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Prognostic significance of new onset atrial fibrillation in acute
Prognostic significance of new onset atrial fibrillation in acute

... course of acute coronary syndrome (ACS). Previous studies have shown that new onset of AF is associated with increased short- and long-term mortality in patients presenting either with or without ST-segment elevation ACS [1–12]. Other studies however have not shown this [12–14]. On the other hand, i ...
Managing Hyperlipidemia: An Evidence
Managing Hyperlipidemia: An Evidence

... long acting over-the-counter preparations have been associated with higher rates of hepatotoxicity. The fibric acid derivatives, gemfibrozil (Lopid®) and fenofibrate (Tricor®), are another class of lipid lowering agents.They work as ligands for peroxisome profilerator-activated receptors, which are ...
Severity of coarctation and location of aneurysm clearly
Severity of coarctation and location of aneurysm clearly

... Dr. B. Peters1, Dr. M. Prsa1, Dr. S. Schubert1, Prof. F. Berger1 The German Heart Institute Berlin (DHZB) is a hospital noted for its treatment of cardiac, thoracic and vascular disease, artificial heart implantations, and transplantations of the heart and lungs. At DHZB, about 3,500 open heart surg ...
No Slide Title
No Slide Title

... . in HR and SV during exercise cause cardiac output (Q) to increase. w Blood flow and blood pressure change. w All result in allowing the body to efficiently meet the increased demands placed on it. ...
A Patient`s Guide to Heart Surgery
A Patient`s Guide to Heart Surgery

... through these primary risk factors. For example, obesity is often associated with hypertension, elevated blood glucose, and high cholesterol levels, which is the reason why obese patients have a higher risk of CAD. On the other side, regular exercise helps prevent CAD, because it promotes weight los ...
State of the Art - Central blood pressure: to the heart of the matter
State of the Art - Central blood pressure: to the heart of the matter

Bangor, Maine and Coordinating Center
Bangor, Maine and Coordinating Center

... either baseline or at any of the three follow-up time periods. The largest difference was observed at 6 weeks and was only 2.3 torr higher than baseline. This represents a 1.8% increase over baseline, which is not a clinically significant difference. There are no differences in the DBP trend for tho ...
Review Article Safety Profile of Nonsteroidal Antiflammatory Drugs
Review Article Safety Profile of Nonsteroidal Antiflammatory Drugs

4
4

... Nevertheless, and notwithstanding the substantial evidence of their beneficial effects in LHF, the use of β-blockers is currently contra-indicated for patients with PH.1 This recommendation ...
Congenital Heart Disease
Congenital Heart Disease

... mixing of well-oxygenated and poorly oxygenated blood at the site of the anomalous pulmonary venous connection and the large right-to left shunting through ...
Investigation and management of congestive heart failure
Investigation and management of congestive heart failure

... available. It also acknowledged, however, that average life expectancy is only about three years after diagnosis, which is much worse than for many other serious illnesses such as cancer of the breast or colon.1 The condition is associated with poor quality of life, frequent hospital admissions, and ...
Hypoplastic Left Heart Syndrome
Hypoplastic Left Heart Syndrome

... This is the most complex of the three operations. It is typically performed in the first week of life. The goal of the Norwood procedure is to let the right ventricle become the sole pumping chamber of the heart, delivering blood to both the body and the lungs. Three major steps are involved: • The ...
B20 C8 Notes Circulation Mar. 22 2016
B20 C8 Notes Circulation Mar. 22 2016

...  Read pg. 275 – 276. Why is “Individual C” considered exceptionally fit? Why does regular cardiovascular exercise increase the resting stroke volume of your heart, and why should cardiovascular exercise be a regular part of your exercise regime? Blood Flow through the Coronary System The coronary s ...
Syncope and shock
Syncope and shock

... – Caused by sudden failure of the heart as an effective pump. It occurs most commonly as a complication of acute myocardial infarction, but it may also be seen in patients with severe bradyor tachyarrhythmias, valvular heart disease, or in terminal stage of chronic heart failure (ischemic heart dise ...
Else Being Equal, Men and Women Are Still Not the Same
Else Being Equal, Men and Women Are Still Not the Same

... espite growing awareness of the burden of cardiovascular disease (CVD) in women over the past 2 decades, reports of disparities in the delivery of health care for these diseases have persisted over time.1 Under-treatment of women as compared with men has been described for primary prevention, stable ...
Mock circulatory system for Ventricular Assist Device (VAD) Testing
Mock circulatory system for Ventricular Assist Device (VAD) Testing

... settings and observed values are listed in table 1. This figure shows the results for the range test, which demonstrates the system is capable of simulating a wide range of systolic and diastolic pressures and pulse pressures. The ability to achieve results outside the areas of greatest concern is g ...
FULL TEXT - Biology of Sport
FULL TEXT - Biology of Sport

... It should be noted that tissue synthesis of aldosterone is enhanced in overgrown organs that is also in heart muscle and skeletal muscles [5,7,20,21,23,29,36]. The organic or tissue RAAS exhibits a local activity intracellular, on cells sphere or inside of the neighbouring cells. The system function ...
Congenital Heart Diseases - Institute of Physical Medicine
Congenital Heart Diseases - Institute of Physical Medicine

... • ASDs occur at the lowest part of the atrial septum • can extend to the mitral and tricuspid valves, reflecting the close relationship between development of the septum primum and endocardial cushion. • Abnormalities of the atrioventricular valves are usually present, typically in the form of a cle ...
International Journal of Cardiovascular Research
International Journal of Cardiovascular Research

... has been reported in numerous studies, showing that hypertensive disease is strongly associated with overall cardiovascular risk. Increased blood pressure contributes indeed to both cardiovascular and cerebrovascular endpoints, including heart failure, myocardial infarction, and stroke [15,16]. In f ...
Horlings Heart
Horlings Heart

... 3. race/ethnicity (African Americans high risk) ...
I IIa IIb III
I IIa IIb III

... • Degree of NYHA class- Not linearly related • NYHA classes II & III - much more likely arrhythmia than class IV • Pts with NYHA IV - ↑mortality from progressive pump failure • Primary prevention ICD trials have excluded pts with NYHA IV ...
Peripheral Augmentation Index Defines the
Peripheral Augmentation Index Defines the

... during administration of NTG and pacing, interventions known to modify waveform morphology and/or the relationship between peripheral and central blood pressure. NTG reduces AI and has a greater effect on central than on peripheral blood pressure.10 Heart rate is negatively associated with AI, and i ...
Ventricular Septal Defect - American Heart Association
Ventricular Septal Defect - American Heart Association

... Ventricular Septal Defect (VSD) Note: before reading the specific defect information and the image(s) that are associated with them, it will be helpful to review normal heart function. What is it? A VSD is an opening or hole (defect) in the wall (septum) between the heart’s two pumping chambers (ven ...
ACC Heart Failure Guideline Slide Set
ACC Heart Failure Guideline Slide Set

... Addition of an aldosterone antagonist is recommended in selected patients with moderately severe to severe symptoms of HF and reduced LVEF who can be carefully monitored for preserved renal function and normal potassium concentration. Creatinine should be less than or equal to 2.5 mg/dL in men or le ...
Beneficial effects of trimetazidine (Vastarel MR) in patients with
Beneficial effects of trimetazidine (Vastarel MR) in patients with

... It has been observed that TMZ could reduce endothelin release in cardiac patients [12, 33–34]. Growth factors, vasoactive substances and mechanical stress are involved in the endothelin-1 (ET-1) increase in heart failure patients. Despite the known adaptive aspect of supporting contractility of the ...
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Antihypertensive drug



Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers.Which type of medication to use initially for hypertension has been the subject of several large studies and resulting national guidelines. The fundamental goal of treatment should be the prevention of the important endpoints of hypertension, such as heart attack, stroke and heart failure. Patient age, associated clinical conditions and end-organ damage also play a part in determining dosage and type of medication administered. The several classes of antihypertensives differ in side effect profiles, ability to prevent endpoints, and cost. The choice of more expensive agents, where cheaper ones would be equally effective, may have negative impacts on national healthcare budgets. As of 2009, the best available evidence favors the thiazide diuretics as the first-line treatment of choice for high blood pressure when drugs are necessary. Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most people (from both efficacy and cost points of view), an ACE inhibitor is recommended by NICE in the UK for those under 55 years old.
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