Reservoir and conduit function of right atrium: impact on - AJP
... The purpose of this study was to investigate the relationship between right atrial (RA) reservoir and conduit function and to determine how hemodynamic changes influence this relationship and its impact on cardiac output. In 11 open-chest sheep, RA reservoir and conduit function were quantified as R ...
... The purpose of this study was to investigate the relationship between right atrial (RA) reservoir and conduit function and to determine how hemodynamic changes influence this relationship and its impact on cardiac output. In 11 open-chest sheep, RA reservoir and conduit function were quantified as R ...
The Pulmonary Circulation in Pulmonary Hypertension Novel insights into
... essential role in disease progression in pulmonary hypertension patients. However, the problem with the currently used measures of RV systolic and diastolic function are that they are load-dependent33. This means that they not solely reflect RV systolic and diastolic function, but also reflect the i ...
... essential role in disease progression in pulmonary hypertension patients. However, the problem with the currently used measures of RV systolic and diastolic function are that they are load-dependent33. This means that they not solely reflect RV systolic and diastolic function, but also reflect the i ...
PDF - Bentham Open
... Abstract: Background: The aim is to correlate pulmonary arterial (PA) remodeling estimated by PA fibrosis in PA hypertension (PAH) with clinical follow-up. Histology of PA specimens is also performed. Methods: 19 patients, aged 54±16 (4 men), functional class II-III were studied with right heart cat ...
... Abstract: Background: The aim is to correlate pulmonary arterial (PA) remodeling estimated by PA fibrosis in PA hypertension (PAH) with clinical follow-up. Histology of PA specimens is also performed. Methods: 19 patients, aged 54±16 (4 men), functional class II-III were studied with right heart cat ...
2015 ESC Guidelines for the management of patients with
... ESC Working Groups: Cardiac Cellular Electrophysiology, Cardiovascular Pharmacotherapy, Cardiovascular Surgery, Grown-up Congenital Heart Disease, Myocardial and Pericardial Diseases, Pulmonary Circulation and Right Ventricular Function, Thrombosis, Valvular Heart Disease. The content of these Europ ...
... ESC Working Groups: Cardiac Cellular Electrophysiology, Cardiovascular Pharmacotherapy, Cardiovascular Surgery, Grown-up Congenital Heart Disease, Myocardial and Pericardial Diseases, Pulmonary Circulation and Right Ventricular Function, Thrombosis, Valvular Heart Disease. The content of these Europ ...
Pericardial Diseases
... infarction and consists of fever, pleuropericardial pain, malaise, and evidence of pleural and pericardial effusions. The syndrome is a contraindication to anticoagulant therapy because pericardial hemorrhage can occur, increasing the likelihood of tamponade. The incidence of this syndrome has been ...
... infarction and consists of fever, pleuropericardial pain, malaise, and evidence of pleural and pericardial effusions. The syndrome is a contraindication to anticoagulant therapy because pericardial hemorrhage can occur, increasing the likelihood of tamponade. The incidence of this syndrome has been ...
2015 ESC Guidelines for the management of patients with
... Disclaimer: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity ...
... Disclaimer: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity ...
Interaction between systolic and diastolic time intervals in atrial
... left ventricular contractile state resulting from variation in the interval between beats be shown to affect filling time at rest. The striking sensitivity of left ventricular filling time to rapid heart rate in atrial fibrillation suggests that it may be a major factor limiting cardiac performance. ...
... left ventricular contractile state resulting from variation in the interval between beats be shown to affect filling time at rest. The striking sensitivity of left ventricular filling time to rapid heart rate in atrial fibrillation suggests that it may be a major factor limiting cardiac performance. ...
2015 ESC Guidelines for the management of
... Disclaimer: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity ...
... Disclaimer: The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of any contradiction, discrepancy and/or ambiguity ...
2015 ESC Guidelines for the management of patients with
... ESC Working Groups: Cardiac Cellular Electrophysiology, Cardiovascular Pharmacotherapy, Cardiovascular Surgery, Grown-up Congenital Heart Disease, Myocardial and Pericardial Diseases, Pulmonary Circulation and Right Ventricular Function, Thrombosis, Valvular Heart Disease. The content of these Europ ...
... ESC Working Groups: Cardiac Cellular Electrophysiology, Cardiovascular Pharmacotherapy, Cardiovascular Surgery, Grown-up Congenital Heart Disease, Myocardial and Pericardial Diseases, Pulmonary Circulation and Right Ventricular Function, Thrombosis, Valvular Heart Disease. The content of these Europ ...
De Novo Synthesis of Myocardial Adenine Nucleotides in the Rat
... De novo synthesis of adenine nucleotides was measured in rat hearts in situ and in isolated perfused rat hearts under normal conditions and during recovery from asphyxia or ischemia. Using l-14C-glycine as the precursor substrate, rates of de novo synthesis were determined from the total radioactivi ...
... De novo synthesis of adenine nucleotides was measured in rat hearts in situ and in isolated perfused rat hearts under normal conditions and during recovery from asphyxia or ischemia. Using l-14C-glycine as the precursor substrate, rates of de novo synthesis were determined from the total radioactivi ...
Print - Circulation
... not injected before the patient had started to strain. From each two-second sample of arterial blood 0.2 cc. were pipetted into planchettes and dried overnight. The radioactivity of all samples from each patient was quantitated on the same day with a thin-window Geiger-Mueller tube (TracerlabTGC-2) ...
... not injected before the patient had started to strain. From each two-second sample of arterial blood 0.2 cc. were pipetted into planchettes and dried overnight. The radioactivity of all samples from each patient was quantitated on the same day with a thin-window Geiger-Mueller tube (TracerlabTGC-2) ...
Heart rate modulates the slow enhancement of contraction due to
... Intimate mechanisms concerned with force-frequency relationships are reasonably well established. Steady-state and transient changes in stimulus frequency are associated with changes in [Ca]i that parallel the force change. It is admitted (2) that, in most mammals, heart rate (HR) elevation within t ...
... Intimate mechanisms concerned with force-frequency relationships are reasonably well established. Steady-state and transient changes in stimulus frequency are associated with changes in [Ca]i that parallel the force change. It is admitted (2) that, in most mammals, heart rate (HR) elevation within t ...
Loss of Cardiac Magnesium in Experimental Heart Failure
... heart failure victims, similar in magnitude to our experimental findings. Some of these patients, however, were receiving long-term diuretic agents, digoxin or other medications, which increase magnesium clearance by the kidney. Therefore, it was previously unclear whether magnesium deficiency is an ...
... heart failure victims, similar in magnitude to our experimental findings. Some of these patients, however, were receiving long-term diuretic agents, digoxin or other medications, which increase magnesium clearance by the kidney. Therefore, it was previously unclear whether magnesium deficiency is an ...
Transcatheter Mitral Valve Repair
... tion (FMR) who are at prohibitive risk for open surgery who receive TMVR with MitraClip, the evidence includes primarily single-arm cohort studies. Relevant outcomes are overall survival, morbid events, functional outcomes, and treatment-related morbidity. The evidence for the use of MitraClip among ...
... tion (FMR) who are at prohibitive risk for open surgery who receive TMVR with MitraClip, the evidence includes primarily single-arm cohort studies. Relevant outcomes are overall survival, morbid events, functional outcomes, and treatment-related morbidity. The evidence for the use of MitraClip among ...
THE ROLE OF MAGNESIUM IN CARDIAC ARRHYTHMIAS
... According to Nair and Morillo, both meta-analyzes show that magnesium does not have advantage over conventional atrioventricular node blockers (calcium antagonists, beta-blockers) and antiarrhythmic agents (amiodaron, class I drugs). However, magnesium is better than placebo, particularly in combina ...
... According to Nair and Morillo, both meta-analyzes show that magnesium does not have advantage over conventional atrioventricular node blockers (calcium antagonists, beta-blockers) and antiarrhythmic agents (amiodaron, class I drugs). However, magnesium is better than placebo, particularly in combina ...
Factors Associated With Major Bleeding Events
... moderate-to-high risk for stroke. Elevated risk was indicated by a history of stroke, transient ischemic attack (TIA), or systemic embolism or at least 2 of the following risk factors: heart failure or a left ventricular ejection fraction 35%; hypertension; age 75 years; or diabetes mellitus. The ...
... moderate-to-high risk for stroke. Elevated risk was indicated by a history of stroke, transient ischemic attack (TIA), or systemic embolism or at least 2 of the following risk factors: heart failure or a left ventricular ejection fraction 35%; hypertension; age 75 years; or diabetes mellitus. The ...
Factors Associated With Major Bleeding Events
... moderate-to-high risk for stroke. Elevated risk was indicated by a history of stroke, transient ischemic attack (TIA), or systemic embolism or at least 2 of the following risk factors: heart failure or a left ventricular ejection fraction 35%; hypertension; age 75 years; or diabetes mellitus. The ...
... moderate-to-high risk for stroke. Elevated risk was indicated by a history of stroke, transient ischemic attack (TIA), or systemic embolism or at least 2 of the following risk factors: heart failure or a left ventricular ejection fraction 35%; hypertension; age 75 years; or diabetes mellitus. The ...
ACCF/AHA Practice Guideline: Focused Update
... *Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as gender, age, history of diabetes, history of prior myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imp ...
... *Data available from clinical trials or registries about the usefulness/efficacy in different subpopulations, such as gender, age, history of diabetes, history of prior myocardial infarction, history of heart failure, and prior aspirin use. A recommendation with Level of Evidence B or C does not imp ...
Chick Embryo - Circulation Research
... systole (Figure 3). In addition, the mature ventricle changes shape during isovolumic contraction,23 and a similar mechanism would change the amount of the embryonic ventricle imaged in a single plane during isovolumic contraction. Despite this overlap of atrial and ventricular contraction, we defin ...
... systole (Figure 3). In addition, the mature ventricle changes shape during isovolumic contraction,23 and a similar mechanism would change the amount of the embryonic ventricle imaged in a single plane during isovolumic contraction. Despite this overlap of atrial and ventricular contraction, we defin ...
Implantable Cardioverter Defibrillator
... Eligibility criteria for ICD implantation in 13 of the 14 studies included both ischemic or nonischemic dilated cardiomyopathy (DCM) and left ventricular ejection fraction (LVEF) <35%. Most of the studies excluded adults over 70-80 years of age. Heart failure (HF) class varied between studies. While ...
... Eligibility criteria for ICD implantation in 13 of the 14 studies included both ischemic or nonischemic dilated cardiomyopathy (DCM) and left ventricular ejection fraction (LVEF) <35%. Most of the studies excluded adults over 70-80 years of age. Heart failure (HF) class varied between studies. While ...
Genetic mutations and mechanisms in dilated cardiomyopathy
... Genetic mutations account for a significant percentage of cardiomyopathies, which are a leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac output is limited by the thickened myocardium through impaired filling and outflow. Mutations in the genes encoding the thi ...
... Genetic mutations account for a significant percentage of cardiomyopathies, which are a leading cause of congestive heart failure. In hypertrophic cardiomyopathy (HCM), cardiac output is limited by the thickened myocardium through impaired filling and outflow. Mutations in the genes encoding the thi ...
IAB-BK
... The balloon pump is a machine that shuttles a light-weight gas (helium) in and out of the balloon. The pump is set to inflate and deflate with your heartbeat. Balloon pump therapy assists your heart during both the work phase (systole) and the rest phase (diastole) of the cardiac cycle. The balloon ...
... The balloon pump is a machine that shuttles a light-weight gas (helium) in and out of the balloon. The pump is set to inflate and deflate with your heartbeat. Balloon pump therapy assists your heart during both the work phase (systole) and the rest phase (diastole) of the cardiac cycle. The balloon ...
"Artificial Heart Valves". In: Encyclopedia of Biomedical Engineering
... valves is clearly demonstrated by known pathologic situations. For example, in aortic stenosis, the heart muscle attempts to compensate for deficiencies in blood flow by growing in mass (hypertrophy). Consequently, regression of myocardial mass after valve replacement is one of the major clinical in ...
... valves is clearly demonstrated by known pathologic situations. For example, in aortic stenosis, the heart muscle attempts to compensate for deficiencies in blood flow by growing in mass (hypertrophy). Consequently, regression of myocardial mass after valve replacement is one of the major clinical in ...
Aortic stenosis: Who should undergo surgery, transcatheter valve
... the Western world, affects mainly people over age 60. It is characterized by years to decades of slow progression followed by rapid clinical deterioration and a high death rate once symptoms develop. Drug therapy for it remains ineffective, and surgical aortic valve replacement is the only effective ...
... the Western world, affects mainly people over age 60. It is characterized by years to decades of slow progression followed by rapid clinical deterioration and a high death rate once symptoms develop. Drug therapy for it remains ineffective, and surgical aortic valve replacement is the only effective ...
Cardiopulmonary exercise testing in patients with
... a well-accepted and widely utilized diagnostic test in patients with heart failure (HF) and for those individuals presenting with unexplained exertional dyspnea.2– 4 With respect to patients with HF, there is a robust body of literature demonstrating the diagnostic5–9 and prognostic10 –14 utility of ...
... a well-accepted and widely utilized diagnostic test in patients with heart failure (HF) and for those individuals presenting with unexplained exertional dyspnea.2– 4 With respect to patients with HF, there is a robust body of literature demonstrating the diagnostic5–9 and prognostic10 –14 utility of ...
Coronary artery disease
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), atherosclerotic heart disease, atherosclerotic cardiovascular disease, and coronary heart disease, is a group of diseases that includes: stable angina, unstable angina, myocardial infarction, and sudden coronary death. It is within the group of cardiovascular diseases of which it is the most common type. A common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Occasionally it may feel like heartburn. Usually symptoms occur with exercise or emotional stress, last less than a few minutes, and gets better with rest. Shortness of breath may also occur and sometimes no symptoms are present. The first sign is occasionally a heart attack. Other complications include heart failure or an irregular heartbeat.Risk factors include: high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol, among others. Other risks include depression. The underlying mechanism involves atherosclerosis of the arteries of the heart. A number of tests may help with diagnoses including: electrocardiogram, cardiac stress testing, coronary computed tomographic angiography, and coronary angiogram, among others.Prevention is by eating a healthy diet, regular exercise, maintaining a healthy weight and not smoking. Sometimes medication for diabetes, high cholesterol, or high blood pressure are also used. There is limited evidence for screening people who are at low risk and do not have symptoms. Treatment involves the same measures as prevention. Additional medications such as antiplatelets including aspirin, beta blockers, or nitroglycerin may be recommended. Procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) may be used in severe disease. In those with stable CAD it is unclear if PCI or CABG in addition to the other treatments improve life expectancy or decreases heart attack risk.In 2013 CAD was the most common cause of death globally, resulting in 8.14 million deaths (16.8%) up from 5.74 million deaths (12%) in 1990. The risk of death from CAD for a given age has decreased between 1980 and 2010 especially in the developed world. The number of cases of CAD for a given age has also decreased between 1990 and 2010. In the United States in 2010 about 20% of those over 65 had CAD, while it was present in 7% of those 45 to 64, and 1.3% of those 18 to 45. Rates are higher among men than women of a given age.