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Opexa Therapeutics, Inc.
Opexa Therapeutics, Inc.

... our current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated as a result of various risks and uncertainties which include, without limitation, risks associated with the ...
Upper respiratory tract infection, heterologous immunisation and
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... meningococcal disease versus household contacts might be overestimated. The results of the present study support previous observations regarding the association between an upper respiratory tract infection and the occurrence of meningococcal disease [5-81. This predisposing effect has been explained ...
U.S. SECURITY AND THE RISK POSED BY INFECTIOUS DISEASES
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... Although HIV/AIDS first spread through the relatively open American homosexual community, it is now most often spread among intravenous drug users. According to the CDC, half of all new infections currently result from the sharing of needles to inject heroin and cocaine.18 The threat of HIV/AIDS in ...
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... [Mishra et al. 2015/J. Livestock Sci. 6: 36-43 with a high mortality rate, often accompanied by hemorrhagic lymphadenitis. In dogs, humans, horses, and pigs, it is usually less acute. B anthracis spores can remain infective in soil for many years. During this time, they are a potential source of in ...
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... burning sensations often tend to come and go and move around the body. For example, one day the joint pain might be in the knees. Three days later, it's in the shoulders, and two days later it's in the ankles.The same symptoms can happen with Lyme neuropathy, where the bacteria have affected the ner ...
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Infectious Mononucleosis

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African trypanosomiasis



African trypanosomiasis or sleeping sickness is a parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei. There are two types that infect humans, Trypanosoma brucei gambiense (T.b.g) and Trypanosoma brucei rhodesiense (T.b.r.). T.b.g causes over 98% of reported cases. Both are usually transmitted by the bite of an infected tsetse fly and are most common in rural areas.Initially, in the first stage of the disease, there are fevers, headaches, itchiness, and joint pains. This begins one to three weeks after the bite. Weeks to months later the second stage begins with confusion, poor coordination, numbness and trouble sleeping. Diagnosis is via finding the parasite in a blood smear or in the fluid of a lymph node. A lumbar puncture is often needed to tell the difference between first and second stage disease.Prevention of severe disease involves screening the population at risk with blood tests for T.b.g. Treatment is easier when the disease is detected early and before neurological symptoms occur. Treatment of the first stage is with the medications pentamidine or suramin. Treatment of the second stage involves: eflornithine or a combination of nifurtimox and eflornithine for T.b.g. While melarsoprol works for both it is typically only used for T.b.r. due to serious side effects.The disease occurs regularly in some regions of sub-Saharan Africa with the population at risk being about 70 million in 36 countries. As of 2010 it caused around 9,000 deaths per year, down from 34,000 in 1990. An estimated 30,000 people are currently infected with 7000 new infections in 2012. More than 80% of these cases are in the Democratic Republic of the Congo. Three major outbreaks have occurred in recent history: one from 1896 to 1906 primarily in Uganda and the Congo Basin and two in 1920 and 1970 in several African countries. Other animals, such as cows, may carry the disease and become infected.
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