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M.Sc. Medical I (First) Year Annual Examination 2014-15 Course Code:MSC103 Paper ID:0571124 Basics of Biochemistry Time: 3 Hours Max. Marks: 75 Note: Attempt six questions in all. Q. No. 1 is compulsory. 1. a) b) c) d) e) f) g) h) Answer any five of the following (limit your answer in 50 words). (3x5=15) Write the function of DNA polymerase enzyme. Antioxidants. What is PSP excretion test? What is glucose-6-phosphate dehydrogenase deficiency? What is FIGLU test? What are tumour markers? Role of iron What is glycosylated hemoglobin? 2. Describe the mitochondrial electron transport chain. Write a note on inhibitors of respiratory chain. (8+4) 3. Describe the chemistry, functions, RDA, and deficiency manifestations of vitamin C. Write a note on hypervitaminosis C. (9+3) 4. Write short notes on following: a) Mucopolysaccharides b) Essential and semi-essential amino acids c) Plasma lipoproteins (4x3=12) 5. Write short notes on following: a) Serum diagnostic enzymes b) Structue of immunoglobulins c) Xenobiotics (4x3=12) 6. Describe in brief: (6+6) a) Body distribution, functions, and deficiency manifestations of calcium b) Gluconeogenesis 7. Describe in brief: a) Post-translational modification of proteins b) Liver Function Tests (LFT) 8. (6+6) Describe fluid mosaic model of membrane structure and functions of cell membrane. (12)