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Eosinophil in health and disease
Eosinophil in health and disease

... Trafficking of human eosinophils in postcapillary venules of the rabbit mesentery. (A) labeled eosinophils were injected into the terminal mesentery artery bloodstream 6 h after interleukin-1 (IL-1) administration. intravital microscopy (IVM).) Rolling of a single fluorescently labeled eosinophil i ...
The purpose of this summary is exclusively educational, to provide
The purpose of this summary is exclusively educational, to provide

... AFRS: (i) 5 -10% of cases of chronic rhinosinusitis (CRS); (ii) mainly caused by Aspergillus sp (other causal fungi: Bipolaris, Exserohilum, Curvularia, Alternaria); (iii) more frequent in humid and warm regions; (iv) pathophysiology: entry of fungal spores in the sinuses → fungal growth → IgE produ ...
The role of different monocyte subsets and macrophages in asthma
The role of different monocyte subsets and macrophages in asthma

... INTRODUCTION Asthma affects approximately 300 million people worldwide and thereby it constitutes one of the most serious global health problems. Asthma is a chronic inflammatory disease of large and small airways that is closely related to complex interactions among numerous inflammatory cells and ...
(95% CI) OR
(95% CI) OR

... Chicago, IL USA ...
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite

... to asthma and allergy,1,2 but the dramatic increase in the prevalence of these conditions in westernized countries in the past halfcentury suggests that the environment also plays a critical role.3 The importance of environmental exposures in the development of asthma is most exquisitely illustrated ...
Toxocara infection and its Association with Allergic Manifestations
Toxocara infection and its Association with Allergic Manifestations

... The inverse association between helminth infections and allergy has been extensively reported. Van den Biggelaar et al. have shown that chronic infection with Schistosoma haematobium in an endemic area in Gabon was negatively associated with skin-test reactivity to HDM. In addition, schistosome-spec ...
PDF
PDF

... (20). The short-chain galactooligosaccharides (scGOS) and longchain fructooligosaccharides (lcFOS) are human milk oligosaccharides that have attracted research interest for their potential use in infant formula. Prebiotic human milk oligosaccharides have immune-modulating effects. Acidic milk oligos ...
Gut microbiota, probiotics, and vitamin D: Interrelated exposures
Gut microbiota, probiotics, and vitamin D: Interrelated exposures

... Potential explanations for the link between obesity and asthma include pleiotropic genetic effects,5,11,12 altered lung mechanics,13 resistance to treatment with inhaled corticosteroids,14-16 diet and vitamin D deficiency,17-21 coexisting morbidity (eg, gastroesophageal reflux), and reduced or alter ...
Increased frequency of detection of Chlamydophila pneumoniae in asthma G.L. Biscione
Increased frequency of detection of Chlamydophila pneumoniae in asthma G.L. Biscione

... normal subjects [18]. The impaired immune response included deficient production of IFN-c in response to rhinovirus. IFNc is an antiviral cytokine, which is also known to be important in immune responses to C. pneumoniae infections [19, 20]; it is, therefore, possible that impaired production of IFN ...
59-year old male with shortness of breath
59-year old male with shortness of breath

... wheezing, cough. Denies asthma, bronchitis, COPD, sputum. Cardiac: Admits to pressure, dyspnea. Denies HTN, ...
Tips to Remember: What is an allergic reaction
Tips to Remember: What is an allergic reaction

... inflammatory cells to that site, resulting in additional inflammation. Many symptoms of chronic allergic disease—such as swelling, excessive mucus and hyperresponsiveness to irritating stimuli— are the result of tissue inflammation due to ongoing exposure to allergens. It is not yet fully understood ...
Expanding Allergy Treatment in Primary Care
Expanding Allergy Treatment in Primary Care

...  Remove carpet from child’s ...
- Sussex Research Online
- Sussex Research Online

... symptoms of asthma and associated allergic conditions in many countries,[1;2] and there is consistent evidence that adoption of a western lifestyle and increased urbanization are associated with increased risk of allergic diseases.[1-3] One hypothesis that has attracted much recent interest is that ...
Non-pharmacological treatment
Non-pharmacological treatment

... EPR-2007: Consider inactivated influenza vaccination for patients who have asthma. It is safe for administration to children more than 6 months of age and adults (Evidence A). The Advisory Committee on Immunization Practices of the CDC recommends vaccination for persons who have asthma, because they ...
Asthma as a chronic disease of the innate and adaptive immune
Asthma as a chronic disease of the innate and adaptive immune

... group and in severe cases is associated with the subsequent development of a prolonged wheezing illness that in some cases may extend at least to adolescence (9–16). The role of severe RSV infection as a risk factor for asthma in adulthood is less certain but is still under study. Meanwhile, more re ...
Corticosteroids: a miracle drug that must be handled with care
Corticosteroids: a miracle drug that must be handled with care

... ulcerative colitis, temporal arteritis, psoriasis and even cases of poison ivy.  But as with any strong remedy, corticosteroids come with a downside: side effects that can sometimes be as serious as the ailments they are intended to treat.  Last week I told about a friend with severe asthma who deve ...
Unit 3 - TRANSPORTATION SYSTEMS Respiratory System Test
Unit 3 - TRANSPORTATION SYSTEMS Respiratory System Test

... 7. Which of the following is NOT a reason objects inhaled are more likely to lodged in the right bronchus? a. More vertical b. Wider c. Longer d. Shorter Objective 3.06 – Describe the diseases and disorders associated with the respiratory system. 8. What respiratory condition is caused by a bacteriu ...
Diagnosis and Mangement of Inhalant Allergens
Diagnosis and Mangement of Inhalant Allergens

... Dog and Cat dander ...
The circadian clock and asthma
The circadian clock and asthma

... overnight, particularly in the early hours of the morning. Nocturnal symptoms in asthma are common and are an important indicator for escalation of treatment. An extensive body of research has demonstrated that nocturnal symptoms of cough and dyspnea are accompanied by circadian variations in airway ...
Slide 1
Slide 1

... • Late-phase response – Occurs within 4 to 10 hours after initial attack – Can be more severe than early phase and can last for 24 hours or longer – If airway inflammation is not treated or does not resolve, it may lead to irreversible lung damage. ...
Full Text Article - European Journal of Biomedical and
Full Text Article - European Journal of Biomedical and

... Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing. These episodes cause airflow obstruction, often reversible either spontaneously or with treatment.[1] ...
021709.M1-Immuno.AllergySelfStudy
021709.M1-Immuno.AllergySelfStudy

... the severity of atopic diseases. The IL-4 receptor-a gene is one example.  Other genes may have an influence on the response to medications used in treating allergic diseases ...
H = Heart (CHF/ACS)
H = Heart (CHF/ACS)

...  No NTG without … _______________ ...
Asbestos Related Lung Disease
Asbestos Related Lung Disease

... “Disease characterized by variable airflow obstruction and/or airway hyper-responsiveness due to causes and conditions attributable to a particular work environment and not to stimuli encountered outside the workplace” • It is usually new-onset asthma, but can occur in people with pre-existing asthm ...
MU Brno - med.muni
MU Brno - med.muni

... Basophils are granulocytes that circulate in the blood of most vertebrates, in humans, they account for 0,5-1,0% of the circulating white blood cells. ...
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Asthma



Asthma (from the Greek ἅσθμα, ásthma, ""panting"") is a common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction and bronchospasm. Common symptoms include wheezing, coughing, chest tightness, and shortness of breath.Asthma is thought to be caused by a combination of genetic and environmental factors. Its diagnosis is usually based on the pattern of symptoms, response to therapy over time and spirometry. It is clinically classified according to the frequency of symptoms, forced expiratory volume in one second (FEV1), and peak expiratory flow rate. Asthma may also be classified as atopic (extrinsic) or non-atopic (intrinsic) where atopy refers to a predisposition toward developing type 1 hypersensitivity reactions.Treatment of acute symptoms is usually with an inhaled short-acting beta-2 agonist (such as salbutamol) and oral corticosteroids. In very severe cases, intravenous corticosteroids, magnesium sulfate, and hospitalization may be required. Symptoms can be prevented by avoiding triggers, such as allergens and irritants, and by the use of inhaled corticosteroids. Long-acting beta agonists (LABA) or antileukotriene agents may be used in addition to inhaled corticosteroids if asthma symptoms remain uncontrolled. The occurrence of asthma has increased significantly since the 1970s. In 2011, 235–300 million people globally were diagnosed with asthma, and it caused 250,000 deaths.
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