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Shier, Butler, and Lewis: Hole’s Human Anatomy and Physiology, 11th ed. Chapter 9: Muscular System Chapter 9: Muscular System I. Structure of a Skeletal Muscle A. Introduction 1. A__________________________________ is an organ of the skeletal system. 2. A skeletal muscle is composed of ____________________________________ B. Connective Tissue Coverings 1. Fascia is ________________________________________________________ 2. A tendon is ______________________________________________________ 3. Tendons connect a muscle to ________________________________________ 4. An aponeurosis is _________________________________________________ 5. Epimysium is ____________________________________________________ 6. Perimysium is____________________________________________________ 7. A fascicle is _____________________________________________________ 8. Endomysium is___________________________________________________ 9. Deep fascia is ____________________________________________________ 10. Subcutaneous fascia is ____________________________________________ 11. Subserous fascia is _______________________________________________ C. Skeletal Muscle Fibers 1. A skeletal muscle fiber is a single ____________________________________ 2. The sarcolemma is ________________________________________________ 3. The sarcoplasm is _________________________________________________ 4. The sarcoplasm contains ___________________________________________ 5. Myofibrils are _________________ and are located in the ________________ 6. Myofibrils play a fundamental role in _________________________________ 7. Thick myofilaments are composed of _________________________________ 8. Thin myofilaments are composed of __________________________________ 9. The organization of myofilaments produce _____________________________ __________________________________________________________________ 9-1 10. A sarcomere is __________________________________________________ 11. Myofibrils may be thought of as _____________________ joined end to end. 12. I bands are composed of __________________________________________ 13. Z lines are ______________________________________________________ 14. A bands are composed of __________________________________________ 15. The H zone is ___________________________________________________ 16. The M line is ___________________________________________________ 17. Titin connects ___________________________________________________ 18. A sarcomere extends from one _____________________________________ 19. Each myosin molecule consists of ___________________________________ __________________________________________________________________ 20. Thin filaments consist of double ____________________________________ 21. Actin has a binding site to which ___________________________ can attach. 22. Troponin and tropomyosin associate with _____________________________ 23. Sarcoplasmic reticulum is _________________________________________ 24. Transverse tubules are ____________________________________________ 25. Cisternae are____________________________________________________ 26. A triad is formed by ______________________________________________ II. Skeletal Muscle Contraction A. Neuromuscular Junction 1. Each skeletal muscle is functionally connected to ________________________ 2. A motor neuron passes outward from _________________________________ 3. Normally, a skeletal muscle fiber contracts only upon ____________________ __________________________________________________________________ 4. A neuromuscular junction is ________________________________________ 5. A motor end plate is _______________________________________________ 6. A motor unit is ___________________________________________________ 7. A synaptic cleft separates___________________________________________ 8. Synaptic vesicles store _____________________________________________ 9-2 B. Stimulus for Contraction 1. __________________________ is the neurotrasnmitter that motor neurons use to control skeletal muscle. 2. ACh is synthesized in the cytoplasm of ________________________________ and is stored in _____________________________________________________ 3. When a nerve impulse ________________________ , acetylcholine is released into the synaptic cleft. 4. ACh combines with ____________________________ on the motor end plate, and stimulates ______________________________________________________ 5. A muscle impulse is _______________________________________________ 6. A muscle impulse changes __________________________________________ 7. Ultimately the muscle impulse reaches ________________________________ C. Excitation Contraction Coupling 1. The sarcoplasmic reticulum has a high concentration of ___________________ 2. In response to a muscle impulse, the membranes ________________________ ___________________________, and the calcium ________________________ __________________________________________________________________ 3. When a muscle fiber is at rest, ________________________ block the binding sites on the actin molecules. 4. Calcium ions bind to ____________________, changing its _______________ and altering ________________________________________________________ 5. The movement of the tropomyosin molecule exposes _____________________ __________________________, allowing________________________________ D. The Sliding Filament Model of Muscle Contraction 1. The functional unit of skeletal muscles is ______________________________ 2. According to the sliding filament model, when sarcomeres shorten, _________ __________________________________________________________________ 3. As contraction occurs, ________________ and ______________ get narrower and _____________________________________________ move closer together. E. Cross-bridge Cycling 1. The force that shortens the sarcomeres comes from ______________________ 9-3 __________________________________________________________________ 2. A myosin cross-bridge attaches to actin in order to _______________________ __________________________________________________________________ 3. The cross-bridge can release, straighten, and combine with ________________ __________________________________________________________________ 4. Myosin cross-bridges contain the enzyme ______________________________ 5. ATPase catalyzes _________________________________________________ 6. The force for muscle contraction is provided by _________________________ __________________________________________________________________ 7. Breaking down of ATP puts the myosin cross-bridge in a __________position. 8. When a muscle is stimulated to contract, a ____________________ attaches to ___________________________ and pulls ______________________________ , shortening the ______________________________________________________ 9. When another ATP binds, the ______________________________ is released, then breaks down the ____________________to return to ___________________ 10. The cross-bridge cycle may repeat over and over as long as _______________ __________________________________________________________________ F. Relaxation 1. In order for a muscle fiber to relax, acetylcholine must be decomposed by an enzyme called ______________________________________________________ 2. The action of acetycholinesterase prevents _____________________________ __________________________________________________________________ 3. When acetylcholine is breaks down, __________________________________ ____________________________________________________________ ceases. 4. The calcium pump moves calcium ___________________________________ __________________________________________________________________ 5. When calcium is removed from the cytoplasm, the _______________________ break and _____________________________________ rolls back into its groove, preventing _________________________________________________________ 6. ATP is necessary for both muscle ____________________________________ and _______________________________________________________________ 9-4 7. The trigger for contraction is ________________________________________ G. Energy Sources for Contraction 1. Creatine phosphate is ______________________________________________ 2. Creatine phosphate includes ________________________________________ 3. As ATP is decomposed to ADP, the energy from ________________________ is transferred back to ________________________________________________ 4. After creatine phosphate is used, a muscle cell must depend on _____________ ____________________________to synthesize ___________________________ 5. Typically a muscle stores glucose in the form of ________________________ H. Oxygen Supply and Cellular Respiration 1. Glycolysis occurs _______________________ and is ____________________ 2. Glycolysis releases a few ___________________________________________ 3. The complete break down of glucose occurs in __________________________ and requires ________________________________________________________ 4. The citric acid cycle and electron transport chain produce _________________ __________________________________________________________________ 5. Oxygen is carried in the blood stream bound to _________________________ 6. Myoglobin is _____________________________________________ in color. 7. Myoglobin stores ___________________________________ in muscle tissue. I. Oxygen Debt 1. Lactic acid threshold is ____________________________________________ 2. Under anaerobic conditions, glycolysis breaks down glucose into ___________ and converts it to ____________________________________________________ 3. Lactic acid is carried by the blood to the _______________________________ 4. Liver cells can convert lactic acid to __________________________________ 5. Oxygen debt reflects ______________________________________________ __________________________________________________________________ J. Muscle Fatigue 1. Fatigue is _______________________________________________________ 2. Fatigue may result from ____________________________________________ __________________________________________________________________ 9-5 3. A cramp is ______________________________________________________ 4. The strenuous exercise of aerobic training _____________________________ __________________________________________________________________ K. Heat Production 1. Heat is a by-product of_____________________________________________ 2. Blood transports heat _____________________________________________ , which helps ________________________________________________________ III. Muscle Responses A. Introduction 1. One way to observe muscle contraction is to____________________________ __________________________________________________________________ 2. An________________________ is usually used to produce muscle contraction. B. Threshold Stimulus 1. Threshold stimulus is ______________________________________________ 2. An impulse in _______________________________ normally releases enough ______________________ to bring the muscle fibers in its __________________ to ________________________________________________________________ C. Recording a Muscle Contraction 1. A twitch is ______________________________________________________ 2. A myogram is ____________________________________________________ 3. Three periods of a muscle fiber contraction are__________________________ __________________________________________________________________ 4. During the period of contraction, a muscle fiber is _______________________ __________________________________________________________________ 5. The latent period is________________________________________________ 6. The period of relaxation is __________________________________________ 7. The refractory period is ____________________________________________ 8. An all-or-none response is __________________________________________ __________________________________________________________________ 9. The length to which a muscle is stretched before stimulation affects _________ __________________________________________________________________ 9-6 10. If a muscle is stretched well beyond its normal resting length, the force will __________________________________________________________________ 11. At very short muscle lengths, the sarcomere becomes ___________________ and ___________________________________________________ is not possible. 12. In the whole muscle, the degree of tension reflects ______________________ __________________________________________________________________ D. Summation 1. Twitches in a muscle can combine to become ___________________________ 2. Summation is ____________________________________________________ 3. Tetanic contractions are ____________________________________________ E. Recruitment of Motor Units 1. The _______________ in the motor units, the more ______________________ the movements can be produced in a particular muscle. 2. All muscle fibers in a motor unit are stimulated at __________________ time. 3. Multiple motor unit summation is ____________________________________ 4. Recruitment is ___________________________________________________ 5. As the intensity of stimulation increases, ______________________________ continues until all possible motor units are activated in a muscle. F. Sustained Contractions 1. During sustained contractions, ______________________ are recruited earlier. 2. The larger motor units respond ______________________________________ and more __________________________________________________________ 3. Muscle movements are smooth because _______________________________ __________________________________________________________________ 4. Muscle tone is ___________________________________________________ 5. Muscle tone is important for maintaining ______________________________ G. Types of Contractions 1. An isotonic contraction is __________________________________________ 2. A concentric contraction is _________________________________________ 3. An eccentric contraction is__________________________________________ 4. An isometric contraction is _________________________________________ 9-7 5. An example of an isometric contraction is _____________________________ 6. An example of an isotonic contraction is _______________________________ H. Fast and Slow Twitch Muscle Fibers 1. Type I fibers are __________________________________________________ 2. Examples of type I fibers are ________________________________________ 3. Type I fibers are _________________ in color because ___________________ __________________________________________________________________ 4. Type I fibers are resistant to_________________________________________ 5. Type IIa fibers are ________________________________________________ 6. Type IIa fibers are ________________ in color because __________________ __________________________________________________________________ 7. Type IIb fibers are ________________________________________________ 8. All muscles include ___________________________________ of fiber types. IV. Smooth Muscles A. Smooth Muscle Fibers 1. Compared to skeletal muscle fibers, smooth muscle fibers _________________ __________________________________________________________________ 2. Two major types of smooth muscle are ________________________________ __________________________________________________________________ 3. Multiunit smooth muscle is located ___________________________________ __________________________________________________________________ 4. Visceral smooth muscle is located ____________________________________ __________________________________________________________________ 5. Fibers of visceral smooth muscle are connected by_______________________ 6. Rhythmicity is ___________________________________________________ 7. Peristalsis is _____________________________________________________ 8. Peristalsis helps force ______________________________________________ B. Smooth Muscle Contraction 1. Compared to skeletal muscle fibers, smooth muscle fibers lack _____________ and use _______________________________________ to bind calcium instead. 2. Two neurotransmitters that affect smooth muscle are _____________________ 9-8 __________________________________________________________________ 3. Hormones affect smooth muscle by___________________________________ __________________________________________________________________ 4. Stretching of smooth muscle can trigger _______________________________ 5. Smooth muscle is slower to_________________ and ____________________ than skeletal muscle. 6. Unlike skeletal muscle, smooth muscle fibers can change length without changing __________________________________________________________ V. Cardiac Muscle A. Cardiac muscle appears only in ___________________________________________ B. Cardiac muscle is composed of _______________________________________ cells, forming fibers that are ______________________________________________________ C. Cardiac muscle fibers can contract ___________________ then skeletal muscle fibers. D. Intercalated discs are ____________________________________________________ E. Intercalated discs allow muscle impulses to __________________________________ F. A syncytium is _________________________________________________________ VI. Skeletal Muscle Actions A. Introduction 1. Skeletal muscles generate __________________________________________ 2. The action of each muscle mostly depends upon_________________________ __________________________________________________________________ B. Body Movement 1. Bones and muscles interact as _______________________________________ 2. The four basic components of a lever system are ________________________ __________________________________________________________________ 3. In scissors, the _____________________________________ form a rigid bar. 4. The fulcrum of scissors is __________________________________________ 5. The resistance of scissors is _________________________________________ 6. The force of scissors is supplied by ___________________________________ 7. In a first class lever system, the parts are arranged _______________________ __________________________________________________________________ 9-9 8. Besides scissors, other examples of first class lever systems are ____________ __________________________________________________________________ 9. In a second class lever system, the parts are arranged _____________________ __________________________________________________________________ 10. An example of a second class lever system is __________________________ 11. In a third class lever system, the parts are arranged _____________________ __________________________________________________________________ 12. An example of a third class lever system is ____________________________ 13. In the action of bending the upper limb at the elbow, the rigid bar is _______ , the fulcrum is ____________________, the resistance is ___________________ , and the force is applied by ____________________________________________ 14. Bending the arm at the elbow is an example of a _______________________ class lever system. 15. When the upper limb straightens at the elbow, the rigid bar is ____________ , the pivot is _____________________, the resistance is ____________________ , and the force is applied by ____________________________________________ 16. Straightening the arm at the elbow is a first class lever system because ______ __________________________________________________________________ 17. An example of a second class lever system in the body is ________________ __________________________________________________________________ C. Origin and Insertion 1. The origin of a muscle is ___________________________________________ 2. The insertion of a muscle is _________________________________________ 3. When a muscle contracts, its ________________________________________ is pulled toward its __________________________________________________ 4. The head of a muscle is ____________________________________________ 5. The origins of the biceps brachii are __________________________________ 6. The insertion of the bicep brachii is ___________________________________ 7. When the biceps brachii contracts, the __________________________ bends. D. Interaction of Skeletal Muscles 1. A prime mover is _________________________________________________ 9-10 2. A synergist is ____________________________________________________ 3. An antagonist is __________________________________________________ 9-11