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REPUBLIC UZBEKISTAN MINISTRY OF HEALTH THE CENTER OF DEVELOPMENT OF MEDICAL EDUCATION THE TASHKENT MEDICAL ACADEMY "Approved" Head of main department of personnel and institutions of higher education of Uzbekistan Ministry of Health prof. _______________Sh.E.Atahanov «____»________________ 2011 yil CHAIR: PSYCHIATRY AND NARCOLOGY THE DISCIPLINE NAME: PSYCHIATRY 4 theme: A Schizophrenia. Clinical picture, dynamics, forecast. (For teachers and students of the Higher Medical educational institutions) The uchebno-methodical grant FOR STUDENTS 3 COURSES OF FACULTY «HIGHER MEDICAL NURSE BUSINESS» Tashkent 2011 CHAIR OF PSYCHIATRY AND NARCOLOGY "Approved" Vice-rector for academic, Professor OP Teshaev «___»________ 2011. 5. theme: A Schizophrenia. Clinical picture, dynamics, forecast. FOR STUDENTS 3 COURSES OF FACULTY «HIGHER MEDICAL NURSE BUSINESS» Higher Medical Nurse Business faculty ММК yes checked and approved The report № ______________ «___» ______________ 2011 __ TASHKENT 2011 Topic: A Schizophrenia. Clinical picture, dynamics, forecast. Venue lessons, equipment Department of Psychiatry at the medical psychology at the base Tashkent Сity Clinical Psychiatry Hospital Tables Slides Tables, charts, educational development in electronic format, computer Demonstrated on patients and volunteers 2. Duration of study topics: Number of hours – 4,3 3. The purpose of training. To give a general idea of schizophrenia as a nosological unity; Form an idea about the etiology and pathogenesis of schizophrenia; To classify the various forms of schizophrenia; Give the clinical characteristics of different forms of schizophrenia, indicate their features for differential diagnosis; Tasks The student should know: Give the clinical characteristics of different forms of schizophrenia, indicate their features for Define the term "schizophrenia"; The main provisions of the pathogenesis of schizophrenia; Clinical characteristics of different forms of schizophrenia; The main trends in modern treatment of schizophrenia. The student should be able to: Find an approach to a patient suffering from schizophrenia and collect complaints, history, or Follow-up data to assess mental status, a preliminary diagnosis, determine the level of GPs need treatment on an outpatient basis to a psychiatrist or psychiatric hospitalization. 4. Motivation. Schizophrenia is a pressing problem in psychiatry, which is associated with its prevalence among mental health and often leads to disability. In connection with this study of schizophrenia is of great medical and social importance. Schizophrenia a mental illness (a progressive, endogenous) with a trend to a continuous wave-like or paroxysmal flow, leading to a special non-organic, personality changes in the form of reduced energy capacity, emotional depletion and increasing isolation. 5. Interdisciplinary communication and intersubject. Teaching this topic is based on the knowledge bases of students of physiology, psychology and pharmacology. The knowledge gained will be useful during the passage of all the disciplines of therapeutic and surgical (cardiology, neurology, gynecology, urology, general surgery, etc.) as well as communication with people, including schizophrenia, is inevitable for any medical specialty that is in contact with patients 6. The content of lessons. 6.1 The theoretical part. Schizophrenia - a mental illness (a progressive, endogenous) with a trend to a continuous wave-like or paroxysmal flow, leading to a special non-organic, personality changes in the form of reduced energy capacity, emotional depletion and increasing isolation. In patients with schizophrenia indicated various symptoms that are not absolutely specific to this the disease: delusions, hallucinations, and catatonic or hebephrenic disorder, depression or mania, neurosis and psychopathic disorder, which causes difficulties in diagnosis and treatment, underscoring the relevance of the topic lectures. Epidemiology. The prevalence of schizophrenia - in urban areas, 8.2 per 1000 population (8.44 for women and 7.94 for men). The emergence of schizophrenia may at any age - from childhood to old man's, but mainly in young and middle age range. The etiology and pathogenesis. The causes of schizophrenia (Sch), as well as the pathogenic mechanisms of its development are still not well understood. According to modern concepts Sch refers to a group of diseases with a genetic predisposition. There is a considerable accumulation of schizophrenic psychoses in psychosis, and personality abnormalities in families of patients Sch. 1. Along with the genetic hypothesis manifestation of the disease plays a role of environmental effects. 2. General biological changes due to somatic diseases, endocrine-age factors. 3. Development autointoksikatsionnyh theories associated with the detection in the body of patients Sch variety of physiologically active (toxic) substances, which give neurotrophic effects. In various laboratories around the world isolated from the blood, urine and blood serum of patients with protein taroksein Sch. However, it remains unclear whether these abnormal substances involved in the specific mechanisms of pathogenesis of the disease. Classification. Clinical manifestations of Sch, its course and outcome of different high polymorphism. Sch refers to the duration of the current illness. At different stages of a progressive course of disease is different. Several features of the clinical picture of disease make age, sex, social and cultural factors. Modifications of the clinical picture may be associated with somatic and tserebralnoorganicheskimi influences. All this creates difficulties in classification. In accordance with the classification of Sch (for AV Snezhnevsky) the following types of flow: I. Continuously flowing type (simple, hebephrenic, paranoid, catatonic). Catatonic form has been moved to shuboobrazny type of flow according to latest figures. II. Recurrence or periodic type. III. Paroxysmal or a progressive-type shuboobrazny (ICD-10 refers to this form of schizoaffective disorder) Prognosis depends on the shape and type of flow Sch. Clinic of schizophrenia according to the classification. I. A continuous flow type. II. A simple form of Sch. Characterized by slow, gradual development process. This is accompanied by the growth of apathy, emotional indifference, patients become indifferent to everything around him, there is closure. Patients with no deal, decreased activity, increases intellectual unproductive. Thinking is divorced from reality at times comes to incoherence.2. Hebephrenic form Sch. Is most unfavorable to the forecast, it is called malignant juvenile schizophrenia, and it occurs most often in adolescence. An initial short period and appears in the wrong, strange behavior, like roughness, sharpness, prank. Lost previous interest, performance decreases. Along with this there are "special" attraction - "rassuzhdatelsky 'interest in philosophy, religion (" philosophical intoxication "). In the future there is an increase of symptoms, the patient's behavior is ridiculous, silly. Characterized by theatricality, clowning. With a sharp excitation patients shed their clothes, impulsively throw themselves on others. 3. Paranoid type Sch. Begins gradually, usually after 26 years, but it is and the earlier the disease. Patients appear suspicion, distrust, isolation. For many years, clinical disease is manifested primarily in a systematic delusions (of persecution, hypochondriacal, jealous, etc.), accompanied by the thoroughness of thinking. Hallucinations and other disorders are not observed. This stage of the disease called paranoid. In the future there is a transition in the paranoid form of the disease. The picture of the disease is expanding subject of delirium. Join pseudohallucinations, develops symptoms of the syndrome Kandinsky Clerambault. Along with this, patients have intense anger, passion. Typically, patients arrive in a psychiatric hospital during the period described the expanded picture of the disease. In further a progressive disease delusional disorders lose their systematization. Brad gets a fantastic character, although it loses the appropriate emotional background. Thus, patients with the next stage of the disease - paraphrenic. 4. Catatonic form of Sch. Can occur non-uniform: a progressive-continuous (nuclear form), with periodic recurrence of the upcoming (this option is discussed in Section shuboobraznoy Sch). Catatonic form is characterized by the alternation of periods of catatonic excitement and stupor. Less commonly, symptoms of these states is observed at the same time. An initial period - from several months to a year, during which symptoms occur rudimentary inhibition. The clinical picture of catatonic syndrome in different Sch pronounced negativism. Remissions are short and rare, the disease takes a chronic course in the future. II. Recurrence (periodic) type of schizophrenia. This form differs Sch most favorable prognosis and is characterized by a paroxysmal course. In the course of the disease occur-defined attacks followed by prolonged and deep remission. The disease is characterized by acute onset and is more common in women. The clinical picture of seizures seen in the following syndromes: 1. affective (depressive or manic); 2. oneyroidno-catatonic; 3. affective-delusional. Attention is drawn to the polymorphism of clinical manifestations of recurrent Sch: in some cases the attacks are the same type throughout the illness in others - as time is simplification or complication of previous episodes, and, finally, there is a polymorphism of attacks (combined type). The frequency of attacks is different - from 1 to 5 or more. Duration of remission varied from an average of 3-5 to 10-15 years or more. In the interictal state in patients, usually maintained social and labor adjustment. Personality changes in recurrent Sch are little expressed and manifested in the form of reduced activity, the appearance of vulnerability, isolation, narrowing of interests. III. Paroxysmal, a progressive (shuboobrazny) type of schizophrenia. This form of flow is intermediate between continuously flowing and recurrent forms of Sch. Shuboobraznaya Sch characterized by paroxysmal flow and proceeds from the attacks outlined, which is similar to the recurrent form of the course. At the same time, the clinical picture is a symptom peculiar to a continuously flowing Sch (paranoiac, paranoid disorders, etc.). The clinical picture of seizures in the main is complex and has a variety of symptoms. When shuboobraznoy Sch most common atypical or complex affective syndromes: hallucinatory-delusional, hallucinatoryparanoid, catatonic (lyutsidnaya catatonia) syndromes, as well as Kandinsky syndrome Clerambault. Particular attention should be paid to the peculiarities of shuboobraznoy Sch, flowing with catatonic syndrome. In this acute stage of illness characterized by a predominance of catatonic disorders when there is a change of catatonic excitement and stupor. Catatonic syndrome may develop acutely or gradually, with the latter appear and grow rudimentary signs of inhibition. Catatonic stupor is characterized by the gradual development of general lethargy, symptoms wax flexibility, negativism. The patient appears mutism, he does not respond to questions. Various conditions, such as a pretentious attitude, a symptom of "air bag", etc. In addition, the characteristic symptoms of negativism (active and passive), speech and motor stereotypies. Against this background, there may be delusional, hallucinatory disorders. Catatonic excitement is often replaced by stuporous state and is manifested in the following: not for any purposes excitation with uniform motion. Thinking broken. Certain actions and movements are impulsive and mannerisms. Perhaps hebephrenic stimulation (mere affectation, grimacing, tearing clothes, negativism, etc.). In the catatonic form within shuboobraznoy Sch remissions are of poor quality with severe personality disorders. With each episode (usually after the third) occurs deeper defect of personality and disease takes a chronic course. Differential diagnosis. Diagnosis and Sch delimitation from other mental illnesses based on the characteristic changes of personality, psychopathological features of syndromes. Range of negative disorders, which are typical for Sch, wide enough: autism, reduction of energy potential, emotional Deficits characteristic thought disorder. Autism is characterized by detachment from reality. Reduction of energy potential is manifested in the sharp weakening or loss of mental activity. Emotional Deficits shows quite a wide range of disorders, from a certain leveling of emotional reactions to severe emotional dullness. Diagnosis Sch put not only on the basis of characteristic changes in personality disorders, but also determined by the characteristics of psychiatric conditions and their picture of the dynamics, as well as a progressive disease, which manifests itself more complicated clinical picture, the changing nature of registers from the lighter to heavier, reflecting the large volume and depth disorders of mental activity, as well as the deepening of negative disorders. Sch recurrence must be differentiated from manic-depressive psychosis (MDP). The appearance of the structure of sensory attack of acute delirium, hallucinations, delusions of persecution, the phenomena of mental automatism, catatonic disorders, the formation and growth in the interictal period induces changes in personality diagnosis in favor of Sch. Paroxysmal Sch must be differentiated from symptomatic endoformnymi psychoses. Presence in the structure of psychosis endoformnogo asthenia, slabodushiya, symptomatic episodes of acute psychosis in the evening and night, and the concrete delusions can not be regarded as supporting the differential-diagnostic criteria, as there was evidence of modification of the structure of the endogenous psychopathological syndrome under the influence of physical illness. Endoformnye symptomatic psychoses are rare and must be distinguished from endogenous psychoses triggered by various kinds of exogenous. Differential diagnosis of postpartum psychosis. Prognosis. A look at the outlook has changed significantly Sch. This attitudinal change is related to the revaluation of the concept of dementia in Sch. In place of the concept of dementia has come the notion of defect. The degree of severity of the defect varies with the individual types of Sch, but is an important part of the clinical and social prognosis. Treatment of schizophrenia. Schizophrenia - a progressive chronic current process, polymorphic in clinical manifestations, and therefore treatment should be prolonged, complex and differentiated. The main methods of treatment are treatment psychopharmacological agents, as well as insulinoshokovaya therapy and electroconvulsive therapy in combination with measures of employment and social rehabilitation. By "active" methods of treatment include: 1. Insulinoshokovaya therapy (ISHT). The course of treatment ranged from 25 to 30 shocks (comatose states). Application ISHT shown in any form and type of flow Sch. 2. Electroconvulsive therapy (ECT) - a course of treatment no more than 15 sessions. ECT useful in patients with sluggish, inactive, stuporous, as disinhibited and stimulates their activity. 3. Sulfazin therapy. Best performance in a simple, hebephrenic forms, as well as catatonic excitement. 4. Psychopharmacological treatment. Can be combined with any method of treatment. The duration of treatment and dosage regimen depends on the symptoms and characteristics of the disease. Apply neuroleptics (haloperidol, triftazin, etaperazin, mazheptil, frenolon, moditen depot, chlorpromazine, etc.), antidepressants (imipramine, amitriptyline, nezredal, etc.), tranquilizers (Elenium, seduksen, trioxazine, tazepam, etc.). Other types of therapy, as auxiliary, as used in the treatment Sch. These include general health, detoxification therapy, vitamins, and physiotherapy. In addition, great importance is occupational therapy. Thus, patients in mental status revealed delusions of persecution (persecuted members of the "secret organization"), the impact of the phenomena of mental automatism: the impact of electrocution, equipment and thoughts known to others, putting others' thoughts, influence the emotions, and actions. There have been hearing pseudohallucinations (with a sense of violence, and different from the real, the voices inside your head). The system expands delirium. Mental patient's condition qualifies as a hallucinatory-paranoid syndrome (syndrome Kandinsky Clerambault). To justify the nosological diagnosis should know about changes in personality and clinical course. In this vignette came disease in individuals with schizoid traits in premorbide, the last 8-10 years, runs continuously. Onset of the disease refers to a young age, is characterized by paranoyalnym syndrome (systematized delusions of persecution), which is the last 2 years been transformed into a hallucinatory-paranoid syndrome. The patient became more withdrawn, restricted interests, decreased efficiency and productivity, revealed the emotional coldness and logic-chopping in thinking. Based on this analysis, the presence of hallucinatory-paranoid syndrome with personality changes schizophrenic type, continuous course of illness with the change paranoyalnogo paranoid syndrome diagnoses continuously flowing, the paranoid form. The disease should be differentiated from symptomatic psychogenic and organic psychoses. The establishment of schizophrenic personality changes, lack of trauma history, organic and somatic pathology can stay on the diagnosis of schizophrenia. General practitioner, knowing that such conditions are dangerous for the patient and others (delusions of persecution and impact) and treated with antipsychotic drugs in a psychiatric hospital must hold the patient in the clinic under various pretexts, and seek medical emergency psychiatric care, or the duty psychiatrist in the city, who will direct the patient in a psychiatric hospital. Used in this lesson, new educational technologies: Guidelines and technology of the business game "round table". All students are divided into groups by drawing lots 3 groups of 4 students each. Each group sits at a separate table, prepare a blank sheet of paper and a pen. In the worksheet, write the date, group number, department, name Student participants in this subgroup, the name of the business game. One of the participants in each group takes a question from the envelope. Difficulty level of tasks for all subgroups of approximately the same. Students re-write on a piece of his job. Embarks on a circle sheet. Each student writes his answer sheet and passes the other. To answer every student is given 3 minutes. At the expiration of time shall be a teacher. Range of issues and situational problems for the business game "round table" on a practical lesson on "Schizophrenia." The course and forms of schizophrenia. What are typical symptoms of schizophrenia shuboobraznogo? What syndrome is characterized by a continuous flow of schizophrenia? Describe the main symptoms of hebephrenic schizophrenia. What are the symptoms characteristic of paranoid schizophrenia? List the symptoms of catatonic forms. Disturbances of thinking characteristic of schizophrenia. Disturbances of perception characteristic of schizophrenia. What are the negative symptoms found in schizophrenia. What are the positive symptoms found in schizophrenia. Premorbid features of patients with schizophrenia. 6.2 Analytical part. Situational problems. 1. At the doctor's patient 31, in clear consciousness, properly oriented in space, in time, in his own personality. Tense, anxious, and says that he operate on electric, that feeling the burning in various parts of the body. I am convinced that the special equipment installed at a distance in an adjacent room to work. Tells us that there is a specially created organization to "spying" for him, its members everywhere he is being persecuted. Last noticed not only by employees, but also in public transport, on the streets. Claims that his thoughts known to others, "no matter what he thought," everything becomes known members of this organization. They began to put his thoughts in his head, to control his actions, which prevents him from concentrating, do the job. He became a "robot", even mood depends on their "desire." Periodically hears "voices" inside the head bad content, which talk to him than his desire. These voices are mental, not like the "real". Reports that he had not seen these people, they are "working distance", they chose it for use in research, because He had a lot of interest in astronomy, I read a lot and it aroused the interest of this "secret organization." Said that since childhood, characterized by a closed, silent character. In school, was assiduous, erudite, well-managed. Graduated from high school and technical college. From his youth, became interested in astronomy, I read a lot. Became interested in space exploration. The last 810 years, began to notice that he was being "watched." Initially, it said on the part of that "special" asked about his hobbies and interests in space exploration, their questions, "rechecked" him, noticed that sometimes on his desk "planted" literature, which gradually led him to believe that he was "SHOULD", "test". He noted that the last 2 years for him not only "should," "pursue," but also influenced by equipment, began to talk to him from a distance, send your thoughts. Asked the doctor to check his health, because "For scientific experiments are needed healthy people." 2. At work, became ill cope with their responsibilities, became more withdrawn, lost interest in everything, became indifferent to his family, constantly preoccupied with thoughts about preparing for space research. In an interview verbose circumstances, tends to empty rassuzhdatelstvu. Pereubezhdeniyu not be, explains all the facts and claims from the perspective of their ideas. Identify symptoms of mental confusion, and put a syndromic nosological diagnosis, identify the tactics of GPs. Answer: The mental status of the patient revealed delusions of persecution (persecuted members of the "secret organization"), the impact of the phenomena of mental automatism: the impact of electrocution, equipment and thoughts known to others, putting others' thoughts, influence the emotions, and actions. There have been hearing pseudohallucinations (with a sense of violence, and different from the real, the voices inside your head). The system expands delirium. Mental patient's condition qualifies as a hallucinatory-paranoid syndrome (syndrome Kandinsky Clerambault). To justify the nosological diagnosis should know about changes in personality and clinical course. In this vignette came disease in individuals with schizoid traits in premorbide, the last 8-10 years, runs continuously. Onset of the disease refers to a young age, is characterized by paranoyalnym syndrome (systematized delusions of persecution), which is the last 2 years been transformed into a hallucinatory-paranoid syndrome. The patient became more withdrawn, restricted interests, decreased efficiency and productivity, revealed the emotional coldness and logic-chopping in thinking 4. Based on this analysis, the presence of hallucinatory-paranoid syndrome with personality changes schizophrenic type, continuous course of illness with the change paranoyalnogo paranoid syndrome diagnoses continuously flowing, the paranoid form. The disease should be differentiated from symptomatic psychogenic and organic psychoses. The establishment of schizophrenic personality changes, lack of trauma history, organic and somatic pathology can stay on the diagnosis of schizophrenia. General practitioner, knowing that such conditions are dangerous for the patient and others (delusions of persecution and impact) and treated with antipsychotic drugs in a psychiatric hospital must hold the patient in the clinic under various pretexts, and seek medical emergency psychiatric care, or the duty psychiatrist in the city, who will direct the patient in a psychiatric hospital. 3. Patient R., 24, a disabled first group. For many years, almost continuously in a psychiatric hospital. The unit completely passive, most of the time doing nothing, sitting on a chair, staring into space. The facial expression of dumb, indifferent. Sometimes, at the invitation of the sick, gets to play chess. Playing without interest, always loses, gets up and walks away. It is messy, does not keep track of their appearance, washes her hair and only at the insistence of the hospital staff. At a meeting with the mother goes unwillingly. Not saying hello to her immediately climbs into her bag, pulls out and brought food slightly nodding his head, goes to his room. One day was taken to a lecture on psychiatry. Came in with a kind of complete indifference, sat down, not even glancing at the audience. Answered questions do not readily look at this sideways. An excerpt from the conversation: Professor: How do you feel? You have anything bothering you? Patient: No, no, I'm healthy. Professor: Why, you're in the hospital? Patient: I do not know, the treatment is not finished yet. Professor: What kind of treatment if you are healthy? Patient: He does not answer the question. Professor: I have heard that a few years ago, you jumped out the window and broke his leg. Why did you do that? Patient: So ... buck wanted. Professor: You are many years in the BOP. You do not want to go home, do something? Patient: No, I do not. I'm here to stay. Qualifying condition, disease. Answer: schizophrenia, continuous type of flow, apatiko-abulichesky syndrome. 6.3 The practical part. STEP BY STEP PRACTICAL SKILLS FOR GPs on "Schizophrenia." Purpose: Supervision of schizophrenic patients, staging of the primary diagnosis, assessment of severity of disease and basic treatment assignment № stage event not fully satisfied correctly 1 The patient sits in a chair at a distance of 1-1.5m, the doctor sits in front of the test and asks for his mental status From the complaint: hallucinations or pseudo-real, delusional disorder, solitude and a tendency to wander, change of mood From the history of life: heredity is burdened by a good performance in schools. In the general examination: a serious condition, consciousness is clear. Situation actively. Skin normal color, sweating. Mental Status: Violation of perception in the form of hallucinations, psychosensory disorder, depersonalization and derealization. Emotional and volitional defect apatite abulichesky syndrome, delusions, split personality, autism. Preliminary diagnosis: assignment of survey patients. Possible complications: a defect of personality, suicide attempts 0 15 0 15 0 0 10 10 0 10 0 0 15 10 2 3 4 5 6 7 8 Basic treatment: 1) closed mode 2) antipsychotics 3) antidepressants 4) nootropics 5) disintoxication therapy Total 0 10 0 100 8. Criteria for evaluating the current control. № 1. Progress in number (%) 96-100 2. 91-95 3. 86-90 4. 81-85 5. 76-80 6. 71-75 7. 66-70 8. 61-65 scoring Excellent "5" Good "4" satisfactorily "3" the student's knowledge level rating sums up and makes decisions Creative thinking Independently analyzed Into practice Shows high activity, a creative approach to the conduct of interactive games Correctly solves the case studies with full justification for the answer Understands the subject matter Knows, says confident Has a faithful representation to think creatively Independently analyzed Into practice Shows high activity, a creative approach to the conduct of interactive games Correctly solves the case studies with full justification for the answer Understands the subject matter Knows, says confident Has a faithful representation to independently analyze Into practice Shows high activity, a creative approach to the conduct of interactive games Correctly solves the case studies with full justification for the answer Understands the subject matter Knows, says confident Has a faithful representation into practice Shows high activity during the interactive games Correctly solve situational problems, but the rationale for the answer not full enough Understands the subject matter Knows, says confident Has a faithful representation are active in conducting interactive games Correctly solve situational problems, but not a complete justification of the answer Understands the subject matter Knows, says confident Has a faithful representation correctly solve situational problems, but not a complete justification of the answer Understands the subject matter Knows, says confident Has a faithful representation satisfies Understands the subject matter Correctly solve situational problems, but can not justify a response Knows, says confident Has a faithful representation of some issues topic Admits Error in solving situational problems Knows, says not sure Has a faithful representation of some issues topic Knows says no confidence Has a partial view 10. 55 and below unsatisfactory satisfactorily "2" does not accurately represent Do not know 9. Chronological map of classes (for klinichekim subjects) № stage of training sessions Form Length in minutes. 1 2 180 5 50 225 10 50 10 15 30 40 25 30 25 30 10 20 9. 3. 4. 5. 6. 7. 8. 56-60 An introductory word lecturer (study subjects) Discussion topics practical training, use of new educational The survey, an explanation. technologies (small group discussions, case studies, "the method of snowballs," a round table, etc.) as well as checking the source of knowledge siudentov, the use of visual aids (slides, audio, video tapes, models, phantoms, ECG, X-ray, etc. Summing up the discussion Giving students tasks to perform the practical part of training. Cottage explanations and notes for the task. Self-Supervision The assimilation of skills a student with a teacher (Supervision medical history, clinical rolethematic patient) playing case studies Analysis of the results of laboratory and instrumental studies Working with the clinical thematic patient, differential diagnosis, treatment plan and laboratory instruments rehabilitation, prescriptions, etc. Talk degree goal classes on the basis of developed theoretical Oral questioning, test, debate, knowledge and practical experience on the results of the discussion of the practical student, and with this in mind, evaluation of the group. work Conclusion of the teacher on this lesson. Assessment of the Information, questions for students on a 100 point system and its publication. Cottage set self-study students the next class (a set of questions). 10. Quiz Questions 1. Definition of "endogenous psychoses", "schizophrenia." 2. Clinical manifestations (general psychopathology) in schizophrenia. 3. The clinic, for continuously - the current schizophrenia. 4. The clinic, for recurrence of schizophrenia. 5. The clinic, for paroxysmal - a progressive schizophrenia. 6. Treatment and prevention of schizophrenia. 7. Principles of observation, description and care of patients with schizophrenia. Recommended reading. 1. Zharikov, NM et al. - "Psychiatry". Textbook, 1989. 2. Alimov, HO, Alimov U.H. - "Psychiatry klinikasining mukadimasi." 3. Huzhaeva NI , Shayusupova AU "Psychiatry." Textbook in Uzbek. 4. Guide to Psychiatry, edited by AV Snezhnevsky, Moscow, Volume 1.