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CURRICULUM VITAE MICHAEL JOSEPH BOYER 28 June 2017 1 CURRICULUM VITAE 28 June 2017 PERSONAL DATA Name: Michael Joseph Boyer Date of Birth: 27 Aug 1960 Place of Birth: Sydney, Australia. Address: Royal Prince Alfred Hospital, Missenden Rd Camperdown, NSW 2050 EMPLOYMENT 2007 – present Director of Suydney Cancer Centre, and Area Cancer Services, Sydney South West Area Health Service. Clinical Associate Professor, Department of Medicine, University of Sydney.Senior Staff Specialist, Department of Medical Oncology, Sydney Cancer Centre (Royal Prince Alfred and Concord Hospitals). 2005 -2007 Clinical Associate Professor, Department of Medicine, University of Sydney.Senior Staff Specialist and Area Head, Department of Medical Oncology, Sydney Cancer Centre (Royal Prince Alfred and Concord Hospitals).Area Director of Medical Oncology, Sydney South West Area Health Service 2001–2005: Clinical Associate Professor, Department of Medicine, University of Sydney.Senior Staff Specialist and Area Head, Department of Medical Oncology, Sydney Cancer Centre (Royal Prince Alfred and Concord Hospitals). 1995-2001: Clinical Senior lecturer, Department of Medicine, University of Sydney. Senior Staff Specialist and Area Head, Department of Medical Oncology, Sydney Cancer Centre (Royal Prince Alfred and Concord Hospitals).Visiting Medical Oncologist, Dubbo Base Hospital (until 1998) 1993-1995: Staff Specialist in Medical Oncology, Royal Prince Alfred Hospital, Sydney. Visiting Medical Oncologist, Dubbo Base Hospital Research Fellow and Clinical Fellow, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada. Recipient of Medica’ Research Council of Canada Research Fellowship. 1990-1993: 1989: Haematology Registrar, Royal Prince Alfred Hospital (6 months) and Radiation Oncology Registrar, Westmead Hospital (6 months) 1988: Medical Oncology Registrar, Royal Prince Alfred Hospital 2 1986-1987: Medical Registrar, Royal Prince Alfred Hospital 1985: Medical Resident, Royal Prince Alfred Hospital 1984: Intern, Royal Prince Alfred Hospital, Sydney, Australia. EDUCATION PhD, 1993, University of Toronto Fellow of The Royal Australasian College of Physicians, conferred December 1990. Specialty training in Medical Oncology, 1988-90. MB.BS. with First Class Honors, (Bachelor of Medicine , Bachelor of Surgery) 1984, University of Sydney. Prizes: Prize for Physiology 1980 Prize for Biochemistry 1980 School (primary & secondary) Sydney Grammar School, 1966-1978 Awards: School Prefect. Seventh in State of NSW in Higher School Certificate Examination COMMITTEES Member Radiotherapy Information Strategy Steering Committee (NSW Health) 1998. Member, National Health and Medical Research Council Working Party on Beam and Isotope Radiotherapy, 1993. Chairman COSA Lung Group 1994-6 Chairman, Program Committee, Clinical Oncological Society of Australia Annual Scientific Meeting 1995 Member of Program Committee, Genito-Urinary Oncology Group Scientific Meeting July 1997 Chairman, Scientific Committee (Oncology) International Congress of Chemotherapy, Sydney 1997 Member, Royal Prince Alfred Hospital Drug Committee, 1993 - 1999. Sydney Cancer Centre Management Committee 1995 - present Treasurer, Royal Australasian College of Physicians, 2000 – present Member, International Scientific Committee, 10th World Conference on Lung Cancer, Vancouver 2003. 3 Chairman, Scientific Advisory Committee, Australasian Lung Cancer Trials Group 2004 – present. MEMBERSHIP OF SOCIETIES Member of the Clinical Oncological Society of Australia Member of the American Society of Clinical Oncology Member of the American Association for Cancer Research Member of the Medical Oncology Group of Australia Member of the International Association for the Study of Lung Cancer Member of Australasian Lung Cancer Trials Group PEER REVIEWED GRANTS Boyer MJ, Butow PN, Dunn,SM. Why do cancer patients use alternative therapies. NSW Dept of Health, Customer Focus Unit, 1995. $9,700. Dunn SM, Butow PN, Boyer MJ. Improving communication in the cancer consultation: optimal strategies and empirical outcomes. PHDRC, 19967. $147,627. Cheung A, Boyer MJ. Tumour-specific generation of a cytotoxic agent by aminopeptidase antibody conjugates. Leo and Jenny Foundation. 1996. $50,000. Khadra M, Boyer MJ, Bishop JF. The development of 3D image analysis for the enhancement of prostate cancer diagnosis on transrectal ultrasound. Prostate Cancer Research Foundation 1997-98. $41,530 Viney R, Fulham M, King M, Boyer MJ, McCaughan B. Economic evaluation of positron emission tomography in management of non-small cell lung cancer. NHMRC 1999 - 2001. $284,121 Clark S, Sutherland R, Henshall S, Russell P, Horvath L, Boyer M, Lee CS et al. Methods to predict metastatic spread and responsiveness to chemotherapy in prostate cancer patients with hormonal resistant disease. Cancer Institute NSW 2005 – 2010 $3,750,000 Olver I, Toner G, Marshall V, Boyer M, Mauruff P. The effects of chemotherapy on cognitive function in patients with testicular cancer. NSW Cancer Council 2006 – 2008. $331,000 Davidson A, Boyer M, Fong K, Singhal N, McLachlan S, Stockler M. A randomised phase III trial of adding nitroglycerin to first line chemotherapy in advanced non-small cell lung cancer. NSW Cancer Council 2008 – 2009. $197,850 4 PUBLICATIONS Peer Reviewed Papers 1. Boyer MJ, Friedlander ML, Bannatyne P and Atkinson KH. Hypercalcaemia in association with mucinous adenocarcinoma of the ovary: a case report. Gynae Oncol, 1989; 35: 387-390. 2. Boyer MJ, Raghavan D, Harris PJ, et al. Lack of late toxicity in patients treated with cisplatin-containing combination chemotherapy for testicular cancer. J Clin Oncol, 1990; 8: 21-26. 3. Boyer MJ, Tattersall MHN. Diethylstilbestrol revisited in advanced breast cancer management. Medical and Pediatric Oncology, 1990; 18: 317-320. 4. Tannock IF, Boyer MJ, Karuri A, et al. Prospects for drugs exploiting lower tumor pH. In Dewey WC, Edington M, Fry RJM, Hall EJ, Whitmore GF (eds), Radiation Research: A twentieth century perspective. Academic Press, San Diego, 1992. 5. Celermajer DS, Boyer MJ, Bailey B, Tattersall MHN. Pericardiocentesis for symptomatic malignant pericardial effusion: a study of 36 patients. Med J Aust, 1991; 154: 19-22. 6. Stuart-Harris R, Boyer MJ, Greenberg M, Stevens S, Yung T. The histopathological classification of small cell lung cancer: application of the IASLC classification in124 cases. Lung Cancer, 1992; 8: 63-70. 7. Boyer MJ, Tannock IF. Regulation of intracellular pH in tumor cell lines; influence of microenvironmental conditions. Cancer Research, 1992; 52: 4441-4447. 8. Boyer MJ, Tannock IF. Lysosomes, lysosomal enzymes and cancer. Advances in Cancer Research, 1993; 60: 269-291. 9. Boyer MJ, Horn I, Steele-Norwood D, Firestone R, Tannock IF. pH dependent cell killing by acid activated detergents. British Journal of Cancer, 1993; 67: 81-87. 10.Deslile L, Boyer MJ, Warr D, et al. Ectopic adrenocorticotrophic syndrome and small cell carcinoma of the lung: assessment of clinical features, outcome and complications of chemotherapy. The Archives of Internal Medicine, 1993; 153: 746-752. 11.Boyer MJ, Barnard M, Hedley DW, Tannock IF. Regulation of intracellular pH in subpopulations of cells derived from spheroids and solid tumors. British Journal of Cancer, 1993 ; 68: 890-897 12.Clarke SJ, Boyer MJ. Recent advances in managing non-small-cell lung cancer: Chemotherapy of metastatic cancer. Med J Aust, 1997; 166 (Suppl): S14-S16. 5 13.Ellis P, Stockler M, Boyer MJ. The occurrence of germ cell malignancies in two patients positive for HIV. International Journal of STD and AIDS, 1997;8: 526-7 14.Herman SM, Robinson JTC, McCredie RJ, Adams MR, Boyer MJ, Celermajer DS. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arteriosclerosis, Thrombosis and Vascular Biology, 1997; 17: 2004-2009 15.Boyer MJ, Cox K, Tattersall MHN, Findlay MPN, Grygiel JJ, Rogers J. Active surveillance after orchidectomy for non-seminomatous germ cell tumours: late relapse may occur. Urology, 1997; 50: 588-92 16.Boyer MJ, Zalcberg J, Olver IN, Millward MJ, Richardson G, McKeage MJ. Phase I study of paclitaxel and oral etoposide in previously untreated non-small cell and extensive small cell lung cancer. Ann Oncol, 1997; 8: 485 - 489 17.Butow PN, Maclean M, Dunn SM, Tattersall MHN, Boyer MJ. The dynamics of change. Cancer patients’ preferences for information involvement and support. Ann Oncol, 1997; 8: 857-863 18.Boyer MJ. Bioreductive agents: a clinical update. Oncology Research, 1997; 9: 391395 19.Miller M, Boyer MJ, Butow PN, Gatellari M, Childs A, Dunn S. The use of unproven methods of treatment by cancer patients: frequency, expectations and cost. Supp Care Cancer, 1998; 6: 337 - 347 20.Brown R, Butow PN, Boyer MJ, Tattersall MHN. Promoting patient participation in the cancer consultation: evaluation of a prompt sheet and coaching in question asking. Br J Cancer, 1999; 80: 242 - 248 21.Yip D, Findlay M, Boyer M, Tattersall MH. Hepatocellular carcinoma in central Sydney: a 10-year review of patients seen in a medical oncology department. World Journal of Gastroenterology, 1999; 5: 483 – 487 22.von Pawel J, von Roemeling R, Gatzemeier U, Boyer M, Elisson LO, Clark P, et al. Tirapazamine Plus Cisplatin Versus Cisplatin in Advanced Non–Small-Cell Lung Cancer: A Report of the International CATAPULT I Study Group. J Clin Oncol, 2000; 18: 1351-1359. 23.Dowsett SM, Saul JL, Butow PN, Dunn SM, Boyer MJ, Findlow R, Dunsmore J. Communication styles in the cancer consultation: preferences for a patient-centred approach. Psycho-oncology, 2000; 9: 147 – 156. 24.Rischin D, Boyer M, Smith J, et al. A phase I trial of docetaxel and gemcitabine in patients with advanced cancer. Ann Oncol, 2000; 11: 421-426. 25.Klastersky J, Paesmans M, Rubenstein E, Boyer M, Elting L, Feld R, et al. The MASCC risk index: a multinational scoring system to predict low-risk febrile neutropennic cancer patients. J Clin Oncol, 2000; 18: 3038 – 3051. 6 26.Rischin D, Smith J, Millward M, Lewis C, Boyer M, Richardson G, Toner G, Gurney H, McKendrick J. A phase II trial of paclitaxel and epirubicin in advanced breast cancer. Br J Cancer, 2000; 83: 438 – 442. 27.Rivory LP, Slaviero K, Seale JP, Hoskins JM, Boyer M, Beale PJ, Millward MJ, Bishop JF, Clarke SJ. Optimising the erythromycin breath test for use in cancer patients. Clinical Cancer Research, 2000; 6: 3480 - 3485. 28.Horvath LG, McDowell D, Stevens G, Parkinson R, McCarthy S, Boyer MJ. Unusual presentations of germ cell tumors. J Clin Oncol, 2001; 19: 909-916 29.Boyer MJ, Mitchell P, Goldstein D, Millward MJ, Olver IN, Clarke SJ, Richardson G, Davis I. Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non-small cell lung cancer. Lung Cancer, 2001; 32: 89 - 94. 30.Toner G, Stockler MR, Boyer MJ, Jones M, Thompson DB, Harvey VJ, et al Comparison of two standard chemotherapy regimens for good-prognosis germ cell tumours: a randomised trial. Lancet, 2001; 357: 739 – 745. 31.Boyer MJ, Stockler MR. Testicular cancer management; we have to keep our eye on the ball. Med J Aust, 2001; 174: 320 – 321. 32.Horvath LG, Boyer MJ, Clarke SJ, Beale P, Beith J, Underhill C, Stockler M, Bishop J. Carboplatin and Vinorelbine in untreated locally advanced and metastatic non-small cell lung cancer. Lung Cancer, 2001; 32: 173 – 178. 33.Twelves C, Boyer M, Findlay M, Cassidy J, Weitzel C, Barker C, et al. Capecitabine improves medical resource use compared with 5-fluorouracil plus leucovorin in a phase III trial conducted in patients with advanced colorectal carcinoma. Eur J Cancer, 2001; 37: 597 – 604. 34.Boyer MJ. Diagnosis and management of testicular cancer. Current Therapeutics, 2001; 42: 25 – 29. 35.Van Cutsem E, Twelves C, Cassidy J, Allman D, Bajetta E, Boyer M, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol, 2001; 19: 4097 – 4106. 36.Rivory LP, Clarke SJ, Boyer M, Bishop JF. Highly sensitive analysis of the antifolate pemetrexed sodium, a new cancer agent, in human plasma and urine by highprtformance liquid chromatography. Journal of Chromatography B, 2001; 765: 135 – 140. 37.Horvath LG, McCaughan BC, Stockler M, Boyer MJ. Resection of residual pulmonary masses after chemotherapy in patients with metastatic non-seminomatous germ cell tumours. Internal Medicine Journal, 2002; 32: 79 – 83. 38.Clarke SJ, Abratt R, Goedhals L, Boyer MJ, Millward MJ, Ackland SP. Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapay mnaive patients with 7 advanced non-small-cell lung cancer (NSCLC). Ann Oncol, 2002; 13: 737 - 741. 39.Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favourable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol, 2002; 13: 566 – 575. 40.Boyer MJ, Rosenthal MA, Eisinger D, Goad J, Webb D, Stockler MR. Adjuvant mitoxantrone chemotherapy for men at high risk of relapse following radical prostatectomy: a pilot study. UroOncology, 2002; 2: 15 – 17. 41.Millward MJ, Boyer MJ, Lehnert M, et al. Docetaxel and carboplatin is an active regimen in advanced non-small cell lung cancer: a phase II study in Caucasian and Asian patients. Ann Oncol, 2003; 14: 449 – 454. 42.Advanced Bladder Cancer Meta-Analysis Collaboration. Neoadjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis. Lancet, 2003; 361: 1927 – 1934. (member of collaboration, and involved in drafting final paper). 43.Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, Gatzemeier U, Boyer M, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol, 2003; 21: 2636 – 2644. 44.Zhang M, Boyer M, Rivory L, et al. Radiosensitization of vinorelbine and gemcitabine in NCI-H460 non-small cell lung cancer cells. Int J Radiation Oncology Biol Phys, 2004; 58: 353 – 360. 45.Viney R, Boyer MJ, King MT, et al. A randomised controlled trial of the role of positron emission tomography in the management of Stage I and II non-small cell lung cancer. J Clin Oncol 2004; 22: 2357 – 2362. 46.Butow P, Devine R, Boyer M, et al. A cancer consultation preparation package: Changing patients but not doctors is not enough. J Clin Oncol 2004; 22: 4401 – 4409. 47.Vardy J, Engelhardt K, Jacquet J, McDade A, Boyer M, Beale P, et al. Long-term outcome of radiological-guided insertion of implanted central venous access port devices (CVAPD) for the delivery of chemotherapy in cancer patients: institutional experience and review of the literature. Br J Cancer 2004; 91: 1045 – 1049. 48.Sharma R, Boyer M, Clarke S, Millward M. Gefitinib in advanced non-small cell lung cancer. Internal Medicine Journal 2005; 35: 77 – 82. 49.Joshua A.M., Boyer M.J., Subramanian R. and Clarke S.J. Smoking reduction does work: Resulting alterations in the incidence and histological subtypes of lung cancer in New south wales in the last 20 years. Respirology 10;233-238, 2005 50.Boyer M. The importance of balancing toxicity and efficacy in chemotherapy: focus on pemetrexed. Am J Cancer 2005; 4: 127 – 136. 51.Joshua AM, Nordman I, Venkataswaran R, Clarke S, Stockler MR, Boyer MJ. Weekly docetaxel as second line treatment after mitozantrone for androgen-independent 8 prostate cancer. Internal Medicine Journal 2005; 35: 468 – 472. 52.Clarke SJ, Boyer MJ, Millward M, Underhill C, Moylan E, Yip D, et al. A phase I/II study of pemetrexed and vinorelbine in patients with non-small cell lung cancer. Lung Cancer 49(3):401-12, 2005 53. Stockler MR, Tattersall MHN., Boyer MJ., Clarke SJ., Beale P. and Simes RJ. Disarming the gurded prognosis: predicting survival in newly referred patients with incurable cancer. British Journal of Cancer 2006; 94: 208 – 212. 54. Abratt RP, Lee JS, Han JY, Tsai C-M, Boyer M, Mok T, et al. Phase II trial of gemcitabine-carboplatin-paclitaxel as neoadjuvant chemotherapy for operable nonsmall cell lung cancer. Journal of Thoracic Oncology 2006; 1: 135 – 140. 55. Soo RA, Wang LZ, Tham LS, Yong WP, Boyer M, Lim HL, et al. A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small cell lung cancer. Ann Oncol. 2006; 17: 1128 – 33. 56. Cebon J, Findlay M, Hargreaves C, Stockler M, Thompson P, Boyer M, et al. Somatostatin receptor expression, tumour response and quality of life in patients with advanced hepatocellular carcinoma treated with long-acting octreotide.Br J Cancer. 2007; 96: 1154 57. Findlay M, Storey D, Gebski V, Hargreaves C, Cullingford G, Boyer M, et al. A pilot study of preoperative and postoperative chemotherapy in patients with operable gastric cancer: Australasian Gastrointestinal Trials Group Study 9601. ANZ J Surg. 2007; 77: 247 – 52. 58. Yeo W, Boyer M, Chung HC, Ong SY, Lim R, Zee B, et al. Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicentre study by the Cancer Therapeutics Research Group. Cancer Chemother Pharmacol. 2007; 59: 295 – 300. 59. Oates JE, Clark JR, Read J, Reeves N, Gao K, Jackson M, Boyer M, O’Brien CJ. Prospective evaluation of quality of life and nutrition before and after treatment for nasopharyngeal cancer. Arch Otolaryngol Head Neck Surg 2007; 133: 533 – 540. 60. Chuah B, Lim R, Boyer M, Ong AB, Wong AW, Kong HL, et al. Multi-centre phase II trial of thalidomide in the treatment of unresectable hepatocellular carcinoma. Acta Oncologica. 2007; 46: 234 – 38. 61. Kenny PM, King MT, Viney RC, Boyer MJ, Pollicino CA, McLean JM, et al. Quality of life and survival in the 2 years after surgery for non-small cell lung cancer. J Clin Oncol 2008; 26: 233 – 241. 62. Vinod SK, O’Connell DL, Simonella L, Delaney GP, Boyer M, Peters M, et al. Gaps in optimal care for lung cancer. J Thoracic Oncol 2008; 3: 871 – 879. 63. Martin RC, Fulham M, Shannon K, Hughes C, Gao K, Milross M, Tin MM, Jackson M, Clifford A, Boyer MJ, O’Brien CJ. Accuracy of positron emission tomography in the 9 evaluation of patients treated with chemoradiotherapy for mucosal head and neck cancer. Head and Neck 2009; 31: 244 – 250. 64. Vardy J, Dadasovich R, Beale P, Boyer MJ, Clarke SJ. Eligibility of patients with advanced non-small cell lung cancer for phase III chemotherapy trials. BMC Cancer 2009; 9: 130. 65. Simonella L, O’Connell DL, Vinod SK, Delaney GP, Boyer M, Esmaili N, et al. No improvement in lung cancer care: the management of lung cancer in 1996 and 2002 in New South Wales. Intern Med J 2009 (in press) 66. Soon YY, Stockler MR, Askie L, Boyer MJ. Duration of chemotherapy for advanced nonsmall cell lung cancer: a systematic review and meta-analysis of randomized trials. J Clin Oncol 2009 (in press). 67. Pezaro C, Rosenthal MA, Gurney H, Davis ID, Underhill C, Boyer MJ, et al. An openlabel single arm phase two trial of gefitinib in patients with advanced or metastatic castration-resistant prostate cancer. Am J Clin Oncol 2009 (in press) Invited Papers 1. Tattersall MHN, Boyer MJ. The management of malignant pleural effusions. Thorax, 1990; 45: 81-82. 2. Raghavan D, Boyer MJ. Active surveillance for stage I non-seminomatous germ cell testis tumors: practice and pitfalls. Prog Clin Biol Res, 1990; 350: 309-318. 3. Tannock IF, Boyer MJ. When is a cancer treatment worthwhile? N Engl J Med, 1990; 323: 989-990. 4. Boyer MJ, Tannock IF. Commentary on "Drug resistance testing". Oncology, 1991; 5: 104. 5. Boyer MJ and Raghavan D. Toxicity of treatment of germ cell tumors. Sem. Oncol., 1992; 19: 128-142. 6. Boyer MJ, McGeer A, Feld,R. Recent advances in the management of infections in cancer patients. Crit Rev Oncol Hematol, 1993; 15: 175-190 7. Boyer MJ, Raghavan D. Long Term Morbidity of Treatment of Testicular Cancer. Problems in Urology, 1994; 8:154-166. 8. Boyer MJ, Hedley DW. Measurement of Intracellular pH. Methods In Cell Biology, 1994; 41: 135-148. 9. Boyer MJ. Management of prostate cancer. Australian Prescriber, 1996; 19: 22-24 10 10.Boyer MJ. The economics of lung cancer. Lung Cancer, 1996; 14: 13-17 11.Boyer MJ. Medical management of primary hepatocellular carcinoma. Australian Chinese Medical Association Journal, 1997; 2: 57-58. 12.Boyer MJ. New chemotherapeutic agents in the treatment of non-small cell lung cancer: the Australian experience. Chest, 1998; 113: S24 - S27. 13.Clarke S, Boyer M. Non-surgical therapy for patients with advanced non-small cell lung cancer. Respirology, 1998; 3: 175 - 182. 14.Boyer MJ. Testicular cancer: diagnosis and management. New Ethicals Journal, 2002; 5: 29 – 34 15.Boyer MJ, Clarke SJ. Current Management of Lung Cancer. Current Therapeutics, 2002; 43: 49 – 54. 16.Boyer MJ, Rivory LP, Clarke SJ. Pemetrexed: single agent and combination phase I study overview. Semin Oncol, 2002; 29, Suppl 18: 18 – 23. 17.Boyer M, Byrne M, Clarke S. Alimta: a new treatment option for malignant mesothelioma. Reviews in Clinical Oncology, 2003; 1: 4 – 8. 18.Boyer MJ. Drug therapy of lung cancer. Aust Prescr, 2003; 26: 103 – 105. 19.van Meerbeeck JP, Boyer M. Consensus report: pre-treatment minimal staging and treatment of potentially resectable malignant pleural mesothelioma. Lung Cancer 2005; 49S1: S123 – S127. Book Chapters 1. Raghavan D, Boyer MJ. Extragonadal germ cell tumours. In Testicular Cancer.,pages 297-317. Chapman and Hall, 1991. Horwich A (ed), 2. Boyer MJ, Raghavan D. Extragonadal germ cell tumours. In The Oxford Textbook of Oncology, 1995; 1439-1449. 3. Boyer MJ, Roth B. Side effects of treatment for testicular cancer. In Raghavan D, Scher HI, Liebel S, Lange P eds, Principles and Practice of Genitourinary Oncology, 1997; 741-749. 4. Raghavan D, Boyer MJ. Extragonadal germ cell tumours. In Horwich A(ed), Testicular Cancer. 2nd edition Chapman and Hall, 1996; 345-368. 5. Boyer MJ. Medical Oncology. In Kearsley JH, Morris DL, Williams CJ (eds), Cancer A Comprehensive Clinical Guide, pages 47 - 56. 1998 Harwood Academic Publishers, Amsterdam. 11 6. Boyer MJ, Tannock IF. Cellular and molecular basis of chemotherapy. In Tannock IF, Hill R (eds), The Basic Science of Oncology. 2nd Edition, 1998. McGraw Hill, New York. 7. Boyer M, Jackson M. Cancers of the Urogenital Tract: Systemic and Radiation Treatment. In Bishop JF (ed) Cancer Facts: a concise oncology text, pages 209 - 213. 1999 Harwood Academic Publishers, Amsterdam. 8. Boyer M. Non-Small Cell Lung Cancer: Chemotherapy. In Bishop JF (ed) Cancer Facts: a concise oncology text, pages 118 - 120. 1999 Harwood Academic Publishers, Amsterdam. 9. Boyer MJ, MacLeod C. Small cell carcinoma of the lung. In Harnett P, Cartmill J, Glare P (eds) Oncology: A case based manual, pages 78 – 81, 1999. Oxford University Press, Oxford. 10.Boyer MJ, MacLeod C. Non-small cell lung cancer. In Harnett P, Cartmill J, Glare P (eds) Oncology: A case based manual, pages 81 – 85, 1999. Oxford University Press, Oxford. 11.Boyer MJ and Raghavan D. Extragonadal germ cell tumours. In Souhami RL, Tannock, I, Hohenberger P, Horiot J-C (eds) Oxford Textbook of Oncology 2nd edition, pages 2037 – 2045. Oxford University Press, Oxford 2002. 12.Boyer MJ. Pleural and pericardial effusions. In Fisch MJ & Bruera E (eds) Handbook of Advanced Cancer Care, pages 481 – 487. Cambridge University Press, Cambridge 2003. 13.Horvath L, Boyer MJ. Acute Toxicity of Chemotherapy. In Raghavan D (ed) Germ Cell Tumors, pages 340 – 348. BC Decker Inc, Hamilton 2003 LETTERS 1. Viney RC, Fulham MJ, McCaughan BC, Boyer MJ, Hall JP. Evaluation of the role of positron emission tomography in oncology. Med J Aust, 2000; 172: 459 – 460. ABSTRACTS 1. Boyer MJ and Tattersall MHN. Diethylstilbestrol in advanced breast cancer. Proceedings of the Clinical Oncological Society of Australia 1988. 2. Boyer MJ and Raghavan D. Intensive late toxicity assessment program (LTAP) for patients treated for metastatic germ cell tumours with cisplatin-containing combination chemotherapy. Proc. Amer. Soc. Clin. Oncol., 1989. 3. Boyer MJ, Raghavan D, et al. Pre-emptive intravenous CMV for high grade stage T2 - T4 TCC of bladder. Proceedings of the Clinical Oncological Society of Australia 1989. 12 4. Boyer MJ, Firestone R, Tannock IF. Release of lysosomal enzymes into cytoplasm as a potential mechanism for pH dependent cell killing in tumors. Proc Amer Assoc. Cancer. Res, 1991. 5. Boyer MJ, Tannock IF. Intracellular pH regulation in hypoxic MGH U1 bladder carcinoma cells. Proceedings of the 4th International Meeting on Hypoxia Research, 1991. 6. Boyer MJ, Feld R, Warr D, et al. LDH alone does not predict relapse of small cell lung cancer (SCLC). Proc Amer Assoc. Cancer. Res, 1992. 7. Boyer MJ, Cox K, McNeil E. Active surveillance for non-seminomatous germ cell tumours: late relapse may occur. Proc COSA, 1994, 127. 8. Boyer MJ, Doubrovsky A, Coates AS. Melphalan enhances the cytotoxicity of tirapazamine under hypoxic but not aerobic conditions. Proc Amer Assoc. Cancer. Res., 1995. 9. Miller MJ, Boyer MJ, Dunn SM, Butow PN, Griffin AM. Why do Australian cancer patients use unproven therapies? Proc COSA, 1995, 63. 10. Visvanathan K, McNeil E, Boyer MJ. Changing pattern of admissions in small cell lung cancer patients treated at Royal Prince Alfred Hospital 1985 - 1992. Proc COSA, 1995, 117. 11. Findlay M, M Fulham, D Lord, D Storey, J Thompson, M Boyer, S Clarke, J Bishop. Assessment Of Tumour Response With [18F]Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) In Phase I/II Drug Studies. Proceedings of the New Zealand Society for Oncology Scientific Meeting, 1996, 23 12. Boyer M, Olver I, Millward M, Zalcberg J, Richardson G, McKeage M, Joughin J. Phase I study of two schedules of taxol and oral etoposide in patients with small cell or non-small cell lung cancer. Proc ASCO, 1996; 15: 1177 13. Herman SM, Robinson JTC, McCredie RJ, Adams MR, Boyer MJ, Celermajer DS. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. ANZ J Med, 1997; 27: 91 14. Boyer M, Olver I, Millward M, Zalcberg J, Richardson G, McKeage M, Joughin J. Phase I/II trial of paclitaxel and oral etoposide in patients with small cell or non-small cell lung cancer. Lung Cancer, 1997; 18: 169 15. Clarke S, Boyer M, Millward M, Findlay M, Ackland S, Childs A, Brew S, Walcher V, Watt D, Thornton D. Phase II study of LY231514 in patients with advanced nonsmall cell lung cancer. Lung Cancer, 1997; 18: 34 16. Clarke S, Boyer M, Millward M, Findlay M, Ackland S, Childs A, Brew S, Walcher V, Watt D, Campbell L. Multi-targeted antifolate MTA (LY231514): an active agent in advanced non-small cell lung cancer. Proc Amer Soc Clin Oncol, 1998; 17: 1793 13 17. Boyer MJ, Zalcberg J, Clarke SJ, Millward MJ, Olver IN, Mitchell P, Richardson G, Goldstein D. Phase II trial of taxol and oral etoposide in patients with advanced nonsmall cell lung cancer. Proc Amer Soc Clin Oncol, 1998; 17: 1840 18. Findlay M, Clarke SJ, Boyer MJ, Sullivan A, Dugan M, Statkevich P, Reyderman L, Teriana N, Cox K. Temodal (temozolamide) in patients with hepatocellular carcinoma, cirrhosis and portal hypertension: a phase II / pharmacokinetic study. Proc Amer Soc Clin Oncol, 1998; 17: 923 19. Millward MJ, Bishop J, Lehnert M, Boyer M, et al. Phase II trial of docetaxel and carboplatin in advanced non-small cell lung cancer. Proc Amer Soc Clin Oncol, 1999; 18: 1994 20. Boyer MJ, Rischin D, Millward MJ, et al. Phase I study of gemcitabine and docetaxel in patients with advanced cancer. Proc Amer Soc Clin Oncol, 1999; 18: 785 21. Boyer MJ, Rosenthal MA, Eisinger D, et al. Pilot study of adjuvant mitoxantrone in patients at high risk of relapse following radical prostatectomy for prostate cancer. Proc Amer Soc Clin Oncol, 2000; 19: 1439 22. Gurney H, Boyer MJ, Millward MJ et al. Phase II study of mitoxantrone, carboplatin and prednisolone in patients with hormone refractory prostate cancer. Proc Amer Soc Clin Oncol, 2000; 19: 1455 23. Stockler M, Boyer MJ, Millward M, etr al. Ratings and importance of specific aspects of health related quality of life in advanced hormone resistant prostate cancer. Proc Amer Soc Clin Oncol, 2000; 19: 1467 24. Viney R, Fulham MJ, McCaughan BC, Boyer MJ, et al. Whole body FDG-PET in apparently resectable NSCLC: outline and design of the first randomised controlled trial of FDG-PET in NSCLC. Lung Cancer, 2000; 29 (Suppl 1): 868 25. Boyer MJ, Viney R, Fulham M, et al. A randomised trial of conventional staging (CS) with or without positron emission tomography (PET) in patients (pts) with stage 1 or 2 non-small cell lung cancer (NSCLC). Proc Amer Soc Clin Oncol, 2001; 20; 1233 26. Millward M, Clarke S, Beale P, Boyer M, et al. Phase I trial of pemetrexed (Alimtatm) and vinorelbine in patients (pts) with advanced cancer. Proc Amer Soc Clin Oncol, 2001; 20; 2102 27. Findlay MP, Ackland S, Gebski V, Yuen J, Boyer MJ, et al. Phase II study of irinotecan, leucovorin and 5FU (ILF) in advanced gastric cancer. Proc Amer Soc Clin Oncol, 2001; 20; 655 28. Kong HL, Boyer MJ, Lim R, Clarke S, Millward MJ, Wong JEL. Phase II trial of thalidomide in unresectable hepatocellular carcinoma (HCC)—a cancer therapeutics research group (CTRG) study. Proc Amer Soc Clin Oncol, 2001; 20; 2282 29. Rivory LP, Slaviero KA, Seale P, Dunleavey R, Gurney H, Boyer M, et al. Prognostic inflammatory and nutritional index (PINI) correlates with hepatic drug metabolism in 14 cancer patients. Proc Amer Soc Clin Oncol, 2001; 20; 444 30. Vogelzang NJ, Rusthoven J, Paoletti P, Denham C, Kaukel E, Ruffie P, Gatzmeier U, Boyer MJ, et al. Phase III single blinded study of pemetrexed + cisplatin vs. cisplatin alone in chemonaive patients with malignant pleural mesothelioma. Proc Amer Soc Clin Oncol, 2002; 21; 5 31. Slaviero K, Rivory LP, McLachlan A, Beale PJ, Sullivan A, Boyer MJ et al. Pharmacokinetic-pharmacodynamic relationships of weekly docetaxel therapy. Proc Amer Soc Clin Oncol, 2002; 21: 354. 32. Boyer MJ, Moore M, Leichman L, et al. Phase II study of the novel taxane BMS 184476 in previously treated patients with advanced adenocarcinoma involving the stomach or gastroesophageal junction. Proc Amer Soc Clin Oncol, 2002; 21: 591. 33. Cullingford G, Findlay M, Storey D, Boyer MJ, et al. A phase II feasibility study of pre-operative and post-operative chemotherapy in patients with advanced but operable gastric cancer: an Australasian Gastro-Intestinal Trials Group study. Proc Amer Soc Clin Oncol, 2002; 21: 695. 34. Stockler MR, Toner GC, Lewis C, Craft PS, Boyer MJ, et al. Health related quality of life in a randomised trial of two standard chemotherapy regimens for good prognosis germ cell tumours: the ANZ germ cell trials group good prognosis trial. Proc Amer Soc Clin Oncol, 2002; 21: 743. 35. Featherstone CJ, Beale PJ, Fife K, Shakespeare T, Bishop JF, Stockler MR, Jackson M, Boyer MJ. Phase I study of gemcitabine, vinorelbine, and radiotherapy in stage 3B or mediaclly inoperable stage 1 – 3A non-small cell lung cancer. Proc Amer Soc Clin Oncol, 2002; 21: 1339. 36. Boyer MJ, Clarke S, Millward MJ, et al. Phase I trial of pemetrexed and vinorelbine in patients with advanced or metastatic cancer. Ann Oncol, 2002; 13 Supp 5: 24 37. Joshua AM, Ong S, Noney L,Millward M, Beale P, Clarke SJ, Beith J, Kelly G, Boyer MJ. Phase 1 dose-escalation study of phenoxodiol in patients with advanced cancer. Proc Amer Soc Clin Oncol, 2003; 22: 902. 38. Millward M, Parnis F, Byrne M, Powell A, Dunleavey R, Lynch K, Boyer MJ. Phase II trial of imatinib mesylate in patients with advanced pleural mesothelioma. Proc Amer Soc Clin Oncol, 2003; 22: 912. 39. Leung TW, Mo F, Leow CK, Kpng HL, Boyer MJ, et al. Multicenter validation of the Chinese University Prognostic Index for hepatocellular carcinoma. Proc Amer Soc Clin Oncol, 2003; 22: 1040. 40. Cebon JS, Findlay M, Hargreaves C, Stockler M, Thompson P, Boyer MJ, et al. Somatostatin receptor expression and clinical effects of octreotide LAR in patients with advanced hepatocellular carcinoma. Proc Amer Soc Clin Oncol, 2003; 22: 1163. 41. Boyer MJ, Gurney H, Rosenthal MA, et al. Randomised phase II study of gemcitabine 15 with either carboplatin or docetaxel in patients with locally advanced or metastatic transitional cell carcinoma of the urothelium. Proc Amer Soc Clin Oncol, 2003; 22: 1568. 42. Rosenthal MA, Toner GC, Gurney H, Davis ID, Underhill C, Boyer MJ, et al. Inhibition of the epidermal growth factor receptor in hormone refractory prostate cancer: initial results of a phase II study of gefitinib. Proc Amer Soc Clin Oncol, 2003; 22: 1671. 43. Butow PN, Devine R, Tattersall MHN, Boyer MJ, et al. Preparing patients for oncology consultations: a randomised controlled trial of patient activation materials. Proc Amer Soc Clin Oncol, 2003; 22: 2109. 44. Gralla RJ, Hollen PJ, Liepa AM, Symanowski JT, Boyer MJ, et al. Improving quality of life in patients with malignant pleural mesothelioma: results of the randomised pemetrexed + cisplatin vs. cisplatin trial using the LCSS-meso. Proc Amer Soc Clin Oncol, 2003; 22: 2496. 45. Vogelzang NJ, Emri S, Boyer MJ, et al. Effect of folic acid and vitamin B12 supplementation on risk benefit ratio from phase III study of pemetrexed + cisplatin versus cisplatin in malignant pleural mesothelioma. Proc Amer Soc Clin Oncol, 2003; 22: 2644. 46. Vardy JL, Boyer MJ, Beale P, Barnes D, Clarke SJ. Patients in advanced non-small cell lung cancer chemotherapy trials are not representative of the general lung cancer population. Proc Amer Soc Clin Oncol, 2003; 22: 2668. 47. Beale PJ, Stockler MR, Tattersall MHN, Boyer MJ, Clarke SJ. Improving predictions and discussion of survival time in people with incurable cancer: making the prognosis less guarded. Proc Amer Soc Clin Oncol, 2003; 22: 3035. 48. Boyer MJ, Jassem J, Liepa AM, et al. Symptom and quality of life advantages for pemetrexed + cisplatin versus cisplatin in treatment of malignant pleural mesothelioma. Lung Cancer, 2003; 41: S19. 49. Boyer MJ. PET scanning for operable non-small cell lung cancer. Lung Cancer, 2003; 41: S15 INVITED PRESENTATIONS The Tumour Microenvironment; Biology and Therapeutic Potential. Oncology Grand Rounds, Prince of Wales Hospital, 18th February 1994. Advances in Prostate Cancer. NSW Palliative Care Symposium, Sydney, 11th March 1994. Can we believe what we read? A critical perspective of clinical trials in oncology. New Zealand Society for Oncology Jubilee Conference, February 13th - 16th 1996 (delivered for Ian Tannock). 16 Acidity in tumours: pH regulation and the potential for therapeutic exploitation. New Zealand Society for Oncology Jubilee Conference, February 13th - 16th 1996 (delivered for Ian Tannock). New chemotherapeutic agents in the treatment of non-small cell lung cancer: Australian experience. International Symposium on Thoracic Malignancies, Pittsburgh, April 25th 26th 1996. New drugs for the treatment of lung cancer. University of Sydney Oncology Symposium, Terrigal, August 10th - 11th 1996. Tirapazamine, a novel hypoxic cytotoxin: preclinical rationale and clinical results in combination with radiation therapy or chemotherapy. 3rd International Conference of the Asian Clinical Oncology Society, Kunming, August 15th - 17th 1996. Bioreductive agents: a clinical update. 2nd International Conference on Redox Processes and Cancer, Banff, April 7th - 10th 1997. Prostate and Testicular Cancer. Mens Health Update, Liverpool Hospital April 29th 1997. Small Cell Lung Cancer. Asta Medica Lung Cancer Symposium, Sydney, June 4th 1997. Chemotherapy for metastatic prostate cancer. Inaugural National Meeting of the Genitourinary Oncology Group, Leura, July 25th - 27th. The Management of Stage III Non-Small Cell Lung Cancer. Medical Oncology Group of Australia Annual Meeting, Hamilton Island, September 5th - 7th 1997. Recent Advances in the Management of Non Small Cell Lung Cancer. Satellite Symposium, 4th National Cancer Conference, Bangkok, Thailand, November 11 1997. The Management of Stage IIIA Non-Small Cell Lung Cancer. Royal Australasian College of Surgeons Annual Scientific Meeting, Sydney May 1998 Neoadjuvant and Adjuvant hormonal therapy for prostate cancer. Medical Oncology Group of Australia Annual Meeting, Queenstown, August 12th –16th 1998. Induction Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer. Clinical Oncological Society of Australia Annual Scientific Meeting, Sydney, November 25th – 27th 1998. Update on the management of testicular cancer. Royal Prince Alfred Hospital Grand Rounds. July 1999. Testicular Cancer. Society of Neuromuscular Sciences Annual meeting, Thredbo, August 12th – 13th 1999. Lung Cancer. Society of Neuromuscular Sciences Annual meeting, Thredbo, August 12th – 17 13th 1999. Cancer Biology and The Promise of New Cancer Treatments. Society of Neuromuscular Sciences Annual meeting, Thredbo, August 12th – 13th 1999. New Drugs in the Treatment of Cancer. Chinese Society of Clinical Oncology 3rd Annual Meeting, Dalian, 3rd – 6th October 1999. New Treatments for Breast Carcinoma. The Hong Kong Society of Radiation Therapy and Oncology, Hong Kong, 7th October 1999. Advances in the Chemotherapy of Bladder Cancer. Eli Lilly Regional Medical Conference, Singapore, March 4th – 5th 2000. Role of PET scanning in Urological Tumours. Conjoint meeting of the Genito-Urinary Oncology Group and the Urological Society of Australia. Sydney, 24th March 2000. New Chemotherapeutic Agents for Bladder Cancer. Phillipine Urological Society, Manila, June 9th 2000. The treatment of non-small cell lung cancer in Australia. BMS Oncology Education Weekend. Sydney, June 17th 2000. Chemotherapy for Bladder Cancer. Eli Lilly Regional Medical Conference, Couran Cove, October 27th – 28th 2000. New chemotherapeutic agents for the management of advanced bladder cancer. Urological Society of India Annual Scientific Meeting, Nagpur, India. January 19th 2001. Systemic Therapy for Germ Cell Tumours. Best Practice Workshop in Urological Cancer. Genito Urinary Oncology Group, Sydney June 22nd – 24th 2001. The role of PET scanning in lung cancer management. New England Journal of Medicine Symposium on Lung Cancer, at the Thoracic Society of Australia and New Zealand Annual Scientific Meeting. Cairns 24th – 27th March 2002. Cancer: Past Present and Future. Practical Points in Oncology Conference, Chiang Mai University, Chaing Mai, Thailand. 10th July 2002. Should we give 2nd or 3rd line chemotherapy for Non-Small Cell Lung Cancer. Medical Oncology Group of Australia Annual Meeting. Barossa Valley 14th – 17th August 2002. Current Chemotherapy for Stage IV Non Small Cell Lung Cancer. Medical Oncology Group of Australia Annual Meeting. Barossa Valley 14th – 17th August 2002. Lung Cancer Research Update. Astra Zeneca Weekend Oncology Workshop, Melbourne 7th – 8th September 2002 Chemo-radiotherapy for locally advanced non-small cell lung cancer: data and 18 controversies. Eli Lilly Regional Medical Conference Bangkok, Thailand. 22nd - 23rd February 2003 Australian trials in lung cancer. 4th International Conference on Lung Cancer. Maui, Hawaii, USA. 25th – 28th June 2003. Will novel targeted therapies benefit lung cancer patients. Satellite Symposium, 10th World Conference on Lung Cancer, Vancouver, Canada. 10th August 2003. PET scanning for operable lung cancer. 10th World Conference on Lung Cancer, Vancouver, Canada. 10th – 15th August 2003. Communication in oncology. Grand Rounds, Royal Melbourne Hospital. 23rd October 2003. Induction chemotherapy for stage 1 – 3 non-small cell lung cancer. 8th Asia Pacific Society for Respirology meeting, Kuala Lumpur, Malaysia. 1st – 4th December 2003. Current management of small cell lung cancer. 8th Asia Pacific Society for Respirology meeting, Kuala Lumpur, Malaysia. 1st – 4th December 2003. Update on EGFR inhibition in Cancer treatment. 9th Taiwan Joint Cancer Conference, Astra Zeneca Satellite Symposium. Taipei, Taiwan. May 2nd 2004. The promise of combination therapy of Alimta with Gemzar or other agents. Eli lilly Global medical Conference, New Orleans, USA. 3rd – 4th June 2004. Non-Small Cell Lung Cancer, Chemotherapy II. Invited discussant. ASCO annual meeting, New Orleans, USA. June 5th - 8th 2004. Pemetrexed for Mesothelioma. Eli Lilly Global Medical Conference, Orlando, USA. May 13th 2005. Clinical Cancer Research in Australia. 18th APCC meeting, Seoul, South Korea September 7th – 9th 2005. Multimodality Treatment of Cancer. Postgraduate Course in Oncology, Universiti Sains Malaysia, Kota Bahru, Malaysia. September 29th – October 1st 2005 Chemotherapy for Small Cell and Non-Small Cell Lung Cancer. Postgraduate Course in Oncology, Universiti Sains Malaysia, Kota Bahru, Malaysia. September 29th – October 1st 2005. Integrating Chemotherapy and Novel Therapies in Cancer Management. Postgraduate Course in Oncology, Universiti Sains Malaysia, Kota Bahru, Malaysia. September 29th – October 1st 2005. Future Multidisciplinary Lung Cancer Research. Australian Lung Cancer Conference, Palm Cove , July 2nd 2006. 19 Innovations in the Treatment of Mesothelioma. First Asian Perspectives in Lung Cancer Meeting. Shanghai, August 5th 2006. Combined Modality Treatment Using Targeted Therapies. Chinese Society of Clinical Oncology Annual Meeting, Beijing, September 16th 2006. How Oncologists Use Clinical trial Results. Statistical Society of Australia “Challenges of Running Oncology Clinical Trials Workshop”. Sydney October 27th 2006 Systemic Treatment for Mesothelioma. Education Session 12th World Conference on Lung Cancer, Seoul, South Korea, 3rd September 2007 Lung Cancer. CanRevive (Chinese Community Cancer Support Service) Annual Meeting, Sydney, October 12th 2007 Treatment of Mesothelioma. Lilly Oncology Weekend Symposium, Sydney, October 13th 2007 Controversies in the Management of Stage 3 Non-Small Cell Lung Cancer. Singapore Society of Oncology, 2nd Annual Review Course, Singapore 25th January, 2008 New Therapeutic Approaches for Advanced non-Small Cell Lung Cancer. Singapore Society of Oncology, 2nd Annual Review Course, Singapore 25th January, 2008 Systemic Treatment for Non-Melanoma Skin Cancer. Invited Speaker, Annual Scientific meeting of the Clinical Oncological Society of Australia, Sydney, November 19th 2008 Epidermal Growth Factor Receptor Inhibitors. Invited speaker 13th World Conference on Lung Cancer, to be held August 2009, San Francisco 20