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Last updated on 21 Jul 2014 at 11:55 AM (ED04) Agitated and combative patient A 68 year old NZ European man, with no fixed abode, presents under police escort to the Emergency Department agitated and aggressive. He has presented on previous occasions as intoxicated on alcohol, sedated and non-confrontational. He has also sometimes presented with physical symptoms that can’t be medically explained with the hope of acquiring an overnight stay in hospital. However, on this presentation he has threatened to punch you and the nursing staff when you discussed the need for him to stay in the Emergency Department for further investigations. Applied Science for Medicine Anatomy of the brain Pathophysiology of delirium and dementia Microbiology of herpes simplex virus Role of drug intoxication and withdrawal in altered mental states Awareness of nutritional deficiencies and how this may compound certain presentations e.g. delirium tremens Pharmacology of haloperidol, olanzapine, rispiridone, benzodiazepines Clinical and Communication Skills History from an agitated patient; elicit a collateral history; assess risk factors for delirium Perform a general examination, as complete as is possible; recognise drug withdrawal and intoxication Differential diagnosis of the aggressive patient, delirium Indications for CT head, MRI brain, lumbar puncture Perform capillary glucose level, measurement of blood pressure, lumbar puncture Interpret full blood count, electrolytes, liver function tests, blood glucose level, calcium, thyroid function tests, vitamin B12/folate, toxicology screen, pathology report on cerebrospinal fluid (CSF), chest X-ray, syphilis serology, short synthacen test Management of the challenging patient: pharmacological and non-pharmacological Awareness of high mortality rates with delirium tremens and the medical treatments required for this Role of security staff, levels of observation and de-escalation measures Role of liaison psychiatry, social worker, nurse Understand how medically unexplained physical symptoms can present Personal and Professional Skills Deescalating an aggressive situation Self-care: personal safety Decision-making capacity Best interests principle Assent and consent Legal aspects of compulsory assessment and treatment, Mental Health Act, Right 7(4) of the Health and Disability Commissioner’s Code of Rights Hauora MÄori Cultural safety in examining an agitated person Access to cultural resources in an Emergency Department Ethnic disparities in 'homelessness', mental disorder and alcohol/drug misuse Population Health Epidemiology of delirium/acute confusion state, schizophrenia, substance abuse, substance withdrawal, herpes simplex virus, meningitis Homelessness: reasons, support programmes, discrimination Conditions to be considered relating to this scenario subdural haemorrhage, psychosis of any cause, Common hypoglycaemia, hypoxia, hypo/hypernatraemia, urinary tract infection, hypercalcaemia, hypocalcaemia, concussion, vitamin B12/folate deficiency, hypothyroidism, delirium tremens, Wernicke's encephalopathy, acute coronary syndrome (STEMI, NSTEMI and unstable angina), intoxications, extradural haemorrhage cerebral tumour, tertiary syphilis, meningitis, Less common but encephalitis, subarachnoid haemorrhage 'important not to miss' Whipple's disease, uraemic encephalopathy, hepatic Uncommon encephalopathy, Addison's disease