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Title
Fundamental Chemical and Molecular Sciences
Code
CF102 now changed to CH112
Level
4
Credit rating
10 credits
Type
Compulsory for Pharmaceutical and Chemical Sciences and
MPharm, optional for other courses
Pre-requisites
Introduction to Chemical and Molecular Sciences
Aims
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Learning outcomes
At the end of the module the students should be able to:
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Content
To extend the introduction to chemical and molecular sciences.
To establish basic principles of chemical and molecular sciences
across a broad front.
To prepare students to study chemical and/or molecular sciences
at level two, particularly subjects that are underpinned by
chemistry such as Pharmacy and Pharmaceutical Science.
To increase students' appreciation of the chemical underpinning
of medical and pharmaceutical sciences by using examples of
drugs and hormone chemistry.
demonstrate knowledge of different types of atomic, ionic, and
molecular interactions and use this knowledge to predict
chemical properties.
understand the basic principles of solid state chemistry.
provide IUPAC names of simple organic molecules including
selected drug molecules.
describe carboxylic acids, carboxylic acid derivatives and
sulphonic acid derivatives.
solve simple problems involving the reactivities of the above
organic functional groups.
relate SN1 and SN2 reaction mechanisms to energetics and
stereochemistry.
understand nmr spectra of very simple organic molecules and
drugs.
understand basic theory and practice in chemical kinetics.
understand and use the simple equations for zero, first and
second order reactions.
solve problems that involve using the Arrhenius equation.
demonstrate a basic knowledge about mechanisms of complex
chemical reactions including catalytic mechanisms.
Organic Chemistry (normally 19 hours)
Brief introduction to sulphonic acid derivatives, reactions and
mechanisms (including curly arrows and where appropriate energy
diagrams, kinetic aspects) for alkyl halides (SN1, SN2, E1, E2,
Grignard), alcohols, amines; formation and hydrolysis of carboxylic
acid derivatives and acetals, NMR, reactivity of the allyl halides,
stability and reactivity of organic molecules, pKa of carboxylic acids
and amines and consequences.
1
Inorganic Chemistry (normally 9 hours)
Atomic and molecular structure - wave mechanical model of the
atom, description of atomic orbitals, molecular orbitals and bonding,
solid state chemistry, packing, radius ratio, crystal lattices.
Physical Chemistry (normally 11 hours)
Introduction to formal chemical kinetics: reaction rates and calculus
description; rate constants; rate expressions; molecularity and order of
chemical reaction; mechanism of chemical reaction; rate determining
step; kinetic and thermodynamic control; diffusion controlled processes;
Arrhenius equation; experimental determination of activation energy
and pre-exponential factor; consecutive and concurrent reactions.
Examples of different mechanisms of complex chemical reactions: chain
reactions; photochemical reactions; homogeneous catalysis;
autocatalysis. Introduction to modern theory of chemical kinetics:
collision theory; reaction co-ordinate, activated complex and transition
state (theory of absolute reaction rates).
Teaching and learning
strategies
100 hours in total, comprising normally 38 hours contact time,
32 hours guided study and 30 hours independent study and
assessment time.
Learning support
Organic Chemistry, Vollhardt and Schore, 3rd Edition, Freeman, 1999
Physical Chemistry, Atkins, 7th Edition, OUP, 2002
Inorganic Chemistry, Shriver and Atkins, 3rd Edition, OUP, 1999
Assessment
One MCQ phase test (40%)and an end of module MCQ exam (60%)
Brief description of module
Completes the introduction to chemical and molecular sciences and
provides sufficient depth to allow students to study chemistry and related
molecular sciences such as pharmacy and biomedical sciences at level 2.
Area Examination Board
Chemistry
Module authors
Dr Peter Cragg
Semester offered
2
Date of first approval
8 May 2002
Date of approval of this
version
8 May 2002
Version number
1
Replacement for previous
module
CH109 and PY228
Courses for which module
is acceptable
Compulsory for PCS, MPharm
Optional for other courses
School home
Pharmacy and Biomolecular Sciences
External examiner
Dr P Finch
2