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1.Which of the following type of localized tumors is most likely to have specific tumor-associated antigen CA-125? A. Cancer of the ovaries B. Tumors of the digestive tract C. Hepatocellular carcinoma D. Prostate cancer E. Pancreatic cancer ANSWER: A 2.Which of the following type of localized tumors is most likely to have specific tumor-associated antigen CA-19-9? A. Ovarian cancer B. Tumors of the digestive tract C. Hepatocellular carcinoma D. Prostate cancer E. Cancer of the pancreas ANSWER: E 3.Which of the following type of localized tumors is most likely to have specific tumor-associated antigen PSA? A. Ovarian cancer B. Tumors of the digestive tract C. Hepatocellular carcinoma D. Cancer of the prostate E. Pancreatic cancer ANSWER: D 4.Which of the following type of localized tumors is most likely to have specific tumor-associated antigen AFP? A. Ovarian cancer B. Tumors of the digestive tract C. Hepatocellular carcinoma D. Prostate cancer E. Pancreatic cancer ANSWER: C 5.Which of the following type of localized tumors is most likely to have specific tumor-associated antigen (CEA)? A. Ovarian cancer B. Tumors of the digestive tract C. Tepatocellular carcinoma D. Prostate cancer E. Cancer of the thyroid gland ANSWER: B 6.Which of the following type of localized tumors is most likely to have specific tumor-associated antigen CA 15-3? A. Ovarian cancer B. Tumors of the digestive tract C. Breast cancer D. Prostate cancer E. Pancreatic cancer ANSWER: C 7.What is the tumor-associated antigen most specific to hepatocellular carcinoma? A. CA-125 B. CA-19-9 C. AFP D. CEA E. PSA ANSWER: C 8.What is the tumor-associated antigen most specific to ovarian cancer? A. CA-125 B. CA-19-9 C. AFP D. CEA E. PSA ANSWER: A 9.What is the tumor-associated antigen most specific to pancreatic cancer? A. CA-125 B. CA-19-9 C. AFP D. CEA E. PSA ANSWER: B 10.What is the tumor-associated antigen most specific to colorectal cancer? A. CA-125 B. CA-19-9 C. AFP D. CEA E. PSA ANSWER: D 11.What is the tumor-associated antigen most specific to breast cancer? A. CA-125 B. CA-19-9 C. CA-15-3 D. CEA E. PSA ANSWER: C 12.What is the tumor-associated antigen most specific to gastric cancer? A. CA-125 B. CA-19-9 C. AFP D. CEA E. PSA ANSWER: D 13.What is the tumor-associated antigen most specific to prostate cancer? A. CA-125 B. CA-19-9 C. AFP D. REA E. PSA ANSWER: E 14.What is the tumor-associated antigen most specific for skin melanoma? A. CA-125 B. S-100 protein C. AFP D. CEA E. PSA ANSWER: B 15.What tumor marker used to monitor patients with medullary thyroid cancer? A. Calcitonin B. Thyroglobulin C. Neurospecific enolase D. β2-microglobulin E. Chorionic gonadotropin ANSWER: A 16.What tumor marker used for monitoring patients with chorionepithelioma? A. CA-125 B. TG C. AFP D. β2-microglobulin E. Chorionic gonadotropin ANSWER: E 17.What tumor marker used for monitoring patients with myelomic illness? A. CA-125 B. TG C. AFP D. β2-microglobulin E. Chorionic gonadotrophin ANSWER: D 18.Which of the following lower lip diseases is obligate precancerous lesion? A. Lower lip hyperkeratosis B. Bowen’s disease C. Lower lip angiofibroma D. Keratoacanthoma E. Local erythroplakia ANSWER: E 19.Which of the following lower lip diseases is facultative precancerous lesion? A. Focal dyskeratosis B. Bowen’s disease C. Lower lip hyperkeratosis D. Xeroderma pigmentosum E. Lower lip papilloma ANSWER: C 20.Which of the following risk factors isn’t the cause of lower lip cancer? A. Smoking B. Actinic (sun) damage C. Chronic inflammation and trauma D. Hormonal disorders E. Long-term wind exposure ANSWER: D 21.Focal hyperkeratosis is a pathognomonic sign for: A. Destructive dyskeratosis B. Erythroplakia C. Leucoplakia D. Keratoacanthoma E. Papilloma ANSWER: C 22.Focal epidermodysplasia is a pathognomonic sign for: A. Productive dyskeratosis B. Leucoplakia C. Erythroplakia D. Keratoacanthoma E. Papilloma ANSWER: C 23.Which of the following types of lower lip cancer is not? A. Papillary B. Warty C. Ulcerative D. Eczematous E. Infilrtative ANSWER: D 24.Which of the following lower lip cancers has the worst prognosis? A. Papillary B. Warty C. Ulcerative D. Infiltrative E. Commissural ANSWER: E 25.Which of the following histological types of lower lip cancers is most often? A. Squamous cell carcinoma B. Small cell carcinoma C. Transitional cell carcinoma D. Adenocarcinoma E. Mucoepidermoid tumor ANSWER: A 26.Which of the following histological types of lower lip cancers is most often? A. Adenocarcinoma B. Squamous cell carcinoma with keratinization C. Squamous cell carcinoma without keratinization D. Transitional cell carcinoma E. Mucoepidermoid tumor ANSWER: B 27.By which of the following routes does the lower lip cancer more often give metastases? A. Lymphogenic B. Hematogenic C. By implantation D. Perineural E. By salivary gland ducts ANSWER: A 28.Which of the following methods is most effective for the lower lip cancer III stage treatment? A. Surgery B. Brachytherapy C. Combined D. Chemotherapy E. Distant gamma therapy ANSWER: C 29.In which of the world regions the frequency of oral cavity cancer is the highest? A. West Europe B. Africa C. Australia D. South-East Asia and Kazakhstan E. South and Central America ANSWER: D 30.Which of the following oral cavity diseases is obligate precancerous lesion? A. Leukoplakia B. Leucokeratosis C. Bowen’s disease D. Papillomatosis E. Red flat tinea ANSWER: C 31.Which of the following tumors has epithelial structure? A. Fibroma B. Hemangioma C. Lymphangioma D. Papilloma E. Neurofibroma ANSWER: D 32.Which of the following risk factors isn’t the cause of oral cavity cancer? A. Prolonged smoking B. Actinic (sun) damage C. Chronic inflammation and trauma D. Chronic burns E. Chronic chemical exposure ANSWER: B 33.Which of the following sites is more prevalent for originates tongue cancer? A. Tongue radix B. Tongue apex C. Tongue dorsum D. Tongue margins E. All parts of tongue are affected equal ANSWER: D 34.Which of the following sites is more prevalent for originates oral cavity cancer? A. Buccal mucosa B. Hard palate C. Soft palate D. Mouth floor E. Palatal arcus ANSWER: D 35.Which of the following histological types of tongue cancers is most often? A. Squamous cell B. Small cell C. Transitional cell D. Adenocarcinoma E. Mucoepidermoid tumor ANSWER: A 36.Which of the following methods is most effective for the tongue cancer treatment? A. Surgery B. Radiation C. Chemotherapy D. Hormonotherapy E. Combined ANSWER: E 37.Which of the following cells of the thyroid gland are named after author (Hürthle cells)? A. A-cells B. B-cells C. C-cells D. Metaplastic epithelium E. Parafolicular ANSWER: B 38.By which of the following routes does the thyroid gland follicular cancer more often give metastases? A. Lymphogenic B. Hematogenic C. By implantation D. Perineural E. Through folliculi of thyroid gland ANSWER: B 39.By which of the following routes does the thyroid gland papillary cancer more often give metastases? A. Lymphogenic B. Hematogenic C. By implantation D. Perineural E. They give metastases very rare ANSWER: A 40.What’s the feature of the bones metastases of thyroid gland cancers? A. Consolidative B. Osteoblastic C. Retentive D. Osteolitic E. Mixed ANSWER: D 41.The bones metastases of thyroid gland cancers can be detected by: A. MRI B. CT C. Digital X-ray D. Bones scanning E. Thermography ANSWER: D 42.Which of the following methods is most effective for the treatment of thyroid gland cancer? A. Subtotal resection B. Thyroidectomy C. Limited resection D. Thyroidectomy with resection isthmus E. Subtotal subfascial resection by Nikolaev ANSWER: D 43.Which of the following effects gives hormonotherapy? A. Substitutional effect B. Hold malignancy cells growth C. Restoration effect D. Preventive effect E. Antagonist thyrotropin ANSWER: E 44.Which of the following drugs is used for hormonotherapy of thyroid glad cancer? A. Antithyroid drugs B. Thyroxine C. Thyrotropin D. Antistrumine E. Lactotropin ANSWER: B 45.Which of the following tumors may be monitoring by blood test of calcitonin level? A. Salivary gland B. Larynx C. Lower lip D. Parathyroid glands E. Thyroid gland ANSWER: E 46.Which of the following tumor markers is useful for monitoring the thyroid gland medullary cancer? A. Calcitonin B. Thyroglobulin C. CA 15-3 D. β2 –Microglobulin E. Human chorionic gonadotropin (β-HCG) ANSWER: A 47.Which of the following tumor markers is useful for monitoring the thyroid gland follicular adenocarcinoma? A. Calcitonin B. Thyroglobulin C. CA 15-3 D. β2 –Microglobulin E. Human chorionic gonadotropin (β-HCG) ANSWER: B 48.Which of the following tumor markers is useful for monitoring the thyroid gland papillary adenocarcinoma? A. Calcitonin B. Thyroglobulin C. CA 15-3 D. β2 –Microglobulin E. Human chorionic gonadotropin (β-HCG) ANSWER: B 49.Which of the following 5-year survival rates have the patients with the thyroid gland follicular adenocarcinoma? A. 70 – 90 % B. 40 – 60 % C. 30 % D. 10 % E. 0 % ANSWER: A 50.Which of the following 5-year survival rates have the patients with the thyroid gland papillary adenocarcinoma? A. 90 % B. 40 – 60 % C. 30 % D. 10 % E. 0 % ANSWER: A 51.Which of the following 5-year survival rates have the patients with the thyroid gland medullary carcinoma? A. 90 % B. 40 – 60 % C. 30 % D. 10 % E. 0 % ANSWER: B 52.Which of the following 5-year survival rates have the patients with the thyroid gland undifferentiated cancer? A. 70 % B. 50 % C. 30 % D. 20 % E. 0 % ANSWER: E 53.Which of the following clinical manifestation is most typical for the thyroid gland aberrant cancer? A. Cannot be detected by visual B. Cannot be detected by palpable C. By thyroid fail D. By metastasizing ways E. None ANSWER: D 54.Which of the following risk factors isn’t the cause of larynx cancer? A. Smoking B. Chronic laryngitis C. Chemical carcinogens D. Insolation E. Alcohols ANSWER: D 55.Which of the following symptoms is more often on the onset disease if tumor located in vestibular space? A. Painful swallowing B. Hemoptysis C. Breathing difficulties D. Hoarseness E. Cough ANSWER: A 56.Which of the following symptoms is more often on the onset disease if tumor located on vocal cords? A. Sore throat B. Pharyngeal foreign body feeling C. Breathing difficulties D. Hoarseness E. Cough ANSWER: D 57.Which of the following symptoms is more often on the onset disease if tumor located in glottis? A. Sore throat B. Pharyngeal foreign body feeling C. Breathing difficulties D. Hoarseness E. Cough ANSWER: C 58.Which of the following methods cannot assess the “T” (primary tumor) of larynx cancer? A. Endoscopy B. CT C. Digital X-ray tomography D. MRI E. Ultrasound ANSWER: E 59.Larynx cancer gives metastases by: A. Hematogenic B. Lymphogenic C. By implantation D. By contact E. Doesn’t metastasizes ANSWER: B 60.The site origin of larynx cancer influences on metastasizing. Which of the following more often gives metastases? A. Vestibular space cancer B. Vocal folds cancer C. Subglottic space cancer D. Anterior commissure cancer E. Posterior commissure cancer ANSWER: A 61.The site origin of larynx cancer influences on metastasizing. Which of the following rare gives metastases? A. Vestibular space cancer B. Vocal folds cancer C. Subglottic space cancer D. Ventricle cancer E. Epiglottis cancer ANSWER: B 62.Which of the following methods is most effective for the treatment of laryngeal cancer vestibular space I – II stages? A. Surgery alone B. Radiotherapy C. Chemotherapy D. Photodynamic laserotherapy E. Surgery with neoadjuvant chemotherapy ANSWER: B 63.Which of the following methods is most effective for the treatment of laryngeal cancer subglottic space I-II stages? A. Surgery alone B. Radiotherapy C. Chemotherapy D. Surgery with preoperative RT E. Surgery with postoperative RT ANSWER: A 64.Which of the following methods is most effective for the treatment of laryngeal cancer subglottic space III stage? A. Surgery alone B. Radiotherapy C. Chemotherapy D. Surgery with preoperative RT E. Surgery with postoperative RT ANSWER: A 65.One of the indications to cordectomy is location tumor. In which of the following cases this operation is most likely to be? A. Vestibular space B. Supraglottic space C. Vocal folds D. Subglottic space E. Any location if tumor I stage ANSWER: C 66.Which of the following operations is not radical for the surgical treatment of laryngeal cancer? A. Larynx resection B. Cordectomy C. Laryngectomy D. Tracheostomy E. Pharyngotomy with surgical removal tumor ANSWER: D 67. What is the most frequent complication of radical neck dissection from left side: A. Damage of neck part of thoracic lymphatic duct B. Damage of internal jugularis vein C. Damage of spinal accessory nerve D. Damage of submandibular salivary gland E. Brachial plexitis ANSWER: A 68.Which of the following methods is most effective for the treatment of laryngeal mixed tumors? A. Surgery alone B. Radiotherapy (RT) C. Chemotherapy D. Photodynamic lazerotherapy E. Surgery with preoperative RT ANSWER: A 69.To which of the following groups of laryngeal tumors does the basal fibroid belong? A. Benign epithelial B. Benign nonepithelial C. Malignant epithelial D. Malignant nonepithelial E. Local destructive ANSWER: E 70.Laryngeal fibroids more often originate in: A. Child’s age B. Youth’s age C. Mature age D. Old age E. Senile age ANSWER: B 71.Which of the following sites is more preferable for laryngeal fibroid? A. Larynx arc B. Palate pillar C. Posterior pharyngeal wall D. Pyriform sinus E. Epiglottic fossa ANSWER: A 72.Which of the following methods gives the best result in the patients with laryngeal fibroid? A. Surgery alone B. Radiotherapy (RT) C. Chemotherapy D. Surgery with preoperative RT E. Photodynamic lazerotherapy ANSWER: A 73.Which of the following viruses is associated with laryngeal cancer? A. Herpes virus first type B. Herpes virus second type C. Human papillomavirus (HPV) D. Epstein-Barr virus (EBV) E. Human immunodeficiency virus (HIV) ANSWER: D 74.Which of the following oropharyngeal tumors is more often? A. Epiglottic fossa cancer B. Palate pillar cancer C. Posterior pharyngeal wall cancer D. Lateral pharyngeal wall cancer E. Tonsils cancer ANSWER: E 75.Which of the following methods is most effective for the treatment of nasopharyngeal cancer? A. Surgery alone B. Radiotherapy (RT) C. Chemotherapy D. Hormonotherapy E. Biologic therapy ANSWER: B 76.Which of the following methods is most effective for the treatment of oropharyngeal cancer? A. Surgery alone B. Radiotherapy (RT) C. Chemotherapy D. Hormonotherapy E. Biologic therapy ANSWER: B 77.Which of the following methods is most effective for the treatment of hypopharyngeal cancer? A. Surgery alone B. Radiotherapy (RT) C. Chemotherapy D. Hormonotherapy E. Biologic therapy ANSWER: B 78.Which of the following histological patterns does Schmincke’s tumor have? A. Adenocarcinoma B. Squamouscells C. Mucoepidermoid cells D. Lymphoepithelial cells E. Sarcoma ANSWER: D 79.Which of the following tumors has the worst prognosis? A. Nasopharynx B. Oropharynx C. Hypopharynx D. Palate pillar E. Tonsillar fossa ANSWER: C 80.Which of the following methods is most effective for the treatment of metastases in the neck lymph nodes? A. Surgery B. Radiotherapy C. Chemotherapy D. Immunotherapy E. Photodynamic therapy ANSWER: A 81. What’s the purpose of epidemiology? A. Expose of disease cause B. Prognosticate cancer morbidity in definite region C. Prognosticate seasonal cancer morbidity D. Prognosticate age cancer morbidity E. Cancer diagnostic and treatment ANSWER: A 82.What does “as early as possible diagnosis” mean? A. Diagnosis of obligate precancers B. Diagnosis of cancer in situ C. Diagnosis of cancer in T1-T2 D. Diagnosis of cancer in T3-T4 E. Diagnosis of cancer in any stage ANSWER: A 83.What does “earliest diagnosis” mean? A. Diagnosis of obligate precancers B. Diagnosis of cancer in situ C. Diagnosis of cancer in T1-T2 D. Diagnosis of cancer in T3-T4 E. Diagnosis of cancer in any stage ANSWER: B 84.What does “timely diagnosis” mean? A. Diagnosis of obligate precancers B. Diagnosis of cancer in situ C. Diagnosis of cancer in T1-T2 D. Diagnosis of cancer in T3-T4 E. Diagnosis of cancer in any stage ANSWER: C 85.What does “late diagnosis” mean? A. Prenatal of cancer diagnosis B. Diagnosis of obligate precancers A. Diagnosis of cancer in situ B. Diagnosis of cancer in T1-T2 C. Diagnosis of cancer in T3-T4 with metastases ANSWER: E 86.What does “tumors screening” mean? A. Modern diagnosis methods B. Modern microinvasive treatment methods C. Complex examination of strictly-practical organ interest D. Routine people investigation E. Anticancer vaccination of people ANSWER: D 87.Which of the following procedures is fruitless for screening? A. Chest fluorography B. Cancer-associated antigen blood test C. Fecal occult blood test D. Laparoscopy E. Esophagogastroduodenoscopy ANSWER: D 88.Which of the following acts may improve screening results? A. Forming people-groups with “high risk” of developing cancer B. Use expanded age diapason for screening C. Enlist high-skill oncologists to co-operation D. Use CT as screening method E. Use different form of punishment who tries to miss screening ANSWER: A 89.What’s the purpose of screening? A. Detecting tumor location B. Planning treatment C. Revealing patients with cancer suspicion D. Staging tumors E. Verifying cancer ANSWER: C 90.Screening is more fruitful for one of the following tumors. Which one is it? A. Lungs B. Rectum C. Mammary gland D. Cervix E. Thyroid gland ANSWER: D 91.What is the most frequent premalignant lesion of oral cavity? A. Leukoplakia B. Erythroplakia C. Metaplasia D. Dysplasia E. Papilloma ANSWER: B 92.What gene is associated with oral cavity carcinoma? A. p43 B. p53 C. p63 D. p73 E. BRCA ANSWER: B 93.Which of the following structure is not removed in Crile radical neck dissection? A. Sternocleidomastoid muscle B. Submundibular gland C. Phrenic nerve D. Internal jugular vein E. Lymph nodes ANSWER: C 94. What location of the oral cavity cancer has favorable prognosis? A. Cancer of lip B. Carcinoma cheek C. Carcinoma tongue D. Carcinoma palate E. Nasopharingeal cancer ANSWER: A 95.Regional metastases of buccal mucosa carcinoma present in: A. Neck lymph nodes B. Liver C. Heart D. Brain E. Lung ANSWER: A 96. Commonest malignancy of oral cavity is: A. Adenocarcinoma B. Squamous cell carcinoma C. Adenosquamous carcinoma D. Pleomorhic adenocarcinoma E. Neuroblastoma ANSWER: B 97.Commonest site of metastasis from squamous cell carcinoma of lower lip is: A. Upper neck lymph node B. Supraclavicular lymph node C. Lungs D. Liver E. Mediastinal lymph nodes ANSWER: A 98.What does N3 mean in the classification of oral cavity carcinoma? A. Metastasis in ipsilateral supraclavicular lymph node B. Lymph nodes larger than 6 cm C. No nodes D. Nodes larger than 3 cm E. Sentinel lymph nodes ANSWER: B 99.What does T3 mean in the TNM classification of oral cancer? A. Tumor with deep invasion to muscle or bone B. Tumor large than 4 cm C. Tumor 2 cm or smaller D. Tumor 4 cm or smaller E. Tumor 1 cm ANSWER: B 100.What is the main way of metastatic spread of oral cavity cancer? A. Lymphatic B. Hematogenous C. Implantation D. Perivascular E. Perineural ANSWER: A