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Pollution 20-30% of exam Basic Toxicology Basic Toxicology Toxin=Damages a living organism by ingesting or absorbed. Toxicity=the degree which a toxin harmful. Any thing in high enough quantities may be harmful Ex water Factors to consider Dosage Amount of exposure Size and age or organism Ability of organism to detoxify Sensitivity to substance Synergistic/Antagistic effects Dose response analysis A test to determine the concentrations at which a substance is toxic. Dose response curve-graph showing increased doses and mortality. 2 tests LD 50 when 50% die Poisons-LD50= 50 mg or less Threshold dose=when a negative effect occurs Types of effects Acute-Short exposure to a high level of toxin Ex snake bite Chronic-Long term exposure to a low level toxin. Infections and disease Pathogens-organisms or viruses which enter the body. Infection-when a pathogen enters the body. Disease-when the infection changes the state of health. PAthogens Viruses Bacteria Fungi Protozoa Worms Risk assessment/management Assessment calculations of the risk taken Management=strategies taken to reduce risk Ex flue shots….. Air Pollution Air Pollution 2 sources human and natural Natural=volcano Car=man The majority of the pollution today is from man and occurred after the industrial revolution. Sources Primary pollutants released directly into the lower atmosphere and are toxic. Ex mercury coal burning Secondary-toxins formed in the atmosphere from multiple primary pollutants. SO2 from coal +H2O H2SO4 Sources Moving Stationary Point Non-point EPA Environmental Protection Agency Regulates pollution Regulates 6 “Criteria Pollutants” Carbon monoxide CO-combustion-60% car Lead Pb-from coal and smelting Ozone O3-good in stratosphere-bad in troposphere-from combustion. Nitrogen Dioxide NO2-car engines forms nitric acid Sulfur dioxide SO2 coal and diesel–sulfuric acid Particulates Changes Since 1970 CO and lead have decreased New concerns=VOC volatile organic compounds. Toxic organic compounds from manufacturing, dry cleaning, industrial solvents, form O3 Smog Fog=natural water vaper Smog=Toxic gas Industrial Smog Vs Photochemical Smog Industrial (grey) smog- formed from the burning of coal common 1900-1950. combines with particulate matter. Problems=Sulfuric acid lead particulate matter. Lead to- pneumonia, tuberculosis,heart failure, bronchitis, whooping cough. CO2 Photochemical Smog. The brown cloud found on sunny days. Caused by car combustion and industrial combustion. VOC, NOx, O3 combine, catalyzed by sunlight, to form Common in baltimore Inversion Air is trapped by warmer layers of air in low places. a toxic gas. Climate change Caused By Increasing CO2 and other green house gasses cause the green house effect. 1900-1950 25% caused by combustion 75% by reducing biomass. 1950-today 75% by combustion 25% by reduction in biomass. IPCC (Intergovernmental panel on climate change) report 1-Climate change is occurring There is a correlation between temperature and CO2 levels (greater than 90%) CO2 1950 280ppm 2006 380ppm Methane 1950 715ppm 2005 1774ppm NOx 270-319 Rise in CO2 Effects Additive effect decrease in ice caps= increased temperatures. Increased heat = increased H2O gas=increased heat. Increased temp=less permafrost=more Co2 released from the permafrost. Increased temp= decreased land= less biota and more CO2 Impact Higher levels of water-maryland 4th most at risk Decreasing glaciers=less drinking water Increased storms Ozone depletion Ozone depletion Ozone –in stratosphere is a toxin but in the stratosphere provides a defense from UV radiation. Formation 3O2 + UV sunlight 2O3 Ozone depletion Occurs during the summer months. Caused by Chloroflurocarbons (CFCs) And other compound compounds used in propellants, fire extinguishers, and hair spray. Reaction CFCs break down to Chlorine gas and reacts with ozone Cl + O3 O2+ClO is stored in ice crystals over the winter. In the spring the crystals melt and continue to react ClO+O Cl+O2 Results 26 million square Km zone of thinness (hole). Chronic Exposure= eye cataracts, skin cancer, weakening of immune system. Kill phytoplankton,-primary producers. Acid rain Acid rain: Formed from SO2 and NOx and water into sulfuric and nitric acids pH=range from 5.4-2.3 Caused by coal and auto emmissions Environmental effects Mineral leaching Sulfur and nitrogen buildup in soil/lakes Increased aluminum buildup Leaching of calcium from conifers Lowering of pH in lakes Human respiratory irritation Dissolving stone-monuments buildings exc. 2 types Dry acidic particle deposition-drops few days after Wet deposition-drops 4-14 days 1990 Clean air Act reduced SO2 and NOx levels.