Download S1 Table.

Table S1. Results of the GBST. Description of all significant genes (FDR < 5%) resulting from the gene-based score test (GBST)
according to the Ensembl database.
Phenotype
Time
Ensemble Gene ID
Chromos Gene Size Gene
ome
(# SNPs)
Name
3
1 Unknown
3
11 CD53
3
5 DRAM2
NEFA
NEFA
NEFA
1 ENSBTAG00000030119
1 ENSBTAG00000006466
1 ENSBTAG00000009888
NEFA
NEFA
1 ENSBTAG00000013856
1 ENSBTAG00000012659
NEFA
NEFA
NEFA
NEFA
NEFA
NEFA
NEFA
NEFA
NEFA
2
2
2
2
2
3
3
3
3
ENSBTAG00000016185
ENSBTAG00000013227
ENSBTAG00000047595
ENSBTAG00000042372
ENSBTAG00000043619
ENSBTAG00000030800
ENSBTAG00000030798
ENSBTAG00000003447
ENSBTAG00000003523
16
14
17
12
17
13
13
18
6
NEFA
NEFA
3 ENSBTAG00000017568
3 ENSBTAG00000019642
13
10
3 WFDC13
4 ANKDD1A
3
1
5
3
7
3
NEFA
NEFA
NEFA
NEFA
3
21
21
31
ENSBTAG00000013928
ENSBTAG00000013227
ENSBTAG00000031082
ENSBTAG00000003523
13
14
3
6
NEFA
31 ENSBTAG00000039647
6
37 SSBP2
3 LRIF1
25
1
21
1
1
2
5
12
3
ENAH
SNAI2
FSTL5
SNORA71
U6
WFDC10B
WFDC11
ZNF551
UGT2B15
WFDC2
SNAI2
LOC781576
UGT2B15
5 MGC15201
0
Description
Unknown
CD53 molecule
DNA-damage regulated autophagy
modulator 2
single-stranded DNA binding protein 2
ligand dependent nuclear receptor
interacting factor 1
enabled homolog (Drosophila)
snail homolog 2 (Drosophila)
follistatin-like 5
Small nucleolar RNA SNORA71
U6 spliceosomal RNA
WAP Four-Disulfide Core Domain 10B
WAP four-disulfide core domain 11
Zinc Finger Protein 551
UDP glucuronosyltransferase 2 family.
polypeptide B15
WAP four-disulfide core domain 13
ankyrin repeat and death domain
containing 1A
WAP four-disulfide core domain 2
snail homolog 2 (Drosophila)
mCG1723-like
UDP glucuronosyltransferase 2 family.
polypeptide B15
UDP glucuronosyltransferase 2 family
P-Value
4.36E-09
7.71E-09
2.25E-08
7.74E-08
3.58E-06
2.21E-07
6.28E-07
1.86E-06
6.29E-06
6.67E-06
1.11E-09
7.57E-09
1.71E-06
3.15E-06
5.30E-06
6.10E-06
9.53E-06
5.08E-08
2.07E-07
1.11E-15
1.27E-11
NEFA
NEFA
NEFA
31 ENSBTAG00000014459
31 ENSBTAG00000014449
31 ENSBTAG00000018133
1
1
4
NEFA
NEFA
NEFA
31 ENSBTAG00000030800
31 ENSBTAG00000045396
31 ENSBTAG00000038131
13
15
1
2 WFDC10B
3 U6
2 ABCC5
NEFA
31 ENSBTAG00000020247
4
NEFA
NEFA
31 ENSBTAG00000013452
32 ENSBTAG00000009575
10
9
NEFA
NEFA
32 ENSBTAG00000003447
32 ENSBTAG00000048041
18
11
1 ADCYAP1R
1
5 AQP9
16 C9H6orf17
0
12 ZNF551
9 ACTR1B
NEFA
NEFA
NEFA
NEFA
32
32
32
32
ENSBTAG00000013309
ENSBTAG00000031352
ENSBTAG00000020446
ENSBTAG00000005892
2
7
7
11
3
1
5
19
SRSF4
ZNF554
THOP1
ZAP70
NEFA
NEFA
BHBA
BHBA
BHBA
BHBA
BHBA
BHBA
32
32
1
1
1
1
1
1
ENSBTAG00000044764
ENSBTAG00000047595
ENSBTAG00000013880
ENSBTAG00000002389
ENSBTAG00000046421
ENSBTAG00000015086
ENSBTAG00000019146
ENSBTAG00000031107
9
17
7
15
28
16
17
19
2
21
16
4
5
9
35
8
SNORA25
FSTL5
WWC1
MED19
SFTPD
HSD11B1
OSBP2
HS3ST3A1
1 ENSBTAG00000003418
30
BHBA
1 MAP6D1
1 RPS6
31 SEMA3A
5 MSN
MAP6 domain containing 1
40S Ribosomal Protein S6
sema domain. immunoglobulin domain
(Ig). short basic domain. secreted.
(semaphorin) 3A
WAP four-disulfide core domain 10B
U6 spliceosomal RNA
ATP-binding cassette. sub-family C
(CFTR/MRP). member 5
adenylate cyclase activating polypeptide 1
(pituitary) receptor type I
aquaporin 9
chromosome 9 open reading frame. human
C6orf170
zinc finger protein 551
ARP1 actin-related protein 1 homolog B.
centractin beta (yeast)
serine/arginine-rich splicing factor 4
zinc finger protein 554
thimet oligopeptidase 1
zeta-chain (TCR) associated protein kinase
70kDa
Small nucleolar RNA SNORA25
follistatin-like 5
WW and C2 domain containing 1
mediator complex subunit 19
surfactant protein D
hydroxysteroid (11-beta) dehydrogenase 1
oxysterol binding protein 2
heparan sulfate (glucosamine) 3-Osulfotransferase 3A1
moesin
3.93E-08
3.31E-07
8.05E-07
1.20E-06
1.42E-06
5.85E-06
9.66E-06
2.08E-05
1.18E-08
4.65E-08
1.08E-06
3.53E-06
3.68E-06
5.93E-06
1.14E-05
1.14E-05
1.97E-05
2.29E-10
1.70E-07
6.06E-06
6.28E-06
7.69E-06
9.32E-06
1.23E-05
BHBA
BHBA
1 ENSBTAG00000047490
2 ENSBTAG00000009022
2
25
1 Unknown
1 DNAJC30
BHBA
2 ENSBTAG00000017067
25
3 WBSCR22
BHBA
BHBA
2 ENSBTAG00000000781
2 ENSBTAG00000015155
25
10
32 HIP1
15 PTPLAD1
BHBA
2 ENSBTAG00000015158
10
BHBA
BHBA
BHBA
BHBA
BHBA
BHBA
2
2
2
2
2
21
ENSBTAG00000044466
ENSBTAG00000044221
ENSBTAG00000043885
ENSBTAG00000046907
ENSBTAG00000017075
ENSBTAG00000009022
25
20
17
19
25
25
11 C10H15orf
44
2 SCARNA20
2 SNORA9
2 7SK
2 KRTAP4-12
5 STX1A
1 DNAJC30
BHBA
BHBA
21 ENSBTAG00000046907
21 ENSBTAG00000017067
19
25
2 KRTAP4-12
3 WBSCR22
BHBA
BHBA
BHBA
21 ENSBTAG00000031551
21 ENSBTAG00000046075
21 ENSBTAG00000000405
25
19
25
1 PRSS53
4 LOC777598
2 VKORC1
BHBA
21 ENSBTAG00000046860
29
BHBA
BHBA
BHBA
BHBA
Glucose
Glucose
21
21
32
32
1
1
25
19
18
17
23
3
ENSBTAG00000000781
ENSBTAG00000037943
ENSBTAG00000013157
ENSBTAG00000039316
ENSBTAG00000048116
ENSBTAG00000018893
4 bta-mir2885
32 HIP1
1 Unknown
6 NOVA2
3 ZNF268
1 Unknown
3 AHCYL1
Unknown
DnaJ (Hsp40) homolog. subfamily C.
member 30
Williams Beuren syndrome chromosome
region 22
huntingtin interacting protein 1
protein tyrosine phosphatase-like A
domain containing 1
chromosome 10 open reading frame.
human C15orf44
Small Cajal body specific RNA 20
Small nucleolar RNA SNORA9
7SK RNA
keratin associated protein 4-12
syntaxin 1A (brain)
DnaJ (Hsp40) homolog. subfamily C.
member 30
keratin associated protein 4-12
Williams Beuren syndrome chromosome
region 22
protease. serine. 53
keratin associated protein-like
vitamin K epoxide reductase complex.
subunit 1
bta-mir-2885
1.64E-05
7.27E-12
huntingtin interacting protein 1
Unknown
neuro-oncological ventral antigen 2
zinc finger protein 268
Unknown
adenosylhomocysteinase-like 1
1.77E-05
1.94E-05
2.56E-08
2.63E-06
8.26E-08
1.36E-06
9.22E-10
9.78E-08
4.15E-06
4.86E-06
5.07E-06
5.62E-06
5.92E-06
8.08E-06
1.51E-05
7.44E-08
2.24E-07
1.69E-06
4.69E-06
4.78E-06
5.07E-06
1.55E-05
Glucose
Glucose
Glucose
1 ENSBTAG00000010490
1 ENSBTAG00000004015
1 ENSBTAG00000020964
5
27
3
8 PEX5
8 KAT6A
4 FAM40A
Glucose
Glucose
2 ENSBTAG00000030670
2 ENSBTAG00000013568
1
29
20 PCNT
15 UEVLD
Glucose
Glucose
Glucose
Glucose
Glucose
Glucose
Glucose
Glucose
2
3
3
3
3
3
3
3
ENSBTAG00000021984
ENSBTAG00000017457
ENSBTAG00000045413
ENSBTAG00000024058
ENSBTAG00000001447
ENSBTAG00000027727
ENSBTAG00000021471
ENSBTAG00000047510
1
20
7
11
22
7
7
19
4
14
7
2
5
34
3
4
Glucose
3 ENSBTAG00000030286
7
C21ORF58
STK10
7SK
EGR4
HRH1
BT.94335
GIN1
LOC100302
389
7 GABRA1
Glucose
3 ENSBTAG00000001485
7
7 PPIP5K2
Glucose
3 ENSBTAG00000014642
14
3 NAPRT1
Glucose
Glucose
3 ENSBTAG00000011717
3 ENSBTAG00000040583
19
23
11 SAP30BP
1 LOC526989
Glucose
21 ENSBTAG00000013568
29
15 UEVLD
Glucose
21 ENSBTAG00000015843
20
5 SLC6A3
Glucose
Glucose
Glucose
21 ENSBTAG00000039409
21 ENSBTAG00000044890
21 ENSBTAG00000004629
20
6
20
1 Unknown
2 5S_rRNA
3 SLC9A3
peroxisomal biogenesis factor 5
K(lysine) acetyltransferase 6A
family with sequence similarity 40.
member A
pericentrin
UEV and lactate/malate dehyrogenase
domains
chromosome 21 open reading frame 58
serine/threonine kinase 10
7SK RNA
early growth response 4
histamine receptor H1
Unknown
gypsy retrotransposon integrase 1
uncharacterized LOC100302389
2.72E-06
5.45E-06
8.87E-06
gamma-aminobutyric acid (GABA) A
receptor. alpha 1
diphosphoinositol pentakisphosphate
kinase 2
nicotinate phosphoribosyltransferase
domain containing 1
SAP30 binding protein
olfactory receptor. family 2. subfamily B.
member 8 pseudogene-like
UEV and lactate/malate dehyrogenase
domains
solute carrier family 6 (neurotransmitter
transporter). member 3
Unknown
5S ribosomal RNA
solute carrier family 9 (sodium/hydrogen
1.09E-05
2.90E-07
1.37E-06
2.96E-06
6.35E-08
1.02E-07
3.81E-07
1.19E-06
2.07E-06
4.04E-06
7.61E-06
1.36E-05
1.63E-05
2.48E-05
2.66E-05
1.61E-08
3.10E-07
6.08E-07
2.01E-06
3.59E-06
Glucose
Glucose
Glucose
21 ENSBTAG00000000944
21 ENSBTAG00000011405
21 ENSBTAG00000018188
20
20
29
5 LPCAT1
14 CEP72
2 NDUFC2
Glucose
31 ENSBTAG00000030286
7
7 GABRA1
Glucose
Glucose
Glucose
31 ENSBTAG00000004015
31 ENSBTAG00000001244
32 ENSBTAG00000039316
27
27
17
8 KAT6A
7 PLAT
3 ZNF268
exchanger). member 3
lysophosphatidylcholine acyltransferase 1
centrosomal protein 72kDa
NADH dehydrogenase (ubiquinone) 1.
subcomplex unknown. 2. 14.5kDa
gamma-aminobutyric acid (GABA) A
receptor. alpha 1
K(lysine) acetyltransferase 6A
plasminogen activator. tissue
zinc finger protein 268
7.47E-06
1.15E-05
1.34E-05
4.55E-07
4.55E-06
5.81E-06
5.20E-08