Intranasal (IN) Medication Administration MBED Clinical Practice
... CLINICAL PHARMACOLOGY: Dexmedetomidine is a selective α2-adrenergic receptor agonist that has sedative, analgesic, anesthetic and sympatholytic properties. Its effects are thought to be linked to the activation of G-proteins by the alpha2a receptors in the brainstem, which results in the inhibition ...
... CLINICAL PHARMACOLOGY: Dexmedetomidine is a selective α2-adrenergic receptor agonist that has sedative, analgesic, anesthetic and sympatholytic properties. Its effects are thought to be linked to the activation of G-proteins by the alpha2a receptors in the brainstem, which results in the inhibition ...
yohimbine as an antagonist to ketamine
... min. In contrast, 35 bears were given intravenous injections of yohimbine, of which 31 (89%) recovered within 10 min (median = 5 min). Heart rates increased an average of 61% within 1 min of intravenous injections. Two bears that were immobilized with ketamine alone (10 mg/kg and 17 mg/kg) did not r ...
... min. In contrast, 35 bears were given intravenous injections of yohimbine, of which 31 (89%) recovered within 10 min (median = 5 min). Heart rates increased an average of 61% within 1 min of intravenous injections. Two bears that were immobilized with ketamine alone (10 mg/kg and 17 mg/kg) did not r ...
Acute administration of typical and atypical antipsychotics reduces
... symptoms in patients. In conscious rats an equivalent dose of ketamine induces key features of animal models of acute psychosis, including hyperlocomotor activity, deficits in prepulse inhibition and gating of auditory evoked potentials, and concomitantly increases the power of ongoing spontaneously ...
... symptoms in patients. In conscious rats an equivalent dose of ketamine induces key features of animal models of acute psychosis, including hyperlocomotor activity, deficits in prepulse inhibition and gating of auditory evoked potentials, and concomitantly increases the power of ongoing spontaneously ...
Veterinary Anesthetic and Analgesic Formulary
... For anesthetic drugs, the duration of action has not been provided. Duration of anesthesia is influenced by the drugs used, strain, age, sex, body weight, procedure performed and the amount of stimulus during the procedure. As a result, any published duration of action would be a generalization. F ...
... For anesthetic drugs, the duration of action has not been provided. Duration of anesthesia is influenced by the drugs used, strain, age, sex, body weight, procedure performed and the amount of stimulus during the procedure. As a result, any published duration of action would be a generalization. F ...
Guidelines: Anesthesia and Analgesia in Laboratory Animals
... consciousness and an absence of motor response to noxious stimuli. This unconsciousness, analgesia, and muscle relaxation should be sufficient to allow the performance of procedures without the subject experiencing pain. In addition to these effects, anesthetics also produce a depressant effect on t ...
... consciousness and an absence of motor response to noxious stimuli. This unconsciousness, analgesia, and muscle relaxation should be sufficient to allow the performance of procedures without the subject experiencing pain. In addition to these effects, anesthetics also produce a depressant effect on t ...
Novel Preoperative Pharmacologic Methods of Preventing
... up to 103 minutes after gargling.20 The authors reported that both levels were below those described to produce analgesia.20 Investigators have suggested that NMDA receptors are found not only in the central nervous system but also in the peripheral nerves.22,23 Moreover, experimental studies point ...
... up to 103 minutes after gargling.20 The authors reported that both levels were below those described to produce analgesia.20 Investigators have suggested that NMDA receptors are found not only in the central nervous system but also in the peripheral nerves.22,23 Moreover, experimental studies point ...
Sedation and anaesthesia
... IV sulphonamide antibiotics Never use at the same time as these drugs as it can cause fatal cardiac arrhythmias (see Section 5.3). Ataxia Romifidine is preferred in many cases as it gives less ataxia and has the longest duration of action of the three; however, it cannot be given IM and is not ava ...
... IV sulphonamide antibiotics Never use at the same time as these drugs as it can cause fatal cardiac arrhythmias (see Section 5.3). Ataxia Romifidine is preferred in many cases as it gives less ataxia and has the longest duration of action of the three; however, it cannot be given IM and is not ava ...
Annex 1 - Emcdda
... Sweden (1) and the United Kingdom (15). It should be noted that in some of these deaths it is likely that other pharmacologically active substances (such as controlled drugs) and/or other medical conditions or trauma may have contributed to and/or been responsible for death. Drowning was the cause o ...
... Sweden (1) and the United Kingdom (15). It should be noted that in some of these deaths it is likely that other pharmacologically active substances (such as controlled drugs) and/or other medical conditions or trauma may have contributed to and/or been responsible for death. Drowning was the cause o ...
Review Article Pro- and Anticonvulsant Effects of Anesthetics (Part 11)
... Stanski D, Saidman L, Meathe E. A model for studying depth of previous sleep and awake EEGs of these epileptics anesthesia and acute tolerance to thiopental. Anesthesiology 1983; (53). Methohexital has never been demonstrated to 59:301-8, with permission.) provoke either EEG or clinical seizure acti ...
... Stanski D, Saidman L, Meathe E. A model for studying depth of previous sleep and awake EEGs of these epileptics anesthesia and acute tolerance to thiopental. Anesthesiology 1983; (53). Methohexital has never been demonstrated to 59:301-8, with permission.) provoke either EEG or clinical seizure acti ...
Drug formulary - Johns Hopkins University
... Independent of the quality of design and integration of an anesthetic and analgesic plan into a research protocol, that plan is only as good as the skill and care with which it is applied. General training is available through the ACUC by means of routinely scheduled classes or by request from indiv ...
... Independent of the quality of design and integration of an anesthetic and analgesic plan into a research protocol, that plan is only as good as the skill and care with which it is applied. General training is available through the ACUC by means of routinely scheduled classes or by request from indiv ...
Presentation: Perioperative Anesthesia for Patients with Post
... PCL=25, after 7 months PCL=67 Repeat SGB brought PCL to 23, leveled out at 34 Five minutes after SGB “a cloud had lifted” from his mind Global feelings of anxiety 8 out of 10 to a 2 out of 10 Great deal of satisfaction ...
... PCL=25, after 7 months PCL=67 Repeat SGB brought PCL to 23, leveled out at 34 Five minutes after SGB “a cloud had lifted” from his mind Global feelings of anxiety 8 out of 10 to a 2 out of 10 Great deal of satisfaction ...
Drug Formulary
... dose or accommodate the duration of the procedure. As a generalization, it is often recommended to re‐administer 25‐30% of the initial dose of the injectable anesthetic to lengthen the surgical anesthesia time. It is not acceptable to perform a surgical procedure unless the animal is fully anesthet ...
... dose or accommodate the duration of the procedure. As a generalization, it is often recommended to re‐administer 25‐30% of the initial dose of the injectable anesthetic to lengthen the surgical anesthesia time. It is not acceptable to perform a surgical procedure unless the animal is fully anesthet ...
efferent vagal discharge and heart rate in response to
... Identification of cardiac and non-cardiac vagal efvagus was dissected free in the neck, covered with paraffin oil at body temperature to prevent drying ferents. Various vagal efferents (named type A, B and filamented under a microscope until single ac- and C in the present study) were identified acc ...
... Identification of cardiac and non-cardiac vagal efvagus was dissected free in the neck, covered with paraffin oil at body temperature to prevent drying ferents. Various vagal efferents (named type A, B and filamented under a microscope until single ac- and C in the present study) were identified acc ...
Balancing Total Intravenous Anesthesia and Inhalant Anesthesia in
... Other alternatives for TIVA include various combinations of ␣2 agonists with propofol. Detomidine (0.015 mg/kg, IV) and propofol (2 mg/kg, IV) were used to induce anesthesia in horses for experimental abdominal surgery, with anesthesia maintained by propofol infusion at an average of 0.18 mg/kg/min. ...
... Other alternatives for TIVA include various combinations of ␣2 agonists with propofol. Detomidine (0.015 mg/kg, IV) and propofol (2 mg/kg, IV) were used to induce anesthesia in horses for experimental abdominal surgery, with anesthesia maintained by propofol infusion at an average of 0.18 mg/kg/min. ...
Procedural Sedation and Analgesia Guideline
... moderate to deep sedation; the majority of patients maintain respiratory effort and protection of airway reflexes at these depths of sedation. In addition, the agents used in general anesthesia (e.g. inhaled anesthestics) are inherently more emetogenic than the agents used for PSA. There are very fe ...
... moderate to deep sedation; the majority of patients maintain respiratory effort and protection of airway reflexes at these depths of sedation. In addition, the agents used in general anesthesia (e.g. inhaled anesthestics) are inherently more emetogenic than the agents used for PSA. There are very fe ...
Ann N Y Acad Sci
... doses. The use of opioids to manage pain in patients with cancer is well accepted. The WHO step-wise algorithm for analgesic therapy based on pain severity reserves the use of opioid therapy for moderate and severe pain. The WHO algorithm has proven to be highly effective for the management of cance ...
... doses. The use of opioids to manage pain in patients with cancer is well accepted. The WHO step-wise algorithm for analgesic therapy based on pain severity reserves the use of opioid therapy for moderate and severe pain. The WHO algorithm has proven to be highly effective for the management of cance ...
Systematic reviews
... (open) postappendicectomy pain: Grade B Iv opioids as a continuous infusion, PCA or NCA, together with a multimodal analgesic strategy including LA wound infiltration, NSAID and PARA is currently suggested practice following appendicectomy. Morphine PCA has been previously shown to be effective, sup ...
... (open) postappendicectomy pain: Grade B Iv opioids as a continuous infusion, PCA or NCA, together with a multimodal analgesic strategy including LA wound infiltration, NSAID and PARA is currently suggested practice following appendicectomy. Morphine PCA has been previously shown to be effective, sup ...
Anesthesia of North American Deer
... recommended with tolazoline or yohimbine at the above dosage. The major complication associated with this technique is hypoxemia. Injectable Anesthesia Short term anesthesia can be readily accomplished with combinations of xylazine and ketamine: White tailed and mule deer: Xylazine 2 mg/kg BW + Ket ...
... recommended with tolazoline or yohimbine at the above dosage. The major complication associated with this technique is hypoxemia. Injectable Anesthesia Short term anesthesia can be readily accomplished with combinations of xylazine and ketamine: White tailed and mule deer: Xylazine 2 mg/kg BW + Ket ...
The thesis
... The sensation of pain is fundamental in the maintenance of the biological integrity of the body, but chronic pain status cause severe somatic and psychic impairment, which give rise to considerable social and economic burden not only on the individual but also on the society. The International Assoc ...
... The sensation of pain is fundamental in the maintenance of the biological integrity of the body, but chronic pain status cause severe somatic and psychic impairment, which give rise to considerable social and economic burden not only on the individual but also on the society. The International Assoc ...
Sedation Controlled
... patients in toxic, septic, or hemodynamic shock cocaine users pts on prolonged catecholamine infusions tyrosine-depleted patients ...
... patients in toxic, septic, or hemodynamic shock cocaine users pts on prolonged catecholamine infusions tyrosine-depleted patients ...
effects of cytochrome p450 enzyme inhibitors and inducers
... S-ketamine is a phencyclidine derivative which functions as an antagonist of the N-methyl-Daspartate (NMDA) receptor in the central nervous system. It is a unique anaesthetic producing “dissociative anaesthesia” in high doses and analgesia in low doses. Studies with human liver microsomes suggest th ...
... S-ketamine is a phencyclidine derivative which functions as an antagonist of the N-methyl-Daspartate (NMDA) receptor in the central nervous system. It is a unique anaesthetic producing “dissociative anaesthesia” in high doses and analgesia in low doses. Studies with human liver microsomes suggest th ...
Other Species - UNC Research
... no ceiling effect; when given IV, slow injection mandatory to hypotension associated release with histamine release; vomiting is very common ...
... no ceiling effect; when given IV, slow injection mandatory to hypotension associated release with histamine release; vomiting is very common ...
34 ECDD 2006/4.3 ...
... the right, in a dose-related manner, but does not change the slope of the curve. Respiratory drive to CO2 may be depressed as much as 15 to 22%. This effect is similar to that of opioids, but dissimilar from most sedative hypnotics and anaesthetics, suggesting that opioid receptors may play a role i ...
... the right, in a dose-related manner, but does not change the slope of the curve. Respiratory drive to CO2 may be depressed as much as 15 to 22%. This effect is similar to that of opioids, but dissimilar from most sedative hypnotics and anaesthetics, suggesting that opioid receptors may play a role i ...
Ketamine
Ketamine (INN) is a medication used mainly for starting and maintaining anesthesia. Other uses include sedation in intensive care, as a pain killer, as treatment of bronchospasm, as a treatment for complex regional pain syndrome and as an antidepressant. It induces a trance-like state while providing pain relief, sedation, and memory loss. Heart function, breathing, and airway reflexes generally remain functional.Common side effects include psychological reactions as the medication wears off. These reactions may include agitation, confusion, or psychosis. Elevated blood pressure and muscle tremors are relatively common, while low blood pressure and a decrease in breathing is less so. Spasms of the larynx may rarely occur.Pharmacologically, ketamine is classified as an NMDA receptor antagonist, but it also acts at numerous other sites (including opioid receptors and monoamine transporters). Like other drugs of the arylcyclohexylamine class, such as phencyclidine (PCP), ketamine is classified as a dissociative agent.Ketamine was first developed in 1962. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is legally sold under a very wide variety of brand names, including Ketalar. Ketamine's use as a recreational drug has been implicated in a number of annual deaths.