Download Unit 1 Intro Sheet

Genetics Study Guide
Unit 1: Cells & Cancer Chapters 2&18
Objectives: These are the major concepts you will be tested on at the conclusion of this unit. The
emphasis in this unit is on cell organelles involved in genetic disease, mitosis/the cell cycle, cancer, and
stem cells.
1. Describe how the organelles work together to coordinate basic life functions.
 Identify organelles at fault for the genetic traits/diseases discussed in class.
 Describe what causes the inherited disorder adrenoleukodystrophy, or ALD.
2. Identify the major macromolecular constituents of cells.
3. Differentiate between different stages of the cell cycle. (G 0, G1, S, G2, M)
 Describe the relationship between the cell cycle and cancer.
4. Demonstrate the process of mitosis. (M stage of the cell cycle)
 Explain what happens at each step of mitosis and cytokinesis.
 Describe the relationship between telomere length and cell division
5. Predict changes that would result from errors at checkpoints in the cell cycle.
6. Differentiate between pluripotent, totipotent, and progenitor cells.
7. Explain how microarrays are used to diagnose and treat cancer.
8. Identify checkpoint genes in the cell cycle that if mutated, can cause cancer.
9. Compare cancer cells with non-cancerous cells.
 Distinguish between germline and somatic causes of cancer.
 List the four major characteristics of cancer cells.
10. Compare how oncogenes and tumor-suppressor genes cause cancer.
 Identify the relationship between proto-oncogenes and oncogenes
11. List things you can do to minimize your risk of cancer.
12. Discuss groups that are at risk for human papilloma virus infections, and how this can be
prevented.
13. Explain how work is done in a laboratory in a way that minimizes safety issues.
14. Be prepared to explain any laboratories in this unit and demonstrate the use of any techniques
used in the laboratory setting.
Vocabulary: The quiz will be in a matching format. 15-20 of the words below can/will be on the section
reading quizzes. By the end of the unit you must understand the meaning of each word in the context of
this unit.
somapoeumut-stasis
oncprotonucproanametastasis
malignant
enzyme
romcentr-mer
mitotelointra-ase
-oma
oncogene
proto-oncogene
tumor-suppressor genes
BRCA1 gene
benign
chromatin
chromatid
centromere
telomere
apoptosis
totipotent
pluripotent
progenitor
carcinogen
mutagen
somatic cell
germ cell
p53 gene
OVER 
Resources:
Text:
Lewis, R. Human Genetics: Concepts and Applications, 6th ed. (2003). McGraw-Hill: New York, NY.
ch 2 & 18
Class Website:
http://fhsdfhc.sharpschool.net/contact_us/staff_directory/science/maxwell__kimberly/genetics/
Text Website: www.mhhe.com/lewisgenetics6
Links: http://www.insidecancer.org/
http://www.g2conline.org/
http://www.dnaftb.org/dnaftb/7/concept/index.html
http://www.dnaftb.org/dnaftb/15/concept/index.html
http://nobelprize.org/educational/medicine/2001/cellcycle.html
http://www.phschool.com/science/biology_place/biocoach/mitosisisg/intro.html
http://www.biology.arizona.edu/cell_bio/activities/cell_cycle/cell_cycle.html
IMPORTANT DATES
ONQ = Open note quiz
8/8 – ONQ Sections 2.1-2.2 (19-29)
8/12 – ONQ Section 2.3 (30-35)
8/15 – ONQ Sections 2.4-2.5 (35-40)
8/19 – ONQ Sections 18.1-18.3 (348-354)
8/22 – ONQ Sections 18.4-18.6 (356-367)
8/27 - Unit 1 Test