Oldrich Vinar by Leo E. Hollister
... Diseases I thought there would be neurological patients. It was a surprise to find I had to treat psychiatric patients. My first feeling was, this is terrible. What could two doctors, including one who just graduated from medical school with no experience in psychiatry, do with one thousand patients ...
... Diseases I thought there would be neurological patients. It was a surprise to find I had to treat psychiatric patients. My first feeling was, this is terrible. What could two doctors, including one who just graduated from medical school with no experience in psychiatry, do with one thousand patients ...
Synaptic transmission & antipsychotic drugs
... As effective as typical drugs on positive symptoms; better for negative symptoms (Bilder et al, 2002) More effective with treatment-resistant patients (DeNayer et al, 2003) Less risk of EPS, but other side effects may occur (e.g. blood disorders) ...
... As effective as typical drugs on positive symptoms; better for negative symptoms (Bilder et al, 2002) More effective with treatment-resistant patients (DeNayer et al, 2003) Less risk of EPS, but other side effects may occur (e.g. blood disorders) ...
Neuropharmacology I Parkinson`s Disease and Movement
... Selegiline: Irreversible inhibitor of the enzyme MAO-B, the subtype of MAO responsible for most central metabolism of dopamine. Symptomatic benefit arises from reduction in the rate of dopamine breakdown; magnitude of this effect is modest. Has been proposed that selegiline might have neuroprotectiv ...
... Selegiline: Irreversible inhibitor of the enzyme MAO-B, the subtype of MAO responsible for most central metabolism of dopamine. Symptomatic benefit arises from reduction in the rate of dopamine breakdown; magnitude of this effect is modest. Has been proposed that selegiline might have neuroprotectiv ...
Biopsychology of Psychiatric Disorders - U
... that certain norepinephrine and serotonin receptors are elevated in untreated depressed patients; this may be due to low levels of transmitters eliciting a compensatory increase in receptors called ...
... that certain norepinephrine and serotonin receptors are elevated in untreated depressed patients; this may be due to low levels of transmitters eliciting a compensatory increase in receptors called ...
Initial Dosing and Clinical Titration of Antipsychotic Drugs in
... agents which produce, on average, good clinical efficacy with reduced extrapyramidal side effects (Table). However, the optimal dose for several agents for some clinical indications remains uncertain. Higher doses may be more effective in treatment resistant patients. These have not yet been systema ...
... agents which produce, on average, good clinical efficacy with reduced extrapyramidal side effects (Table). However, the optimal dose for several agents for some clinical indications remains uncertain. Higher doses may be more effective in treatment resistant patients. These have not yet been systema ...
Early treatment of psychosis
... • Partial agonist at D2 receptor • Intrinsic activity depends on synaptic levels of DA • Affinity for muscarinic, α1-adrenergic, serotonin and histamine receptors • Good oral absorption, 3-5 hr to peak plasma concentration, long elimination half life • Few extrapyramidal side effects ...
... • Partial agonist at D2 receptor • Intrinsic activity depends on synaptic levels of DA • Affinity for muscarinic, α1-adrenergic, serotonin and histamine receptors • Good oral absorption, 3-5 hr to peak plasma concentration, long elimination half life • Few extrapyramidal side effects ...
HYPERTENSION IN ICU
... Hypercarbiabronchodilators,steroids,CPT,NIV,ventilator Maneuvers to reduce ICP- medications,ventilator Adjust transducer height Urinary retension-catheterize,definitive treatment Comfortable position for the patients Reintroduction of pre admission antihypertensives Psychological support- trust with ...
... Hypercarbiabronchodilators,steroids,CPT,NIV,ventilator Maneuvers to reduce ICP- medications,ventilator Adjust transducer height Urinary retension-catheterize,definitive treatment Comfortable position for the patients Reintroduction of pre admission antihypertensives Psychological support- trust with ...
Slide 1
... Atypicals are very expensive – cost effectiveness not proven Need more rigorous studies to accurately define older firstgeneration drugs ...
... Atypicals are very expensive – cost effectiveness not proven Need more rigorous studies to accurately define older firstgeneration drugs ...
SCHIZOPHRENIA2001
... Origins of antipsychotic drug development: Laborit ~ accidentally found that antihistamines reduced anxiety in presurgical patients. Charpentier ~ chlorpromazine “quieted hyperactive” mental patients & “activated withdrawn” mental patients. Since the early drugs (e.g., chlorpromazine and reserpi ...
... Origins of antipsychotic drug development: Laborit ~ accidentally found that antihistamines reduced anxiety in presurgical patients. Charpentier ~ chlorpromazine “quieted hyperactive” mental patients & “activated withdrawn” mental patients. Since the early drugs (e.g., chlorpromazine and reserpi ...
تقسیم بندی
... ventricular arrhythmias, cardiac conduction block, and sudden death; it is not certain whether thioridazine can cause these same disorders when used in therapeutic doses. In view of possible additive antimuscarinic and quinidine-like actions with various tricyclic antidepressants, thioridazine shou ...
... ventricular arrhythmias, cardiac conduction block, and sudden death; it is not certain whether thioridazine can cause these same disorders when used in therapeutic doses. In view of possible additive antimuscarinic and quinidine-like actions with various tricyclic antidepressants, thioridazine shou ...
CNS Drugs - Centegra Health System
... Potency (‘oomph’) (‘oomph’) –– Phenothiazines Phenothiazines––low lowpotency potency –– Butyrophenones Butyrophenones––high highpotency potency ...
... Potency (‘oomph’) (‘oomph’) –– Phenothiazines Phenothiazines––low lowpotency potency –– Butyrophenones Butyrophenones––high highpotency potency ...
Drug Therapy of Parkinsonism
... So the Strategies of drug treatment of parkinsonism involve increasing dopamine activity in the brain or decreasing muscarinic cholinergic activity in the brain (or both). A. Levodopa: precursor of dopamine. 1.Mechanisms : because dopamine has low bioavailability and does not readily cross the blood ...
... So the Strategies of drug treatment of parkinsonism involve increasing dopamine activity in the brain or decreasing muscarinic cholinergic activity in the brain (or both). A. Levodopa: precursor of dopamine. 1.Mechanisms : because dopamine has low bioavailability and does not readily cross the blood ...
Gastro17-GIPharm2
... See figure in powerpoints – shows variety of pathways that lead to the complex reflex of vomiting o Do not memorize chart, but know that the stimuli of nausea and vomiting come from lots of different places o Eg/ toxic substances – sensed in chemosensor areas of brain where there is poor blood bra ...
... See figure in powerpoints – shows variety of pathways that lead to the complex reflex of vomiting o Do not memorize chart, but know that the stimuli of nausea and vomiting come from lots of different places o Eg/ toxic substances – sensed in chemosensor areas of brain where there is poor blood bra ...
Sympathomimetics
... Phenmetrazine is a variant phenylisopropylamine with amphetamine-like effects. It has been promoted as an anorexiant and is also a popular drug of abuse. Methylphenidate is an amphetamine variant whose major pharmacologic effects and abuse potential is similar to those of amphetamine. It has efficac ...
... Phenmetrazine is a variant phenylisopropylamine with amphetamine-like effects. It has been promoted as an anorexiant and is also a popular drug of abuse. Methylphenidate is an amphetamine variant whose major pharmacologic effects and abuse potential is similar to those of amphetamine. It has efficac ...
ANTIPSYCHOTICS
... 11) Retinitis Pigmentosa 12) Known poor CYP2D6 metabolizer 13) Concomitant use with drugs that inhibit thioridazine metabolism (fluvoxamine, propranolol, pindolol) 14) Concomitant use with drugs that inhibit CYP2D6 (fluoxetine, paroxetine) Relative: 1) Pregnancy/nursing mothers 2) History of drug in ...
... 11) Retinitis Pigmentosa 12) Known poor CYP2D6 metabolizer 13) Concomitant use with drugs that inhibit thioridazine metabolism (fluvoxamine, propranolol, pindolol) 14) Concomitant use with drugs that inhibit CYP2D6 (fluoxetine, paroxetine) Relative: 1) Pregnancy/nursing mothers 2) History of drug in ...
FDA Requests Boxed Warnings on Older Class of Antipsychotic Drugs
... types are associated with an increased risk of death when used in elderly patients treated for dementia-related psychosis. Antipsychotic drugs commonly are categorized into two classes, the older “conventional” antipsychotics and the newer “atypical” antipsychotics. Both classes of drugs are dopamin ...
... types are associated with an increased risk of death when used in elderly patients treated for dementia-related psychosis. Antipsychotic drugs commonly are categorized into two classes, the older “conventional” antipsychotics and the newer “atypical” antipsychotics. Both classes of drugs are dopamin ...
Therapy of Bipolar Disorder
... thoughts (particularly in shizophrenia and bipolar disorder) – At conditions of acute patologic agressivity and agitation (chlorpromazine, levopromazine, haloperidol) ...
... thoughts (particularly in shizophrenia and bipolar disorder) – At conditions of acute patologic agressivity and agitation (chlorpromazine, levopromazine, haloperidol) ...
Mechanisms of Therapeutic Actions and Adverse Side Effects
... All antipsychotics (both conventional and atypical) bind to some degree at dopamine D2 receptors. It is believed that D2 antagonism mediates antipsychotics’ ability to reduce positive symptoms of schizophrenia, including hallucinations and delusions. What sets the atypical antipsychotics apart from ...
... All antipsychotics (both conventional and atypical) bind to some degree at dopamine D2 receptors. It is believed that D2 antagonism mediates antipsychotics’ ability to reduce positive symptoms of schizophrenia, including hallucinations and delusions. What sets the atypical antipsychotics apart from ...
pharmalogical emergencies
... Extrapyramidal Side Effects (EPSEs) • The first generation (conventional) antipsychotics may cause significant extrapyramidal side effects, more so than the second generation antipsychotic agents. • Risperidone and Ziprasidone more likely to cause EPSEs amongst second generation antipsychotic agent ...
... Extrapyramidal Side Effects (EPSEs) • The first generation (conventional) antipsychotics may cause significant extrapyramidal side effects, more so than the second generation antipsychotic agents. • Risperidone and Ziprasidone more likely to cause EPSEs amongst second generation antipsychotic agent ...
Antipsychotics - TOP Recommended Websites
... Occasional cases of neuroleptic malignant syndrome ...
... Occasional cases of neuroleptic malignant syndrome ...
CYAMEMAZINE
... • If antiparkinsonian agents are being used, they should generally be continued for a few weeks after high dose cyamemazine is discontinued ...
... • If antiparkinsonian agents are being used, they should generally be continued for a few weeks after high dose cyamemazine is discontinued ...
ZUCLOPENTHIXOL
... responses of individual patients can occasionally vary greatly from one atypical antipsychotic to another • Patients with inadequate responses to atypical antipsychotics may benefit from a trial of augmentation with a conventional antipsychotic such as zuclopenthixol or from switching to a convention ...
... responses of individual patients can occasionally vary greatly from one atypical antipsychotic to another • Patients with inadequate responses to atypical antipsychotics may benefit from a trial of augmentation with a conventional antipsychotic such as zuclopenthixol or from switching to a convention ...
Mechanism of Action
... Fluoxetine is eliminated very slowly by the human body. The half-life of fluoxetine after a single dose is two days. The liver metabolizes fluoxetine to a desmethyl metabolite. ...
... Fluoxetine is eliminated very slowly by the human body. The half-life of fluoxetine after a single dose is two days. The liver metabolizes fluoxetine to a desmethyl metabolite. ...
Chlorpromazine
Chlorpromazine (CPZ) — marketed as Thorazine among others — is a dopamine antagonist of the typical anti-psychotic class of medications possessing additional antiadrenergic, anti-serotonergic, anticholinergic and antihistaminergic properties used to treat schizophrenia. First synthesized on December 11, 1951, chlorpromazine was the first drug developed with specific antipsychotic action and would serve as the prototype for the phenothiazine class of drugs, which comprises several other agents. The introduction of chlorpromazine during the 1950s has been described as the single greatest advance in the history of psychiatric care, improving the prognosis of people in psychiatric hospitals.Chlorpromazine works on a variety of receptors in the central nervous system, producing potent anticholinergic, antidopaminergic, antihistaminic, and antiadrenergic effects. Both the clinical indications and side effect profile of CPZ are determined by the broadness of its action: its anticholinergic properties cause constipation, sedation, and hypotension but also help relieve nausea. It also has anxiolytic (anxiety-relieving) properties. Its antidopaminergic properties can cause extrapyramidal symptoms, such as akathisia (restlessness, where the patient walks almost constantly, despite having nowhere to go due to mandatory confinement) and dystonia. It is known to cause tardive dyskinesia, which can be irreversible. In acute settings, it is often administered as a syrup, which has a faster onset of action than tablets, and it can also be given by intramuscular injection. IV administration is very irritating and is not advised; its use is limited to severe hiccups, surgery, and tetanus.Chlorpromazine is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.