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Online Appendix for the following JACC article TITLE: Coronary Stents: Part 2—Looking Forward AUTHORS: Scot Garg, MB, ChB, Patrick W. Serruys, MD, PhD Appendix 1 Trial Acronyms Trial Acronym Trial ABSORB A bioresorbable everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions ATLANTA Assessment of The Latest Non-Thrombogenic Angioplasty stent CARE Cardiomind Sparrow DES Trials Reference (112-114,125) (85,88,90) (169) COSTAR Cobalt Chromium Stent With Anti-proliferative for Restenosis (46,48) CREATE Multi-Center Registry of Excel Biodegradable Polymer Drug Eluting Stents (27) CUSTOM XTENT studies (33,34) DEBIUT Drug Eluting Balloon in Bifurcation Trial (194,197) DESIRE Double versus Single balloon stent delivery systems for bifurcation lesions (149) DIVERGE Drug Eluting Stent Intervention for Treating Side Branches Effectively (32) EuroSTAR The European cobalt Stent with Anti-proliferative for Restenosis trial (47) EVOLVE Randomised comparison of the standard and low dose SYNERGY everolimus eluting stent with the PROMUS (35) Element stent. EXCELLA Elixir Medical Clinical Evaluation of the Novolimus-Eluting Coronary Stent System (14,15,23) HEALING-II Healthy Endothelial Accelerated Lining Inhibits Neointimal Growth ISAR-TEST Intracoronary Stenting and Angiographic Restenosis–Test Equivalence Between 2 Drug-Eluting Stents ISAR-TEST 2 Intracoronary Stenting and Angiographic Restenosis – Test Efficacy of Three Limus Eluting Stents ISAR-TEST 3 Intracoronary Stenting and Angiographic Restenosis Investigators – Test Efficacy of Rapamycin-eluting Stents (97-99) (65) (82,83) (80,81) with Different Polymer Coating Strategies JACTAX Juxtaposed Abluminal Coating TAXUS stent study LEADERS Limus Eluted from A Durable versus Erodable Stent coating NEVO-RES NEVO RES-ELUTION NOBORI NOBORI stent trials OCTDESI The Optical Coherence Tomography Drug Eluting Stent Investigation (41) (29,30) (28) (31,51,54) (57) OPEN Stentys coronary bifurcation stent system for the Percutaneous Treatment of de novo lesions in native bifurcated (160,161) coronary arteries (186,187) PACCOCATH ISR Paclitaxel-Coated Balloon Catheter for In-Stent Restenosis PAINT Percutaneous Intervention with biodegradable-polymer based paclitaxel-eluting, sirolimus-eluting, or bare stents for (39) the treatment of de novo coronary lesions PEPCAD Paclitaxel-Eluting PTCA-Balloon Catheter in Coronary Artery Disease PERSEUS A Prospective Evaluation in a Randomized Trial of the Safety and Efficacy of the Use of the TAXUS Element Paclitaxel-Eluting Coronary Stent System for the Treatment of De Novo Coronary Artery Lesions (188-190,193,195) (16,17) PICCOLETO Paclitaxel-eluting balloon versus paclitaxel-eluting stent in small coronary vessel disease PISCES The Paclitaxel In-Stent Controlled Elution Study PLATINUM A Prospective, Randomized, Multicenter Trial to Assess an Everolimus-Eluting Coronary Stent System [PROMUS (191) (45) (35) Element] for the Treatment of up to Two De Novo Coronary Artery Lesions PROGRESS AMS Clinical Performance and Angiographic Results in Absorbable Metal Stents study REMEDEE Randomized Evaluation of an Abluminal sirolimus coated Bio-Engineered Stent RESOLUTE Evaluation of the new generation zotarolimus-eluting coronary stent system (116,140) (37) (13,18,20-22) RESORB REVA Endovascular Study of a Bioresorbable Coronary Stent (36) SECRITT Santorini Criteria for Investigating and Treating Thin Capped Fibroatheroma Trial (167) SERIES Study of the Supralimus® Sirolimus Eluting Stent in the treatment of patients with real world coronary artery (26,44) lesions SIMPLE Safety and Efficacy of the Infinnium Paclitaxel-Eluting Stent (40) TIDE Randomized Trial Comparing Titan vs. Endeavor-stents. (94) TiNOX TITAX-AMI Randomized Comparison of a Titanium-Nitride-Oxide–Coated Stent With a Stainless Steel Stent for Coronary (86,91) Revascularization A Prospective, Randomized Trial Comparing TITAN-2® Stent and TAXUS-Liberte® Stent in Acute Myocardial (92,93) Infarction TOP TMI Ostial Preservation (148) (87,100) TRIAS-HR TRI-stent Adjudication Study VESTASYNC Hydroxyapatite Polymer-Free Sirolimus-Eluting Stent for the Treatment of Single De Novo Coronary Lesions (115) WHISPER FIM study of the IDEAL Poly (Anhydride Ester) Salicylic acid stent Please refer the paper’s reference list. Appendix 2 Devices and Manufacturers Device (64,78) Manufacturer Adsorbable Metal Stent (AMS) Biotronik, Berlin, Germany Amazonia PAX Minvasys, Genevilliers, France Antares TriReme Medical Inc., Pleasanton, CA, USA Axxess Devax, Lake Forest, CA, USA BioFREEDOM Biosensors, Morges, Switzerland BioMatrix Flex Biosensors, Morges, Switzerland Bioresorbable Vascular Scaffold (BVS) Abbott Vascular, Santa Clara, CA, USA Cardiomind Sparrow Cardiomind Inc, Sunnyvale, CA, USA Catania CeloNova Biosciences, Newnan, GA, USA Combo stent Orbus Neich, Fort Lauderdale, Fl, USA Coroflex DEBlue B.Braun, Melsungen, Germany Cypher Cordis, Johnson and Johnson, Warren, NJ, USA DIOR Eurocor, Bonn, Germany Elixir DESyne Elixir Medical, Sunnyvale, CA, USA ENDEAVOR Medtronic, Santa Rosa, CA, USA ENDEAVOR Resolute Medtronic, Santa Rosa, CA, USA Excel JW Medical System, Weihai, China GENIE Acrostak, Winterthur, Switzerland Genous Orbus Neich, Fort Lauderdale, Fl, USA IDEAL Bioabsorbable Therapeutics, Inc. Menlo Park, Ca, USA Igaki-Tamai Kyoto Medical Planning. Co. Ltd., Kyoto, Japan IN.PACT Falcon Invatec S.r.l., Brescia, Italy Infinnium Sahajanand Medical, Gujrat, India Invatec Twin-Rail Invatec S.r.l., Brescia, Italy JacPro Boston Scientific, Natick, MA, USA JACTAX Boston Scientific, Natick, MA, USA Labcoat Element Boston Scientific, Natick, MA, USA Multi-Link Frontier Abbott Vascular, Santa Clara, CA, USA NEVO Cordis, Johnson and Johnson, Warren, NJ, USA Nile Croco Minvasys, Genevilliers, France Nile Pax Minvasys, Genevilliers, France NOBORI Terumo, Leuven, Belgium Paccocath Bayer AG, Leverkusen, Germany Petal Boston Scientific, Natick, MA, USA Promus Element Boston Scientific, Natick, MA, USA REVA Generation I REVA Medical, Inc., San Diego, CA, USA REZolve REVA Medical, Inc., San Diego, CA, USA SeQuent Please B.Braun, Melsungen, Germany Sideguard Cappella, Auburndale, MA, USA SideKick Y-Med, San Diego, CA, USA SLK-View Advance Stent Technologies, Pleasanton, CA, USA Stentys Stentys SAS, Clichy, France Supralimus Sahajanand Medical, Gujarat, India SYNERGY Boston Scientific, Natick, MA, USA TAXUS Liberté Boston Scientific, Natick, MA, USA TAXUS Element Boston Scientific, Natick, MA, USA TiNOX Hexacath, Rueil-Malmaison, France Tryton Tryton Medical, Newton, MA, USA VESTAsync MIV Therapeutics, Atlanta, GA, USA vPROTECT Prescient Medical, Inc., Doylestown, PA, USA Xience V Abbott Vascular, Santa Clara, CA, USA XTENT Xtent Inc, Menlo Park, CA, USA Yukon Translumina, Hechingen, Germany