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HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... amphetamine sulfate extended-release capsules are indicated for the treatment of attention deficit hyperactivity disorder (ADHD). The efficacy of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, amphetamine sulfate extended-release in the treatment of ADHD ...
... amphetamine sulfate extended-release capsules are indicated for the treatment of attention deficit hyperactivity disorder (ADHD). The efficacy of dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, amphetamine sulfate extended-release in the treatment of ADHD ...
Amphetamine Paradoxically Augments Exocytotic Dopamine Release and Phasic Dopamine Signals
... Analysis of exocytotic dopamine release and neuronal dopamine uptake. Voltammetric dopamine signals resulting from delivery of current pulse trains were analyzed using a kinetic model describing evoked levels as a balance between dopamine release and uptake mechanisms (Wu et al., 2001), as shown in ...
... Analysis of exocytotic dopamine release and neuronal dopamine uptake. Voltammetric dopamine signals resulting from delivery of current pulse trains were analyzed using a kinetic model describing evoked levels as a balance between dopamine release and uptake mechanisms (Wu et al., 2001), as shown in ...
Control of Extracellular Dopamine at Dendrite and Axon Terminals
... To confirm the chemical identity of the fast-scan cyclic voltammetry (FSCV) signal, dopamine and 5-HT were applied by the iontophoretic application of either dopamine hydrochloride or serotonin hydrochloride as a single pulse (25–100 nA, 5–25 ms, [DA] 1 M, [5-HT] 0.5 M) from thin-walled iontophoreti ...
... To confirm the chemical identity of the fast-scan cyclic voltammetry (FSCV) signal, dopamine and 5-HT were applied by the iontophoretic application of either dopamine hydrochloride or serotonin hydrochloride as a single pulse (25–100 nA, 5–25 ms, [DA] 1 M, [5-HT] 0.5 M) from thin-walled iontophoreti ...
1
... improvement of previous ADHD studies, are: a) the application for the first time of voxel-based morphometry analysis to compare ADHD children with non familyrelated control children; b) the design and application of a new, easy to apply, manual method of caudate nucleus segmentation. The results con ...
... improvement of previous ADHD studies, are: a) the application for the first time of voxel-based morphometry analysis to compare ADHD children with non familyrelated control children; b) the design and application of a new, easy to apply, manual method of caudate nucleus segmentation. The results con ...
... combined into a single category: Attention Deficit Hyperactivity Disorder. In 1994, DSMIV once again subdivided ADHD, this time into predominantly inattentive subtype, predominantly hyperactive-impulsive subtype and combined subtypes (1). 1.1.3 ETIOLOGY The specific causes of ADHD are not yet known, ...
Print - Circulation
... perfused, innervated rat heart model previously described in detail.18"19 Rats were anesthetized with pentobarbital (60 mg/kg IP) and heparinized (200 U per rat IV). The chest was opened and a metal cannula inserted into the ascending aorta to start coronary perfusion in situ. The perfusate was a mo ...
... perfused, innervated rat heart model previously described in detail.18"19 Rats were anesthetized with pentobarbital (60 mg/kg IP) and heparinized (200 U per rat IV). The chest was opened and a metal cannula inserted into the ascending aorta to start coronary perfusion in situ. The perfusate was a mo ...
... characterized by inattention, hyperactivity and impulsivity symptoms and estimate to affect 5% of worldwide population. Until recently, symptoms were thought to ameliorate with age. However, a recent 10 year follow-up study indicated that 35% of paediatric patients still meet criteria and it’s been ...
NIH Public Access Emotional dysregulation and Attention-Deficit/Hyperactivity Disorder Author Manuscript
... emotion regulation: orienting to emotionally salient stimuli and the evaluation of signals for reward. In order for emotion to be regulated, posterior attention systems must both detect salient stimuli and signal that control is needed (77, 79). Evidence suggests anomalies in early orienting to emot ...
... emotion regulation: orienting to emotionally salient stimuli and the evaluation of signals for reward. In order for emotion to be regulated, posterior attention systems must both detect salient stimuli and signal that control is needed (77, 79). Evidence suggests anomalies in early orienting to emot ...
ADHD Parents Medication Guide Prepared by:
... in children with tic disorders. Historically, stimulants have been thought to either cause tics to begin or worsen, which led to warnings in the product information suggesting that children with ADHD and tics as well as children with a family history of tics should not be treated with a stimulant me ...
... in children with tic disorders. Historically, stimulants have been thought to either cause tics to begin or worsen, which led to warnings in the product information suggesting that children with ADHD and tics as well as children with a family history of tics should not be treated with a stimulant me ...
pathophysiology of attention deficit/ hyperactivity disorder
... on ADHD symptoms. In contrast, neurocognitive symptoms are do not respond well to TCA treatment. Because of rare reports of sudden death among TCA-treated children, these drugs are not a first-line treatment for ADHD and are only used after carefully weighing the risks and benefits of treating or no ...
... on ADHD symptoms. In contrast, neurocognitive symptoms are do not respond well to TCA treatment. Because of rare reports of sudden death among TCA-treated children, these drugs are not a first-line treatment for ADHD and are only used after carefully weighing the risks and benefits of treating or no ...
Product Monograph
... Amphetamines have a potential for abuse, misuse, dependence, or diversion for non-therapeutic uses that physicians should consider when prescribing this product (see Precautions, Dependence Liability.) The misuse of amphetamines may cause serious cardiovascular adverse events and sudden death. Pre-e ...
... Amphetamines have a potential for abuse, misuse, dependence, or diversion for non-therapeutic uses that physicians should consider when prescribing this product (see Precautions, Dependence Liability.) The misuse of amphetamines may cause serious cardiovascular adverse events and sudden death. Pre-e ...
Dopamina. Monografia del farmaco.
... Dopamine's direct inotropic effect on the myocardium which increases cardiac output at low or moderate doses is related to a favorable prognosis. Increased output has been associated with unchanged or decreased systemic vascular resistance (SVR). The association of static or decreased SVR with low o ...
... Dopamine's direct inotropic effect on the myocardium which increases cardiac output at low or moderate doses is related to a favorable prognosis. Increased output has been associated with unchanged or decreased systemic vascular resistance (SVR). The association of static or decreased SVR with low o ...
Paresthesia (including formication) (postmarketing AE), reformating
... Pre-existing Structural Cardiac Abnormalities or Other Serious Heart Problems and Sudden Death Children/Adolescents: Sudden death has been reported with sympathomimetic drugs used for ADHD treatment at therapeutic doses in children/adolescents with structural cardiac abnormalities or other serious ...
... Pre-existing Structural Cardiac Abnormalities or Other Serious Heart Problems and Sudden Death Children/Adolescents: Sudden death has been reported with sympathomimetic drugs used for ADHD treatment at therapeutic doses in children/adolescents with structural cardiac abnormalities or other serious ...
adderall xr - Shire Canada
... Amphetamines have a potential for abuse, misuse, dependence, or diversion for non-therapeutic uses that physicians should consider when prescribing this product( see PRECAUTIONS, Dependence Liability.) The misuse of amphetamines may cause serious cardiovascular adverse events and sudden death. Pre-e ...
... Amphetamines have a potential for abuse, misuse, dependence, or diversion for non-therapeutic uses that physicians should consider when prescribing this product( see PRECAUTIONS, Dependence Liability.) The misuse of amphetamines may cause serious cardiovascular adverse events and sudden death. Pre-e ...
Approved Drug Utilization Review Board Edits
... The C-II Stimulants belong to a drug class that is included on the Medicaid Preferred Drug List (PDL). Please view the Medicaid website for the PDL list of preferred and non-preferred drugs in ...
... The C-II Stimulants belong to a drug class that is included on the Medicaid Preferred Drug List (PDL). Please view the Medicaid website for the PDL list of preferred and non-preferred drugs in ...
Methylphenidate
Methylphenidate (trade names Concerta, Methylin, Medikinet, Ritalin, Equasym XL, Quillivant XR, Metadate) is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Methylphenidate has been studied and researched for over 50 years and has a very good efficacy and safety record for the treatment of ADHD. The original patent was owned by CIBA, now Novartis Corporation. It was first licensed by the U.S. Food and Drug Administration (FDA) in 1955 for treating what was then known as hyperactivity.Prescribed to patients beginning in 1960, the drug has become increasingly prescribed since the 1990s, when the diagnosis of ADHD itself became more widely accepted. Between 2007 and 2012 methylphenidate prescriptions increased by 50% in Britain and in 2013 global methylphenidate consumption increased to 2.4 billion doses, a 66% increase compared to the year before. The US continues to account for more than 80% of global consumption.ADHD and other similar conditions are believed to be linked to sub-performance of the dopamine and norepinephrine functions in the brain, primarily in the prefrontal cortex, responsible for self-regulatory function (e.g., inhibition, motivation, and memory) and executive function (e.g., reasoning, organizing, problem solving, and planning). Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor. Methylphenidate acts by blocking the dopamine transporter and norepinephrine transporter, leading to increased concentrations of dopamine and norepinephrine within the synaptic cleft. This effect in turn leads to increased neurotransmission of dopamine and norepinephrine. Methylphenidate is also a 5HT1A receptor agonist.