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SG-R / SG-S - 2.24 Fold change SG-R / SG-rev - 2.00 30S ribosomal protein S14 - 3.42 - 3.28 rpSG 30S ribosomal protein S6 - 2.26 - 1.98 SA0354 rpsR 30S ribosomal protein S18 - 2.11 - 1.83 SA0497 rplJ 50S ribosomal protein L10 - 2.13 - 2.20 SA0498 rplL 50S ribosomal protein L7/L12 - 2.16 - 2.18 - 2.05 (- 1.86; p = 0.123) SA0503 rpsL Hypothetical protein, similar to ribosomal protein L7Ae-like 30S ribosomal protein S12 - 2.30 (- 1.61; p = 0.336) SA1112 SA1414 infB rpsT Translation initiation factor IF-2 30S ribosomal protein S20 - 2.12 - 1.74 - 1.59 - 2.02 SA1473 rplU 50S ribosomal protein L21 - 2.19 - 2.08 SA1502 rplT 50S ribosomal protein L20 - 2.89 - 2..35 SA1503 rpmI 50S ribosomal protein L35 - 2.45 - 2.09 SA1504 SA1083 infC Translation initiation factor IF-3 InfC - 2.62 - 1.93 trmD tRNA-(guanine-N1)-mehtyltranSGerase - 2.25 (- 1.58; p = 0.127) SA2016 rpsI 30S ribosomal protein S9 - 2.13 - 1.76 SA2033 rplF 50S ribosomal protein L6 - 2.46 - 2.29 SA2035 rplE 50S ribosomal protein L5 - 2.33 - 2.30 ORF annotation SAS052 gene rpsD Product of putative function 30S ribosomal protein S4 SAS079 rpsN SA0352 SA0502 a SG-rev / SG-S Functional category Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Protein synthesis: Translation factors Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Protein synthesis: Translation factors Protein synthesis: tRNA and rRNA base modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification 1 SG-R / SG-S - 2.44 Fold change SG-R / SG-rev - 2.45 50S ribosomal protein L14 - 2.16 - 2.70 - 2.02 - 11.52 - 1.86 - 9.32 - 2.80 - 2.79 - 4.67 - 4.63 (1.85; p = 0.058) 2.11 2.59 - 2.03 2.22 - 1.23 - 1.23 - 1.85 - 2.72 - 2.96 ORF annotation SA2036 Gene rplX Product of putative function 50S ribosomal protein L24 SA2037 rplN SA0266 SA0293 SA0531* SA0616 SA0617 SA0640 proP vraF vraG SA1183* opuD Conserved hypothetical protein Hypothetical protein, similar to formate transporter NirC Hypothetical protein, similar to branched-chain amino acid uptake carrier Hypothetical protein, similar to outer membrane protein precursor Proline/betaine transporter homologue ABC transporter ATP-binding protein ABC transporter permease Hypothetical protein, similar to ABC transporter required for expression of cytochrome bd Glycine betaine transporter mrsA Peptide methionine sulfoxide reductase 3.45 5.61 - 2.17 - 2.03 SA1987 Hypothetical protein, similar to Na+-transporting ATP synthase Glycine betaine transporter OpuD homolog 1.54 2.21 SA2205 Conserved hypothetical protein -2.02 - 1.70 SA0294 SA0295 a,b SA1257 SA1815 a SA2156 L-lactate permease lctP homolog - 12.73 - 11.48 SA1270 Hypothetical protein, similar to amino acid pearmease Hypothetical protein, similar to Amino acid transporter Fibronectin-binding protein homolog ABC transporter 2-oxoglutarate/malate translocator homolog - 3.45 (- 2.95; p = 0.175) 2.75 3.03 2.53 - 57.87 - 2.62 2.18 - 40.7 - 2.19 5.34 4.97 SA2239 SA2291 SA2302 SA2486 a,b SA2489 stpC Hypothetical protein, similar to high-affinity nickel-transport protein SG-rev / SG-S Functional category Ribosomal proteins: Synthesis and modification Ribosomal proteins: Synthesis and modification Transport and binding proteins Transport and binding proteins: Anions Transport and binding proteins: Amino acids, peptides and amines Transport and binding proteins 2.59 3.18 Transport and binding proteins Transport and binding proteins Transport and binding proteins Transport and binding proteins Transport and binding proteins: Amino acids, peptides and amines Transport and binding proteins: Carbohydrates, organic alcohols, and acids Transport and binding proteins: Cations and iron carrying compounds Transport and binding proteins: Amino acids, peptides and amines Transport and binding proteins: Cations and iron carrying compounds Transport and binding proteins: Carbohydrates, organic alcohols, and acids Transport and binding proteins: Amino acids, peptides and amines Transport and binding proteins: Amino acids, peptides and amines Transport and binding proteins Transport and binding proteins Transport and binding proteins: Anions Transport and binding proteins: Cations and iron carrying compounds 2 SG-R / SG-S 2.85 Fold change SG-R / SG-rev 3.48 Type 1 signal peptidase 1B 2.28 2.47 ctpA Carboxy-terminal processing proteinase CtpA 1.50 2.02 SA1549* htrA 2.63 4.51 SA1725 sspB Heat shock protein homolog, similar to serine proteinase Staphopain cysteine protease - 7.05 - 4.10 SA1758 sak Staphylokinase precursor - 3.83 - 4.95 Methionine sulfoxide reductase B (MsrB) 3.23 4.45 prsA Peptidyl-prolyl cis/trans isomerase homolog 3.09 4.22 azlC brnQ gltS Putative amino acid permease Branched-chain amino acid permease Sodium/glutamate symporter Aspartate kinase homolog NADH dehydrogenase subunit 5 Quinol oxidase polypeptide III QoxC - 2.12 - 2.14 - 4.20 -2.48 - 2.47 - 2.15 - 2.29 (- 2.11; p= 0.081) - 5.42 - 1.75 (- 2.32; p= 0.071) - 1.90 Protein fate: Degradation of proteins, peptides, and glycopeptides Protein fate: Degradation of proteins, peptides, and glycopeptides Protein fate: Degradation of proteins, peptides, and glycopeptides / Pathogenesis Protein fate: Degradation of proteins, peptides, and glycopeptides Post-translational modification, protein turnover and chaperones Post-translational modification, protein turnover and chaperones Amino acid transport and metabolism Amino acid transport and metabolism Amino acid transport and metabolism Amino acid biosynthesis: Aspartate family Energy metabolism: Electron transport Energy metabolism: Electron transport - 2.53 (- 2.28; p = 0.22) Energy metabolism: Electron transport - 2.62 (- 2.65; p= 0.177) Energy metabolism: Electron transport - 2.20 - 1.76 Energy metabolism: TCA cycle tcaA Cytochrome d ubiquinol oxidase subunit 1 homolog Sytochrome D ubiquinol oxidase subunit II homolog Succinate dehydrogenase iron-sulfur protein subunit Isocitrate dehyrogenase Anti repressor Teicoplanin resistance-associated protein 2.15 2.68 4.65 1.96 1.94 5.55 Energy metabolism: TCA cycle Energy metabolism: Electron transport Energy metabolism: Electron transport a narK Nitrite extrusion protein - 27.82 - 20.32 Energy metabolism: Electron transport a narG Respiratory nitrate reductase alpha chain - 3.18 (- 2.44; p= 0.269) (2.60; p = 0.10) 3.31 ORF annotation SA0825* Gene spsA Product of putative function Type-I signal peptidase SA0826 spsB SA1253* a,b a,b SA1256 a,b SA1659* a,b SA0010 SA0180 SA2135 SA1163 SA0411 a SA0911 SA0937 ndhF qoxC SA0938 SA0996 sdhB SA1517 SA1801 a,b SA2146* citC SA2176 SA2185 a,b SA2220* Hypothetical protein SG-rev / SG-S Functional category Protein fate: Protein and peptide secretion and trafficking Protein fate: Protein and peptide secretion and trafficking Energy metabolism: Anaerobic Energy metabolism: Glycolysis/gluconeogenesis 3 ORF annotation a SA0232 srrB srrA rot Truncated (hlb) SA1755 SA1812 SA1813 SA2097 SA0904 4.00 2.84 - 2.86 - 2.06 - 125.74 2.71 - 2.56 - 2.05 - 100.55 Hypothetical protein, similar to secretory antigen precursor SsaA Hypothetical protein, similar to extracellular matrix and plasma binding Alpha-Hemolysin Staphylococcal respiratory response protein SrrB Staphylococcal respiratory response protein SrrA Repressor of toxins Rot Truncated beta-hemolysin - 2.40 - 2.52 Pathogenesis - 1.87 - 2.08 Pathogenesis - 6.50 - 2.28 - 2.78 - 2.91 3.09 - 4.39 - 1.81 - 2.25 - 2.94 2.42 Pathogenesis Pathogenesis Pathogenesis Pathogenesis Pathogenesis Chemotaxis-inhibiting protein CHIPS Uncharacterized leukocidin-like protein 1 precursor Hypothetical protein, similar to leukocidin chain LukM Hypothetical protein, similar to secretory antigen precursor SsaA IgG-binding protein SBI Antibacterial protein (phenol soluble modulin 1) Antibacterial protein (phenol soluble modulin 2) Methicillin resistance regulatory protein Staphylococcal accessory regulator A homologue Hypothetical protein, similar to transcription regulator LysR Hypothetical protein, probable ATL autolysin transcription regulator - 3.27 - 4.26 - 4.25 - 3.98 Pathogenesis Pathogenesis - 6.34 (- 4.66 ; p = 0.052) Pathogenesis 4.19 3.34 Pathogenesis - 2.51 -11.34 - 2.11 - 12.80 Pathogenesis Pathogenesis - 27.42 - 27.11 Pathogenesis - 2.05 - 5.39 - 3.98 - 1.87 - 5.38 - 3.47 Regulatory functions Regulatory functions: DNA interactions Regulatory functions: DNA interactions - 6.15 - 4.97 Regulatory functions: DNA interactions hld spa SA0745 SA2206 SACOL1186 / SAUSA300_1067 SACOL1187 / SAUSA300_1068 SA0039 SA0108 SA0836 2.94 PTS system, glucose-specific enzyme II, A component Conserved hypothetical protein L-lactate dehydrogenase Delta-hemolysin Immunoglobulin G binding protein A precursor a,b SA1007 SA1322 SA1323 SA1583 SA1752 Fold change SG-R / SG-rev - 74.07 Product of putative function L-lactate dehydrogenase SA1255* SA2378 SA2395 SAS065 a SA0107 SA0270 SG-R / SG-S - 104.54 Gene lctE sbi mecR sarH1 SG-rev / SG-S Functional category Energy metabolism: Glycolysis/gluconeogenesis Energy metabolism: Glycolysis / Gluconeogenesis Energy metabolism: Pyruvate dehydrogenase Energy metabolism Pathogenesis Pathogenesis 4 ORF annotation SA0949 a,b SA1195 Gene msrR SA2092 SA1665 SA1804 SA2103* a,b SA2108 SA2296* mecA SA0038 SA0127 SA0205 SA0243 tagB SA0265 a,b SA0909* lytM fmtA SA1474 a,b sgtB a,b murZ SA1691* SA1926* SAUSA300_0939 / SACOL1043 SA0129 SA0341 a,b SA0591 SA2006 Product of putative function Conserved hypothetical protein Peptide methionine sulfoxide reductase regulator MsrR Hypothetical protein similar to transcriptional regulator Hypothetical protein Putative phage transcriptional regulator Hypothetical protein, similar to lyt divergon expression attenuator LytR Hypothetical protein, similar to transcription regulator, RpiR Hypothetical protein, similar to transcriptional regulator, MerR Penicillin-binding protein 2a Hypothetical protein, similar to capsular polysaccharide synthesis protein 14L Hypothetical protein, similar to lysostaphin precursor Hypothetical protein, similar to teichoic acid biosynthesis protein B Peptidoglycan hydrolase Fmt, autolysis and methicillin resistant-related protein Hypothetical protein, similar to cell shape determinant mreD Monofunctional glycosyltranSGerase UDP-N-acetylglucosamine 1-carboxylvinyl tranSGerase 2 Glycosyl tranSGerase, group 1 family protein (GT1_gtfA_like) Hypothetical protein Hypothetical protein, similar to low-temperature requirement A protein (LtrA) Hypothetical protein Putative MHC class II analog SG-R / SG-S - 2.09 2.92 Fold change SG-R / SG-rev - 1.83 4.11 - 2.82 - 1.81 - 2.42 4.39 - 2.30 4.46 Regulatory functions: DNA interactions Regulatory functions: DNA interactions 6.75 8.74 Regulatory functions: DNA interactions - 2.53 - 2.64 Regulatory functions: DNA interactions 2.82 3.12 Regulatory functions: DNA interactions - 3.46 - 2.01 - 4.13 - 1.61 2.03 (1.93; p=0.058) Cell envelope biogenesis Cell envelope: Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides Cell envelope biogenesis - 3.12 - 2.32 Cell envelope biogenesis 4.93 1.65 6.45 2.00 - 2.01 (- 1.40; p= 0.217) 5.88 7.01 Cell envelope biogenesis Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan Cell envelope: Biosynthesis and degradation of murein sacculus and peptidoglycan Cell envelope biogenesis 2.53 2.56 Cell envelope biogenesis - 5.95 - 4.82 Cell envelope biogenesis - 13.54 - 3.07 - 15.36 - 2.80 Cell envelope Cell envelope 7.16 8.41 Cell envelope 5.13 4.37 Cell envelope SG-rev / SG-S Functional category Regulatory functions: DNA interactions Regulatory functions - 1.55 Regulatory functions: DNA interactions 5 ORF annotation a SA2303 Gene smpC SA0895 SA0964 a Product of putative function Hypothetical protein, similar to membrane spanning protein Hypothetical protein, similar to menaquinonespecific isochorismate synthase Hypothetical protein, similar to heme synthase SG-R / SG-S - 31.35 Fold change SG-R / SG-rev - 27.84 - 1.78 - 2.03 - 2.92 - 2.92 SG-rev / SG-S Functional category Cell envelope Biosynthesis of cofactors, prosthetic groups, and carriers: Menaquinone and ubiquinone Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin Biosynthesis of cofactors, prosthetic groups, and carriers: Heme, porphyrin, and cobalamin Inorganic ion transport and metabolism Inorganic ion transport and metabolism Inorganic ion transport and metabolism SA0965 ctaB Cytochrome caa3 oxidase (assembly factor) homolog - 2.44 - 2.34 SA1491 hemL Glutamate-1-semialdehyde 2,1-aminomutase - 2.02 (- 1.75; p= 0.091) SA1494 hemC Porphobilinogen deaminase - 2.72 - 2.23 SA1495 hemX HemA concentration negative effector hemX - 2.32 (- 1.85; p= 0.069) SA2186 naSG uroporphyrin-III C-methyl tranSGerase - 2.40 (- 2.036; p= 0.204) SA0110 SA0111 SA0566 sirB sirA Iron compound ABC transporter Iron compound ABC transporter Hypothetical protein, similar to iron-binding protein Hypothetical protein, similar to Cobalt transport protein Hypothetical protein, similar to cation ABC transporter Hypothetical protein Hypothetical protein similar to 4Diphosphocytidyl-2-methyl-D-erithritol synthase - 2.15 - 3.77 - 2.00 - 1.56 - 3.28 (- 1.96; p =0.061) - 2.20 - 1.67 Inorganic ion transport and metabolism - 2.24 - 1.84 Inorganic ion transport and metabolism - 2.27 - 2.12 - 2.18 - 1.64 Hypothetical protein, similar to N-hydroxyarylamine O-acetyltranSGerase Alcohol dehydrogenase I 2.77 2.61 Inorganic ion transport and metabolism Biosynthesis of secondary metabolites:Terpenoid backbone biosynthesis) Biosynthesis of secondary metabolites - 10.15 (- 5.97; p = 0.133) a SA0927 SA0928 SA1016 SA0241 ispD a,b SA2490 a SA0562 adh1 Central intermediary metabolism 6 ORF annotation SA1365 Gene a SA2183 a SA2187 SA2189 nasE a SA2312 ddh SA2413* SG-R / SG-S - 2.18 Fold change SG-R / SG-rev (- 1.49; p = 0.210) - 2.20 (- 2.23; p= 0.246) - 2.62 (- 2.08; p = 0.299) Hypothetical protein, similar to NirR - 7.07 (- 2.90; p = 0.198) D-specific D-2-hydroxyacid dehydrogenase - 3.60 (- 2.74; p = 0.062) Sulfite reductase flavoprotein (NADPH) (1.78; p = 0.092) 2.76 Product of putative function Glycine dehydrogenase (decarboxylating) subunit 2 homolog Hypothetical protein, similar to nitrate reductase delta Assimilatory nitrite reductase SACOL2024 a,b SA1701* SA1700* SACOL2023 SACOL2025 SACOL2026 SA2326 SA0189 agrD vraS AgrD protein Two-component sensor histidine kinase - 3.28 4.58 - 3.14 6.86 vraR agrB agrC agrA ptsG hsdR Two-component response regulator Accessory gene regulator B Accessory gene regulator C Accessory gene regulator A PTS system, glucose-specific IIABC component Type I restriction modification enzyme 3.01 - 3.54 - 3.65 - 4.62 - 2.54 - 3.64 4.39 - 3.67 - 3.34 (- 2.94; p = 0.075) (- 1.70; p = 0.082) - 2.31 SA0353 ssb - 2.28 - 1.72 SA0746 a,b SA1282* nuc recU (prfA) Single-strand DNA-binding protein of phage phi PVL Staphylococcal nuclease Recombination protein U homolog - 4.63 (1.90; p =0.070) - 4.69 2.59 SA1929 pyrG CTP synthase - 2.67 - 2.33 SA0022 Hypothetical protein, similar to 5-nucleotidase - 2.68 - 2.33 SA0182 Hypothetical protein, similar to indole-3-pyruvate decarboxylase Glycerol-3-phosphate transporter Glucose uptake protein homolog - 3.70 (- 2.25 ; p = 0.088) - 2.96 - 2.42 - 2.22 - 2.53 Major facilitator transporter - 3.39 (- 2.93; p = 0.171) superoxide dismutase - 5.67 - 5.43 SA0325 a SA2053 glpT a SA1269 SA0128 sodM SG-rev / SG-S Functional category Central intermediary metabolism Central intermediary metabolism: Nitrogen metabolism Central intermediary metabolism: Nitrogen metabolism Central intermediary metabolism: Nitrogen metabolism Central intermediary metabolism: pyruvate metabolism Central intermediary metabolism: Sulfur metabolism Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction Signal transduction: PTS DNA metabolism: Restriction/modification DNA metabolism: DNA replication, recombination, and repair DNA replication and repair DNA metabolism: DNA replication, recombination, and repair Purines, pyrimidines, nucleosides, and nucleotides: Pyrimidine ribonucleotide biosynthesis Nucleotide transport and metabolism Carbohydrate transport and metabolism/Coenzyme metabolism Carbohydrate transport and metabolism Carbohydrate transport and metabolism Drug resistance transporters Cellular processes: Detoxification 7 SG-R / SG-S 2.74 Fold change SG-R / SG-rev 2.37 1-phosphatidylinositol phosphodiesterase - 3.21 - 2.46 acpD geh NAD(P)H dehydrogenase homologue glycerol ester hydrolase - 5.44 - 4.27 - 5.78 - 4.67 SA1073 fabD Malonyl CoA-acyl carrier protein transacylase - 2.16 (- 1.76; p = 0.16) SA1074 fabG 3-oxoacyl- reductase - 2.22 - 1.94 SA2480* SA0007 a,b SAS016 SAS020 drp35 DPR35 Conserved hypothetical protein Hypothetical protein 2.99 -2.55 21.13 3.22 - 2.29 51.87 Hypothetical protein, similar to phosphoglycerate mutase Hypothetical protein Hypothetical protein Conserved hypothetical protein Hypothetical protein, similar to isochorismatase PTS enzyme II, glucose-specific, factor IIA homologue Conserved hypothetical protein Hypothetical protein Hypothetical protein, similar to flavohemoprotein - 1.96 - 2.13 - 2.02 2.42 - 4.24 - 2.16 - 4.08 - 1.2 2.12 -3.57 -1.73 -3.27 - 2.23 - 4.66 - 4.52 -2.35 -4.24 (-3.08; p = 0.23) hypothetical protein Hypothetical protein conserved hypothetical protein Hypothetical protein Hypothetical protein, similar to autolysin (Nacetylmuramoyl-L-alanine amidase Sle1 precursor) Hypothetical protein, similar to indigoidine systhesis protein Conserved hypothetical protein Mercuric reductase homologue Hypothetical protein Putative exported protein - 2.48 - 6.45 - 2.85 3.11 - 2.11 - 1.89 - 4.42 - 2.91 2.40 - 2.32 Unknown Unknown Unknown Unknown Unknown - 4.26 - 4.42 Unknown - 2.04 - 2.05 - 2.36 1.96 - 1.70 - 1.45 - 1.50 2.06 Unknown Unknown Unknown Unknown ORF annotation SAUSA300_1964/ SAV1991 SA0091 Gene Product of putative function Conserved hypothetical phage protein plc SA0204 a SA0309 SAS028 SAS037 SA0175 SA0181 SA0183 SA0213 SA0228 a SA0231 SA0267 SA0269 SA0271 SA0395 a SA0423 SA0530 SA0543 SA0551 SA0552 SAS0630 glcA SG-rev / SG-S - 2.45 Functional category Mobile and extrachromosomal element functions: Prophage functions Fatty acid and phospholipid metabolism: Degradation Fatty acid and phospholipid metabolism Fatty acid and phospholipid metabolism: Degradation Fatty acid and phospholipid metabolism: Biosynthesis Fatty acid and phospholipid metabolism: Biosynthesis Beta-lactam resistance Unknown Unknown Unknown - 1.69 - 1.59 Unknown Unknown Unknown Unknown Unknown (Amino acid and sugar metabolism) Unknown Unknown Unknown 8 ORF annotation SA0645 SA0666 SA0667 SA0681 Gene SA0755 SA0817 SA0824 SA0882 a,b SA0914* SA0959 SA0966 SA1002 SA1015 SA1017 SA1020 SA1040 a,b SA1049 SA1152 a,b SA1254* SA1265 SA1316 SA1472 SA1476* SA1514 SA1576 SA1617 SA1702* a,b a,b SA1703* SA1705 a,b SA1712* SA1738 SA1803 yvqF SG-R / SG-S - 2.34 - 2.13 - 2.21 1.94 Fold change SG-R / SG-rev (- 1.97; p = 0.058) (- 1.47; p = 0.144) -1.89 2.15 1.98 2.12 Unknown (1.52; p = 0.103) 2.21 Unknown 4.06 - 2.02 4.73 (-1.95; p= 0.123) Unknown Unknown 3.19 3.89 Unknown GTP-binding elongation factor homolog Conserved hypothetical protein Hypothetical protein Hypothetical protein Hypothetical protein Conserved hypothetical protein Conserved hypothetical protein Hypothetical protein - 2.44 - 3.05 - 1.99 - 5.58 - 2.42 - 2.16 - 2.03 2.20 - 2.04 - 2.87 - 2.09 - 5.09 - 2.78 - 1.81 - 1.43 1.64 Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Hypothetical protein Conserved hypothetical protein - 2.96 3.90 - 2.23 3.73 Unknown Unknown Conserved hypothetical protein Hypothetical protein conserved hypothetical protein Hypothetical protein Hypothetical protein Conserved hypothetical protein - 2.90 - 1.80 - 1.98 11.65 - 2.31 - 2.44 - 2.85 - 2.01 - 2.15 21.97 - 2.19 - 1.73 Unknown Unknown Unknown Unknown Unknown Unknown Hypothetical protein similar to latent nuclear antigen Conserved hypothetical protein - 2.84 (-1.99; p= 0.195) Unknown 5.71 7.45 Unknown Product of putative function Conserved hypothetical protein 6-pyruvoyl tetrahydrobiopterin synthase homologue Hypothetical protein Hypothetical protein, similar to multidrug resistance protein Hypothetical protein, similar to general stress protein Hypothetical protein, similar to NADH-dependent flavin oxidoreductase Conserved hypothetical protein Hypothetical protein, similar to competence transcription factor (ComK) Hypothetical protein, similar to chitinase B SG-rev / SG-S - 1.88 Functional category Unknown Unknown Unknown Unknown Hypothetical protein 7.19 8.61 Unknown Conserved hypothetical protein Hypothetical protein - 2.04 5.44 (-1.86; p= 0.0503) 5.37 Unknown Unknown Hypothetical protein Hypothetical protein 2.10 5.40 (2.16; p=0.122) 5.36 Unknown Unknown 9 ORF annotation SA1840 SA1898 SA1942 SA2001 Gene SA2062 SA2113* SA2191 SA2192 a,b SA2221* a Hypothetical protein SA2268 SA2297* Product of putative function Conserved hypothetical protein Hypothetical protein similar to SceD protein Hypothetical protein Hypothetical protein, similar to oxidoreductase, aldo/keto reductase Hypothetical protein Hypothetical protein Hypothetical protein, similar to NirC Hypothetical protein Hypothetical protein a,b SA2310 SA2328 SA2329 SA2343*a,b SA2377 SA2431 SA2432 a SA2479 a,b SA2481 SA2487 SAUSA300_0768 / SACOL0850 SAUSA300_0938 / SACOL1042 SAUSA300_1210 / SACOL1345 SAUSA300_1211 / SACOL1346 SAUSA300_1212/ SACOL1347 SACOL1999 SACOL2433 SACOL2559 isaB SG-R / SG-S - 2.78 2.18 -2.21 3.69 Fold change SG-R / SG-rev - 2.77 2.33 (-2.15; p=0.092) 3.70 - 2.69 9.79 - 2.08 - 3.25 6.88 -2.09 12.58 -1.96 -3.29 7.48 Unknown Unknown Unknown Unknown Unknown - 13.96 -13.12 Unknown SG-rev / SG-S Functional category Unknown Unknown Unknown Unknown Hypothetical protein, similar to GTPpyrophosphokinase Conserved hypothetical protein Conserved hypothetical protein Conserved hypothetical protein Hypothetical protein 3.06 4.19 Unknown - 3.40 - 2.01 - 2.04 50.92 -2.75 (-1.47; p= 0.316) -1.89 64.19 Unknown Unknown Unknown Unknown Conserved hypothetical protein Immunodominant antigen B Conserved hypothetical protein Conserved hypothetical protein - 5.09 - 1.50 - 4.30 - 2.05 - 5.01 - 2.38 - 3.74 - 1.97 Conserved hypothetical protein 3.46 3.65 Unknown Hypothetical protein, similar to RarD protein Conserved hypothetical protein - 3.32 - 2.16 -3.03 -1.77 Unknown Unknown Conserved hypothetical protein - 4.39 -4.15 Unknown Conserved hypothetical protein - 3.44 -2.72 Unknown Conserved hypothetical protein - 3.70 -2.91 Unknown Conserved hypothetical protein - 2.26 -2.14 Unknown Hypothetical protein Hypothetical protein Hypothetical protein 2.38 - 2.34 - 2.21 (1.63; p = 0.086) -1.95 (-2.25; p= 0.0506) Unknown Unknown Unknown 1.60 Unknown Unknown Unknown Unknown 10