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The AHA Guidelines Including Pediatric Resuscitation
The AHA Guidelines Including Pediatric Resuscitation

... He is on no medicine and has no allergies. He has had a “cold” with a fever and a cough for several days. He is cyanotic and has bilateral rales greater on the right than on the left, with intercostal retractions. His weight is 35 kg. Vital signs are pulse rate 160, respiratory rate 52, temperature ...
- Journal of Clinical Investigation
- Journal of Clinical Investigation

... It soon developed from our studies that digitalis intoxication had a marked effect on the femoral venous oxygen content. Therefore, it became necessary to adopt certain definite criteria for classifying our patients in this regard. Accordingly, any individual who had been receiving, digitalis was co ...
Physiology of congenital heart disease
Physiology of congenital heart disease

... enlarged right heart chambers (fig 1). Cardiac These patients are typically pink with pul- catheterisation is not required unless there is concern about the pulmonary vascular resistmonary plethora on chest radiography. A communication between the systemic and ance, which rises only very slowly. How ...
Autonomic Nervous System Regulation
Autonomic Nervous System Regulation

... obtaining information on the astronauts’ blood pressures in the microgravity environment. They used more sophisticated instruments to continuously measure blood pressure and heart rate. Blood pressure is generally obtained by using a sphygmomanometer and a stethoscope. Heart rate can be obtained by ...
left ventricular endocardial longitudinal and transverse changes during
left ventricular endocardial longitudinal and transverse changes during

... crystals (Fig. 1). Necropsy after death showed the crystals in the correct position. The hemodynamic parameters at the time of data acquisition are shown in Table 1. Sinus rhythm was present in all sheep after they were weaned from bypass. Mitral valve closure during IVC. The mitral valve was open f ...
Arrhythmia Risk and Arterial Stiffness
Arrhythmia Risk and Arterial Stiffness

... the latest studies in the area, their implications for cardiovascular prevention, clinical practice and therapy. The relationship between increased heart rate and pulse wave velocity (PWV) is explained by the autonomic tone, functional changes of the elastic fibers in the vascular wall, increased me ...
In Vivo Magnetic Resonance Spectroscopy
In Vivo Magnetic Resonance Spectroscopy

... globin to assess skeletal muscle oxygenation. Both oxygenated and deoxygenated forms absorb light at 850 nm, whereas at 760 nm absorption is primarily from deoxygenated forms.1314 The correlation of 760- to 850-nm absorption changes with venous hemoglobin oxygen saturation has been demonstrated in e ...
1 - JACC: Cardiovascular Imaging
1 - JACC: Cardiovascular Imaging

... low-risk, and cost-effective coronary angiography would represent important progress in the diagnosis of obstructive CAD. Magnetic resonance imaging (MRI) and multislice computed tomography (CT) have been proposed as noninvasive imaging modalities to determine the presence of coronary artery stenosi ...
Heart Failure - Visiting Nurse Service of New York
Heart Failure - Visiting Nurse Service of New York

... pictures are taken of the blood vessels that bring blood to the heart, allowing blocked blood vessels to be detected. ...
CRT Troubleshooting HRUK accreditation course October 2010
CRT Troubleshooting HRUK accreditation course October 2010

Genetic Predictors of Cardiovascular Mortality During
Genetic Predictors of Cardiovascular Mortality During

... for a large part of the increased morbidity, mortality, and socioeconomic burden of this disease (1–3). Since hyperglycemia is the defining characteristic of diabetes, near normalization of blood glucose levels by intensive glycemic control has been proposed as one of the interventions that can be us ...
Role of atrioventricular nodal ablation and pacemaker therapy in
Role of atrioventricular nodal ablation and pacemaker therapy in

... to AV nodal ablation with either RV pacing or CRT. The group with CRT showed greater improvement in exercise tolerance and greater preservation of ejection fraction than the group who received RV pacing [37] . A meta-ana­lysis of three randomized CRT AF trials [35,38–40] showed a trend toward improv ...
March 2016
March 2016

... When we think of a stroke, we often think of older people. However, most people don’t realize that strokes can occur at any age, even in younger adults. An estimated 10–15 percent of the roughly 795, 000 yearly stroke victims in the United States are younger than 45. It also appears that the percent ...
Cardiac electrophysiology
Cardiac electrophysiology

... will increase the heart rate and potentially cause palpitations or tachycardias. Causes include stress, ingested or injected substances (ie: caffeine, amphetamines, alcohol—see Holiday heart syndrome), and an overactive thyroid gland (hyperthyroidism). Individuals who have a tachycardia are often ad ...
Postoperative Atrial Fibrillation Following Open Cardiac Surgery
Postoperative Atrial Fibrillation Following Open Cardiac Surgery

... the mortality and morbidity and consequently leads to a longer hospital stay, and more use of resources, driving up the cost of care.10,11 This prospective study was conducted to determine the incidence of postoperative AF in patients undergoing a variety of open cardiac surgery procedures and ident ...
- The Journal of Thoracic and Cardiovascular Surgery
- The Journal of Thoracic and Cardiovascular Surgery

... that no global increase in the donor pool has been seen in more than 3 decades.3 Some of that lack of growth is related to the decreasing numbers of high-quality donors from public health initiatives, as well as to improved acute neurologic care that may prevent progression to brain death.28 The ind ...
special communication - Regulatory, Integrative and Comparative
special communication - Regulatory, Integrative and Comparative

... (27) were found. The diversity in the animal preparation, varying from open chest conditions up to measuring in a conscious restrained state, is most likely responsible for this. However, with none of these aforementioned techniques is it possible to monitor CO continuously over time in unrestrained ...
Cardiovascular adaptations to 10 days of cycle exercise
Cardiovascular adaptations to 10 days of cycle exercise

... sought to determine whether the increased inotropic response to b-adrenergic stimulation would be related to the increases in cardiac output and stroke volume during peak exercise. METHODS ...
Ventricular Assist Devices and Total Artificial Hearts
Ventricular Assist Devices and Total Artificial Hearts

Estudi de la regeneració miocàrdica en la
Estudi de la regeneració miocàrdica en la

... WARNING. On having consulted this thesis you’re accepting the following use conditions: Spreading this thesis by the TDX (www.tdx.cat) service has been authorized by the titular of the intellectual property rights only for private uses placed in investigation and teaching activities. Reproduction wi ...
Stroke Volume
Stroke Volume

... leen reviewed in previouis papers.7-10 The uiltrasouniid exatminiation-s were perfofrmed with a comm-tercially available uiltrasonioscope utilizing a 2.25mc, 0.75-inichl transducer withl a repetitioni rate of 1,000 imptulses per secon-id. For recordinig the echoes, the "slow sweep" or "time-motion" ...
Na/K pump regulation of cardiac repolarization
Na/K pump regulation of cardiac repolarization

... Understanding the electrophysiological basis of this phenomenon is also of clinical relevance, since the initial prolongation phase has been associated with an increased vulnerability to atrial tachyarrhythmia initiation in patients with paroxysmal supraventricular tachyarrhythmias [26]. Single-cell ...
Prognostic value of LDL to HDL cholesterol ratio in patients
Prognostic value of LDL to HDL cholesterol ratio in patients

... atherogenic, whereas a higher high-density lipoprotein cholesterol (HDL-C) level is cardioprotective. A series of studies suggested that the use of the ratio of LDL-C to HDL-C, which can be obtained from a standard lipid profile, is superior to the use of HDL-C or LDL-C alone and that the ratio of L ...
Fetal echocardiography at 1113 weeks by transabdominal
Fetal echocardiography at 1113 weeks by transabdominal

... the cardiologist, but in seven (7%) cases the latter identified additional features to those reported by the obstetrician. In four (4%) cases there was agreement on the fact that the heart was abnormal, but the obstetrician’s diagnosis was different from the one made by the cardiologist. ...
BIOREDUCIBLE POLYMER-MEDIATED GENE  THERAPY FOR THE TREATMENT OF ISCHEMIC HEART DISEASE
BIOREDUCIBLE POLYMER-MEDIATED GENE THERAPY FOR THE TREATMENT OF ISCHEMIC HEART DISEASE

... disease that remains the number one cause of death in developed nations. ...
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Myocardial infarction



Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.
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