Dilated cardiomyopathy in mice deficient for the lysosomal cysteine
... impaired in all ctsl⫺/⫺ hearts, which can be explained by the histopathological alterations that affect the myocardium of all CTSL-deficient mice. For example, fractional shortening, which provides a measure of left ventricular contraction, was significantly reduced in all CTSL-deficient mice, where ...
... impaired in all ctsl⫺/⫺ hearts, which can be explained by the histopathological alterations that affect the myocardium of all CTSL-deficient mice. For example, fractional shortening, which provides a measure of left ventricular contraction, was significantly reduced in all CTSL-deficient mice, where ...
Mean Velocity of Fiber Shortening
... studied during diagnostic left heart catheterization. Their diagnoses are listed in tables 1-3. The first group consisted of 13 patients in whom mechanical performance of the left ventricle was considered to be normal. Tension-velocity data in six of these subjects have been reported previously.' Th ...
... studied during diagnostic left heart catheterization. Their diagnoses are listed in tables 1-3. The first group consisted of 13 patients in whom mechanical performance of the left ventricle was considered to be normal. Tension-velocity data in six of these subjects have been reported previously.' Th ...
Persistent left superior vena cava with an absent right superior vena
... venogram was implemented with 2 venous lines placed into both forearms. This allows the exclusion of all venous connections that may not be detected with only 1 side contrast injection. A persistent LSVC may be also suspected during other tests: for example, by a chest X-ray which reveals a widened ...
... venogram was implemented with 2 venous lines placed into both forearms. This allows the exclusion of all venous connections that may not be detected with only 1 side contrast injection. A persistent LSVC may be also suspected during other tests: for example, by a chest X-ray which reveals a widened ...
Netherlands Heart Journal Supplements Abstracts of the Scientifi c Spring
... < 6 months after delivery, 18 women were lost to follow up, rendering 183 pregnancies in 173 women available for follow up. Late CVC were observed after 12 pregnancies (6.6%). Women with CVC during pregnancy were at risk for late CVC (HR 7.1, 95% CI 2.2-23.2,p=0.001,figure 1). In women with CVC duri ...
... < 6 months after delivery, 18 women were lost to follow up, rendering 183 pregnancies in 173 women available for follow up. Late CVC were observed after 12 pregnancies (6.6%). Women with CVC during pregnancy were at risk for late CVC (HR 7.1, 95% CI 2.2-23.2,p=0.001,figure 1). In women with CVC duri ...
Left Ventricular Noncompaction
... (LV) trabeculae, a thin compacted layer, and deep intertrabecular recesses. Individual variability is extreme, and trabeculae represent a sort of individual “cardioprinting.” By itself, the diagnosis of LVNC does not coincide with that of a “cardiomyopathy” because it can be observed in healthy subj ...
... (LV) trabeculae, a thin compacted layer, and deep intertrabecular recesses. Individual variability is extreme, and trabeculae represent a sort of individual “cardioprinting.” By itself, the diagnosis of LVNC does not coincide with that of a “cardiomyopathy” because it can be observed in healthy subj ...
Cardiovascular Disease Prevention and Rehabilitation 2012
... cardiology practice. Together with improvements in public health, these advances have contributed to considerably lower mortality rates following acute coronary syndromes. As a consequence, the influence that cardiac rehabilitation post myocardial infarction or revascularisation may have on mortalit ...
... cardiology practice. Together with improvements in public health, these advances have contributed to considerably lower mortality rates following acute coronary syndromes. As a consequence, the influence that cardiac rehabilitation post myocardial infarction or revascularisation may have on mortalit ...
Case Report: Congenital sub mitral left ventricle aneurysm with
... Valve2. It is typically diagnosed in young adults, presenting mostly with features of Mitral regurgitation, congestive heart failure, systemicembolization, arrhythmia and sometimes sudden death. But in our case mitral valve was almost normal and the patient presented with progressive worsening dyspn ...
... Valve2. It is typically diagnosed in young adults, presenting mostly with features of Mitral regurgitation, congestive heart failure, systemicembolization, arrhythmia and sometimes sudden death. But in our case mitral valve was almost normal and the patient presented with progressive worsening dyspn ...
Cardiovascular System
... Veins have the same three layers as arteries have and have a flap-like valve inside to prevent backflow of blood. ...
... Veins have the same three layers as arteries have and have a flap-like valve inside to prevent backflow of blood. ...
University of Groningen Pathophysiology of thoracic
... Introduction: The risk of early radiation-induced lung toxicity (RILT) limits the dose and efficacy of radiotherapy of thoracic tumors. In addition to lung dose, co-irradiation of the heart is a known risk factor in the development RILT. The aim of the present study is to identify the underlying phy ...
... Introduction: The risk of early radiation-induced lung toxicity (RILT) limits the dose and efficacy of radiotherapy of thoracic tumors. In addition to lung dose, co-irradiation of the heart is a known risk factor in the development RILT. The aim of the present study is to identify the underlying phy ...
Chapter 13 Cardiovascular System
... Veins have the same three layers as arteries have and have a flap-like valve inside to prevent backflow of blood. ...
... Veins have the same three layers as arteries have and have a flap-like valve inside to prevent backflow of blood. ...
Congenital Heart Disease with Left to Right Shunt
... Ostium primum ASD just superior to the plane of the AV – valve Large VSD beneath the plane of the AV - valve Cleft in the anterior leaflet of the mitral valve Cleft in septal leaflet of tricuspid valve The common AV-valve has 5 leaflets Shortened left ventricle inlet Left ventricle papillary muscle ...
... Ostium primum ASD just superior to the plane of the AV – valve Large VSD beneath the plane of the AV - valve Cleft in the anterior leaflet of the mitral valve Cleft in septal leaflet of tricuspid valve The common AV-valve has 5 leaflets Shortened left ventricle inlet Left ventricle papillary muscle ...
Congenitally Corrected Transposition of the Great Arteries
... TGA for siblings of ccTGA patients is 2.6% with an overall recurrence risk of 5.2% for ccTGA siblings to have some type of congenital heart defect (Piacentini et al., 2005). A recurrence risk of >5% is higher than expected, as the risk is typically thought to be 1-3% for unaffected parents to have a ...
... TGA for siblings of ccTGA patients is 2.6% with an overall recurrence risk of 5.2% for ccTGA siblings to have some type of congenital heart defect (Piacentini et al., 2005). A recurrence risk of >5% is higher than expected, as the risk is typically thought to be 1-3% for unaffected parents to have a ...
Cardiovascular Responses During Downhill Treadmill Walking at
... vasculature (Rothe, 1986). The additional physiological variable that relates to the required oxygen consumption is the arteriovenous oxygen difference (a-v O2 diff)— the oxygen difference between the arterial blood and mixed venous return indicating oxygen extracted by muscles (e.g., De Cort, Innes ...
... vasculature (Rothe, 1986). The additional physiological variable that relates to the required oxygen consumption is the arteriovenous oxygen difference (a-v O2 diff)— the oxygen difference between the arterial blood and mixed venous return indicating oxygen extracted by muscles (e.g., De Cort, Innes ...
Effect of Different Formulations of Magnesium Chloride Used As
... but its physiological effects including those at cardiac level are not well-characterized. We used an in vitro isolated perfused systemic heart preparation from the common octopus, Octopus vulgaris, to investigate: (a) if in vivo exposure to MgCl2 formulations had an effect on cardiac function in vi ...
... but its physiological effects including those at cardiac level are not well-characterized. We used an in vitro isolated perfused systemic heart preparation from the common octopus, Octopus vulgaris, to investigate: (a) if in vivo exposure to MgCl2 formulations had an effect on cardiac function in vi ...
Hypertrophic Cardiomyopathy - Pathophysiology
... sequelae to their disease (although a small percentage may die suddenly). This means that it is possible that when a veterinarian examines an older cat and identifies, for example, moderate HCM, the disease has been present for much of the cat’s life. Cats that develop severe disease may go on to ha ...
... sequelae to their disease (although a small percentage may die suddenly). This means that it is possible that when a veterinarian examines an older cat and identifies, for example, moderate HCM, the disease has been present for much of the cat’s life. Cats that develop severe disease may go on to ha ...
THE TOTAL CAVOPULMONARY CONNECTION RESISTANCE: A
... flow. Studies have reported a 40% drop in the PVR as a result of this phenomenon in addition to the local vasodilation that occurs to improve exercise tolerance43. Therefore the PVR in our model was gradually dropped from 1.96 WU as measured from catheterization to 1.1 WU based on the severity of ex ...
... flow. Studies have reported a 40% drop in the PVR as a result of this phenomenon in addition to the local vasodilation that occurs to improve exercise tolerance43. Therefore the PVR in our model was gradually dropped from 1.96 WU as measured from catheterization to 1.1 WU based on the severity of ex ...
Temporal Evolution of Left Ventricular Strain Late After Repair of
... mass/EDV ratio were significantly greater in the CoA group. The gradient between right arm and leg SBP was increased (range 214 to 38, median 12 mmHg in the CoA group). The length between apex and base shortened less in the CoA group ðp , 0:001Þ: Mass indexed to BSA tended to be higher in the CoA gr ...
... mass/EDV ratio were significantly greater in the CoA group. The gradient between right arm and leg SBP was increased (range 214 to 38, median 12 mmHg in the CoA group). The length between apex and base shortened less in the CoA group ðp , 0:001Þ: Mass indexed to BSA tended to be higher in the CoA gr ...
Lipomatous Hypertrophy of the Interatrial Septum
... that existence of embryonal mesenchymal cells within the primitive atria forming the interatrial septum can develop into adipocytes with an appropriate stimulus.7 Other investigators have proposed that the association between lipomatous hypertrophy ...
... that existence of embryonal mesenchymal cells within the primitive atria forming the interatrial septum can develop into adipocytes with an appropriate stimulus.7 Other investigators have proposed that the association between lipomatous hypertrophy ...
Transcriptional Regulation of Heart Development in Zebrafish
... Tbx20 is an ancient T-box protein whose cardiac expression initiates at the time when cardiac progenitor cells emerge from mesoderm and persists to adulthood [33–37]. In mice, Tbx20 overexpression promotes cardiomyocyte proliferation whereas Tbx20 deficiency results in impaired cardiomyocyte differe ...
... Tbx20 is an ancient T-box protein whose cardiac expression initiates at the time when cardiac progenitor cells emerge from mesoderm and persists to adulthood [33–37]. In mice, Tbx20 overexpression promotes cardiomyocyte proliferation whereas Tbx20 deficiency results in impaired cardiomyocyte differe ...
Shear stress-induced vasodilation in porcine coronary - AJP
... branches of the epicardial coronary conduit arteries were visualized by perfusing them with 0.3 ml of an india inkgelatin-PSS solution. This was prepared by adding 0.2 ml of india ink (Koh-I-Noor; Bloomsbury, NJ) and 0.36 g of porcine skin gelatin (Sigma; St. Louis, MO) to 10 ml of warm PSS as previ ...
... branches of the epicardial coronary conduit arteries were visualized by perfusing them with 0.3 ml of an india inkgelatin-PSS solution. This was prepared by adding 0.2 ml of india ink (Koh-I-Noor; Bloomsbury, NJ) and 0.36 g of porcine skin gelatin (Sigma; St. Louis, MO) to 10 ml of warm PSS as previ ...
Acetylcholine stimulated dilatation and stretch induced myogenic
... acetylcholine (ACh-) induced relaxation of isolated vascular preparations of MI-rats to investigate mechanisms of endothelial dysfunction. The majority of studies with isolated aortic rings suggest that endothelial dysfunction in this model of post-MI CHF is a time-dependent process with progressive ...
... acetylcholine (ACh-) induced relaxation of isolated vascular preparations of MI-rats to investigate mechanisms of endothelial dysfunction. The majority of studies with isolated aortic rings suggest that endothelial dysfunction in this model of post-MI CHF is a time-dependent process with progressive ...
Diastolic Time during Static and Dynamic Exercise in Myocardial
... DT = e7#{176}#{176}#{176}’42 HR for static ...
... DT = e7#{176}#{176}#{176}’42 HR for static ...
Myocardial infarction
Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, occurs when blood flow stops to a part of the heart causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Often it is in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat, or feeling tired. About 30% of people have atypical symptoms, with women more likely than men to present atypically. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, or cardiac arrest.Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake, among others. The mechanism of an MI often involves the rupture of an atherosclerotic plaque, leading to complete blockage of a coronary artery. MIs are less commonly caused by coronary artery spasms, which may be due to cocaine, significant emotional stress, and extreme cold, among others. A number of tests are useful to help with diagnosis, including electrocardiograms (ECGs), blood tests, and coronary angiography. An ECG may confirm an ST elevation MI if ST elevation is present. Commonly used blood tests include troponin and less often creatine kinase MB.Aspirin is an appropriate immediate treatment for a suspected MI. Nitroglycerin or opioids may be used to help with chest pain; however, they do not improve overall outcomes. Supplemental oxygen should be used in those with low oxygen levels or shortness of breath. In ST elevation MIs treatments which attempt to restore blood flow to the heart are typically recommended and include angioplasty, where the arteries are pushed open, or thrombolysis, where the blockage is removed using medications. People who have a non-ST elevation myocardial infarction (NSTEMI) are often managed with the blood thinner heparin, with the additional use angioplasty in those at high risk. In people with blockages of multiple coronary arteries and diabetes, bypass surgery (CABG) may be recommended rather than angioplasty. After an MI, lifestyle modifications, along with long term treatment with aspirin, beta blockers, and statins, are typically recommended.Worldwide, more than 3 million people have ST elevation MIs and 4 million have NSTEMIs each year. STEMIs occur about twice as often in men as women. About one million people have an MI each year in the United States. In the developed world the risk of death in those who have had an STEMI is about 10%. Rates of MI for a given age have decreased globally between 1990 and 2010.