 191-195, 2011 14. A fully validated method for the determination of vardenafil in blood, using gas chromatography/mass spectrometry Papoutsis I, Nikolaou P, Athanaselis S, Pistos C, Maravelias C, Spiliopoulou C. J. Mass Spectrom. 23,71-76, 2011 15. Development and validation of a highly sensitive GC/MS method for the determination of buprenorphine and nor-buprenorphine in blood Papoutsis I, Nikolaou P., Athanaselis S., Pistos C., Spiliopoulou Ch., Maravelias C. J. Pharm. Biomed. Anal., 54 (3), 588-591, 2011 16. Validated GC/MS method for the simultaneous determination of clozapine and norclozapine in human plasma. Application in psychiatric patients under clozapine treatment Vardakou I, Dona A, Pistos C, Alevisopoulos G, Athanaselis S, Maravelias C, Spiliopoulou C. Journal of Chromatography B, 878 (25), 2327-2332, 2010 17. Spice drugs as a new trend: mode of action, identification and legislation 3 Vardakou I, Pistos C, Spiliopoulou Ch. Toxicol. Lett., 197 (3), 157-162, 2010 18. Development and validation of an EI-GC-MS method for the determination of benzodiazepine drugs and their metabolites in blood: Applications in clinical and forensic toxicology Papoutsis I., Athanaselis S., Nikolaou P., Pistos C., Spiliopoulou C., Maravelias C. J. Pharm. Biomed. Anal., 52 (4), 609-614, 2010 19. Mass intoxication with datura innoxia-case series and confirmation by analytical toxicology Papoutsis I., Nikolaou P., Athanaselis S., Stefanidou M., Pistos C., Spiliopoulou C., Maravelias C. Clin. Tox., 48 (2), 143-145, 2010 20. Investigation of the identification point system adaptation in cocaine, benzoylecgonine and ecgonine methyl ester using a single quadrupole mass spectrometer Pistos C., Karampela S., Papoutsis I., Athanaselis S., Spiliopoulou Ch., Maravelias C. rapid comm. mass spec., 23 (23), 3772-3780, 2009 21. Development and validation of an EI-GC-MS method for the determination of Methadone and its major metabolites (EDDP and EMDP) in human breast milk P. Nikolaou, I. Papoutsis, C. Maravelias, Ch Spiliopoulou, C. Pistos, A. Calokerinos, J. Atta-Politou J. Anal. Tox., 32, 478-484, 2008 22. Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria Pistos C., Papoutsis I., Dona A., Stefanidou M., Athanselis S., Maravelias C., Spiliopoulou C. Forensic Sci. Int. 4, 178 (2-3):192-8, 2008 23. Application of the ion pair concept to the n-octanol-water partitioning of cefepime and cefpirome S.-A.Koufopoulou, C. Pistos, C. Giaginis, A. Tsantili-Kakoulidou Inter. J. of Pharm., 316, 52-57, 2006 24. Investigation of the retention/pH profile of zwitterionic fluoroquinolones in reversed-phase and ion-interaction high performance liquid chromatography C. Pistos, M. Koupparis, A. Tsantili-Kakoulidou J. Pharm Biomed. Anal., 39 (3-4), 438-443, 2005 25. Liquid chromatographic tandem mass spectrometric determination of trandolapril in human plasma Constantinos Pistos, Maria Koutsopoulou, Irene Panderi. Anal. Chim. Acta, 540 (2), 375-382, 2005 26. Improved liquid chromatographic tandem mass spectrometric determination and pharmacokinetic study of glimepiride in human plasma C. Pistos, M. Koutsopoulou, I. Panderi-research article Biomed. Chromatogr., 19 (5), 394-401, 2005 27. Bioequivalence evaluation of two brands of glimepiride 4 mg tablets in healthy human volunteers 4 C. Pistos, M. Kalovidouris, C. Astraka, G. Kontopoulos and M. Koutsopoulou Inter. J. of Clin. Pharm. and Therap., 43 (4), 203-208, 2004 28. Assay of the simultaneous determination of acetaminophen-caffeinebutalbital in serum using a monolithic column C. Pistos and James T. Stewart J. Pharm Biomed. Anal, 36 (4), 737-741, 2004 29. Liquid chromatography-positive ion electrospray mass spectrometry method for the quantification of citalopram in human plasma C. Pistos, J. Atta-Politou, I. Panderi J. Chromatogr. B, 810 (2), 237-246, 2004 30. Bioequivalence evaluation of two brands of Cefuroxime axetil 250mg tablets in healthy human volunteers C. Pistos, M. Kalovidouris, S. Michalea, G. Kontopoulos and M. Georgarakis Inter. J. of Clin. Pharm. and Therap., 42 (7), 367-372, 2004 31. Α Validated liquid chromatography-tandem mass spectrometry method for the determination of mirtazapine and demethylmirtazapine in human plasma: application to a pharmacokinetic study C. Pistos, M. Koutsopoulou, I. Panderi Anal. Chim. Acta, 514 (1), 15-26, 2004 32. Direct injection HPLC method for the determination of selected benzodiazepines in plasma using a Hisep column C. Pistos and James T. Stewart J. Pharm Biomed. Anal., 33 (5), 1135-1142, 2003 33. Direct injection HPLC method for the determination of selected phenothiazines in plasma using a Hisep column C. Pistos, James T. Stewart Biomed. Chromatogr., 17 (7), 465-470, 2003 34. Rapid method for analysis of aspirin-butalbital in serum utilizing a monolithic column C. Pistos and J. T. Stewart J. Liq. Chromatogr., 26 (15), 2567-2579, 2003 35. The effect of ion pairing reagents in the retention profile of zwitterionic cephalosporines C. Pistos, A. Tsantili-Kakoulidou and M. Koupparis J. Liq. Chromatogr, 26 (6), 937-952, 2003 36. Determination of ethylenediamine tetra acetic acid in injective solution of paracetamol by ion pair chromatography C. Pistos and M. Parisi-Poulou J. Pharm. Biomed. Anal., 28 (6), 1073-1079, 2002 5