notes - UK Research - University of Kentucky
... Guidance on the use of anesthetics, analgesics, and other categories of drugs for the prevention or relief of pain and distress in laboratory animals comes from several documents. Appropriate parts of those documents are listed below. The U.S. Government Principles for the Utilization and Care of Ve ...
... Guidance on the use of anesthetics, analgesics, and other categories of drugs for the prevention or relief of pain and distress in laboratory animals comes from several documents. Appropriate parts of those documents are listed below. The U.S. Government Principles for the Utilization and Care of Ve ...
Nonhuman Primate Anesthesia and Analgesia
... procedures (suturing small wounds, catheter placement, MRI, CT scan, etc). It is also well suited for induction and endotracheal intubation for gas anesthesia. When used alone, it must be given by constant rate infusion or by repeated boluses if procedures longer than a few minutes are to be perform ...
... procedures (suturing small wounds, catheter placement, MRI, CT scan, etc). It is also well suited for induction and endotracheal intubation for gas anesthesia. When used alone, it must be given by constant rate infusion or by repeated boluses if procedures longer than a few minutes are to be perform ...
IV DRUGS in the EMERGENCY ROOM
... 9. Amnesia is while Propofol is starting to work, NOT when it is wearing off. 10. After the first dose of 1.5 mg/kg the patient may still be talking etc, but as long you have the given the patient adequate pre-analgesia, they will have amnesia for the event. ...
... 9. Amnesia is while Propofol is starting to work, NOT when it is wearing off. 10. After the first dose of 1.5 mg/kg the patient may still be talking etc, but as long you have the given the patient adequate pre-analgesia, they will have amnesia for the event. ...
EQUINE ANESTHESIA
... • Longer sedative effect than detomidine • Similar in all other aspects with xylazine and detomidine Butorphanol • Not used alone due to excitement, so always given with sedatives as part of sedative/opioid combination • Also, do not use morphine, oxymorphone, or etorphine alone in healthy horses. ( ...
... • Longer sedative effect than detomidine • Similar in all other aspects with xylazine and detomidine Butorphanol • Not used alone due to excitement, so always given with sedatives as part of sedative/opioid combination • Also, do not use morphine, oxymorphone, or etorphine alone in healthy horses. ( ...
Supplementary Files
... with greater affinity to agonist sites on high-affinity dopamine D2 receptors than to NMDARs[20]. Thus the clinical effects of ketamine may relate to a number of actions and not just those on the NMDAR[21]. . The common side-effects of nausea, headache, dizziness and confusion relate to the various ...
... with greater affinity to agonist sites on high-affinity dopamine D2 receptors than to NMDARs[20]. Thus the clinical effects of ketamine may relate to a number of actions and not just those on the NMDAR[21]. . The common side-effects of nausea, headache, dizziness and confusion relate to the various ...
Intranasal midazolam delivery procedure
... o Sufentanil will also cause deeper sedation and in doses over 1.5 mcg/kg has been noted to cause respiratory depression. o Dexmedetomidine takes longer to take effect (20 minutes) and lasts longest of all (over 1 hour). Combination therapy with midazolam plus either sufentanil or ketamine may wor ...
... o Sufentanil will also cause deeper sedation and in doses over 1.5 mcg/kg has been noted to cause respiratory depression. o Dexmedetomidine takes longer to take effect (20 minutes) and lasts longest of all (over 1 hour). Combination therapy with midazolam plus either sufentanil or ketamine may wor ...
SUBSTÂNCIAS DE ABUSO II
... hallucinogenic drugs rarely results in true hallucinations. The hallucinogens are a chemically diverse class. Grouping the hallucinogens based on their chemical structure includes, but is not limited to, three major classes: indolealkylamines or tryptamines (e.g. LSD, psilocybine and psilocin), phen ...
... hallucinogenic drugs rarely results in true hallucinations. The hallucinogens are a chemically diverse class. Grouping the hallucinogens based on their chemical structure includes, but is not limited to, three major classes: indolealkylamines or tryptamines (e.g. LSD, psilocybine and psilocin), phen ...
Anesthesia and Analgesia in Research Animals Overview
... Isoflurane is encouraged as the first choice anesthetic in mice. It should be delivered as a known percentage (1-‐3% for maintenance; up to 5% for induction) in medical grade oxygen from a precision ...
... Isoflurane is encouraged as the first choice anesthetic in mice. It should be delivered as a known percentage (1-‐3% for maintenance; up to 5% for induction) in medical grade oxygen from a precision ...
LSD and other hallucinogens
... cholinergic (ACh systems) miscellaneous synthetic hallucinogens e.g. phencyclidine (PCP) and ketamine little resemblance to any known neurotransmitter ...
... cholinergic (ACh systems) miscellaneous synthetic hallucinogens e.g. phencyclidine (PCP) and ketamine little resemblance to any known neurotransmitter ...
ECSTASY, GHB, KETAMINE, PCP , h h d Dextromethorphan and
... • N‐methyl‐D‐aspartate (NMDA) receptor antagonist Binds NMDA receptor causing a blockade of calcium flow p g through these channels ‐ Blockade of calcium associated with altered perception, memory, and cognition • Some evidence suggests that ketamine can inhibit the Some evidence suggests that k ...
... • N‐methyl‐D‐aspartate (NMDA) receptor antagonist Binds NMDA receptor causing a blockade of calcium flow p g through these channels ‐ Blockade of calcium associated with altered perception, memory, and cognition • Some evidence suggests that ketamine can inhibit the Some evidence suggests that k ...
Ketofol_in_the_ED
... • Rapid onset • Brief duration of action • Provides adequate sedation and analgesia • Minimal respiratory and hemodynamic effects ...
... • Rapid onset • Brief duration of action • Provides adequate sedation and analgesia • Minimal respiratory and hemodynamic effects ...
The Effects of Small-Dose Ketamine on Propofol Sedation
... End-expiratory Pco2 was lower in the Coadministration group (P ⬍ 0.0001). Mood and MMSE scores were higher in the Coadministration group (P ⬍ 0.004 and P ⫽ 0.001, respectively). Pain scores and analgesic consumption after discharge were less in the Coadministration group (P ⫽ 0.0004 and P ⬍ 0.0001, ...
... End-expiratory Pco2 was lower in the Coadministration group (P ⬍ 0.0001). Mood and MMSE scores were higher in the Coadministration group (P ⬍ 0.004 and P ⫽ 0.001, respectively). Pain scores and analgesic consumption after discharge were less in the Coadministration group (P ⫽ 0.0004 and P ⬍ 0.0001, ...
NMDA Receptor Antagonists
... Nicotine nasal spray dose of 3 mg versus NS nasal spray placebo during closure. VAS scores Nicotine grp: 44-5 VAS scores Placebo grp: 77 -8 Analgesic effects last 24 hours despite 45 minute kinetics lifespan of nasal nicotine. Flood P, Daniel D. Intranasal nicotine for postoperative pain treat ...
... Nicotine nasal spray dose of 3 mg versus NS nasal spray placebo during closure. VAS scores Nicotine grp: 44-5 VAS scores Placebo grp: 77 -8 Analgesic effects last 24 hours despite 45 minute kinetics lifespan of nasal nicotine. Flood P, Daniel D. Intranasal nicotine for postoperative pain treat ...
Chapter 10 - Laboratory Animal Boards Study Group
... but an increase in reflex activity. Which of the following statements regarding urethane is TRUE: a. Urethane may not be used for long duration anesthesia b. Urethane is rapidly metabolized c. Urethane causes liver damage and pulmonary edema d. Urethane is noncarcenogenic True or False: Ether is sel ...
... but an increase in reflex activity. Which of the following statements regarding urethane is TRUE: a. Urethane may not be used for long duration anesthesia b. Urethane is rapidly metabolized c. Urethane causes liver damage and pulmonary edema d. Urethane is noncarcenogenic True or False: Ether is sel ...
Hallucinogens and Dissociative Drugs
... but not to drugs such as marijuana, amphetamines, and PCP, which do not act directly on the serotonin receptors affected by LSD. Tolerance for LSD is shortlived—it is lost if the user stops taking the drug for several days. There is no evidence that LSD produces physical withdrawal symptoms when chr ...
... but not to drugs such as marijuana, amphetamines, and PCP, which do not act directly on the serotonin receptors affected by LSD. Tolerance for LSD is shortlived—it is lost if the user stops taking the drug for several days. There is no evidence that LSD produces physical withdrawal symptoms when chr ...
PREMEDICATION OF THE CHILD UNDERGOING SURGERY C. A
... midazolam was not superior in reducing a child's anxiety than sedation alone12. It has been shown that parental presence during induction of anesthesia is mostly beneficial in children older than 4 years of age who share a “calm” baseline personality with the accompanying parent13,14. Limitations to ...
... midazolam was not superior in reducing a child's anxiety than sedation alone12. It has been shown that parental presence during induction of anesthesia is mostly beneficial in children older than 4 years of age who share a “calm” baseline personality with the accompanying parent13,14. Limitations to ...
NIDA Research Report - Hallucinogens and
... altering distribution of the neurotransmitter glutamate throughout the brain. Glutamate is involved in perception of pain, responses to the environment, and memory. rugs such as PCP (phenPCP is considered the typical cyclidine) and ketamine, dissociative drug, and the which were initially descriptio ...
... altering distribution of the neurotransmitter glutamate throughout the brain. Glutamate is involved in perception of pain, responses to the environment, and memory. rugs such as PCP (phenPCP is considered the typical cyclidine) and ketamine, dissociative drug, and the which were initially descriptio ...
NIDA Research Report- Hallucinogens and
... former LSD users report experifor other hallucinogenic drugs ences known colloquially as such as psilocybin and mescaline, “flashbacks” and called “HPPD” but not to drugs such as mariby physicians. These episodes juana, amphetamines, and PCP, are spontaneous, repeated, which do not act directly on t ...
... former LSD users report experifor other hallucinogenic drugs ences known colloquially as such as psilocybin and mescaline, “flashbacks” and called “HPPD” but not to drugs such as mariby physicians. These episodes juana, amphetamines, and PCP, are spontaneous, repeated, which do not act directly on t ...
Analgesic Effects of Topical Ketamine
... therapy of complex pain. The advantage of topical agents is that they provide effective analgesia via the peripheral site of (nerve) injury and are free of peak plasma concentrations that may cause systemic side effects, and thus might increase compliance.2 One of the more potent topical analgesi ...
... therapy of complex pain. The advantage of topical agents is that they provide effective analgesia via the peripheral site of (nerve) injury and are free of peak plasma concentrations that may cause systemic side effects, and thus might increase compliance.2 One of the more potent topical analgesi ...
other drugs - Australian Indigenous HealthInfoNet
... • Memory loss or memory disturbance (amnesia) • Convulsions • Abnormal heart rhythms (cardiac arrhythmia) • Overdose. Harms from long-term use Regular heavy use can result in problems with mood (e.g. feeling depressed or paranoid) as well as memory and reasoning. ‘Flashbacks’ have been reported, w ...
... • Memory loss or memory disturbance (amnesia) • Convulsions • Abnormal heart rhythms (cardiac arrhythmia) • Overdose. Harms from long-term use Regular heavy use can result in problems with mood (e.g. feeling depressed or paranoid) as well as memory and reasoning. ‘Flashbacks’ have been reported, w ...
Rodent Anesthetics and Analgesics
... combined with Xylazine or Xylazine plus Acepromazine are the preferred anesthetics when gas anesthesia cannot be used. Advantages: Ketamine has a wide margin of safety in most species; residual analgesic effect following anesthetic recovery, most commonly used drug (in combination) for injectable an ...
... combined with Xylazine or Xylazine plus Acepromazine are the preferred anesthetics when gas anesthesia cannot be used. Advantages: Ketamine has a wide margin of safety in most species; residual analgesic effect following anesthetic recovery, most commonly used drug (in combination) for injectable an ...
Psychedelic Experiential Pharmacology
... RY: Academics focusing on errors and guessing at the location and tribal identity of the sage in Castaneda’s accounts ignore the most important aspect of his books, which is his consummate shamanic act. The details of sacred plant use in Carlos’s books were inaccurate, and whether Don Juan actually ...
... RY: Academics focusing on errors and guessing at the location and tribal identity of the sage in Castaneda’s accounts ignore the most important aspect of his books, which is his consummate shamanic act. The details of sacred plant use in Carlos’s books were inaccurate, and whether Don Juan actually ...
Location of enkephalinase and functional effects of
... The results of this study confirm previous findings of opiates having excitatory properties on the feline SO [ 1, 121. The opiate agonists morphine, [Leus]enkephalin and ketamine thus induced a contraction of the PDS and the BDS. The response to [Leus]enkephalin was dosedependent and was significant ...
... The results of this study confirm previous findings of opiates having excitatory properties on the feline SO [ 1, 121. The opiate agonists morphine, [Leus]enkephalin and ketamine thus induced a contraction of the PDS and the BDS. The response to [Leus]enkephalin was dosedependent and was significant ...
Ketofol for bone marrow aspiration and lumbar puncture in Children
... ketamine (4:1) (24). Akin et al published a trial of 60 patients undergoing cardiac catheterization who received sedation with propofol or propofol plus ketamine (3:1). They found a significant decrease in MAP in 11 patients in the propofol monotherapy group and three patients in the ketofol group ( ...
... ketamine (4:1) (24). Akin et al published a trial of 60 patients undergoing cardiac catheterization who received sedation with propofol or propofol plus ketamine (3:1). They found a significant decrease in MAP in 11 patients in the propofol monotherapy group and three patients in the ketofol group ( ...
Ketamine
Ketamine (INN) is a medication used mainly for starting and maintaining anesthesia. Other uses include sedation in intensive care, as a pain killer, as treatment of bronchospasm, as a treatment for complex regional pain syndrome and as an antidepressant. It induces a trance-like state while providing pain relief, sedation, and memory loss. Heart function, breathing, and airway reflexes generally remain functional.Common side effects include psychological reactions as the medication wears off. These reactions may include agitation, confusion, or psychosis. Elevated blood pressure and muscle tremors are relatively common, while low blood pressure and a decrease in breathing is less so. Spasms of the larynx may rarely occur.Pharmacologically, ketamine is classified as an NMDA receptor antagonist, but it also acts at numerous other sites (including opioid receptors and monoamine transporters). Like other drugs of the arylcyclohexylamine class, such as phencyclidine (PCP), ketamine is classified as a dissociative agent.Ketamine was first developed in 1962. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. It is legally sold under a very wide variety of brand names, including Ketalar. Ketamine's use as a recreational drug has been implicated in a number of annual deaths.