Download Broccoli compound identified for heart benefits

HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay Public Trust Act, 1950 (Regn.no.641 dated 29-04-2004)
(Formerly Indian Health Foods And Dietary Supplements Association - INHADSA)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected] , [email protected]
WEBSITE: www.hadsa.com, wwww.inhadsa.com
(Member of International Alliance of Dietary Supplements Association- IADSA, www.iadsa.org )
HADSA NEWSLETTER
Breaking News on Nutraceuticals & SupplementsNo.1128
HEADLINES
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6.
7.
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9.
10.
Broccoli compound identified for heart benefits
Crude palm oil may lower blood fat levels
Research targets better sweet potato pigments for foods
Daily cuppa may compare to calcium for bones
Low zinc levels may raise pneumonia risk in the elderly
Full-fat dairy may protect prostates from cancer
Fruit, veg antioxidant profile increases with time
Chocolate study signals way to personalised health diets
Vitamin D deficiency linked to greater pain
Garlic's heart benefits pinpointed
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
1. Broccoli compound identified for heart benefits
The heart healthy effects of cruciferous vegetables like broccoli and cauliflower may be due to their
ability to influence the secretion of a cholesterol transporter, researchers have reported. The study,
published in the Journal of Nutrition, significantly deepens our understanding of a class of
vegetables more commonly linked to reducing the risk of certain cancers, especially lung, colon,
breast, ovarian cancer, and, more recently, bladder cancer. The research, led by Geoffrey K.
Maiyoh from the University of Hawaii at Manoa, reports that the indole-based compound, indole-3carbinol, was able to reduce the secretion of apolipoprotein B-100 (apoB) by 56 per cent, and
thereby confer cardiovascular benefits. ApoB is the main apolipoprotein of LDL cholesterol and is
responsible for the transport of cholesterol to tissues. In high concentrations it has been linked to
plaque formation in the blood vessels, although the mechanism behind this is not clear.
Cardiovascular health is an increasing topic of concern, and cardiovascular disease causes almost
50 per cent of deaths in Europe, and is reported to cost the EU economy an estimated €169 billion
($202 billion) per year. According to the American Heart Association, 34.2 percent of Americans
(70.1 million people) suffered from some form of cardiovascular disease (CVD) in 2002. Maiyoh
and co-workers performed in vitro experiments using HepG2 cells, and report that the indolecompound reduced secretion in a dose-dependent manner. Indeed, at a concentration of 100
micromoles per litre, apoB secretion was cut by 56 per cent, they said. The researchers also report
significant decreases in the production of lipids in the cells, including triglycerides and cholesterol
esters, "indicating that limited lipid availability is a major factor in the regulation of apoB
secretion." "The results indicate that plant indoles have beneficial effects on lipid synthesis that
could contribute to their potential cardioprotective effect," concluded the researchers. The same
compound has previously been identified as a possible bioactive constituent against cancers (British
Journal of Cancer, Vol. 94, pp.407-426). A report from the European Union showed that global
fruit and vegetable production was over 1 230 million tonnes in 2001-2002, worth over $50 billion
(€ 41 000 million). Asia produced 61 per cent, while Europe and North/Central America both
producing nine per cent.
Reference: Journal of Nutrition
October 2007, Volume 137, Pages 2185-2189
"Cruciferous Indole-3-Carbinol Inhibits Apolipoprotein B Secretion in HepG2 Cells1-3"
Authors: Geoffrey K. Maiyoh, J.E. Kuh, A. Casaschi and A.G. Theriault
2. Crude palm oil may lower blood fat levels
A diet rich in crude palm oil, different from the refined industrial oil, may reduce blood levels of
very LDL-C and triacylglycerol in healthy, young individuals, Brazilian researchers report. The
study, published on-line in the Elsevier journal Nutrition, adds to the debate on palm oil and heart
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
health - a controversial topic with conflicting reports in the literature on the efficacy and health
profile. The controversy is centred on the saturated fat content of palm oil, with almost half of the
oil composed of palmitic oil, a C16:0 saturated fatty acid. However, researchers have noted that the
nature of the oil may affect the cholesterol-influencing properties. In crude palm oil, the palmitic
acid is attached to the glycerol molecule in the alpha position instead of the beta-position, as is
observed in butter - a fat with known cholesterol-raising activity. The new study, by researchers
from the Bahia Foundation for the Development of Sciences, the Federal University of Bahia
Medical School, and the Bahian Hypertension and Atherosclerosis League, looked at the effect of a
crude palm oil-rich diet on the blood lipid levels of 34 young individuals (average age 21.9). The
subjects (average BMI 22.0 kg per sq. m), consumed 10 millilitres of previously boiled crude palm
oil after lunch or dinner once a day for two weeks. At the end of the study, the researchers report
that all lipid fractions decreased, with a mild, statistically significant 11.5 per cent decrease in
concentrations of vLDL-cholesterol and triacylglycerol. "This study offered an opportunity to
observe the influence of the daily consumption of boiled crude palm oil on the lipid profile of
young and healthy non-dyslipidemic subjects," wrote lead author Ana Marice Ladeia. "It is
important to point out that the methodology of this study tried to reproduce the amount and
conditions in which crude palm oil is consumed with common foods typical of Bahian cuisine and
its African traditions," she added. The researchers also noted gender-specific effects, with men
showing a mildly significant rise in LDL-cholesterol levels (18 per cent), while females showed a
mildly significant drop in all blood lipid levels, except for HDL-cholesterol. The mechanism for the
lipid-lowering effects of the crude palm oil may depend on multiple factors, said the researchers,
including the attachment of plamitic acid to glycerol. They also added that crude palm oil is a very
rich source of vitamin E, beta-carotene, and tocotrienols, previously reported to have cholesterollowering effects. "The data of the present study reinforce the evidence that palm oil cannot be
classified as a cholesterol-raising oil," wrote Marice Ladeia. "Plasma lipid response to a palm oilrich diet was found to be mild in intensity and appeared to be dependent on variables such as age,
gender, increased BMI, daily cholesterol ingestion, and the crude, refined, or synthetic nature of the
oil consumed. "Furthermore, scientific evidence of palm oil as an atherogenic edible oil for humans
is still lacking and awaits further well-designed studies," she concluded.
Reference : Nutrition (Elsevier)
Published on-line ahead of print, doi:10.1016/j.nut.2007.08.013
"A palm oil-rich diet may reduce serum lipids in healthy young individuals"
Authors: Ana Marice Ladeia, E. Costa-Matos, R. Barata-Passos and A. Costa
Guimaraes
3. Research targets better sweet potato pigments for foods
Fermenting purple sweet potatoes may lead to better extraction and stability of the anthocyanin
pigments for use as natural food colourings, Chinese researchers report. Gongjian Fan and coPresident
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
workers from Nanjing Agricultural University investigated the extraction of the pigment from
purple sweet potato, and tap into the trend to source natural alternatives to artificial food colours
such as Sunset Yellow, Tartrazine and Quinoline Yellow. Market figures confirm the trend. While
the European colouring market faces an annual growth rate of just 1 per cent between 2001 and
2008, the colouring foodstuffs market is ripping ahead on growth of 10 per cent to 15 per cent.
"Anthocyanidins extracted from fermented purple sweet potato were more pure than chemistry
extraction," wrote the researchers in the journal LWT-Food Science and Technology. "The research
result has a positive implication for using purple sweet potato anthocyanins (PSPAs) as natural
colourants in food industry," they added. Fan and co-workers compared the extraction of the
pigments from purple sweet potato culture fermented by Suzhou wine starter (Rhizopus 3.851,
3.866 and Saccharomyces cerevisiae), with those extracted chemically (hydrochloric acid-ethanol,
5:95 per cent). They report that five major anthocyanins were detected from the extracts, using high
performance liquid chromatography (HPLC). The major anthocyanidins were found to be cyanidin
and peonidin, with over 80 per cent of the PSPAs present as acylated anthocyanins. When tested
under acid conditions (pH 2.0 to 4.0), excellent stability was reported for the pigments, while they
were found to be less stable at higher pH (pH 5.0 to 6.0) "The anthocyanins solution was red at pH
2.0 and gradually turned to more red-lilac by raising pH to 7.0," wrote the researchers. "It is
believed that at low pH, anthocyanin exists as flavylium cation which is the most stable form. This
bright red form transforms into blue quinonoidal bases or colourless carbinol pseudobases as the
pH-value increases." They added that further study was necessary for the determination of
pyroanthocyanins requires. Natural red pigments have focussed on betanin, the main betacyanin
compound found in red beetroots and listed in Europe as E162. It is used in a variety of processed
foods because it colours without changing the flavour profile. However, stability issues of the
betalains have so far restricted their use mostly to foods with short shelf lives. The compounds are
reported to be sensitive to heat, pH, light, moisture and oxygen. Recently a study, published in the
journal Food Research International (Vol. 39, pp. 667-677), looked at the pigment stability and
colour of betacyanins extracted from the purple pitaya, a fruit reportedly attracting interest as an
alternative to red beet.
Reference : LWT-Food Science and Technology
Published on-line ahead of print, doi:10.1016/j.lwt.2007.09.003
"Composition and colour stability of anthocyanins extracted from fermented purple
sweet potato culture"
Authors: Gongjian Fan, Y. Han, Z. Gu and F. Gu
4. Daily cuppa may compare to calcium for bones
Drinking tea regularly may lead to improvements in bone health similar to that observed with
calcium or physical exercise, suggests new research from Australia. Writing in the October issue of
the American Journal of Clinical Nutrition, Amanda Devine and co-workers from the University of
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
Western Australia report that bone mineral density levels were 2.8 per cent greater in tea drinkers
than non-tea drinkers, suggesting the beverage has the potential to aid in the prevention of
osteoporosis. The condition is currently second only to cardiovascular disease in terms of global
healthcare burden, according to the World Health Organisation, affecting some 200 million people
today but the number of sufferers is set to increase steadily with growing numbers of elderly living
longer, and obesity adding extra strain on bones. The new study involved 1500 elderly women (age
range 70 to 85) taking part in a five year prospective trial looking at the effects of oral calcium
supplements on osteoporotic fractures. Tea consumption data were collected using 24 hour dietary
recall in a subset of 275 subjects, while all the subjects completed a self-administered food
frequency questionnaire on beverage consumption at the end of the trial. Devine and co-workers
report that total bone mineral density (BMD) was 2.8 per cent higher in tea drinkers, compared to
non-tea drinkers. Over the course of four years, the researchers add that tea drinkers lost an average
of 1.6 per cent of their total hip BMD, while non-tea drinkers lost significantly more (4.0 per cent).
"Tea drinking is associated with preservation of hip structure in elderly women. This finding
provides further evidence of the beneficial effects of tea consumption on the skeleton," they
concluded. The results add to an ever-growing body of science linking consumption to a wide range
of health benefits, including lower risk of certain cancers, weight loss, heart health, and protection
against Alzheimer's. Green tea contains between 30 and 40 per cent of water-extractable
polyphenols, while black tea (green tea that has been oxidized by fermentation) contains between 3
and 10 per cent. The four primary polyphenols found in fresh tealeaves are epigallocatechin gallate
(EGCG), epigallocatechin, epicatechin gallate, and epicatechin. Indeed, it is these polyphenols that
were identified by Devine and co-workers as the potential bioactives in the beverage. "Tea-derived
flavonoids and lignans may be important in maintaining BMD, particularly in older women, who
have low concentrations of endogenous oestrogen," wrote Devine. "A recent review suggests that
flavonoids from green tea may be associated with increases in BMD via a potent stimulatory effect
on osteoblast function." "A major tea flavonoid, (-)-epigallocatechin-3-gallate, has been shown to
increase the expressions of osteogenic genes, elevate bone marker activity, and augment
mineralization in a murine bone marrow mesenchymal stem cell line. "These findings suggest a
stimulatory effect of the compound as a possible mechanism for the associated higher BMD seen in
tea drinkers," she said.
Reference : American Journal of Clinical Nutrition
October 2007, Volume 86, Pages 1243-1247.
"Tea drinking is associated with benefits on bone density in older women"
Authors: Amanda Devine, J.M. Hodgson, I.M. Dick, and R.L. Prince
5. Low zinc levels may raise pneumonia risk in the elderly
Low blood levels of zinc may be linked to an increased risk of pneumonia amongst the elderly,
suggesting the benefits of supplements for this at risk population, says new research. "Normal
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
serum zinc concentrations in nursing home elderly are associated with a decreased incidence and
duration of pneumonia, a decreased number of new antibiotic prescriptions, and a decrease in the
days of antibiotic use," wrote lead author Simin Meydani in the American Journal of Clinical
Nutrition. "Zinc supplementation to maintain normal serum zinc concentrations in the elderly may
help reduce the incidence of pneumonia and associated morbidity." Zinc is one of the most plentiful
trace elements in the body, second only to iron. It mediates many physiological functions and is
believed to be essential for maintaining a healthy immune system. The researchers, from the US
Department of Agriculture, Tufts University, and Boston University, investigated the effect of low
serum zinc concentrations on the incidence of pneumonia in elderly men and women (average age
84.6) living in nursing homes. The study was part of study to evaluate the effect of vitamin E
supplements on respiratory infections. Over the course of 12 months, the subjects received vitamin
E and a supplement containing half of the recommended dietary allowances (RDA) of other
essential micronutrients, including zinc. Meydani and co-workers report that participants with low
zinc levels at the end of the study, defined as having levels less than 70 micrograms per decilitre,
had increased incidence of pneumonia, longer pneumonia episodes, about 50 per cent more new
antibiotic prescriptions, and more days of antibiotic use. "Our finding of a significantly lower allcause mortality rate (by 39 per cent) in those with normal baseline serum zinc concentrations than
in those with low baseline serum zinc concentrations suggests that zinc may play a crucial role in
influencing mortality in the elderly," wrote Meydani. Other studies have suggested that zinc
deficiency may be a risk factor for immune deficiency and subsequent infection relapses in the
elderly, based on zinc role in membrane integrity and DNA synthesis. The mineral also acts a
cofactor to more than 300 enzymes. "The results from our current study, in addition to these earlier
findings, suggest that elderly with low serum zinc concentrations might benefit from zinc
supplementation," stated the authors. "Such a measure has the potential to reduce not only the
number of episodes and duration of pneumonia and the number of new antibiotic prescriptions and
days of antibiotic use due to pneumonia but also all-cause mortality in the elderly. An adequately
powered randomised, double-blind, controlled trial seems to be the likely next step. Such a study is
needed to determine the efficacy of zinc supplementation as a potential low-cost intervention to
reduce morbidity and mortality due to pneumonia in this vulnerable population," they concluded.
Reference: American Journal of Clinical Nutrition
October 2007, Volume
"Serum zinc and pneumonia in nursing home elderly"
Authors: S.N. Meydani, J.B. Barnett, G.E. Dallal, B.C. Fine, P.F. Jacques, L.S. Leka,
D.H. Hamer
6. Full-fat dairy may protect prostates from cancer
An increased intake of full fat dairy products may reduce the risk of prostate cancer, says a new
study from Hawaii. The study, by researchers from the University of Hawaii, also reports that the
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
benefits were not related to calcium or vitamin D, opening up possibilities that the bioactive
ingredients are a specific type of fat in the milk. "Although the findings from this study do not
support an association between the intakes of calcium and vitamin D and prostate cancer risk, they
do suggest that an association with milk consumption may vary by fat content, particularly for early
forms of this cancer," wrote lead author Song-Yi Park in the American Journal of Epidemiology.
Over half a million news cases of prostate cancer are diagnosed every year world wide, and the
cancer is the direct cause of over 200,000 deaths. More worryingly, the incidence of the disease is
increasing with a rise of 1.7 per cent over 15 years. The Multiethnic Cohort Study (1993-2002)
followed 82,483 for an average of eight years. Dietary intakes were evaluated using a detailed
quantitative food frequency questionnaire (FFQ). The researchers documented 4,404 cases of
prostate cancer, but when they calculated the risks with respect to calcium and vitamin D intake,
whether from foods, supplements or in total, no associations were found with prostate cancer.
Indeed, this null association was observed across all racial/ethnic groups. In relation to the
consumption of dairy products, no associations were again observed. However, when the
researchers considered intakes of specific dairy products they noted a significant 12 per cent
reduction in total prostate cancer risk by increased whole milk consumption. On the other hand,
low-/nonfat milk was related to 16 per cent increased risk. The research appears at odds with an
ever-growing body of evidence linking vitamin D status with incidence and risk of various cancers,
including breast, colorectal and prostate. "Because dairy products contain a variety of components
in addition to calcium, such as fat, protein, lactose, phosphorus, and added vitamin D, the results of
[these other] studies may reflect the effects of any of these constituents," wrote the researchers. The
link between vitamin D intake and protection from cancer is not and dates from the 1940s when
Frank Apperly demonstrated a link between latitude and deaths from cancer, and suggested that
sunlight gave "a relative cancer immunity." The new study does have several notable limitations,
particularly the use of the food frequency questionnaires which introduce error from subjects' recall
accuracy.
Reference: American Journal of Epidemiology
Published on-line ahead of print, doi:10.1093/aje/kwm269
"Calcium, Vitamin D, and Dairy Product Intake and Prostate Cancer Risk - The
Multiethnic Cohort Study"
Authors: Song-Yi Park, S.P. Murphy, L.R. Wilkens, D.O. Stram, B.E. Henderson and
L.N. Kolonel
7. Fruit, veg antioxidant profile increases with time
The antioxidant capacity of fresh fruit and vegetables does not decrease during storage, and the
polyphenol content even increases, suggests new research. According to Belgian researchers from
the University of Liege, storing selected fruit and vegetables at room temperature or under
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
refrigeration did not result in any loss of phenolic compounds, ascorbic acid or flavonols - a trio of
chemical classes associated with antioxidant content. The health benefits of consuming a diet rich
in fruit and vegetables are backed up by a multitude of studies, with the Five-a-day message now
well engrained in the consumer's awareness. However, applying this does not seem to be filtering
down into everyday life, with recent studies indicating that the average consumption of people in
developed countries is three portions a day. "The new and interesting result of this study was the
relative stability of the antioxidant capacity in most fruits and vegetables during storage," wrote
lead author Claire Kevers in the Journal of Agricultural and Food Chemistry. "In general, fruits and
vegetables visually spoil before any significant antioxidant capacity loss occurs. Nevertheless, it
could be stressed that, in general, polyphenolic content increased." Kevers and co-workers obtained
various fruit and vegetables from Belgian market and, after measuring its initial antioxidant
content, stored the produce at room temperature or refrigerated them (four degrees Celsius). The
antioxidant levels of the fruit and vegetables were measured at various times until the produce
visually spoiled. The antioxidant capacities were evaluated using three measure: the total phenolic
content; the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay; and the oxygen
radical absorbance capacity (ORAC). According to the researchers, black grapes contained the
highest phenolic levels (582 mg of CAE per 100 g), followed by bananas, green grape, lemon,
strawberry, and plum. Red and yellow peppers topped the phenolic ranking for vegetables with 296
and 284 mg of CAE per 100 g, respectively. Similar results were observed in terms of radical
scavenging activity, with grapes, bananas, and lemon leading the way with DPPH measures, while
the red, yellow and green peppers had DPPH values six times that of the other vegetables. The
ORAC assay ranked strawberry, cherry, plum, and black grape as the top four for the fruit, while
peppers again ranked high for the vegetables. These were closely followed by spinach, broccoli,
and garlic. After storage, Kevers and co-workers report that the DPPH values were, in general,
relatively stable. However, the phenolic content - particularly the flavonoid content - did increase
during storage. "The preservation of fruit phenolic content has a great impact on the quality of fruits
because of the contribution of phenols not only in enzymatic browning reactions but also on
nutritional value of the product, as antioxidant capacity," wrote the researchers. "The results of this
study indicated that in most fruits and vegetables the storage did not affect negatively the
antioxidant capacity. In some cases an increase of the antioxidant capacity was observed in the days
following their purchase," they stated. "A validation of the antioxidant capacity approach is
essential for investigating the role of food antioxidants in human health," they added. A report from
the European Union showed that global fruit and vegetable production was over 1,230 million
tonnes in 2001-2002, worth over $50bn (€41,000m). Asia produced 61 per cent, with Europe and
North/Central America both producing nine per cent.
Reference : Journal of Agricultural and Food Chemistry
Published on-line ahead of print. ASAP Article, doi: 10.1021/jf071736j
"Evolution of Antioxidant Capacity during Storage of Selected Fruits and
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
Vegetables"
Authors: Claire Kevers, M. Falkowski, J. Tabart, J.-O. Defraigne, J. Dommes, J.
Pincemail
8. Chocolate study signals way to personalised health diets
A study has shed new light on people's food preferences and a specific chemical signature that can
be programmed into the metabolic system, leading the way to healthy diets that cater to an
individual's needs. Proteome research is a relatively new area which involves characterising the
structure of all the proteins produced by our genes, so as to understand the metabolic changes that
take place when we digest food. The scientists, from the Nestle Research Center in Lausanne,
Switzerland, say their findings from laboratory work on chocolate-eaters break new ground and
could eventually help with the classification of individuals by metabolic type. This, in turn, could
be used to design healthier diets that are in tune to an individual's needs, they say. "We know that
some people can eat a diet that is high in steak and carbs and generally remain healthy, while the
same food in others is unhealthy," said lead researcher Sunil Kocchar. "Knowing one's metabolic
profile could open the door to dietary or nutritional interventions that are customised to you type so
that your metabolism can be nudged into a healthier status." The controlled clinical study, which is
published next month in the American Chemical Society's Journal of Proteome Research involved
22 men, half of whom classified themselves in questionnaires as 'chocolate-desiring', and half of
whom 'chocolate-indifferent'. The men ate either chocolate or a placebo over a five day period,
during which their blood and urine samples were also analysed using spectroscopy-based
metabotyping Methods and multivariate statistics to identify specific metabolic subclasses. They
found that the chocolate-lovers had a hallmark metabolic profile that involved low levels of LDL
cholesterol and marginally elevated levels of the beneficial protein albumin. This profile was
expressed even when they ate no chocolate. Moreover, there were distinct differences in the activity
of the gut microbes in the chocolate-lovers. "Our study shows that food preferences, including
chocolate, might be programmed or imprinted into our metabolic system in such a way that the
body becomes attuned to a particular diet," said Kochhar. No women were included in the study
group because the researchers wanted to avoid metabolic variations linked to the menstrual cycle
skewing the results. But Kohhar and his team do plan to conduct further studies in the area to see if
there is a gender-specific response to chocolate. He predicts that spur blood or urine tests to
determine metabolic type could one day be available. But since proteome research is a relatively
new field, these could still be five years away, as more research is needed. Chocolate makers,
including Barry Callebaut and Mars, as well as Nestle, have been keenly researching the potential
benefits of chocolate for human health, with a slate of promising results communicated in the last
couple of years. In addition to the light the new results shed on metabolic types, the researchers say
it could also lead to the discovery of additional biomarkers that can identify new health benefits
linked to chocolate and other foods.
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
Reference: Journal of Proteome Research, November 2, 2007
DOI: Not available at time of article publication
Title: Human Metabolic Phenotypes Link Directly to Specific Dietary Preferences in
Healthy Individuals
Authors: Serge Rezzi, Ziad Ramadan, Francüois-Pierre Martin, Laurent Fay, Peter
van Bladeren, John Lindon, Jeremy Nicholson, and Sunil Kochhar
9. Vitamin D deficiency linked to greater pain
A new study has linked vitamin D and a reduction of chronic pain, lending to voices calling for
increased fortification or supplementation of the nutrient in diets. The study, presented at the
American Society of Anesthesiologists 2007 Annual Meeting in San Francisco, found that one in
four patients who suffer from chronic pain also have inadequate blood levels of vitamin D. As such,
the researchers put forth that the vitamin D deficiency possibly contributed to the patients' ongoing
pain.Vitamin D deficiency - which can lead to osteopenia, osteoporosis, muscle weakness,
fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases s been found to be lacking particularly in inhabitants of colder climates. A recent study, for
example, indicated that the median adult intake of vitamin D in the US is only 230 IU per day,
versus the researchers' recommended 2000 IU per day. The latest study, undertaken at the Mayo
Comprehensive Pain Rehabilitation Center in Rochester, Minnesota, involved 267 adults
undergoing outpatient treatment for chronic pain. The researchers recorded their serum vitamin D
levels, pain medication (morphine), as well as general health, and found patients lacking sufficient
vitamin D also required higher doses of morphine for a longer period of time. Of these patients, 26
per cent had vitamin D inadequacy and needed almost twice the dose of morphine of the group with
adequate vitamin D levels. The vitamin D inadequacy groups were also reported as using morphine
for an average of 71.1 months compared to 43.8 months for the other group. As well, the vitamin D
deficient group showed lower levels of physical functioning and poorer overall health. "This is the
first time that we have established the prevalence of vitamin D inadequacy among a diverse group
of chronic pain patients," said study author, Michael Hooten, medical director and anesthesiologist
at the Mayo Comprehensive Pain Rehabilitation Center. However, inadequate levels of vitamin D
have long been associated with causing pain and muscle weakness and studies have suggested that
pain-related symptoms of vitamin D inadequacy respond poorly to pain medications. One possible
outcome is supplementing patients with vitamin D. "The implications are that in chronic pain
patients, vitamin D inadequacy is not the principal cause of pain and muscle weakness, however, it
could be a contributing but unrecognized factor," said Hooten. Vitamin D inadequacy can be easily
and inexpensively treated using a prescription supplement, once or twice a week for four to six
weeks, according to Hooten. Deficiency in vitamin D affects inhabitants of colder climates, because
sunlight induces synthesis of vitamin D in humans. As such, if a consumer is not getting adequate
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
exposure to the sun for vitamin D and its subsequent impact on their serum 25 (OH)D levels, they
should be supplementing with vitamin D. Vitamin D refers to two biologically inactive precursors D3, also known as cholecalciferol, and D2, also known as ergocalciferol. The former, produced in
the skin on exposure to UVB radiation (290 to 320 nm), is said to be more bioactive. The latter is
derived from plants and only enters the body via the diet.
Reference: American Journal of Clinical Nutrition
July 2007, Volume 86, Number 1, Pages 124-130
Authors: J.A. Williams, Y.S. Choe, M.J. Noss, C.J. Baumgartner and V.A. Mustad
10. Garlic's heart benefits pinpointed
The chemical compounds behind garlic's breath-tainting properties may also be the source of its
heart benefits, according to new research from the US. Metabolism of garlic's active ingredient
allicin produces hydrogen sulphide, which signals blood vessels to relax, increase blood flow and
boost heart health, wrote the researchers in the prestigious Proceedings of the National Academy of
Sciences. The research could lead to a method to standardise dietary garlic supplements, said lead
researcher Gloria Benavides from the University of Alabama at Birmingham, by simply measuring
the production of hydrogen sulphide in red blood cells. Like all plants, garlic varies greatly from
crop to crop in its make-up and the amount of allicin in regular garlic supplements varies greatly,
with much destroyed through the distillation process or by stomach acid and heat. The research was
welcomed by a UK-based expert as "interesting study", but Judy O'Sullivan from the British Heart
Foundation stressed that excessive consumption of garlic in supplemental form may adversely
interact with blood thinning drugs and produce dangerous side effects. Benavides and co-workers
extracted juice from supermarket garlic and added minute amounts to human red blood cells.
Allicin is unstable in aqueous solution and quickly decomposes to form diallyl sulfide (DAS),
diallyl disulfide (DADS), diallyl trisulfide (DATS), and ajoene. Once exposed to these compounds,
the red blood cells immediately began emitting hydrogen sulphide. Additional experiments showed
that the key chemical reactions occurred at the surface of the red blood cells. The researchers then
used intact aorta rings from rats and, under physiologically relevant oxygen levels, exposed the
rings, a model for blood vessels, to the garlic-derived organic polysulfides. Again, liberated
hydrogen sulphide was observed. It was also observed that the garlic extracts reduced the tension
within the vessels in a dose-dependent manner. A 200 micromole garlic solution relaxed the vessels
by 40 per cent, while a 500 micromoles per millilitre solution of garlic relaxed the vessels by 75 per
cent. "Few plants other than garlic contain allyl-substituted sulfur compounds, and garlic is the only
one of these with a dietary use," wrote the authors. "We propose that hydrogen sulphide production
from these garlic-derived organic polysulphides provides the basis for the long-term beneficial
effects obtained from the habitual consumption of garlic," they added. Commenting independently
on the research, O'Sullivan said: "This interesting study suggests that garlic may provide some heart
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com
HEALTH FOODS AND DIETARY SUPPLEMENTS ASSOCIATION
Registered as Public Trust under Section 18 of the Bombay PublicTrust Act,1950 (Regn.no.6dated 2904-2004)
(Formerly Indian Health Foods And Dietary Supplements Association)
Admin.Office:1001, Dalamal House,10th Floor,Nariman Point,Mumbai 400021.
TEL:91 22 22872557/58/59,FAX:91 22 22872560
Regd.Office:4/23,Margdarshan,N.S.Phadke Road,Andheri-East,Mumbai-400069.
TEL:91 22 26836013,FAX:91 22 26822660
EMAIL :[email protected],[email protected]
WEBSITE:www.hadsa.com,wwww.inhadsa.com
health benefits. "However, there remains insufficient evidence to support the notion of eating garlic
as medicine in order to reduce the risk of developing coronary heart disease." Indeed, researchers
meeting under the auspices of the US National Heart, Lung and Blood Institute in 2002 found that
there was little scientific data to support many of the claims about garlic. Consumer awareness of
the health benefits of garlic, mostly in terms of cardiovascular and immune system health, has
benefited the supplements industry, particularly since consumers seek the benefits of garlic without
the odours that accompany the fresh bulb.Garlic supplements are worth more than $100m (€79.5m)
in the US and are also one of the biggest sellers in the UK market. According to a 1998 survey by
Hartman and New Hope, garlic supplements are used twice as much as other herbal supplements.
Reference: Proceedings of the National Academy of Sciences (PNAS)
Published on-line ahead of print, ARTICLE #07-05710, doi: 10.1073/pnas.0705710104
"Hydrogen sulfide mediates the vasoactivity of garlic"
Authors: Gloria A. Benavides, G.L. Squadrito, R.W. Mills, H.D. Patel, T.S. Isbell,
R.P. Patel, V.M. Darley-Usmar, J.E. Doeller, and D.W. Kraus
For membership and more information about Health Foods and Dietary Supplements
Association (HADSA) please contact:
Mr. Ajit Singh, Associated Capsules Ltd.: 22872557- Mumbai
Mr. Arvind Junagade, Amway Enterprises: 26282781 - Delhi
Mr. Sebastian Thomas, Parry Nutraceuticals: 25306816/17/24 – Chennai
Dr. Bhushan Karnik, GCI Nutrients India: 28496260/62 - Mumbai
President
Ajit Singh
Associated Capsules group
Mumbai
Tel: 91 22 22872557
Fax: 91 22 22872560
[email protected]
Vice president
Secretary
Treasurer
Sebastian Thomas
Arvind Junagade
Dr. Bhushan Karnik
Parry Nutraceutiucals
Amway India Enterprise
GCI Nutrients India
Chennai
New Delhi
Mumbai
Tel : 91 44 25306816/17/24
Tel : 91 11 6282781
Tel : 91 22 26822248
Fax : 91 44 5250396
Fax : 91 11 6237348
Fax : 91 22 26822660
[email protected] [email protected] [email protected]
www.amway.com
www.gcinutrients.com
www.nutrientlibrary.com