Download Exam 1

King Saud University
College of Pharmacy
Department of Pharmacology
Biochemistry
PHL 213
Dr. Hala Abou El-Fetouh Attia
Student Name:
Student Number:
Question I: Choose ONE best answer:
1- At physiological pH, arginine amino acid will carry:
a) no charge
b) equal negative and positive charge
c) positive charge
d) negative charge
2- The number of peptide bonds in aspartame is:
a) 0
b) 1
c) 2
d) 3
3-
Phenyl alanine is:
a) non polar, essential and glucogenic
b) polar, essential and ketogenic
c) non polar, essential and mixed glucogenic & ketogenic
d) non polar, non essential and ketogenic
4- All of the following are helical proteins Except:
a) collagen
b) globulin
c) keratin
d) elastin
5-
Complete deficiency of HGPRTase leads to:
a) Gout
b) orotic aciduria
c) severe anemia
d) Lesh-Nyahn syndrome
6-
Which of the following is essential and polar amino acid?
a) serine
b) leucine
c) threonine
d) glutamate
7- Cooley anemia is caused by deficiency of:
a) one β-globin gene
b) three α-globin genes
c) two β-globin genes
d) two α-globin genes
8-
Heterozygous patients with sickle cell anemia have:
a) Hb AC
b) Hb CC
c) Hb SS
d) Hb AS
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9- The purine base present in inosine monophosphate (IMP) is:
a) adenine
b) guanine
c) xanthine
d) hypoxanthine
10- N3 of purines and pyrimidines is derived from:
a) aspartate
b) glutamine
c) glycine
d)
N10- formyl THF
11- Which of the following is increased in the blood of patients with myocardial
infarction?
a) myoglobin
b) hemoglobin
c) cytochrome oxidase
d) ceruloplasmin
12- All of the following may lead to gout Except:
a) deficiency of glutamine-PRPP amidotransferase
b) increased levels of PRPP
c) deficiency of salvage enzymes
d) overbreakdown of purine nucleotides
13- All of the following concerning histidine are true Except:
a) polar amino acid
b) semiessential
c) gives positive Pauly reaction
d) ketogenic amino acid
e) basic heterocyclic amino acid
14-
In electrophoretic separation of serum proteins, which of the following
moves faster to the anode?
a) α2- globulin
b) α1-globulin
c) β-globulin
d) γ-globulin
15- Ceruloplasmin is an example on:
a) α1-globulin
b) α2- globulin
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c) β-globulin
Question II: Match ( Put the number besides its matched letter)
AMetalloprotein
metal
Mg++
1-
Cytochrome oxidase
a-
2-
Glutathione peroxidase
b- iron and Cu++
3-
Carbonic anhydrase
c-
4-
Kinases
d- selenium and iron
5-
Ceruloplasmin
e- Zn++
Cu++
B1- HDL
a- derived protein
2- Flavoprotein
b- nucleoprotein
3- Casein of milk
c- chromoprotein
4- Gelatin
d- lipoprotein
5- Chromosome
e- phosphoprotein
C1- α-helix
a- structure resulting from combination of secondary
structures
2- β-b-sheet
three b- functional and three dimensional unit of the protein
3- motif
c- spiral structure resulting from hydrogen bonding between one
peptide bond and the fourth one in the single polypeptide
chain
4- domain
d- short polypeptide segment that connects successive secondary
structures
5-
e- two polypeptide chains linked by hydrogen bonding between
adjacent peptide bonds
turn
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D1- Ig G
a-
antibody against parasites
2- Ig A
b- pentamer with the highest molecular weight
3- Ig E
c-
give immunity to infants and newborn
4- Ig M
e-
present in breast milk and tears as diamer
Question III: Illustrate using biochemical equations:
1- Conversion of UTP into CTP
2- Rate limiting step in purine biosynthesis
Question VI: Draw the structure of the following:
1- Essential sulfur containing amino acid
2- GMP
Question V: Give the name of each of the following:
1- Main storage form of iron in the body…………………………………….
2- Drug used in treatment of gout by inhibiting xanthine oxidase………….
3- Disease resulting from absence of the four genes of α- globin
chain…………………………………………………
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