Analysis of the Expression Pattern of Transmembrane
... amino acids rich in leucine residues. In the innate immune system, the LRR acts as a protein-protein binding motif able to interact with a wide variety of antigens. This diversity, together with their enriched expression in the nervous system, makes the eLRR-TMs to be good candidates to add complex ...
... amino acids rich in leucine residues. In the innate immune system, the LRR acts as a protein-protein binding motif able to interact with a wide variety of antigens. This diversity, together with their enriched expression in the nervous system, makes the eLRR-TMs to be good candidates to add complex ...
Palliative Care in Amyotrophic Lateral Sclerosis - A Review of
... consensus criteria21 for the diagnosis of cognitive and behavioural syndromes in ALS, the practical application of the criteria can be problematic. Formal neuropsychological testing may be particularly difficult due to disease specific factors such as dysarthria, physical disability, hypercapnia and ...
... consensus criteria21 for the diagnosis of cognitive and behavioural syndromes in ALS, the practical application of the criteria can be problematic. Formal neuropsychological testing may be particularly difficult due to disease specific factors such as dysarthria, physical disability, hypercapnia and ...
Word
... excluded the cardinal symptoms and signs of M.E. and instead focused almost entirely on ‘fatigued persons.’ CFS was created in a response to an outbreak of what was unmistakably M.E., but this new name and definition did not describe the known signs, symptoms, history and pathology of M.E. It descri ...
... excluded the cardinal symptoms and signs of M.E. and instead focused almost entirely on ‘fatigued persons.’ CFS was created in a response to an outbreak of what was unmistakably M.E., but this new name and definition did not describe the known signs, symptoms, history and pathology of M.E. It descri ...
Phys. Rev. E - University of Warwick
... the initial conditions and the choice of the parameters, we observed the coupled system desynchronizing and settling in an antiphase locked oscillatory state 共see Fig. 3 upper right兲. The “hot-spot” near the upper left corner of Fig. 2 is indicative of a different attractor on the synchronous manifo ...
... the initial conditions and the choice of the parameters, we observed the coupled system desynchronizing and settling in an antiphase locked oscillatory state 共see Fig. 3 upper right兲. The “hot-spot” near the upper left corner of Fig. 2 is indicative of a different attractor on the synchronous manifo ...
health management in aquaculture
... This is the first textbook on diseases of cultured warmwater fish and shrimps in the Philippines. Eleven chapters cover essential information on the basic principles of disease causation, major diseases of cultured fish and crustaceans, particularly shrimps, and methods of prevention and control. Em ...
... This is the first textbook on diseases of cultured warmwater fish and shrimps in the Philippines. Eleven chapters cover essential information on the basic principles of disease causation, major diseases of cultured fish and crustaceans, particularly shrimps, and methods of prevention and control. Em ...
A Case of Isolated Middle Cerebral Artery Stenosis with Hemichorea
... the left MCA (Figure 2A and B). Conventional cerebral angiography was performed, and luminal irregularity with 48% stenosis of the left M1 segment and mild luminal irregularity of the right M1 segment were documented. The ICA and other intracranial arteries had no significant stenosis or luminal irr ...
... the left MCA (Figure 2A and B). Conventional cerebral angiography was performed, and luminal irregularity with 48% stenosis of the left M1 segment and mild luminal irregularity of the right M1 segment were documented. The ICA and other intracranial arteries had no significant stenosis or luminal irr ...
Morphological and biochemical characterization of apoptosis
... calpain activity and apoptosis during spinal cord injury (35). In accordance with this, we also used a Western blot analysis of the production of 150-kD calpain-cleaved -fodrin fragment to assess calpain activity in motor neurons of spinal cord slices (21). A synthetic and cell-permeable fluorogeni ...
... calpain activity and apoptosis during spinal cord injury (35). In accordance with this, we also used a Western blot analysis of the production of 150-kD calpain-cleaved -fodrin fragment to assess calpain activity in motor neurons of spinal cord slices (21). A synthetic and cell-permeable fluorogeni ...
Neuronal Cell Death and Degeneration through Increased
... HIV-infected people are unclear. Therefore, this study was aimed to investigate the mechanisms of increased neurodegeneration in 5-month old male HIV-1 Transgenic (Tg) rats compared to the age- and gender-matched wild-type (WT) by evaluating histological changes and biochemical parameters of the key ...
... HIV-infected people are unclear. Therefore, this study was aimed to investigate the mechanisms of increased neurodegeneration in 5-month old male HIV-1 Transgenic (Tg) rats compared to the age- and gender-matched wild-type (WT) by evaluating histological changes and biochemical parameters of the key ...
Granulomatous Meningoencephalomyelitis in Dogs
... with accumulation of pigment and adhesions to the underlying choroid may also occur.13,14 Occasionally, classic perivascular lesions may extend into the sclera.15,17 The origin of inflammatory cells in GME is controversial. These cells may result from the migration of blood-derived inflammatory cell ...
... with accumulation of pigment and adhesions to the underlying choroid may also occur.13,14 Occasionally, classic perivascular lesions may extend into the sclera.15,17 The origin of inflammatory cells in GME is controversial. These cells may result from the migration of blood-derived inflammatory cell ...
Multidrug Resistance-Associated Proteins: Expression and Function
... expression of P-gp (Cole et al., 1992). Mrp1 was subsequently cloned and sequenced in several other species including mouse, rat, dog, monkey, and cow (Stride et al., 1996; Ma et al., 2002; Taguchi et al., 2002; Yang et al., 2002; Godinot et al., 2003). In humans, MRP1 is widely expressed, with high ...
... expression of P-gp (Cole et al., 1992). Mrp1 was subsequently cloned and sequenced in several other species including mouse, rat, dog, monkey, and cow (Stride et al., 1996; Ma et al., 2002; Taguchi et al., 2002; Yang et al., 2002; Godinot et al., 2003). In humans, MRP1 is widely expressed, with high ...
Endogenous morphine-like compound immunoreactivity increases
... using mice that are unable to synthesize dopamine due to a genetic deletion of tyrosine hydroxylase specifically in dopaminergic neurons, showed that endogenous dopamine is necessary for endogenous morphine formation in normal mammalian brain (Neri et al., 2008). Those dopamine-null mice displayed b ...
... using mice that are unable to synthesize dopamine due to a genetic deletion of tyrosine hydroxylase specifically in dopaminergic neurons, showed that endogenous dopamine is necessary for endogenous morphine formation in normal mammalian brain (Neri et al., 2008). Those dopamine-null mice displayed b ...
Complexins: Cytosolic Proteins That Regulate
... mune and immune sera using two independent syntaxin antibodies showed that immune but not preimmune sera precipitated complexins and the core complex (Figure 1). Second, as described above, quantitations of the approximate ratios of the precipitated proteins demonstrated nearly stoichiometric concen ...
... mune and immune sera using two independent syntaxin antibodies showed that immune but not preimmune sera precipitated complexins and the core complex (Figure 1). Second, as described above, quantitations of the approximate ratios of the precipitated proteins demonstrated nearly stoichiometric concen ...
Activity and expression pattern of cyclin-dependent
... et al., 1992) and mouse (M. Meyerson and L.-H. T., unpublished results) share 99% identity with each other at the protein level suggesting that this protein is highly conserved within vertebrate species. In this study, we have found that cdk5 has patterns of expression and kinase activity in the ner ...
... et al., 1992) and mouse (M. Meyerson and L.-H. T., unpublished results) share 99% identity with each other at the protein level suggesting that this protein is highly conserved within vertebrate species. In this study, we have found that cdk5 has patterns of expression and kinase activity in the ner ...
Ocular Dominance and Patterned Lateral Connections in a Self
... ocular dominance, and retinotopy can emerge from simple self-organizing processes (e.g. Goodhill 1993; Miller 1994; Obermayer et al.1992; von der Malsburg 1973). These models assume that the neuronal response properties are primarily determined by the afferent connections, and concentrate only on th ...
... ocular dominance, and retinotopy can emerge from simple self-organizing processes (e.g. Goodhill 1993; Miller 1994; Obermayer et al.1992; von der Malsburg 1973). These models assume that the neuronal response properties are primarily determined by the afferent connections, and concentrate only on th ...
Leptin Receptor Immunoreactivity in Chemically Defined Target
... lular domain of short LR isoform a, which is present in db/db mice, contains the box 1 motif but lacks the box 2 motif, required for activation of cytoplasmic tyrosine kinases of the janus kinase (JAK) family (Chen et al., 1996; Lee et al., 1996). JAKs phosphorylate cytoplasmic target proteins such ...
... lular domain of short LR isoform a, which is present in db/db mice, contains the box 1 motif but lacks the box 2 motif, required for activation of cytoplasmic tyrosine kinases of the janus kinase (JAK) family (Chen et al., 1996; Lee et al., 1996). JAKs phosphorylate cytoplasmic target proteins such ...
Second consensus statement on the diagnosis of multiple
... shown preserved sympathetic postganglionic neurons in MSA, in contrast to PD21; however, some MIBG studies have shown denervation in MSA,22 and a recent investigation with PET and [11C]hydroxyephedrine ([11C]HED) revealed severe cardiac denervation in MSA.23 Parkinsonism. Most MSA patients develop p ...
... shown preserved sympathetic postganglionic neurons in MSA, in contrast to PD21; however, some MIBG studies have shown denervation in MSA,22 and a recent investigation with PET and [11C]hydroxyephedrine ([11C]HED) revealed severe cardiac denervation in MSA.23 Parkinsonism. Most MSA patients develop p ...
Development of a Far-Red to Near-Infrared Fluorescence Probe for
... acid (BAPTA) moiety. The fluorophore and chelator were coupled via a short linker to afford the new probe, CaSiR-1 (Figure 1a).3 First we examined the photophysical properties of CaSiR-1. The fluorescence intensity increased with increasing concentration of free Ca2+, while the absorption spectrum scar ...
... acid (BAPTA) moiety. The fluorophore and chelator were coupled via a short linker to afford the new probe, CaSiR-1 (Figure 1a).3 First we examined the photophysical properties of CaSiR-1. The fluorescence intensity increased with increasing concentration of free Ca2+, while the absorption spectrum scar ...
Regulation of brain glutamate metabolism by nitric oxide and S
... guanosine 5′-triphosphate (GTP) (for glu- determined by one-way analysis of variance (ANOVA) with Tukey post hoc analysis (n = 3 mice per genotype). tamate dehydrogenase) and aminooxyacetic (C) Genotypic differences in steady-state glutamine/glutamate metabolism. 15N enrichment of glutamine/ acid (A ...
... guanosine 5′-triphosphate (GTP) (for glu- determined by one-way analysis of variance (ANOVA) with Tukey post hoc analysis (n = 3 mice per genotype). tamate dehydrogenase) and aminooxyacetic (C) Genotypic differences in steady-state glutamine/glutamate metabolism. 15N enrichment of glutamine/ acid (A ...
The Neuropathology of Manganese
... levels of manganese can cause neurotoxicity with the development of a form of parkinsonism known as manganism. It has recently been hypothesized that manganese exposure might also cause or accelerate the development of Parkinson disease (PD). This article is a review of the pathologic studies that h ...
... levels of manganese can cause neurotoxicity with the development of a form of parkinsonism known as manganism. It has recently been hypothesized that manganese exposure might also cause or accelerate the development of Parkinson disease (PD). This article is a review of the pathologic studies that h ...
Hypertension and Dementia: Epidemiological and Experimental
... A reasonable amount of evidence shows that the reduction in peripheral resistance in the individual patient correlates with an improvement in abnormal remodeling of resistance vessel [33]. Hypertension worsens vascular dysfunctions, a typical condition of ageing, and accelerates the same processes t ...
... A reasonable amount of evidence shows that the reduction in peripheral resistance in the individual patient correlates with an improvement in abnormal remodeling of resistance vessel [33]. Hypertension worsens vascular dysfunctions, a typical condition of ageing, and accelerates the same processes t ...
Local synaptic connections of basal forebrain neurons
... of the cerebral cortex, the hippocampus, and the neostriatum [17,20,63,65]. Identified PV cells in the BF discharged at 7–15 Hz, regular or in random modes and showed positive correlation in their discharge pattern to concurrent EEG desynchronization (Duque, Balatoni, Detari and Zaborszky, in press) ...
... of the cerebral cortex, the hippocampus, and the neostriatum [17,20,63,65]. Identified PV cells in the BF discharged at 7–15 Hz, regular or in random modes and showed positive correlation in their discharge pattern to concurrent EEG desynchronization (Duque, Balatoni, Detari and Zaborszky, in press) ...
Neuropeptides in the Drosophila central complex in modulation of
... The central complex is one of the most prominent neuropils in the insect brain. It has been implicated in the control of locomotor activity and is considered as a pre-motor center. Several neuropeptides are expressed in circuits of the central complex, and thus may be modulators of locomotor behavio ...
... The central complex is one of the most prominent neuropils in the insect brain. It has been implicated in the control of locomotor activity and is considered as a pre-motor center. Several neuropeptides are expressed in circuits of the central complex, and thus may be modulators of locomotor behavio ...
Detection of an Autoantibody from Pug Dogs with Necrotizing
... infiltrates were very mild. The differing histologic appearance of these brain lesions might be due to the different clinical histories; dog No. 1 survived for only 2 months and dog No. 2 survived for 17 months after clinical onset. Thus, dog No. 1 represents a subacute stage and dog No. 2 represent ...
... infiltrates were very mild. The differing histologic appearance of these brain lesions might be due to the different clinical histories; dog No. 1 survived for only 2 months and dog No. 2 survived for 17 months after clinical onset. Thus, dog No. 1 represents a subacute stage and dog No. 2 represent ...
The Pathogenesis of Lyme Neuroborreliosis: From Infection to
... the previous tick bite or the EM—a phenomenon that was observed even years before the spirochetal etiology of Bannwarth’s syndrome was known (77). In their report, the authors proposed that the (at that time unknown) microbe would migrate along the peripheral nerves or lymphatic vessels to the centr ...
... the previous tick bite or the EM—a phenomenon that was observed even years before the spirochetal etiology of Bannwarth’s syndrome was known (77). In their report, the authors proposed that the (at that time unknown) microbe would migrate along the peripheral nerves or lymphatic vessels to the centr ...
Bacteria general - Austin Community College
... prokaryotes have a very simple structure but show an almost unlimited variety of metabolic pathways bacteria show more metabolic diversity than all other kingdoms combined àevery kind of food eaten by any other form of life can be eaten by some species of bacteria àsome nutrients can only be used by ...
... prokaryotes have a very simple structure but show an almost unlimited variety of metabolic pathways bacteria show more metabolic diversity than all other kingdoms combined àevery kind of food eaten by any other form of life can be eaten by some species of bacteria àsome nutrients can only be used by ...
Neurodegeneration
Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases including amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells. As research progresses, many similarities appear that relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.